Digital Commons Network^™

Improved Pcr Design For Mouse Dna By Training Finite State Machines, Salik R. Yadav, Steven M. Corns

Engineering Management and Systems Engineering Faculty Research & Creative Works

This project presents an updated method for classification of polymerase chain reaction primers in mice using finite state classifiers. This is done to compensate for many lab, organism and chemical specific factors that are costly. using Finite State Classifiers can help decrease the number of primers that fail to amplify correctly. for training these classifiers, five different evolutionary algorithms that use an incremental fitness reward are used. Variations to the number of generations and the values in the fitness reward are examined, and the resulting designs are presented. by controlling the fitness reward correctly, there is a potential to develop …

Florida Sentinel Bulletin, August 20, 2010, Gwen Hayes

Florida Sentinel Bulletin Collection

The August 20, 2010, issue of the Florida Sentinel Bulletin.

Muc4, The Integral Membrane Modulator Of Erbb2:The Effects Of Muc4 Expression On Erbb2 And Erbb3 Phosphorylation, Receptor Levels And Sub-Cellular Localization In Breast Cancer Cells Treated With Neuregulin, Patricia F. Boothe

Open Access Dissertations

Muc4, a heterodimeric transmembrane mucin containing EGF-like domains, has been described as an ErbB2-binding protein which modulates signaling via the ErbB2-ErbB3 pathway. In Muc4-transfected MCF-7 cells, Muc4 expression resulted in alteration of both the time course and phosphorylation levels of NRG beta 1 induced phosphorylation and activation of both ErbB2 and ErbB3. Muc4 significantly enhanced the autophosphorylation of ErbB2 over the early (defined 0-30 min) and intermediate (30-120 min) NRG beta 1 treatment times at three sites, Y1248, Y1221 and Y1139. The sites displayed differential maximal phosphorylation times. At Y1248 and Y1139, maximal phosphorylation occurred entirely during the early treatment …

Ay 10-11 Meeting 2010-08-19, Faculty Senate

Faculty Senate Minutes

No abstract provided.

2010-08-19 Unm News Minute, University Of New Mexico Communication And Marketing Department

UNM News Minute 2010

No abstract provided.

Social Science Division Meeting Minutes 08/19/2010, Social Science Division

Social Science Division

No abstract provided.

The Weekly Challenger, August 19, 2010, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The August 19, 2010, issue of The Weekly Challenger.

A Study Of Academic Achievement Differences Between The Genders, Marissa Housman

Theses and Dissertations

This study seeks to explore the academic achievement gap between male and female students by comparing grade point averages across genders. Specifically, the researcher hypothesized that such a gap exists and that females would academically surpass their male counterparts in the classroom. Participants consisted of 300 students in grades 5, 8, and 11 from a public school district in suburban New Jersey. Grade point average (GPA) was generated by converting letter grades into numbers (4.0-0.0) and then averaged. A two-way between-groups analysis of variance (ANOVA) confirmed the hypothesis that females have a higher average GPA than males, as a whole …

Hamilton Decompositions Of 6-Regular Abelian Cayley Graphs, Erik E. Westlund

Dissertations, Master's Theses and Master's Reports - Open

In 1969, Lovasz asked whether every connected, vertex-transitive graph has a Hamilton path. This question has generated a considerable amount of interest, yet remains vastly open. To date, there exist no known connected, vertex-transitive graph that does not possess a Hamilton path. For the Cayley graphs, a subclass of vertex-transitive graphs, the following conjecture was made:

Weak Lovász Conjecture: Every nontrivial, finite, connected Cayley graph is hamiltonian.

The Chen-Quimpo Theorem proves that Cayley graphs on abelian groups flourish with Hamilton cycles, thus prompting Alspach to make the following conjecture:

Alspach Conjecture: Every 2k-regular, connected Cayley graph on a …

Shifts In Postdiscrimination Gradients Within A Stimulus Dimension Based On Female Waist-To-Hip Ratios, Adam Derenne, Michael Breitstein, Rebecca J. Cicha

The Psychological Record

Fifteen participants were trained on a within-subjects basis with two discrimination training conditions and one simple generalization training (control) condition to determine whether gradient shifts can be obtained within a stimulus dimension consisting of women’s waist-to-hip ratios (WHRs). In one discrimination condition, the S– consisted of the “optimal” WHR; in the other, the S– consisted of the approximate mean WHR for adult women. For all three conditions, the S+ was an intermediate value. Under both discrimination training conditions, the generalization gradient was observed to shift away from the S– and toward extreme values on the opposite end of the dimension; …

2010 Fall Convocation Program, Office Of Communications & Marketing, Morehead State University.

Communications and Marketing Publications Archive

Fall convocation program held on August 18, 2010.

Jsphylosvg: A Javascript Library For Visualizing Interactive And Vector-Based Phylogenetic Trees On The Web, Samuel A. Smits, Cleber C. Ouverney

Faculty Publications, Biological Sciences

Background
Many software packages have been developed to address the need for generating phylogenetic trees intended for print. With an increased use of the web to disseminate scientific literature, there is a need for phylogenetic trees to be viewable across many types of devices and feature some of the interactive elements that are integral to the browsing experience. We propose a novel approach for publishing interactive phylogenetic trees.

Methods/Principal Findings
We present a javascript library, jsPhyloSVG, which facilitates constructing interactive phylogenetic trees from raw Newick or phyloXML formats directly within the browser in Scalable Vector Graphics (SVG) format. It is …

The Murray Ledger And Times, August 18, 2010, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Governmental Public Health: An Overview Of State And Local Public Health Agencies, Eileen Salinsky

National Health Policy Forum

The Patient Protection and Affordable Care Act significantly expands federal support for community prevention and public health. This paper describes the governmental public health infrastructure at both the state and local level in terms of organizational structure, activities, financing, workforce, partnerships, and performance improvement efforts.

Integrated Affinity Column Capillary Electrophoresis Microdevices For Biomarker Analysis, Weichun Yang

Theses and Dissertations

In this dissertation, microfluidic systems that integrate antibody-based sample preparation methods with electrophoretic separation are developed to analyze multiple biomarkers in a point-of-care setting. To form an affinity column, both monolith materials and wall-coated channels were explored. I successfully demonstrated that monolith columns can be prepared in microfluidic devices via photopolymerization. The selectivity of monolith columns was improved by immobilizing antibodies on the surface. These affinity columns can selectively enrich target analytes and reduce the signal of contaminant proteins up to 25,000 fold after immunoaffinity extraction. These results clearly demonstrate that microchip affinity monoliths can selectively concentrate and purify target …

Tickets Available To Unh Therapeutic Riding Program Benefit Luncheon Sept. 18, Cindy Burke

Media Relations

No abstract provided.

The Daily Egyptian, August 18, 2010, Daily Egyptian Staff

August 2010

No abstract provided.

Modulating Emotion To Understand Prosocial Behavior, Nakia S. Gordon

Psychology Faculty Research and Publications

Reviews the book, Prosocial motives, emotions, and behavior: The better angels of our nature edited by Mario Mikulincer and Phillip R. Shaver

This book serves as a well-organized primer for anyone interested in factors governing prosocial behaviors. Importantly, it also highlights why behaving prosocially is beneficial not only to the recipient but also to the provider, even when that deed is as simple as forgiveness. The broad goal of this book is to integrate what is known about prosocial behavior. The editors do a magnificent job making this edited work tell a cohesive story. In sum, this book does more …

Inhibition Of Allogeneic Inflammatory Responses By The Ribonucleotide Reductase Inhibitors, Didox And Trimidox, Mohammed S. Inayat, Ismail S. El-Amouri, Mohammad Bani-Ahmad, Howard L. Elford, Vincent S. Gallicchio, Oliver R. Oakley

Health and Clinical Sciences Faculty Publications

BACKGROUND: Graft-versus-host disease is the single most important obstacle facing successful allogeneic stem cell transplantation (SCT). Even with current immunosuppressive therapies, morbidity and mortality rates are high. Current therapies including cyclosporine A (CyA) and related compounds target IL-2 signaling. However, although these compounds offer great benefit, they are also associated with multiple toxicities. Therefore, new compounds with a greater efficacy and reduced toxicity are needed to enable us to overcome this hurdle.

METHODS: The allogeneic mixed lymphocyte reaction (MLR) is a unique ex vivo method to study a drug's action on the initial events resulting in T-cell activation and proliferation, …

Historic Class

News Releases

No abstract provided.

Blood Lipids, Infection, And Inflammatory Markers In The Tsimane Of Bolivia, Sarinnapha Vasunilashorn, Eileen M. Crimmins, Jung Ki Kim, Jeff Winking, Michael Gurven, Hillard Kaplan, Caleb Finch

ESI Publications

Objectives—Little is known about blood cholesterol (blood-C) levels under conditions of infection and limited diet. This study examines blood-C and markers of infection and inflammation in the Tsimane of the Bolivian Amazon, indigenous forager farmers living in conditions that model preindustrial European populations by their short life expectancy, high load of infections and inflammation, and limited diets.

Methods—We use multivariate models to determine the relationships between lipid levels and markers of infection and inflammation. Adult Tsimane (N = 418, age 20–84) were characterized for blood lipids, cells, and inflammatory markers in relation to individual loads of parasites and …

Mitochondrial Control Region Variation Among The Subspecies Of Sarus Crane (Grus Antigone), Ranajit Das

Theses

Sarus cranes (Grus antigone) are the tallest members of the crane family, Gruidae. They are found in four geographically distinct regions: northwest India (Indian Sarus- Grus antigone antigone), southeast Asia (Burmese Sarus- Grus antigone sharpei) and northern Australia (Australian Sarus- Grus antigone gillae). Although the three subspecies are morphologically distinct, their genetic distinctness is unclear. In this study, I focused on control region sequences of mitochondrial DNA (mtDNA) to assess the genetic and phylogeographic distinctness of Sarus subspecies. I used samples from four fragmented populations, seven from India, 16 from southeast Asia, five from Myanmar and eight from Australia. Phylogenetic …

Quantification Of Aflatoxin B1 In Ready-To-Use Food Thickeners In South-East Geo-Political Zone In Nigeria, G. I. Okwu, Premila N. Achar, Santosh K. Sharma

Faculty Articles

A total of 150 ready to use food thickeners were randomly collected from various markets in both urban and rural settings. Four of the samples tested Achi (Brachystegia eurycoma), Akpalata (Afzelia africana), Ofor (Detarium microcarpum), and Ukpo (Mucuna flagellipes) were contaminated with fungal flora. The most common and prevalent fungi observed on incubated powdered form of food thickeners on media, were the Aspergillus group namely Aspergillus flavus, Aspergillus parasiticus and Aspergillus niger. Pure isolates of A. flavus and A. parasiticus from various food thickeners from open markets in Nigeria were screened for their potential to produce aflatoxin B-1 (AFB(1)) on …

What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang

Open Access Publications

No abstract provided.

Development And Applications Of The Hint Forcefield In Prediction Of Antibiotic Efflux And Virtual Screening For Antivirals, Aurijit Sarkar

Theses and Dissertations

This work was aimed at developing novel tools that utilize HINT, an empirical forcefield capable of quantitating both hydrophobic and hydrophilic (hydropathic) interactions, for implementation in theoretical biology and drug discovery/design. The role of hydrophobicity in determination of macromolecular structure and formation of complexes in biological molecules is undeniable and has been the subject of research across several decades. Hydrophobicity is introduced, with a review of its history and contemporary theories. This is followed by a description of various methods that quantify this all-pervading phenomenon and their use in protein folding and contemporary drug design projects – including a detailed …

The Social Outcomes Of School Mathematics: Standard, Unintended Or Visionary?, Paul Ernest

2009 - 2019 ACER Research Conferences

This session is also available as an audiorecording.

Mechanisms Of Oxidant Generation By Catalase, Diane E. Heck, Michael Shakarjian, Hong-Duck Kim, Jeffrey Laskin, Anna M. Vetrano

NYMC Faculty Publications

The enzyme catalase converts solar radiation into reactive oxidant species (ROS). In this study, we report that several bacterial catalases (hydroperoxidases, HP), including Escherichia coli HP-I and HP-II also generate reactive oxidants in response to ultraviolet B light (UVB). HP-I and HP-II are identical except for the presence of NADPH. We found that only one of the catalases, HPI, produces oxidants in response to UVB light, indicating a potential role for the nucleotide in ROS production. This prompts us to speculate that NADPH may act as a cofactor regulating ROS generation by mammalian catalases. Structural analysis of the NADPH domains …

Opioid Receptor Active Compounds, William J. Walsh, Seong Jae Yu, Anil Nair

UMSL Patents

The invention provides compounds of formula I: wherein R¹ to R⁴ and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating pain and treating other conditions which involve, for example, binding opioid receptors using compounds of formula I.

Trans-Excision-Splicing Ribozyme And Methods Of Use, Stephen M. Testa, Michael A. Bell

Chemistry Faculty Patents

A group I intron-derived ribozyme which binds RNA in trans, excises an internal segment from within the RNA, and splices the remaining 5′ and 3′ ends of the RNA back together (the trans-excision-splicing reaction) is disclosed. The excised segment can be as long as 28 nucleotides, or more, and as little as one nucleotide. The ribozymes of the invention are easily modified to alter their sequence specificity. Such ribozymes represent a new and potentially powerful class of generally adaptable genetic therapeutics.

Synthesis And Characterization Of Mechanical Properties Of A Novel Bioceramic Composite Material For Biological Applications, Jillian Ladegard

Engineering

Bioceramics are used in a wide range of human skeletal repair and restoration applications as a synthetic bone substitute. 45S5 Bioglass, a bioactive ceramic, exhibits poor mechanical properties limiting the potential of the material and preventing its use in major load bearing applications. This investigation evaluated the synthesis and mechanical properties of a 45S5 Bioglass composite reinforced with different weight percentages of multi-wall carbon nanotubes. The material was analyzed using an X-Ray Diffractometer and a scanning electron microscope to determine the crystal structure, microstructural homogeneity, and surface texture of the composite material. The material was evaluated during the synthesis process …