Digital Commons Network^™

Deglacial Abrupt Climate Change In The Atlantic Warm Pool: A Gulf Of Mexico Perspective, Carlie Williams, Benjamin P. Flower, David W. Hastings, Thomas P. Guilderson, Kelly A. Quinn, Ethan A. Goddard

Marine Science Faculty Publications

During the last deglaciation, Greenland ice core and North Atlantic sediment records exhibit multiple abrupt climate events including the Younger Dryas cold episode (12.9-11.7 ka). However, evidence for the presence of the Younger Dryas in the Gulf of Mexico (GOM) and the relationship between GOM sea surface temperature (SST) and high-latitude climate change is less clear. We present new Mg/Ca-SST records from two varieties of the planktonic foraminifer Globigerinoides ruber (white and pink) to assess northern GOM SST history from approximately 18.4-10.8 ka. Thirty-five accelerator mass spectrometry (AMS) C-14 dates from Orca Basin core MD02-2550 provide excellent age control and …

The Current Volume 21 : Issue 16, Nova Southeastern University

Student Newspapers

No abstract provided.

Type Ii Protein Arginine Methyltransferase 5 (Prmt5) Is Required For Circadian Pperiod Determination In Arabidopsis Thaliana, Sunghyun Hong, Hae-Ryoung Song, Kerry Lutz, Randall A. Kerstetter, Todd P. Michael, C. Robertson Mcclung

Dartmouth Scholarship

Posttranslational modification is an important element in circadian clock function from cyanobacteria through plants and mammals. For example, a number of key clock components are phosphorylated and thereby marked for subsequent ubiquitination and degradation. Through forward genetic analysis we demonstrate that protein arginine methyltransferase 5 (PRMT5; At4g31120) is a critical determinant of circadian period in Arabidopsis. PRMT5 is coregulated with a set of 1,253 genes that shows alterations in phase of expression in response to entrainment to thermocycles versus photocycles in constant temperature. PRMT5 encodes a type II protein arginine methyltransferase that catalyzes the symmetric dimethylation of arginine residues (Rsme2). …

An Analytic Model Of Neutron Ambient Dose Equivalent And Equivalent Dose For Proton Radiotherapy, Rui Zhang, Angélica Pérez-Andújar, Jonas D. Fontenot, Phillip J. Taddei, Wayne D. Newhauser

Faculty Publications

Stray neutrons generated in passively scattered proton therapy are of concern because they increase the risk that a patient will develop a second cancer. Several investigations characterized stray neutrons in proton therapy using experimental measurements and Monte Carlo simulations, but capabilities of analytical methods to predict neutron exposures are less well developed. The goal of this study was to develop a new analytical model to calculate neutron ambient dose equivalent in air and equivalent dose in phantom based on Monte Carlo modeling of a passively scattered proton therapy unit. The accuracy of the new analytical model is superior to a …

Estimate Of The Uncertainties In The Relative Risk Of Secondary Malignant Neoplasms Following Proton Therapy And Intensity-Modulated Photon Therapy, Jonas D. Fontenot, Charles Bloch, David Followill, Uwe Titt, Wayne D. Newhauser

Faculty Publications

Theoretical calculations have shown that proton therapy can reduce the incidence of radiation-induced secondary malignant neoplasms (SMN) compared with photon therapy for patients with prostate cancer. However, the uncertainties associated with calculations of SMN risk had not been assessed. The objective of this study was to quantify the uncertainties in projected risks of secondary cancer following contemporary proton and photon radiotherapies for prostate cancer. We performed a rigorous propagation of errors and several sensitivity tests to estimate the uncertainty in the ratio of relative risk (RRR) due to the largest contributors to the uncertainty: the radiation weighting factor for neutrons, …

Assessment Of Targeting Accuracy Of A Low-Energy Stereotactic Radiosurgery Treatment For Age-Related Macular Degeneration, Phillip J. Taddei, Erik Chell, Steven Hansen, Michael Gertner, Wayne D. Newhauser

Faculty Publications

Age-related macular degeneration (AMD), a leading cause of blindness in the United States, is a neovascular disease that may be controlled with radiation therapy. Early patient outcomes of external beam radiotherapy, however, have been mixed. Recently, a novel multimodality treatment was developed, comprising external beam radiotherapy and concomitant treatment with a vascular endothelial growth factor inhibitor. The radiotherapy arm is performed by stereotactic radiosurgery, delivering a 16 Gy dose in the macula (clinical target volume, CTV) using three external low-energy x-ray fields while adequately sparing normal tissues. The purpose of our study was to test the sensitivity of the delivery …

Adjustment Of The Lateral And Longitudinal Size Of Scanned Proton Beam Spots Using A Pre-Absorber To Optimize Penumbrae And Delivery Efficiency, Uwe Titt, Dragan Mirkovic, Gabriel O. Sawakuchi, Luis A. Perles, Wayne D. Newhauser, Phillip J. Taddei, Radhe Mohan

Faculty Publications

In scanned-beam proton therapy, the beam spot properties, such as the lateral and longitudinal size and the minimum achievable range, are influenced by beam optics, scattering media and drift spaces in the treatment unit. Currently available spot scanning systems offer fewoptions for adjusting these properties. We investigated a method for adjusting the lateral and longitudinal spot size that utilizes downstream plastic pre-absorbers located near a water phantom. The spot size adjustment was characterized usingMonte Carlo simulations of a modified commercial scanned-beam treatment head. Our results revealed that the pre-absorbers can be used to reduce the lateral full width at half …

Methodology For Determining Doses To In-Field, Out-Of-Field And Partially In-Field Organs For Late Effects Studies In Photon Radiotherapy, Rebecca M. Howell, Sarah B. Scarboro, Phillip J. Taddei, Sunil Krishnan, Stephen F. Kry, Wayne D. Newhauser

Faculty Publications

An important but little examined aspect of radiation dosimetry studies involving organs outside the treatment field is how to assess dose to organs that are partially within a treatment field; this question is particularly important for studies intended to measure total absorbed dose in order to predict the risk of radiogenic late effects, such as second cancers. The purpose of this investigation was therefore to establish a method to categorize organs as in-field, out-of-field or partially in-field that would be applicable to both conventional and modern radiotherapy techniques. In this study, we defined guidelines to categorize the organs based on …

Risk Of Second Malignant Neoplasm Following Proton Versus Intensity-Modulated Photon Radiotherapies For Hepatocellular Carcinoma, Phillip J. Taddei, Rebecca M. Howell, Sunil Krishnan, Sarah B. Scarboro, Dragan Mirkovic, Wayne D. Newhauser

Faculty Publications

Hepatocellular carcinoma (HCC), the sixthmost common cancer in theworld, is a global health concern. Radiotherapy for HCC is uncommon, largely because of the likelihood of radiation-induced liver disease, an acute side effect that is often fatal. Proton beam therapy (PBT) and intensity-modulated radiation therapy (IMRT)may offer HCC patients a better option for treating the diseased liver tissue while largely sparing the surrounding tissues, especially the nontumor liver. However, even advanced radiotherapies carry a risk of late effects, including second malignant neoplasms (SMNs). It is unclear whether PBT or IMRT confers less risk of an SMN than the other. The purpose …

Predicted Risks Of Second Malignant Neoplasm Incidence And Mortality Due To Secondary Neutrons In A Girl And Boy Receiving Proton Craniospinal Irradiation, Phillip J. Taddei, Anita Mahajan, Dragan Mirkovic, Rui Zhang, Annelise Giebeler, David Kornguth, Mark Harvey, Shiao Woo, Wayne D. Newhauser

Faculty Publications

The purpose of this study was to compare the predicted risks of second malignant neoplasm (SMN) incidence and mortality from secondary neutrons for a 9-year-old girl and a 10-year-old boy who received proton craniospinal irradiation (CSI). SMN incidence and mortality from neutrons were predicted from equivalent doses to radiosensitive organs for cranial, spinal and intracranial boost fields. Therapeutic proton absorbed dose and equivalent dose from neutrons were calculated using Monte Carlo simulations. Risks of SMN incidence and mortality in most organs and tissues were predicted by applying risks models from the National Research Council of the National Academies to the …

Report: The Illinois State University Faculty-Staff Newsletter, December 7, 2010, Illinois State University

Illinois State University Report (1966-2012)

Illinois State University bi-weekly employee newsletter.

Cobalt-Catalyzed Asymmetric Cyclopropanation Of Electron-Deficient Olefins, X. Peter Zhang

USF Patents

Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins.

Cancer Treatment Using C-Type Natriuretic Peptide, David L. Vesely

USF Patents

The present invention includes a method of utilizing four peptide hormones to inhibit the growth of cancer(s). A dramatic decrease in the number of human pancreatic adenocarcinoma cells (i.e., the type of cancer with the highest mortality, with patients only surviving four months) was observed responsive to treatment. The application of the invention would be to utilize one or more of these peptide hormones alone and/or in combination to treat cancer. The ability of these peptide hormones to decrease the number of adenocarcinoma cells has implications for adenocarcinomas at other sites in the body with the majority of cancers of …

Heterosubstituted N-Thiolated Beta-Lactam Compounds And Methods Of Use, Edward Turos, Praveen Ramaraju

USF Patents

The invention relates to heterosubstituted N-thiolated beta-lactams, compositions comprising these compounds, methods for their production, and methods of use as antibiotics to inhibit the growth of bacteria. In one embodiment, the compounds have the structure shown in formula (A) or formula (B) or formula (C):

wherein the R groups are as defined in the specification. The antibacterial agents of the invention can be administered to a human or animal to treat or inhibit bacterial infection, such as that of Staphylococcus species, including methicillin-resistant Staphylococcus aureus (MRSA).

Image Reconstruction For A General Circle-Plus Trajectory, Alexander Katsevich

UCF Patents

Methods, apparatus and systems for an exact filtered back projection process for circle-plus trajectories, which consist of two components: C and L. The first component C, is analogous to a circle in the traditional circle-plus trajectories, is any closed (not necessarily planar) continuous curve. The second component L is almost any continuous curve. The only condition is that L starts below C and ends above C. The process does not depend on the global properties of L. When the source is located on L, one needs to know only how C projects onto the corresponding detector and the properties of …

A Personal Constitution, Michael Serota

NULR Online

Today’s law school graduates face two disturbing trends in the professional world. Each is well known, but neither is openly discussed in the law school setting. First, lawyers suffer from chronic professional dissatisfaction. Approximately one out of every four lawyers is dissatisfied with her job. Second, this dissatisfaction exacts an extraordinarily high price on lawyers, the legal profession, and society as a whole. Most startling, however, is the fact that the widespread dissatisfaction and the associated mental health-related problems prevalent in the legal profession actually begin in law school.

Defining Teaching Excellence: A Phenomenological Study Of Seven Nationally Recognized Secondary Educators, Rosalee A. Swartz

Department of Agricultural Leadership, Education, and Communication: Dissertations, Theses, and Student Research

Change has been an integral part of the American education system since the 1830s (Lucas, 1999) when universities began preparing students to teach. Over the past 20 years, changes including federal mandates (Disabilities Education Act, 1990; No Child Left Behind, 2003) and increasing diversity in school populations require a responding sensitivity from classroom teachers. In the midst of challenges that these changes present, teachers are increasingly asked to do more.

Research shows that nearly 50 percent of new teachers leave within the first five years of teaching, citing issues such as lack of preparation and mentorship, working conditions, pay, and …

Investigation Of Spatial And Temporal Processes Of Lake–Aquifer Interactions In The Nebraska Sand Hills, John T. Ong

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

Interaction between surface water and groundwater is an important component of the water cycle that affects the physicochemical and biological characteristics of lakes, streams, wetlands, and seacoasts. Due to the complex interaction of geologic, topographic, and hydrologic factors, flow between lakes and groundwater remains poorly understood. Evolution of conceptual models over the past 30 years describes processes of advection, dispersion, and free convection that occur in different lake flow regimes. Few detailed field studies document the validity of these conceptual models because of the difficulty of studying the subsurface and the prohibitive cost of instrumenting large areas. In the semi-arid …

Stage Of Diagnosis Of Breast Cancer And Socioeconomic Status In A Universal Healthcare System: A Population-Based Study In Emilia-Romagna, Italy., Daniel Friedberg

Master of Public Health Capstone Presentations

Research has shown that lower socioeconomic status (SES) is associated with later stage of diagnosis of breast cancer in the United States healthcare system, where access to services may be an issue. However, limited data exists as to whether this effect is present in a universal healthcare system, without financial barriers to services. We sought to determine the association between stage of diagnosis of breast cancer and SES using data from Emilia-Romagna, a large region in northern Italy. We identified a population of women with incident breast cancer from 2002-2003 regional cancer registries, including information on cancer stage based on …

Direct Patterning Of Silanized-Biomolecules On Semiconductor Surfaces, Dorjderem Nyamjav, Richard C. Holz

Chemistry Faculty Research and Publications

A novel approach to pattern silanized-biomolecules directly onto glass (SiO_x) substrates via Dip-Pen nanolithography (DPN) and microcontact printing (μCP) is presented. Subsequent hybridization reactions of DPN patterned silanized-DNA with its complementary strands provide “proof-of-concept” that the patterned oligonucleotides maintain their biological activities. The fabrication strategy does not require premodification of substrates and offers a cheap and robust way to immobilize molecules on electronically important semiconductor surfaces.

Sound Mind, Sound Body, Laura Davis

Linfield Magazine

Jesús Ilundáin-Agurruza uses examples from everyday life to explain complex philosophical ideas to his students. He adheres to the Greek ideal of “sound mind, sound body” and gets some of his best ideas while riding his bicycle.

Linfield Center For The Northwest: Hands-On Hub And Diverse Learners, Mardi Mileham

Linfield Magazine

Linfield’s new Center for the Northwest was a catalyst for research this summer – from pavement ants and diverse learners to the Oregon Wine History Project™.

Standard Protocols For The 3 Mst Markers Evaluated, Microbial Source Tracking

EPA Study

This protocol outlines the procedure developed for the EPA Gulf of Mexico grant to Harwood, Lepo and Wang to process environmental water samples via DNA extraction from membrane filters. DNA is then used in PCR-based microbial source tracking assays for human-associated Bacteroides (HBac), M. smithii (Msmithii) and human polyomavirus BK and JC (HPyVs) targets.

Estate Gift Establishes Scholarship For Aspiring Physicians, Winthrop University

Winthrop News 2010

• Dr. Bell finished at Winthrop College in 1934 with a degree in chemistry, then earned a Master of Science degree from Emory and an M.D. from Woman’s Medical College of Pennsylvania.
• It is estimated that her generous estate gifts, totaling more than $326,000, will generate approximately $10,000 in scholarship dollars each year in perpetuity.

Spartan Daily December 6, 2010, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 135, Issue 50

Mustang Daily, December 6, 2010

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

The Statesman, V. 54, I. 15, Stony Brook University

Stony Brook Statesman-Sucolian

v. 54, i. 15

Umsl Magazine - Fall 2010, University Of Missouri-St. Louis

UMSL Magazine and other UMSL Magazines

The University of Missouri–St. Louis publishes UMSL Magazine for alumni and friends. The magazine highlights excellence at the university. Circulation is 79,000, and the magazine is released twice a year.

Current, December 06, 2010, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

December 6, 2010, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.