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Articles 661 - 690 of 18900
Full-Text Articles in Entire DC Network
Multixenobiotic Resistance (Mxr) Inhibition And Interactive Toxic Effects Of The Cationic Surfactant, Benzalkonium Chloride, In Embryonic Medaka (Oryzias Latipes), John Gondek
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Contaminated environments represent a challenge to resident species. Organisms must possess underlying mechanisms of resistance to protect against a broad range of environmental insults. One mechanism likely conferring resistance is expression of low substrate specificity membrane efflux transporters termed multixenobiotic resistance (MXR). MXR transporters confer resistance by preventing toxics from entering into cells and also by expelling potentially cyto- and genotoxic metabolites. Chemicals known as chemosensitizers, which can inhibit MXR function thus represent a threat to aquatic organisms. This study used embryos of medaka (Oryzias latipes) to measure MXR activity and inhibition through a dye exclusion assay. This assay was …
Butterfly Movement In A Post Agricultural Landscape, Norah Warchola
Butterfly Movement In A Post Agricultural Landscape, Norah Warchola
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
A central question in landscape ecology is how organisms move through fragmented landscapes. To explore this I have studied how butterflies behave at habitat borders and how readily they move through matrix (non habitat) vegetation. My work focuses on a guild of fruit feeding nymphalid butterflies and how they react to fragmentation in a post agricultural landscape, with emphasis on the behavior and distribution of the Hackberry Emperor Asterocampa celtis and the Question Mark Polygonia interrogationis. Using a combination of observations at habitat edges and large scale trapping across different vegetation types, I measured nymphalid vegetation preference and how this …
The Role Of The Hemopexin Domain Of Matrix Metalloproteinases In Cell Migration, Antoine Hugues-Olivier Dufour
The Role Of The Hemopexin Domain Of Matrix Metalloproteinases In Cell Migration, Antoine Hugues-Olivier Dufour
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
The biological functions of matrix metalloproteinases (MMPs) extend beyond extracellular matrix degradation. Non-proteolytic activities of MMPs are just beginning to become understood. The role of proMMPs in cell migration was herein evaluated using transfected COS-1 cells with various proMMP cDNAs employed in a Transwell chamber migration assay. Latent MMP-2 and MMP-9 enhanced cell migration to a greater extent than latent MMP-1,. 3,. 11 and. 28. To examine if proteolytic activity is required for MMP-enhanced cell migration, three experimental approaches including a fluorogenic substrate degradation assay, transfection of cells with catalytically inactive mutant of MMP cDNAs, and addition of MMP inhibitors …
Home Range, Habitat Selection, And Migratory Pathways Of Canada Geese Wintering At The Santee National Wildlife Refuge, Molly Giles
All Theses
Information on local and flyway-scale space use is lacking for the cohort of migrant geese (Branta canadensis interior) that winter in and adjacent to the Santee National Wildlife Refuge in Summerton, South Carolina. I examined home range and habitat selection of Canada geese in this region. I deployed transmitters on 17 geese (9 VHF and 8 PTT) on wintering grounds at Santee NWR during the winter of 2009-2010. Estimates of fixed kernel home range size ranged from 214.2 to 263.6 ha for VHF-marked geese and 1190.2 to 1915.6 ha for PTT-marked geese. Home ranges of all birds were compact and …
Mundos Subterráneos, No. 21, December 2010, José G. Palacios-Vargas
Mundos Subterráneos, No. 21, December 2010, José G. Palacios-Vargas
KIP Articles
Contents: Las Cuevas Biogénicas. Morfogénesis De Dos Formas Inversas Del Relieve En La Plataforma Insular De Cuba -- La Aplicación Del Índice De Perturbación Cárstica En La Valoración Del Impacto Antropogénico De La Gruta De Atoyac (Veracruz, México) -- Perspectivas Carso-espeleológicas Que Ofrece Costa Rica -- Las Exploraciones Espeleológicas En La Zona De Cerro Brujo, Ocozocoautla, Chiapas, México -- Colémbolos Cavernícolas Y De Otros Ambientes Subterráneos De Quintana Roo, México -- Dos Nuevas Cavidades De Iztacxochitla, Puebla, México -- “espeleo Rescate México” 10 Años México, Urion -- Topografía De La Cueva “mediceos”, Iztacxochitla, Puebla -- Topografía De La Cueva El …
Wing Pathology Of White-Nose Syndrome In Bats Suggests Life-Threatening Disruption Of Physiology, Paul M. Cryan, Carol Uphoff Meteyer, Justin G. Boyles, David S. Blehert
Wing Pathology Of White-Nose Syndrome In Bats Suggests Life-Threatening Disruption Of Physiology, Paul M. Cryan, Carol Uphoff Meteyer, Justin G. Boyles, David S. Blehert
KIP Articles
White-nose syndrome (WNS) is causing unprecedented declines in several species of North American bats. The characteristic lesions of WNS are caused by the fungus Geomyces destructans , which erodes and replaces the living skin of bats while they hibernate. It is unknown how this infection kills the bats. We review here the unique physiological importance of wings to hibernating bats in relation to the damage caused by G. destructans and propose that mortality is caused by catastrophic disruption of wing-dependent physiological functions. Mechanisms of disease associated with G. destructans seem specific to hibernating bats and are most analogous to disease …
How Much Anguish Is Enough? Baby Switching And Negligent Infliction Of Emotional Distress, Marc D. Ginsberg
How Much Anguish Is Enough? Baby Switching And Negligent Infliction Of Emotional Distress, Marc D. Ginsberg
DePaul Journal of Health Care Law
No abstract provided.
Dec. 10, 2010, Ifc Performance Standards_V2, Ifc
Dec. 10, 2010, Ifc Performance Standards_V2, Ifc
IFC E&S Performance Standards
No abstract provided.
Expression Of Functional Bacterial Undecaprenyl Pyrophosphate Synthase In The Yeast Rer2{Delta} Mutant And Cho Cells., Jeffrey S. Rush, Sergey Matveev, Ziqiang Guan, Christian R H Raetz, C J Waechter
Expression Of Functional Bacterial Undecaprenyl Pyrophosphate Synthase In The Yeast Rer2{Delta} Mutant And Cho Cells., Jeffrey S. Rush, Sergey Matveev, Ziqiang Guan, Christian R H Raetz, C J Waechter
Molecular and Cellular Biochemistry Faculty Publications
During evolution the average chain length of polyisoprenoid glycosyl carrier lipids increased from C55 (prokaryotes) to C75 (yeast) to C95 (mammalian cells). In this study, the ability of the E. coli enzyme, undecaprenyl pyrophosphate synthase (UPPS), to complement the loss of the yeast cis-isoprenyltransferase in the rer2Δ mutant was tested to determine if (55)dolichyl phosphate (Dol-P) could functionally substitute in the protein N-glycosylation pathway for (75)Dol-P, the normal isoprenologue synthesized in S. cerevisiae. First, expression of UPPS in the yeast mutant was found to complement the growth and the hypoglycosylation of carboxypeptidase Y defects suggesting that the (55)polyprenyl-P-P intermediate was …
Topology And Function Of Nyctalopin In Yeast And In-Vitro Translation Systems., Pasano Pasano Bojang
Topology And Function Of Nyctalopin In Yeast And In-Vitro Translation Systems., Pasano Pasano Bojang
Electronic Theses and Dissertations
Congenital stationary night blindness 1 (CSNBl) is a genetic disorder characterized in humans by night blindness, low visual acuity and myopia. CSNB 1 is caused by defects in genes that are involved in signaling between photoreceptors and depolarizing bipolar cells (DBCs). DBCs utilize a metabotropic glutamate receptor-6 (Grm6) cascade that modulates the activity of a non-specific cation channel. CSNBI is diagnosed by a reduced b-wave in the electroretinogram (ERG). A b-wave indicates that DBCs are depolarized in response to a flash of light. In the dark, there is a tonic release of glutamate from the photoreceptors into the synaptic cleft. …
Decd2010, Robert Kelly
Decd2010, Robert Kelly
Robert Kelly Manuscripts
From December 2010 Robert Kelly Archives
The Conduit, Volume 10, No. 2, December 2010, Annette Summers Engel
The Conduit, Volume 10, No. 2, December 2010, Annette Summers Engel
The KWI Conduit
Contents: Welcome to The Conduit -- President's Corner -- 2011 Karst Award Recipient: William “Bill” Jones -- KWI Happenings -- Upcoming KWI Conference in 2011: Carbonate Geochemistry -- Wilson Scholarship Fundraising Campaign Continues -- 2011 William L. Wilson Scholarship Competition -- Reports from KWI Sponsored Conference Activities -- KWI Sponsorship Levels for Conferences -- Some KWI Books Now Available Online -- Publication Order Form
The Legal-Political Barriers To Ramping Up To Hydro, Dan Tarlock
The Legal-Political Barriers To Ramping Up To Hydro, Dan Tarlock
Chicago-Kent Law Review
Hydroelectric energy is the oldest major source of non-carbon, renewable energy and is the only conventional renewable resource in the current energy mix. Increased hydro capacity would seem to be a key element of any United States energy policy designed to promote the greater use of renewable resources. However, for several decades hydro has been perceived as a mature, fully developed technology. This article argues that any effort to stimulate substantial new hydro capacity will face a series of environmental legal and policy constraints. Efforts to adapt to global climate change will further complicate efforts to increase hydro electric generation. …
Green Diesel: Finding A Place For Algae Oil, Fred Bosselman
Green Diesel: Finding A Place For Algae Oil, Fred Bosselman
Chicago-Kent Law Review
The prospect of obtaining domestically-produced biodiesel from algae has attracted wide investor interest. Although many analysts predict that economic production is five to ten years away, the production process involves such a wide range of environmental and land use issues that it is not premature to begin thinking about the kinds of places in which "green biodiesel" could be efficiently made in the United States. Our land use and environmental laws were all drafted by people who never imagined the possibility that huge volumes of algae would be an important energy resource; nor could they have known that the location …
Using An Audience Response System (Ars) A.K.A. “Clicker” To Do Attention Research, Roger A. Kendrick
Using An Audience Response System (Ars) A.K.A. “Clicker” To Do Attention Research, Roger A. Kendrick
Department of Teaching, Learning, and Teacher Education: Theses and Other Student Research
This study makes an effort to examine whether a student’s attention or engagement is increased by possession of an Audience Response System (ARS, or clicker). This experiment tested a difference in performance. This study makes an effort to examine whether a student’s attention or engagement is increased by possession of an Audience Response System (ARS, or clicker). This experiment tested a difference in performance between students who possessed an ARS and those who did not. The experiment was conducted at a small state college in the Midwest where small class size is typical. Approximately half the students in each tested …
Reducing Estate And Trust Litigation Through Disclosure, In Terrorem Clauses, Mediation And Arbitration, Jonathan G. Blattmachr
Reducing Estate And Trust Litigation Through Disclosure, In Terrorem Clauses, Mediation And Arbitration, Jonathan G. Blattmachr
ACTEC Law Journal
No abstract provided.
Application Of Double Sampling To Combine Measured And Imputed Genotype Data In Genetic Association Studies, Qilong Yuan
Application Of Double Sampling To Combine Measured And Imputed Genotype Data In Genetic Association Studies, Qilong Yuan
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Genotype imputation provides an essential technique for genome-wide association studies (GWAS) with hundreds of thousands of SNPs. Understanding the connection between imputation inconsistencies and the power to detect association at imputed markers or the disease genes close to them is important for the optimal design of imputation-based GWAS since genotype misclassification can significantly decrease statistical power to detect association. Double sampling of genotypes is a statistical procedure in which a portion of subjects receive a second and more precise genotyping. This paper applies the likelihood ratio test allowing for errors (LRT-AE), which incorporates double sample information for genotypes on a …
The Specific Interactions Between Dendritic Cells And Porphyromonas Gingivalis, Amir Emanuel Zeituni
The Specific Interactions Between Dendritic Cells And Porphyromonas Gingivalis, Amir Emanuel Zeituni
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
The broad objective of this dissertation is to elucidate the specific interactions between Porphyromonas gingivalis (P. gingivalis) and dendritic cells (DCs). P. gingivalis is a black pigmented, anaerobic, Gram-negative bacterium that is associated with most cases of chronic periodontitis. P. gingivalis expresses a myriad of virulence factors, most notably, fimbrial adhesins that enable it to bind to and invade host epithelial cells, endothelial cells, macrophages and DCs. While much is known about the 41 kDa major fimbria adhesins of P. gingivalis, the minor fimbriae have received little attention. The results presented here suggest that the minor fimbriae may serve as …
Ecological Effects Of Benthic Suspension Feeding On Plankton Community Structure In Coastal Systems, Jer¢Nimo Pan
Ecological Effects Of Benthic Suspension Feeding On Plankton Community Structure In Coastal Systems, Jer¢Nimo Pan
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
This dissertation explored biological benthic-pelagic coupling in model shallow systems (coastal lagoons) currently at alternative ecological states, most likely the product of intense anthropogenic exploitation of estuarine resources (extractive shellfisheries). Currently, dominant grazers of algae include planktonic microorganisms (nanoflagellates, heterotrophic dinoflagellates, ciliates) instead of significant filtration by macrobenthos. The research focused on the role of benthic suspension-feeding animals in modulating composition, trophic structure, and ecological processes in the planktonic food web at current and hypothetically-increased population densities that would result from restoration.Firstly, laboratory experiments explored the potential of marine mussels (Geukensia demissa, Mytilus edulis) and clams (Mercenaria mercenaria) in grazing …
Mechanism Of Reversion Of Calcium-Induced Differentiation In Keratinocytes, Azadeh Jadali
Mechanism Of Reversion Of Calcium-Induced Differentiation In Keratinocytes, Azadeh Jadali
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Terminal differentiation defines cells that permanently exit the cell cycle in the process of specialization. Under some circumstances, however, this process is reversed as demonstrated by the ability of differentiated keratinocytes to form hair bearing skin epithelia when transplanted onto a suitable environment. To gain insights into the mechanism of reversion of keratinocyte differentiation, a well characterized culture of mouse keratinocytes, in which calcium (Ca2+) concentrations above 0.1 mM induce differentiation was used. A low Ca2+ switch in differentiated cultures triggered culture-wide morphological and biochemical changes indicated by re-initiation of proliferation, de-repression of cyclin D1, and acquisition of basal cell-like …
Synthesis Of Novel Fused Tricyclic And Tetracyclic Skeletons Through Rh(I)-Catalyzed [2+2+2+1] Cycloaddition Of Enediyne Derivatives With Carbon Monoxide, Joseph Junior Kaloko
Synthesis Of Novel Fused Tricyclic And Tetracyclic Skeletons Through Rh(I)-Catalyzed [2+2+2+1] Cycloaddition Of Enediyne Derivatives With Carbon Monoxide, Joseph Junior Kaloko
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Natural products (NP) and their metabolites isolated from diverse origins have been an extraordinary source of active pharmaceuticals, agrochemicals and other applications. Often, NP also serve as templates to obtain more potent and selective agents through structure-activity relationship (SAR) studies. A ubiquitous feature of NP and their metabolites is that they often contain fascinating fused-ring skeletons. Unfortunately, the vast majority of NP cannot be isolated in large quantities from their natural source. Consequently, the need to develop highly efficient synthetic methods that provide access to fused ring-skeletons with handles for further modification is necessary. Transition metal-catalyzed carbocyclization and cycloaddition reactions …
Multinuclear Solid-State Nmr Studies Of Phosphate Uptake By Aluminum (Hydr)Oxides, Wei Li
Multinuclear Solid-State Nmr Studies Of Phosphate Uptake By Aluminum (Hydr)Oxides, Wei Li
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Phosphorus is an essential nutrient for plant growth and agriculture. In aqueous environments, interaction of dissolved phosphate with the surfaces of Al oxyhydroxides and clays is important for controlling its transport, fate and bioavailability. Understanding the reaction mechanisms responsible for phosphate uptake at the molecular level can provide significant insight and improved prediction of phosphate uptake behavior, leading to better strategies for phosphate fertilizationand regulation. In this research, I examined the specific adsorption of phosphate on boehmite (γ-AlOOH) and other Al (hydr)oxides by combining mainly batch sorption techniques, 31P solid-state NMR spectroscopy, quantum chemical calculations and Fouriertransform infrared (FTIR) spectroscopy. …
The Role Of Mesd In Wnt Signaling And Lipoprotein Metabolism, Janet Lighthouse
The Role Of Mesd In Wnt Signaling And Lipoprotein Metabolism, Janet Lighthouse
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Deletion of the mesoderm development (Mesd) gene region blocks gastrulation and mesoderm differentiation in mice. In cell culture, MESD is required for the localization of WNT co-receptors LRP5/6 to the cell membrane. For this reason, loss of LRP5/6 from the cell surface in Mesd mutants likely prevents WNT signaling and is responsible for the polarity defects observed in Mesd-deficient embryos. In this study, we generated a targeted Mesd knockout and verified that loss of Mesd blocks WNT signaling in vivo and mesoderm differentiation. We also identified essential domains in the MESD protein, and demonstrated that MESD function in vitro was …
Functional Analysis Of The Protein Tyrosine Phosphatase Family In Mammary Epithelial Cell Models Of Breast Cancer, Guang Lin
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
The protein tyrosine phosphatase (PTP) superfamily of enzymes is encoded by ~100 genes. In coordinating with protein tyrosine kinases (PTK), they regulate signaling pathways that control a broad spectrum of fundamental physiological processes and their disruption underlie human diseases. To date, however, the functional analysis of PTPs is not as advanced as for PTKs. Therefore, the ultimate goal of this dissertation is to develop the tools for global analysis of the function of PTPs through RNAi-mediated loss-of-function screens. I constructed a PTP short-hairpin RNA (shRNA) library, which contains ~5 shRNAs specifically designed to target each of the PTPs. In collaboration …
From Sin To Sickness: A Qualitative Content Analysis Of Four Major American Newpapers' Representations Of Alcoholism, Amy Platt
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
AbstractFrom Sin to Sickness: A Qualitative Content Analysis of Four Major American Newspapers' Representation of AlcoholismByAmy PlattSchool of Social Welfare The purpose of this study is to explore how four major American newspapers represent alcoholism. These newspapers are: The New York Times, Los Angeles Times, Chicago Tribune, and the Wall Street Journal. Articles were collected over a five year period (2004-2008) using a constructed, random sample. The principal research questions are: (1) How do different newspapers portray alcoholism?, (2) How much emphasis do the articles place on the moral model of addiction? (3) How much emphasis do the articles place …
Contributions Of The Inhibitor Of Kappa B Kinases (Ikks) In Macrophages And Neutrophils After Francisella Tularensis Live Vaccine Strain (Lvs) Infection., Sylvia Samaniego
Contributions Of The Inhibitor Of Kappa B Kinases (Ikks) In Macrophages And Neutrophils After Francisella Tularensis Live Vaccine Strain (Lvs) Infection., Sylvia Samaniego
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
The immune system is a complex network of cells regulated by a number of signaling pathways to drive specific host defenses against invading pathogens. The NF-&kappaB (nuclear factor of the kappa light chain enhancer in B cells) family of inducible transcription factors is a critical regulator of many innate and adaptive immune responses. NF-&kappaB activation by several receptors converges upon two upstream kinases, IKK&alpha and IKK&beta, that regulate gene induction. Many studies report that IKK&beta is the critical kinase involved in NF--&kappaB activation, although at a transcriptional level, both kinases are needed to obtain the full spectrum of gene induction. …
I. Synthesis Of Aryl C-Nucleosides And Retinoid Analogs Ii. Investigation Into Docking Studies Of Bisabosqual Analogs, Erik Stolarzewicz
I. Synthesis Of Aryl C-Nucleosides And Retinoid Analogs Ii. Investigation Into Docking Studies Of Bisabosqual Analogs, Erik Stolarzewicz
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Currently, there are three major approaches used for the synthesis of aryl C-2-deoxyriboses. The first approach uses a common sugar derivative developed by Kool, 1,2-dideoxy-3,5-O-p-toluoyl-alpha-1-chloro-D-ribofuranose. The second approach uses Woski's 2-deoxyribonolactone glycal. The third approach uses a functionalize sugar involving tin reagents developed by Daves. All three methods have certain drawbacks. In efforts to finding a more efficient and alternative approach to making aryl C-deoxynucleosides, we developed a nine step synthetic route from commercially available inexpensive starting materials. In humans, epidermal keratinocytes are unique in their ability to convert Vitamin A1 (retinol) into Vitamin A2 (3,4-didehydroretinol). Each of these alcohols …
Enhancing Solar Disinfection: The Effect, Robert J Wallace
Enhancing Solar Disinfection: The Effect, Robert J Wallace
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Escherichia coli contamination is a continuing issue in the developing world. Lack of funding and difficulty in instituting new projects makes it necessary to discover an affordable, low-cost alternative to traditional methods of sanitation. Recent studies have shown that the hydroxyl radical, which is known to be produced from iron-bearing minerals through the Fenton reaction, can be damaging to both single-celled and multi-cellular organisms. Using hydroxyl radicals produced from low-cost, common materials would be a viable solution to the problem of contamination. It is proposed that using inexpensive, wide-spread, iron-rich materials to produce the hydroxyl radicals could lead to a …
Chromatin Protein Hmgb2 In Neural Progenitor Cells And Adult Neurogenesis, Ariel Benjamin Abraham
Chromatin Protein Hmgb2 In Neural Progenitor Cells And Adult Neurogenesis, Ariel Benjamin Abraham
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Neural stem cells (NSCs) and neural progenitor cells (NPCs) are distinct groups of cells present in the embryonic and adult mammalian central nervous system (CNS). Proliferation of NSCs and NPCs is regulated by several molecular factors including the cyclin dependant kinase inhibitors (CDKI), such as p16Ink4a, and negative regulators of cell cycle, such as p19Arf. Chromatin proteins, including chromatin protein high mobility group A2 (HMGA2), regulate the expression of p16Ink4a and p19Arf in NSCs and NPCs, demonstrating the critical regulatory role that chromatin proteins play in NSC and NPC proliferation. In addition to HMGA2, it is likely that other chromatin …
Correlation Between Structure And Thermoelectric Properties: Searching For Better Thermoelectric Materials, Qing Jie
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
The wide-spread application of thermoelectric devices is important for effective utilization of energy and environment. The market share of thermoelectric devices could potentially reach billions of dollars per year and urgently needs new materials with high energy conversion efficiency, which depends primarily on the thermoelectric figure of merit (ZT). ZT = S2T/(ΡΚ), where S, Ρ, Κ, T are Seebeck coefficient, electrical resistivity, thermal conductivity and absolute temperature, respectively, and S2/Ρ is the power factor (P.F.). ZT could be enhanced by either decreasing the thermal conductivity or increasing the power factor of the material under study. In this work, the relationship …