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2010

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Genome-Wide Screening For Functional Factors In Listeria Monocytogenes Biofilm Formation, Yong Ouyang Aug 2010

Genome-Wide Screening For Functional Factors In Listeria Monocytogenes Biofilm Formation, Yong Ouyang

All Theses

ABSTRACT
Listeria monocytogenes is a ubiquitous gram positive food borne pathogen. Ingestion of L.monocytogenes contaminated food can cause serious infections in immune-compromised persons. In addition to planktonic growth, this pathogen can also grow as biofilms under adverse conditions, which has been proved to be more resistant than its planktonic counterpart to various eradications, such as antibiotic treatments. Compared with the extensively studied intracellular replication mechanisms, L.monocytogenes biofilm developmental process is not well understood.
Our research group initiated a systemic study on the molecular mechanisms of L.monocytogenes biofilm formation. A whole genome-scale screening for functional factors involved in L.monocytogenes biofilm development …

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In Vitro Analysis Of Auto-Loom Woven Test Patches For Hernia Repair, Bryant Mersereau Aug 2010

In Vitro Analysis Of Auto-Loom Woven Test Patches For Hernia Repair, Bryant Mersereau

All Theses

Hernias are defects in the layers of the abdominal wall that can cause discomfort or pain and lead to serious health problems if left untreated. A significant portion of the world's population is afflicted by hernia formation, and the cost of treating those affected is in the billions of dollars in the US alone. The current best practices for repairing hernias involve the surgical implantation of polymeric meshes over and around the defect site. The mesh, acting as a synthetic replacement for the damaged abdominal wall layers, provides a barrier to further visceral protrusions through the defect, a support framework …

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An Economic Analysis Of Sediment Control Use At Construction Sites In Greenville County, South Carolina, Jamey Lowdermilk Aug 2010

An Economic Analysis Of Sediment Control Use At Construction Sites In Greenville County, South Carolina, Jamey Lowdermilk

All Theses

Soil erosion from construction sites can cause sedimentation of nearby water bodies. Mandatory sediment controls can reduce sedimentation. What determines the degree to which sediment controls meet regulatory standards for installation and maintenance? A conditional-multinomial logit model is estimated with data from 85 construction sites that were audited in 2001 or 2005 in Greenville County, SC to determine whether 147 sediment ponds or traps were installed correctly, properly maintained, or both. Costs of maintenance positively affect the probability that a sediment pond or trap is properly maintained. Engineering experience positively affects the probability that a structure is properly maintained. Construction …

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Autecology Of The Timber Rattlesnake (Crotalus Horridus) In The South Carolina Mountains., Jeff Mohr Aug 2010

Autecology Of The Timber Rattlesnake (Crotalus Horridus) In The South Carolina Mountains., Jeff Mohr

All Dissertations

Although the most common rattlesnake in the eastern United States, the timber rattlesnake (Crotalus horridus) is little studied and remains poorly understood. Furthermore, populations have been severely diminished throughout its range and only a few scattered metapopulations remain in what was once a large and extensive North American range. Whereas some timber rattlesnake populations in woodland communities of the northeastern and western US have been studied, information on those occurring along the southern part of its range is virtually non-existent. In South Carolina there has been relatively little research done on this rattlesnake and there has been no formal study …

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Probing The Mechanisms Of Platelet Adhesion To Adsorbed Plasma Proteins, Balakrishnan Sivaraman Aug 2010

Probing The Mechanisms Of Platelet Adhesion To Adsorbed Plasma Proteins, Balakrishnan Sivaraman

All Dissertations

Despite over three decades of research in blood-material interactions, the biomaterials field has been unsuccessful in developing a truly non-thrombogenic biomaterial. This is due to an incomplete understanding of the factors underlying biomaterial-associated thrombosis, especially the mechanisms mediating the interactions of platelets with the adsorbed plasma protein layer(s) on the implant surface. The work presented here is motivated by the primary goal of delineating these mechanisms, and understanding the platelet receptors involved, as well as the domains/amino acid sequences they bind to in the protein molecules.
It is critical to differentiate between the amount and the conformation of the adsorbed …

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Modeling Of Cell Transfer And Process-Induced Cell Damage In Laser-Assisted Cell Direct Writing, Wei Wang Aug 2010

Modeling Of Cell Transfer And Process-Induced Cell Damage In Laser-Assisted Cell Direct Writing, Wei Wang

All Dissertations

Laser-assisted cell direct-write technique has been obtaining more and more attention in different biomaterial direct writing applications. A typical laser-assisted cell direct-write process can be divided into two main stages: the cell droplet ejection and cell droplet landing. The objective of this study is to model the cell mechanical profile during the cell droplet ejection and cell landing and further model the cell damage.
The possible cell damage during the droplet ejection process in laser-assisted cell direct writing may come from two different sources: the phase explosion-induced bubble expansion and the thermoelastic stress wave. The bubble expansion-induced stress wave is …

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The Role Of Car And Pxr In Toxicant Sensitivity, Linda Mota Aug 2010

The Role Of Car And Pxr In Toxicant Sensitivity, Linda Mota

All Dissertations

The Constitutive Androstane Receptor (CAR) and the Pregnane X Receptor (PXR) are nuclear receptors of significant importance in the regulation of enzymes that metabolize, detoxify and eliminate compounds from the body. In this study we assessed the protective role of CAR and PXR in the basal and inducible regulation of Cytrochrome P450s (CYPs), and the potential of CAR and PXR to help protect individuals from the organophosphate, parathion and the plasticizer, nonylphenol, putatively due to improved metabolism and elimination. Knockout models of these receptors were used to model susceptible populations such as children that are known to have lower CAR …

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An Examination Of Heritage Resource Internship Experiences And Land Management Agency's Role In Inspiring Emerging Leaders, Carin Vadala Aug 2010

An Examination Of Heritage Resource Internship Experiences And Land Management Agency's Role In Inspiring Emerging Leaders, Carin Vadala

All Dissertations

To address the shortage of people seeking to fill employment vacancies, the land management agencies are using the Student Conservation Association (SCA) and internships as a means of recruiting the next generation of leaders. Yet little research has been conducted on internships in cultural and natural heritage resource parks. This study used a two-phase linear exploratory method to investigate the experiences of cultural and natural heritage resource interns. Additionally, the study sought to determine if and how internships shape vocational, recreational, social and personal identities concerning parks and protected areas. Using significant life experiences, environmental socialization and emerging adulthood theories, …

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Chemical Modification And Biological Activity Exploration Of The Natural Product-Gossypol, Juanjuan Yin Aug 2010

Chemical Modification And Biological Activity Exploration Of The Natural Product-Gossypol, Juanjuan Yin

All Dissertations

Gossypol is a naturally occurring, highly colored yellow pigment indigenous to the small intercellular pigment glands of the cotton plant genus Gossypium, which is proposed to be part of plant's defense system. Gossypol is characterized by wide contraceptive, antiviral, anticancer and antifungal properties. However, the relatively high toxicity of gossypol precludes its application in medical therapy. For this reason the syntheses and tests of gossypol derivatives, have been tried to enable their application as drugs. In our study, gossypol based methylation, glycosylation and nanoconjugate reactions were explored. The gossypol derivatives were all fully characterized by NMR, MS, FT-IR, UV spectrometry, …

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Effects Of Imperviousness On Family Biotic Index Values In The Southern Appalachian Headwaters And Resulting Extension Education, Jon Calabria Aug 2010

Effects Of Imperviousness On Family Biotic Index Values In The Southern Appalachian Headwaters And Resulting Extension Education, Jon Calabria

All Dissertations

Clear, cool headwater streams in the mountains of North Carolina are inextricably linked to the surrounding landscape. Trickling perennial streams drain precipitation from their catchment and are capable of sustaining excellent water quality to support rich aquatic biodiversity that feeds and beneficially contributes to the stream network below. However, headwater ecosystems can be easily compromised by even seemingly insignificant anthropogenic impacts. Small headwater streams were not mapped until recently, and are now known to be ubiquitous. Although the NC Mountains contain some of the highest headwater streams densities in the nation, they remain very susceptible to changes in the catchments …

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Selection For Increased Starvation Resistance Using Drosophila Melanogaster: Investigating Physiological And Life History Trait Responses To Starvation And Dietary Supplementation In The Context Of An Obese Phenotype, Tiffany Elisse Schwasinger-Schmidt Aug 2010

Selection For Increased Starvation Resistance Using Drosophila Melanogaster: Investigating Physiological And Life History Trait Responses To Starvation And Dietary Supplementation In The Context Of An Obese Phenotype, Tiffany Elisse Schwasinger-Schmidt

School of Biological Sciences: Dissertations, Theses, and Student Research

Artificial selection for starvation resistance provided insight into the relationships between evolved physiological and life history trait responses following exposure to biologically induced stress. Investigations of alterations to body composition, metabolic rate, movement, and life history traits including development time, female egg production, and longevity in response to brief periods of starvation were conducted on genetically based starvation-resistant and control lines of Drosophila melanogaster. Analysis of the starvation-resistant lines indicated increased energy storage with increased triglyceride deposition and conversion of carbohydrates to lipid, as identified by respiratory quotient values. Correlations between reductions in metabolic rates and movement in the starvation-resistant …

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Acyl-Chain Mismatch Driven Superlattice Arrangements In Dppc/Dlpc/Cholesterol Bilayers, Brian Cannon, Anthony Lewis, Pentti Somerharju, Jorma Virtanen, Juyang Huang, Kwan H. Cheng Aug 2010

Acyl-Chain Mismatch Driven Superlattice Arrangements In Dppc/Dlpc/Cholesterol Bilayers, Brian Cannon, Anthony Lewis, Pentti Somerharju, Jorma Virtanen, Juyang Huang, Kwan H. Cheng

Physics and Astronomy Faculty Research

Fluorescence and infrared spectroscopy and cholesterol oxidase activity were employed to investigate the effect of phosphatidylcholine (PC) acyl chain length mismatch on the lateral organizations of lipids in liquid-ordered dipalmitoyl-PC/dilauroyl-PC/cholesterol (DPPC/DLPC/CHOL) bilayers. Plots of steady-state fluorescence emission anisotropy of diphenylhexatriene (DPH) labeled PC (DPH-PC) embedded in the DPPC/DLPC/CHOL bilayers revealed significant peaks at several DPPC mole fractions (YDPPC) when the cholesterol mole fraction (XCHOL) was fixed to particular values. Analogously, the DPH-PC anisotropy peaked at several critical XCHOL’s when YDPPC was fixed. Acyl chain C−H and C═O vibrational peak frequencies of …

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Microcantilever Dynamics In Liquid Environment Dynamic Atomic Force Microscopy When Using Higher-Order Cantilever Eigenmodes, Daniel Kiracofe, Arvind Raman Aug 2010

Microcantilever Dynamics In Liquid Environment Dynamic Atomic Force Microscopy When Using Higher-Order Cantilever Eigenmodes, Daniel Kiracofe, Arvind Raman

Birck and NCN Publications

Dynamic atomic force microscopy is currently evolving from a single to a multifrequency instrument for nanoscale imaging often employing higher-order microcantilever eigenmodes for improved resolution and force spectroscopy. In this work the authors study the fundamentals of cantilever dynamics and energy dissipation when soft cantilevers are driven at their second flexural eigenmode and interact with samples in liquid environments. Contrary to the conventional first eigenmode operation, second eigenmode operation in liquids is often dominated by a subharmonic response (e.g., one tap every four drive cycles) and there is an energy transfer to the first eigenmode creating a new channel of …

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August 2010 Commencement Program, Bowling Green State University Aug 2010

August 2010 Commencement Program, Bowling Green State University

Commencement Programs

No abstract provided.

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Review Of Economics, Culture And Social Theory, John B. Davis Aug 2010

Review Of Economics, Culture And Social Theory, John B. Davis

Economics Faculty Research and Publications

No abstract provided.

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The Effect Of Whey On The Growth And Survival Of Isthmohyla Pseudopuma Tadpoles, August 2010, Patricia L. Stamper Aug 2010

The Effect Of Whey On The Growth And Survival Of Isthmohyla Pseudopuma Tadpoles, August 2010, Patricia L. Stamper

Monteverde Institute: Tropical Ecology and Conservation

Water contamination and poor water quality in general have escalated in recent years. Streams and rivers located near dairy farms are commonly polluted by a byproduct of cheese making,whey. Due to factors such as water degradation, amphibian species have been experiencing rapid population declines worldwide. The purpose of this study was to determine the effects of whey waste on Isthmohyla pseudopuma tadpole growth and survival. It was found that whey waste generally has a negative effect on I. pseudopuma tadpole survival and little effect on the growth. Additional observations such as metamorphosis were observed towards the end of the experiment, …

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A Participatory Assessment Of Immigrant Integration In A Low-Income Suburban Neighborhood, Matthew John Soerens Aug 2010

A Participatory Assessment Of Immigrant Integration In A Low-Income Suburban Neighborhood, Matthew John Soerens

College of Liberal Arts & Social Sciences Theses and Dissertations

While much immigration research has been focused upon urban areas, recent trends in migration patterns show that more and more immigrants are moving to the suburbs, which has resulted in some unique integration challenges. This research focuses on a particular suburban Chicago neighborhood, seeking to determine who is living there, to what extent they are making connections with the larger community and with other groups living within the same neighborhood, and what factors they believe will best assist in their integration. Utilizing a participatory research method that seeks to engage the community in question—the Parkside Apartments in the western suburbs …

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Death At Birth: The Political, Economic And Social Impact Of The Decolonization And Perpetual, Neocolonial Control Of Congo., Jason B. Locke Aug 2010

Death At Birth: The Political, Economic And Social Impact Of The Decolonization And Perpetual, Neocolonial Control Of Congo., Jason B. Locke

College of Liberal Arts & Social Sciences Theses and Dissertations

This work argues that the predatory policies of Western powers, especially the United States, in regards to the decolonization and subsequent neocolonial stranglehold of Congo created a situation in which any nationalistic, truly independent-minded government would be stifled and ultimately fail—a failure documented and exacerbated by the United States Central Intelligence Agency. With the added pressure of a poorly-educated elite class of leaders and military and diplomatic intervention surrounding Congo’s independence in the summer of 1960, questions emerge as to the level of success any new, indigenous government could achieve. These policies of intervention, often clandestine, by foreign powers constitute …

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An Emperical Study Of Diffusion: The Role Of Particle Size, Particle Shape, Gravity, And Edge Effects, Alexis V. Knaub Aug 2010

An Emperical Study Of Diffusion: The Role Of Particle Size, Particle Shape, Gravity, And Edge Effects, Alexis V. Knaub

College of Liberal Arts & Social Sciences Theses and Dissertations

The theories of Brownian motion and diffusion are often treated as separate idea, though Brownian motion is believed to cause diffusion. Both theories were initially studied separately in this project via two experiments; the theories were then studied in conjunction. The Brownian motion experiment examined milk fat globules and Cabosil particles in colloidal suspensions under a microscope, following their trajectory for 10 seconds. A flow model was developed to determine the diffusion coefficients. Drag coefficients revealed the geometry is correlated with the diffusion coefficients. The Diffusion experiment used a custom-made, thermally isolated chamber to study diffusion in the horizontal and …

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Study Of The Efficacy, Biodistribution, And Safety Profile Of Therapeutic Gutless Adenovirus Vectors As A Prelude To A Phase I Clinical Trial For Glioblastoma, Akm Ghulam Muhammad, Mariana Puntel, Marianela Candolfi, A Salem, Kader Yagiz, C Farrokhi, Kurt Kroeger, Weidong Xiong, James Curtin, Chunyan Liu, K Lawrence, Niyati Bondale, Jonathan Lerner, G Baker, David Foulad, Robert Pechnick, Donna Palmer, Philip Ng, Pedro Lowenstein, Maria Castro Aug 2010

Study Of The Efficacy, Biodistribution, And Safety Profile Of Therapeutic Gutless Adenovirus Vectors As A Prelude To A Phase I Clinical Trial For Glioblastoma, Akm Ghulam Muhammad, Mariana Puntel, Marianela Candolfi, A Salem, Kader Yagiz, C Farrokhi, Kurt Kroeger, Weidong Xiong, James Curtin, Chunyan Liu, K Lawrence, Niyati Bondale, Jonathan Lerner, G Baker, David Foulad, Robert Pechnick, Donna Palmer, Philip Ng, Pedro Lowenstein, Maria Castro

Articles

Glioblastoma multiforme (GBM) is the most common and most aggressive primary brain tumor in humans. Systemic immunity against gene therapy vectors has been shown to hamper therapeutic efficacy; however, helper-dependent high-capacity adenovirus (HC-Ad) vectors elicit sustained transgene expression, even in the presence of systemic anti-adenoviral immunity. We engineered HC-Ads encoding the conditional cytotoxic herpes simplex type 1 thymidine kinase (TK) and the immunostimulatory cytokine fms-like tyrosine kinase ligand 3 (Flt3L). Flt3L expression is under the control of the regulatable Tet-ON system. In anticipation of a phase I clinical trial for GBM, we assessed the therapeutic efficacy, biodistribution, and clinical and …

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Targeted Reform Of Commercialized Intercollegiate Athletics, Mattew J. Mitten, James L. Musselman, Bruce W. Burton Aug 2010

Targeted Reform Of Commercialized Intercollegiate Athletics, Mattew J. Mitten, James L. Musselman, Bruce W. Burton

San Diego Law Review

This Article observes that American society’s passion for intercollegiate sports competition is an extremely powerful, naturally evolved cultural force. The marketplace responds to cultural forces, and the commercialization of college sports directly reflects the marketplace realities of our society. For example, colleges and universities rationally utilize their intercollegiate athletic programs, particularly NCAA Division 1 FBS football and basketball, as a means to achieve a wide range of legitimate objectives of higher education. Thus, the authors advocate that university athletic department revenues should continue to be exempt from federal taxation, specifically the unrelated business income tax (UBIT), despite the increasingly commercialized …

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Institutional Data Book 2009-2010, University Of Minnesota, Morris Office Of Institutional Research Aug 2010

Institutional Data Book 2009-2010, University Of Minnesota, Morris Office Of Institutional Research

Institutional Effectiveness and Research Reports

No abstract provided.

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Local Area Agency On Aging Supports In-Home Nutrition Education For High-Nutritional Risk Seniors, Shelly Johnson Aug 2010

Local Area Agency On Aging Supports In-Home Nutrition Education For High-Nutritional Risk Seniors, Shelly Johnson

Journal of Extension

Area Agency on Aging (AAA) and University of Idaho Extension created the Senior Extension Nutrition Program (SENP) to help high-nutritional risk seniors understand the importance of using food to better manage their health and/or health conditions. Paraprofessionals from Food Stamp Nutrition Education are funded using AAA funds and provide in-home visits to at risk seniors. Paraprofessionals receive oversight from UI faculty and a registered dietitian. A retrospective pre-test survey indicates behavior changes in fruit, vegetable, dairy, and water consumption and food frequency intake. The program gives these seniors an increase confidence in how to manage their health.

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Beef, Mutton, Pork, And A Taste Of Turtle: Zooarchaeology And Nineteenth-Century African American Foodways At The Boston-Higginbotham House, Nantucket, Massachusetts, Michael Andrew Way Aug 2010

Beef, Mutton, Pork, And A Taste Of Turtle: Zooarchaeology And Nineteenth-Century African American Foodways At The Boston-Higginbotham House, Nantucket, Massachusetts, Michael Andrew Way

Graduate Masters Theses

In 1774, nearly ten years before slavery was abolished in Massachusetts, an emancipated African American weaver named Seneca Boston purchased a tract of land in the Newtown section of Nantucket, Massachusetts. It is here that over the next thirty years Seneca Boston and his Wampanoag wife, Thankful Micah, would build a house, now known as the Boston-Higginbotham House, and raise six children. The Boston-Higginbotham House was home to the descendents of Seneca Boston and Thankful Micah for over one hundred years. Throughout the 19th century a vibrant and active African American community was developing in Newtown, and several generations of …

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The Challenge Of Head & Neck Squamous Cell Carcinoma Control In Pakistan, Syed Mohammad Asad Zaidi, Nauman Fazal Manzoor, Shabbir Akhtar Aug 2010

The Challenge Of Head & Neck Squamous Cell Carcinoma Control In Pakistan, Syed Mohammad Asad Zaidi, Nauman Fazal Manzoor, Shabbir Akhtar

Section of Otolaryngology, Head & Neck Surgery

No abstract provided.

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Blastocystis Hominis And Dientamoeba Fragilis In Patients Fulfilling Irritable Bowel Syndrome Criteria., Javed Yakoob, Wasim Jafri, Mohammad Asim Beg,, Z Abbas, Shagufta Naz,, Muhammad Islam, Rustam Khan Aug 2010

Blastocystis Hominis And Dientamoeba Fragilis In Patients Fulfilling Irritable Bowel Syndrome Criteria., Javed Yakoob, Wasim Jafri, Mohammad Asim Beg,, Z Abbas, Shagufta Naz,, Muhammad Islam, Rustam Khan

Section of Gastroenterology

Studies have suggested a possible role for Blastocystis hominis and Dientamoeba fragilis in the etiology of irritable bowel syndrome (IBS). We studied the prevalence of B. hominis and D. fragilis in patients with IBS-diarrhea (IBS-D). Three hundred and thirty patients were enrolled, 171 (52%) with IBS-D and 159 (48%) were controls, respectively. Stool microscopy, culture, and polymerase chain reaction (PCR) for B. hominis and D. fragilis were done. B. hominis was positive by stool microscopy in 49% (83/171) of IBS compared to 24% (27/159) in control (p < 0.001). B. hominis culture was positive in 53% (90/171) in IBS compared to 16% (25/159) in control (p < 0.001). B. hominis PCR was positive in 44% (75/171) in IBS compared to 21% (33/159) in control (p < 0.001). D. fragilis microscopy was positive in 3.5% (6/171) in IBS-D compared to 0.6% (1/159) in control (p = 0.123). D. fragilis culture was positive in 4% (7/171) in IBS compared to 1.3% (2/159) in control (p = 0.176). D. fragilis PCR was positive in 4% (6/171) in IBS-D compared to 0% (0/159) in control (p = 0.030). B. hominis is common, while D. fragilis was less prevalent in our patients with IBS-D. B. hominis and D. fragilis culture had a better yield compared to stool microscopy and PCR.

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A Framework For Automatically Repairing Gui Test Suites, Si Huang Aug 2010

A Framework For Automatically Repairing Gui Test Suites, Si Huang

School of Computing: Dissertations, Theses, and Student Research

Testing is an effective means for assuring the quality of software. In programs with Graphical User Interfaces (GUIs), event sequences serve as test cases for executing system tests. To aid in the test generation process, researchers have developed methods that automatically derive graph models from GUIs, which can then be traversed to create sequences for testing. Recent advances using these graph models incorporate combinatorial interaction testing sampling techniques to generate longer GUI test cases, which exercise more event interactions and have been shown to improve fault detection. However, because the models extracted are only approximations of the actual event interactions, …

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Regulation Of Morphogenesis In Filamentous Fungi, Haoyu Si Aug 2010

Regulation Of Morphogenesis In Filamentous Fungi, Haoyu Si

School of Biological Sciences: Dissertations, Theses, and Student Research

One of the distinguishing features of fungal cells is their highly polarized model of growth. Both yeast cells and hyphal cells grow by cell surface expansion at specified cortical sites. Although the same general mechanisms are likely to be involved in controlling the establishment of hyphal polarity in budding yeast and filamentous fungi, it is noticeable that hyphal cells are organized in a fundamentally different manner to yeast dells. For example, hyphal cells organize formins, septins and actins at the division site while simultaneously retain the same machinery at the tip; whereas yeast cells undergo a transient period of isotropic …

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Detection Methods For The Genus Lysobacter And The Species Lysobacter Enzymogenes, Hu Yin Aug 2010

Detection Methods For The Genus Lysobacter And The Species Lysobacter Enzymogenes, Hu Yin

School of Biological Sciences: Dissertations, Theses, and Student Research

Strains of Lysobacter enzymogenes, a bacterial species with biocontrol activity, have been detected via 16S rDNA sequences in soil in different parts of the world. In most instances, however, their occurrence could not be confirmed by isolation, presumably because the species occurred in low numbers relative to faster-growing species of Bacillus or Pseudomonas. In this study, we developed DNA-based detection and enrichment culturing methods for Lysobacter spp. and L. enzymogenes specifically. In the DNA-based method, a region of 16S rDNA conserved among Lysobacter spp. (L4: GAG CCG ACG TCG GAT TAG CTA GTT), was used as the forward …

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Neuropsychological And Emotion Processing Abnormalities In Bipolar Disorder I And Ii, Carol Randall Aug 2010

Neuropsychological And Emotion Processing Abnormalities In Bipolar Disorder I And Ii, Carol Randall

UNLV Theses, Dissertations, Professional Papers, and Capstones

Bipolar disorder illness is marked by emotional lability and mood disturbance, as well as various neuropsychological deficits, and the neuroanatomical correlates of many of these deficits are beginning to be identified. Numerous studies have implicated specific cortical and sub-cortical abnormalities in areas associated with executive function, memory, motor function, and the processing of emotion. Although a large body of research has been devoted to the investigation of cognitive and emotion-processing deficits in bipolar disorder, relatively few studies have been devoted to the investigation of how these deficits differ among bipolar disorder subtypes. This is surprising in light of known symptomatological …

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