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Circadian Rhythms In Patients With St-Elevation Myocardial Infarction, Richard Aplin Md, Dr Holmes Md, Fv Acquirre

Articles

BACKGROUND:

Circadian rhythms with regard to time of symptom onset for patients with acute myocardial infarction have been observed, although their relationship to outcomes has been debated. We evaluated these rhythms in patients with ST-elevation myocardial infarction as a function of the 24-hour circadian cycle.

METHODS AND RESULTS:

The relationship between onset of symptoms during the 24-hour circadian cycle and prehospital delays from symptom onset to hospital arrival, timeliness of reperfusion, and in-hospital death was assessed in 2143 patients with ST-elevation myocardial infarction presenting from 2004-2008 at 1 of 3 tertiary-care healthcare ST-elevation myocardial infarction systems. There was …

Mir-237 Is Likely A Developmental Timing Gene That Regulates The L2-To-L3 Transition In C. Elegans, Xi Li

Master's Theses (2009 -)

Development is regulated in both the spatial and temporal dimensions. The developmental timing pathway in C. elegans is the most extensively studied timing mechanism. Many components of the pathway are conserved across phyla. Postembryonic development of C. elegans is comprised of four larval stages (L1 to L4). The lin-4 microRNA regulates development from the L1 to L3 stages by repressing the expression of key developmental timing genes: lin-14 and lin-28. Another microRNA, mir-237, shares sequence similarity with lin-4 and they are grouped into one microRNA family. mir-237 and lin-4 display closely overlapped temporal expression in the hypodermis. I hypothesize that …

Effects Of Biologics On Pedicle Screw Fixation In A Sheep Model: Histological And Biomechanical Analysis, Akshi Arora

Master's Theses (2009 -)

Objective: Osteoinductive recombinant human bone morphogenetic protein (rhBMP–2) was delivered on an absorbable collagen sponge (ACS) within a novel titanium screw implant in an IACUC approved non–osteoporotic ovine spine model. Biomechanical pull–out strength, undecalcified histology, microradiography, and quantitative histomorphometry were used to assess effects of augmentation with rhBMP–2 on the holding power and peri–implant bone formation.

Methodology: rhBMP–2 (0.43 mg/ml) soaked ACS was placed within and around cannulated and fenestrated titanium pedicle screw implants. Sixty–four implants were randomly divided into 4 treatment groups (n=16 each). Biomechanical pull–out testing was done on half of the screws (n=32) to determine the pull–out …

Noxa Mediates Hepatic Stellate Cell Apoptosis By Proteasome Inhibition., Ivette M. Sosa Seda, Justin L. Mott, Yuko Akazawa, Fernando J. Barreyro, Steven F. Bronk, Scott H. Kaufmann, Gregory J. Gores

Journal Articles: Biochemistry & Molecular Biology

Aim: Induction of hepatic stellate cell (HSC) apoptosis is a viable therapeutic strategy to reduce liver fibrogenesis. Although BH3-only proteins of the Bcl-2 family trigger pro-apoptotic pathways, the BH3-only proteins mediating HSC apoptosis have not been well defined. Our aim, using proteasome inhibition as a model to induce HSC apoptosis, was to examine the BH3-only proteins contributing to cell death of this key liver cell subtype. Methods: Apoptosis was induced by treating LX-2 cells, an immortalized human hepatic stellate cell line, and primary rat stellate cells with the proteasome inhibitor MG-132. Results: Treatment with proteasome inhibitors increased expression of Noxa …

A Journey To Self, Theresa Thewes

Creativity and Change Leadership Graduate Student Master's Projects

The initial intent of this project was to define a future direction by focusing on intuitive problem solving and work with a life coach. The plan exploited a tactile preference with work in fiber, glass and paint. In order to enhance skills of reflection, the plan included lessons in yoga and participation in the Expert2Expert conference and the Creative Problem Solving Institute conference. Key learnings of the project included clarification of a strong preference to embrace the present and a willingness to allow the future to unfurl. It became obvious that I also have a clear preference for tactile, creative …

Breast Cancer Dna Methylation Profiles Are Associated With Tumor Size And Alcohol And Folate Intake, Brock C. Christensen, Karl T. Kelsey, Shichun Zheng, E. Andres Houseman, Carmen J. Marsit, Margaret R. Wrensch, Joseph L. Wiemels, Heather H. Nelson, Margaret R. Karagas

Dartmouth Scholarship

Although tumor size and lymph node involvement are the current cornerstones of breast cancer prognosis, they have not been extensively explored in relation to tumor methylation attributes in conjunction with other tumor and patient dietary and hormonal characteristics. Using primary breast tumors from 162 (AJCC stage I-IV) women from the Kaiser Division of Research Pathways Study and the Illumina GoldenGate methylation bead-array platform, we measured 1,413 autosomal CpG loci associated with 773 cancer-related genes and validated select CpG loci with Sequenom EpiTYPER. Tumor grade, size, estrogen and progesterone receptor status, and triple negative status were significantly (Q-values <0.05) associated with altered methylation of 209, 74, 183, 69, and 130 loci, respectively. Unsupervised clustering, using a recursively partitioned mixture model (RPMM), of all autosomal CpG loci revealed eight distinct methylation classes. Methylation class membership was significantly associated with patient race (P<0.02) and tumor size (P<0.001) in univariate tests. Using multinomial logistic regression to adjust for potential confounders, patient age and tumor size, as well as known disease risk factors of alcohol intake and total dietary folate, were all significantly (P<0.0001) associated with methylation class membership. Breast cancer prognostic characteristics and risk-related exposures appear to be associated with gene-specific tumor methylation, as well as overall methylation patterns.

Foreign Language Acquisition, Motivation And Creativity, Xixi Du

Master's Theses or Doctor of Nursing Practice

Previous research has suggested that advanced Second Language (L2) learners are more intrinsically motivated than beginning L2 learners (e.g., Rivers, 1996), and that Third Language (L3) learners are more intrinsically motivated than L2 learners (Schütz, 2007). However, Chomsky (1975) believes that children have to be creative to learn their first language, and others (e.g., Fraser, 2007; Heath & Wolf, 2005) believe that children are creative even when learning a second language. In this research, 67 L2 learners and 38 L3 learners were recruited. They completed a survey including a language achievement scale, an intrinsic motivation scale, and a creativity scale. …

Determining The Fate Of Hybridized Genomes In The Allopolyploid Brassica Napus, Tina Y. Wang

Master's Theses

Polyploidy is widely acknowledged as a widespread mechanism in the evolution and speciation of the majority of flowering plants. Allopolyploid forms through interspecific hybridization and whole genome duplication. While allopolyploids may display increased vigor relative to their progenitors, they can also face challenges to fertility following hybridization. Genetic changes in allopolyploids result from recombination between the hybridized subgenomes, which can influence phenotype and ultimately determine fitness of future generations. To study dynamic changes that follow allopolyploid formation, Brassica napus lineages were derived by hybridizing Brassica oleracea and Brassica rapa. Two lineages of B. napus were analyzed for genetic and phenotypic …

The Effect Of Adding Organic Polymers On The Handling Properties, Strengths And Bioactivity Of A Ca-Sr-Zn-Si Glass Polyalkenoate Cement, A. W. Wren, N. M. Cummins, A. Coughlan, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

This work demonstrates the addition of a number of naturally occurring proteins/polymers to a zinc-based glass polyalkenoate cements (GPCs). Chitin (Chi.), collagen (Col.), cysteine (Cys.) and keratin (Ker.) were added with the intention of improving the bioactivity of this cement. Initial testing involved characterization of the glass with X-ray diffraction (XRD) and differential thermal analysis (DTA) before and after sterilization with γ-irradiation. No significant changes occurred as a result of sterilization. Handling properties of the modified cements were not significantly different from those of the control, BT 101 (Working T_w-36_s, and setting time T_s-70 …

Ecology, Stable Isotopes, And Management Of Grassland Songbirds At National Park Service Properties On The Great Plains, Sarah E. Rehme

School of Natural Resources: Dissertations, Theses, and Student Research

Grassland ecosystems have been severely reduced and grassland bird populations have experienced consistent declines. National Park Service (NPS) properties on the Great Plains provide breeding habitat for grassland songbirds, though little is known about the quality of this habitat. A short-term study on songbirds at three NPS properties complemented current monitoring, providing an among park comparison addressing grassland bird productivity and fidelity relative to NPS property size. During 2008-2009, I assessed avian species richness, and estimated bird density and grassland songbird nest success. Bird species richness was greatest at small and medium sites, while number of nesting obligate species was …

Chloroacetamid Spray Drift And Leaf Tatters In Hackberry, Ariana P. Miller

School of Natural Resources: Dissertations, Theses, and Student Research

During the last decade, leaf tatters has been reported in white oak and hackberry across several Midwestern states. Herbicide spray drift studies have shown that chloroacetamides can induce leaf tatters. The objectives of this research were to: 1) identify vulnerable bud developmental stages in hackberry and 2) determine if different commercial chloroacetamides affect severity of leaf tatters. In 2008, a preliminary spray drift experiment was conducted on mature trees from a former hackberry provenance test stand. Acetochlor (Harness), S-metolachlor (Dual II Magnum), and dimethenamid (Outlook) were applied at concentrations approximating 27%, 54%, 81%, or 108% of the recommended field rate. …

Holocarboxylase Synthetase-Dependent Biotinylation Of Histone H4, Luisa F. Rios Avila

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Holocarboxylase synthetase (HCS) catalyzes the binding of biotin to lysine (K) residues in histones H3 and H4. Histone biotinylation marks play important roles in the repression of genes and retrotransposons. Preliminary studies suggested that K16 in histone H4 is a target for biotinylation by HCS. Here we demonstrated that H4K16bio is overrepresented in repeat regions {pericentromeric alpha satellite repeats; long terminal repeats (LTR)} compared with euchromatin promoters. H4K16bio was also enriched in the repressed interleukin-2 gene promoter. The enrichment at LTR22 and promoter 1 of the sodium-dependent multivitamin transporter (SMVT) depended on biotin supply; and was significantly lower in fibroblasts …

Rhodium-Catalyzed Hydroboration: Directed Asymmetric Desymmetrization, Judy L. Miska

Department of Chemistry: Dissertations, Theses, and Student Research

Rhodium-catalyzed asymmetric hydroboration in conjunction with directing groups can be used control relative and absolute stereochemistry. Hydroboration has the potential to create new C–C, C–O, and C–N bonds from an intermediate C–B bond with retention of stereochemistry. Desymmetrization resulting in the loss of one or more symmetry elements can give rise to molecular chirality, i.e., the conversion of a prochiral molecule to one that is chiral. Unsaturated amides and esters hold the potential for two-point binding to the rhodium catalyst and have been shown to direct the regiochemistry and impact stereochemistry in asymmetric hydroborations of acyclic β,γ-unsaturated substrates. In …

Bending Nature, Bending Law, David Owen

Faculty Publications

No abstract provided.

Effects Of Hydrogen Bonding On Vibrational Normal Modes Of Pyrimidine, Austin A. Howard, Gregory S. Tschumper, Nathan I. Hammer

Chemistry Faculty Research & Creative Works

The effects of weak intermolecular interactions on 10 vibrational normal modes of pyrimidine are investigated by Raman spectroscopy and electronic structure computations. Hydrogen-bonded networks of water induce a shift to higher energy in certain normal modes of pyrimidine with increasing water concentration, while other modes are relatively unaffected. Pyrimidine molecules also exhibit weak C-H⋯N interactions and shifted normal modes upon crystallization. The selective nature of the shifting of normal modes to higher energy allows for definitive assignments of the nearly degenerate ν8a and ν8b modes with polarized Raman spectroscopy. Natural bond orbital (NBO) analyses indicate that when water molecules donate …

Small Molecule Inhibition Of Macrophage Tnf-A Release, Razwana Wahdat

Seton Hall University Dissertations and Theses (ETDs)

Tumor Necrosis Factor Alpha (TNF-a) is a vital pro-inflammatory cytokine produced in response to the activation ofthe innate immune response via the Toll-like receptor signal transduction pathway. This thesis explores the release and inhibition of TNF-a from RAW 264.7 mouse macrophages and human U937 cells that have been exposed to a potent activator of innate immunity. Using lipopolysaccharide (LPS), a Gram negative bacterial endotoxin, in the presence or absence of proinflammatory cytokine interferon 'Y (IFN-y) as activators ofthe TLR-4 pathway, a robust release ofTNF­ a was observed. Co-incubation of stimulated macrophages with the tyrosine phosphatase inhibitor, sodium vanadate, resulted in …

The Effect Of Virtual Reality On Gait Variability, Dimitrios Kastavelis, Mukul Mukherjee, Leslie M. Decker, Nikolaos Stergiou

Journal Articles

Optic Flow (OF) plays an important role in human locomotion and manipulation of OF characteristics can cause changes in locomotion patterns. The purpose of the study was to investigate the effect of the velocity of optic flow on the amount and structure of gait variability. Each subject underwent four conditions of treadmill walking at their self-selected pace. In three conditions the subjects walked in an endless virtual corridor, while a fourth control condition was also included. The three virtual conditions differed in the speed of the optic flow displayed as follows – same speed (OFn), faster (OFf), and slower (OFs) …

Signs & Symbols, Vol. 10, Summer 2010, Illinois State University, Department Of Sociology And Anthropology

Signs & Symbols

Newsletter of the Illinois State University Department of Sociology and Anthropology

Taylor: A Magazine For Taylor University Alumni, Parents And Friends (Summer 2010), Taylor University

The Taylor Magazine (1963-Present)

The Summer 2010 edition of Taylor Magazine, published by Taylor University in Upland, Indiana.

What Feminists Have To Lose In Same-Sex Marriage Litigation, Mary Anne Case

Public Law and Legal Theory Working Papers

This Article highlights both the rewards in accepting and the risks in rejecting a claim of sex discrimination as one constitutional basis for invalidating restrictions on marriage for same-sex couples. It argues that recognition of same-sex marriage and elimination of enforced sex roles are as inextricably intertwined as the duck is with the rabbit in the famous optical illusion. As the Article demonstrates, this has long been clear to opponents, from the pope to David Blankenhorn, but needs to become as clear to proponents and to judges deciding same-sex marriage cases if we are to preserve and extend the liberty …

Denmark's Achievement Of Energy Independence: What The United States Can Learn, Maya Kaplan

Cardozo Journal of International and Comparative Law

The note contrasts Denmark's successful energy policy with the United States' less effective approach, arguing that Denmark's sustained, broad-based strategy—featuring strict enforcement, tax incentives, and community involvement—offers a model for the U.S. to reduce oil dependency and promote renewable energy. The analysis emphasizes the importance of consistent policy measures and the integration of environmental and social costs into energy pricing to achieve long-term economic and environmental benefits.

Advertising And Social Identity, Mark Bartholomew

Buffalo Law Review

This essay takes a stand in the brewing legal academic debate over the consequences of advertising. On one side are the semiotic democratists, scholars who bemoan the ability of advertisers to take control of the meanings that they create through trademark law and other pro-business legal rules. On the other side are those who are more sanguine about the ability of consumers to rework advertising messages and point to several safety valves for free expression existing in the current advertising regulation regime. My take on this debate is that the participants have failed to address the impact of advertising on …

Is The Export-Led-Growth Hypothesis, Valid For Egypt? A Time Series Approach, Nagwa Khashaba, Abdelhamid Mahboub, William Latham, Mostafa Aboelsoud

Economics

This research addresses important empirical questions regarding the relationship between Egyptian exports and Egyptian economic growth by extending the Dirtsakis’s model (Dritsakis, 2004, p. 1834) with the addition of the labor force into the model. The hypothesis to be tested is, does export expansion cause economic growth in Egypt? In other words, is the Export-Led-Growth (ELG) hypothesis valid for Egypt?

This study analyzes the issue of ELG hypothesis in Egypt using the VAR analysis, quarterly time-series data over the period 1991:q1-2009:q4. The results tend to favor the effectiveness and validity of the ELG hypothesis for Egypt.

Annual Report Of Externally Funded Grants And Contracts, July 1, 2009 - June 30, 2010, Office Of Research And Sponsored Programs. Morehead State University.

Office of Research and Sponsored Programs Reports and Publications

Annual Report of Externally Funded Grants and Contracts from July 1, 2009 - June 30, 2010.

Re-Writing The Bhabhian “Mimic Man”: Akin, The Posthuman Other In Octavia Butler’S Adulthood Rites, Aparajita Nanda

English

Cultural critics have sought to define the term posthuman¹ as primarily a condition that does away with hierarchical forms of power and control. It recognizes a transformation of the human species into a subject position that moves from an oppositional politics of segregating the human “self” from the “other” to one of acknowledging the “other” as part of the human “self.” ² With the advent of the posthuman condition comes the need to re-define human rights in a posthuman context. Octavia Butler’s science fiction novel Adulthood Rites³ introduces us to Oankali, gene-trading aliens who travel through space. They …

Prey Selection By Young Green Crabs (Carcinus Maenas), Rock Crabs (Cancer Irroratus) And American Lobsters (Homarus Americanus) In The Gulf Of Maine, Joseph Sungail

All Theses And Dissertations

The intertidal zone in the Gulf of Maine supports large populations of three species of decapods. Young green crabs (Carcinus maenas), rock crabs (Cancer irroratus) and American lobsters (Homarus americanus) co-exist in close proximity and forage on similar prey species. Competition for prey resources could have major implications for the populations of these predators. This experimental study focuses on determining the potential for interspecific competition between these decapods for prey resources. Young green crabs (25 - 35 mm carapace width), rock crabs (25 - 35 mm carapace width) and American lobsters (25 - 35 mm carapace length), were collected along …

Orsp Research Newsletter - Fall 2010, Office Of Research And Sponsored Programs

ORSP Research Newsletter

No abstract provided.

Obesity And Shift Work In The General Population, Robin Eberly, Harvey Feldman

Internet Journal of Allied Health Sciences and Practice

Purpose: This narrative review examines the hypothesis that shift work contributes to the major public health problem of obesity and suggests ways in which weight gain might be prevented in those who must work at times outside of the conventional 8-hour daytime work period. Methods: A comprehensive literature review was performed using several relevant electronic databases and print journals. Results: Those who do shift work are at a greater risk for weight gain than those who work daytime hours. The exact mechanism by which this occurs is unknown, although eating and exercise habits as well as the disruption in circadian …

Histone H2a And H2b Are Monoubiquitinated At Aid-Targeted Loci, Glen M. Borchert, Nathaniel W. Holton, Kevin A. Edwards, Laura A. Vogel, Erik D. Larson

Faculty Publications – Biological Sciences

Background: Somatic hypermutation introduces base substitutions into the rearranged and expressed immunoglobulin (Ig) variable regions to promote immunity. This pathway requires and is initiated by the Activation Induced Deaminase (AID) protein, which deaminates cytidine to produce uracils and UG mismatches at the Ig genes. Subsequent processing of uracil by mismatch repair and base excision repair factors contributes to mutagenesis. While selective for certain genomic targets, the chromatin modifications which distinguish hypermutating from non-hypermutating loci are not defined. Methodology/Principal Findings: Here, we show that AID-targeted loci in mammalian B cells contain ubiquitinated chromatin. Chromatin immunoprecipitation (ChIP) analysis of a constitutively hypermutating …

Short-Chain Carboxylic Acids From Gray Catbird (Dumetella Carolinensis) Uropygial Secretions Vary With Testosterone Levels And Photoperiod, Rebecca J. Whelan, Tera C. Levin, Mary C. Garvin

Faculty & Staff Scholarship

The uropygial gland of birds produces secretions that are important in maintaining the health and structural integrity of feathers. Non-volatile components of uropygial secretions are believed to serve a number of functions including waterproofing and conditioning the feathers. Volatile components have been characterized in fewer species, but are particularly interesting because of their potential importance in olfactory interactions within and across species. We used solid-phase microextraction headspace sampling with gas chromatography-mass spectrometry to detect and identify volatiles in uropygial secretions of gray catbirds (Dumetella carolinensis), a North American migratory bird. We consistently detected the following carboxylic acids: acetic, …