Digital Commons Network^™

A Roof Runoff Strategy And Model For Augmenting Public Water Supply, Robert Carnahan

USF Tampa Graduate Theses and Dissertations

Water is the essential resource that is becoming extremely scarce worldwide. The 21st century will further stress all available water resources through the growth and expansion of developing nations. It is not only the quantity of cheap water that is being depleted, but the quality of these waters is being endangered. Florida is an example where rapid development and an exploding population are competing for shrinking groundwater resources. Current water use does not address the use of alternative supplies and reuses in the United States.

The objective of this research was to determine a strategy for augmenting existing water supplies …

Design, Combinatorial Synthesis, And Biological Evaluation Of Novel Α-Helical Mimetics Based On Functionalized Piperazines As Antagonists Of P53/Mdm2 Interactions, Melissa Elizabeth Topper

USF Tampa Graduate Theses and Dissertations

The p53 protein promotes tumor eradication upon activation, making it an attractive target in cancer therapies. A reported 50% of all human cancers display aberrant activation of the MDM2 oncoprotein, which directly promotes tumorgenesis by inactivating the transcriptional activity of wild type p53, and is commonly associated with drug, chemo, and radio therapy resistance. Previously reported crystallographic analysis of the p53/MDM2 complex infers that the p53 protein forms a 2.5 turn amphipathic alpha helix whose hydrophobic face interacts within a deep hydrophobic cleft in the NH2-terminal domain of the globular MDM2. This suggests that the synthesis of small molecular antagonists …

Design And Combinatorial Synthesis Approach Of Non-Peptidic Trimeric Small Molecules Mimicking I, I + 4(3), I + 7 Positions Of Alpha-Helices, Mingzhou Zhou

USF Tampa Graduate Theses and Dissertations

Protein-protein interactions are key to several biological processes that facilitate signal transduction and many other processes. These interactions are involved in pathways that are critical to many human diseases. Targeting specific protein-protein interactions is a challenging goal because protein-protein interactions are predominately through hydrophobic interactions. Antagonists of the protein-protein interactions need to be perfectly fit into the binding pockets to ensure the activity. The -helical domain of the proteins behaves as the recognition motifs for numerous protein-protein, and protein-nucleic acid interactions. Research has shown that pathways of many diseases contain protein-protein interactions involving -helical domains, e.g. neurological disorders, bacterial infections, …

Core Promoter Function In Brugia Malayi, Michelle Bailey

USF Tampa Graduate Theses and Dissertations

Previous studies have indicated that the promoters of the human filarial parasite Brugia malayi are unusual in that they do not exhibit the CAAT or TATAA sequences usually found in the core domains of promoters of most eukaryotic organisms. Analysis of the promoters of the ribosomal proteins showed that the region flanking the splice leader (SL) addition site plays an important role in transcription and may function as the core promoter domain in B. malayi. To test the hypothesis that the SL addition domain is the most important essential region of the ribosomal protein promoters, the SL addition site of …

Discrimination Of Human And Non-Human Sources Of Pollution In Gulf Of Mexico Waters By Microbial Source Tracking Methods And The Investigation Of The Influence Of Environmental Factors On Escherichia Coli Survival, Asja Korajkic

USF Tampa Graduate Theses and Dissertations

Water quality worldwide is assessed by enumeration of fecal indicator bacteria (FIB) (fecal coliforms, Escherichia coli, and enterococci) intended to act as surrogates for human enteric pathogens. In environmental waters, this predictive relationship is confounded by many possible sources of FIB with varying implications for human health. Many physico-chemical and biological factors influence the fate of enteric pathogens and FIB in aquatic habitats, but are poorly understood, thus limiting our understanding of the usefulness of FIB as fecal pollution indicators.

These studies explored the field application of a “toolbox” approach to microbial source tracking (MST) intended to discriminate between human …

Evolution Of The Hammerhead Cephalofoil: Shape Change, Space Utilization, And Feeding Biomechanics In Hammerhead Sharks (Sphyrnidae), Kyle Reid Mara

USF Tampa Graduate Theses and Dissertations

The relationship between form and function is often used to elucidate the biological role of a structure. Hammerhead sharks offer a unique opportunity to study form and function through phylogeny. Because sphyrnid sharks display a range of cranial morphologies this group can be used to address questions about the evolution of cranial design and investigate the effects of changes in head morphology on feeding structures and bite force. Geometric morphometrics, volumetric analyses, morphological dissections, and phylogenetic analyses of the cephalofoil were used to gain insight into changes in cranial design through evolutionary history. External morphometrics and internal volumetric analyses indicated …

My Mr. 50s, Jaclyn Burt

Fresh Voices: Composition at Cal Poly

In her essay “My Mr. 50s,” author Jaclyn Burt uses vivid descriptions to explore how a favorite accessory helped shape her identity. Do any of these descriptions stand out to you? If so, why? How does Burt’s use of language bring the relationship between objects and the construction of the self to life for the reader?

Although the author is writing about her glasses, do more universal themes emerge? She discusses the way the glasses helped create an identity for her, but says, “ultimately you’re the one that changes you.” What do you think she means by this? As you …

An International Challenge, Rosalia Rochon

Fresh Voices: Composition at Cal Poly

Rosalia Rochon profiles Cal Poly faculty member Dr. Peggy Papathakis and her sincere concern for public health. What aspects of Papathakis’s personality does Rochon emphasize in this profile, and how does Rochon use specific events to support her claims about Papathakis? A major focus in this essay is Papathakis’s work with HIV-infected mothers and infants. How would the initial focus of the essay shift if Papathakis’s HIV work had a more prominent position in the introduction? Consider how Rochon uses her personal feelings as support for Papathakis’s influential nature and desire to create change in the world beyond her academic …

Where Are The Crazy People?, Caitlin Lee

Fresh Voices: Composition at Cal Poly

Caitlin Lee’s “Where Are the Crazy People?” focuses on Cal Poly Professor Lars Tomanek’s commitment to and passion for the environment. The author organizes her discussion according to a pattern of carefully selected responses to the interview questions that illustrate a particular depiction of her subject. This strategy of relying on Dr. Tomanek’s responses results in a sense of immediacy for the reader, in effect providing the audience a privileged glimpse into the interview and the subject’s worldview. Also, because ideas are sequenced analytically and rhetorically, not strictly chronologically, the essay maintains its focus on the analytical thesis by using …

The Chanticleer, 2010-08-30, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

On Two-Stage Hypothesis Testing Procedures Via Asymptotically Independent Statistics, James Y. Dai, Charles Kooperberg, Michael Leblanc, Ross L. Prentice

UW Biostatistics Working Paper Series

Kooperberg08 proposed a two-stage testing procedure to screen for significant interactions in genome-wide association (GWA) studies by a soft threshold on marginal associations (MA), though its theoretical properties and generalization have not been elaborated. In this article, we discuss conditions that are required to achieve strong control of the Family-Wise Error Rate (FWER) by such procedures for low or high-dimensional hypothesis testing. We provide proof of asymptotic independence of marginal association statistics and interaction statistics in linear regression, logistic regression, and Cox proportional hazard models in a randomized clinical trial (RCT) with a rare event. In case-control studies nested within …

Spartan Daily August 30, 2010, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 135, Issue 2

Commonwealth Times 2010-08-30

Commonwealth Times, 1969-

No abstract provided.

The Statesman, V. 54, I. 01, Stony Brook University

Stony Brook Statesman-Sucolian

v. 54, i. 01

Current, August 30, 2010, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

August 30, 2010, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

The Murray Ledger And Times, August 30, 2010, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Faculty Senate Executive Committee Agenda, August 30, 2010, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• Blackboard Vista License Renewal
• Graduate Council Report
• Send Section 402.4 - 402.13 and 405.11.4 to PRPC
• Research Council Member approval by Faculty Senate

2010 August 30 - Graduate Council Minutes, College Of Graduate And Continuing Studies, East Tennessee State University

Graduate Council Agendas and Minutes

No abstract provided.

The Utah Statesman, August 30, 2010, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

The Daily Gamecock, Monday, August 30, 2010, University Of South Carolina, Office Of Student Media

August

No abstract provided.

Trampling The Public Trust, Debra L. Donahue

Faculty Articles

Livestock production is a chief contributor to many significant and intractable environmental problems This Article examines the causal role of livestock especially beef production in global climate change predator control in the western United States and winter elk feeding in Wyoming It argues that ending livestock grazing on western public lands is a cost effective first step for dealing with these problems and is readily achievable under existing law Removing livestock would lead to improved watershed conditions and make reintroduction of predators politically feasible which would promote further recovery of landscapes impacted by native ungulate populations Ending publicland grazing would …

The Pan American (2010-08-30), Kristen Cabrera

UTPA Archives - The Pan American Newspaper

Vol. 67, No. 1

The Collegian (2010-08-30), Christine Cavazos

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 63, No. 2

Memristive Adaptive Filters, T. Driscoll, J. Quinn, S. Klein, H. T. Kim, B. J. Kim, Yuriy V. Pershin Dr, M. Di Ventra, D. N. Basov

Faculty Publications

Using the memristive properties of vanadium dioxide, we experimentally demonstrate an adaptive filter by placing a memristor into an LC contour. This circuit reacts to the application of select frequency signals by sharpening the quality factor of its resonant response, and thus “learns” according to the input waveform. The proposed circuit employs only analog passive elements, and may find applications in biologically inspired processing and information storage. We also extend the learning-circuit framework mathematically to include memory-reactive elements, such as memcapacitors and meminductors, and show how this expands the functionality of adaptive memory filters.

Dynamic Solidification In Nanoconfined Water Films, Peter M. Hoffmann, Shah H. Khan, George Matei, Shivprasad Patil

Publications

Mechanical properties of nanoconfined water layers are still poorly understood and continue to create controversy, despite their importance for biology and nanotechnology. We report on dynamic nanomechanical measurements of water films compressed to a few single molecular layers. We show that the mechanical properties of nanoconfined water layers change significantly with their dynamic state. In particular, we observed a sharp transition from viscous to elastic response even at extremely slow compression rates, indicating that mechanical relaxation times increase dramatically once water is compressed to less than 3–4 molecular layers.

Trends In Chemical Information Literacy And Collection Development, 2000–2009, Jeremy R. Garritano

Libraries Research Publications

This review covers major trends in the field of chemical information over the past ten years and how they influenced information literacy and collection development practices of chemical information specialists. Particular attention is given to changes in information literacy and discovery practices as they relate to developments in chemical information resources, the integration of various resources online, and the creation of information literacy standards in the 2000s. Also, changes in licensing and purchasing for online resources as they relate to pricing models, ownership, platform, and distribution are discussed as major influences to new collection development practices.

Central Florida Future, Vol. 42 No. 52, August 30, 2010

Central Florida Future

Some teachers get raises; By the numbers; 2010 Election Preview; Sinkronized; Fast-A-Thon honors Ramadan; UCF alum visits campus years later.

Transcriptional Profiles For Glutamate Transporters Reveal Differences Between Organophosphates But Similarities With Unrelated Neurotoxicants, Theodore A. Slotkin, Doug Lobner, Frederic J. Seidler

Biomedical Sciences Faculty Research and Publications

The developmental neurotoxicity of organophosphates involves mechanisms other than their shared property as cholinesterase inhibitors, among which are excitotoxicity and oxidative stress. We used PC12 cells as a neurodevelopmental model to compare the effects of chlorpyrifos and diazinon on the expression of genes encoding glutamate transporters. Chlorpyrifos had a greater effect in cells undergoing nerve growth factor-induced neurodifferentiation as compared to undifferentiated PC12 cells, with peak sensitivity at the initiation of differentiation, reflecting a global upregulation of all the glutamate transporter genes expressed in this cell line. In differentiating cells, chlorpyrifos had a significantly greater effect than did diazinon and …

Chemistry Major Gwen Bitker '11, Le Sueur, Explores And Experiences The Strength Of Bonds, University Relations

Campus News Archive

Bitker is the inaugural recipient of the Chemistry Undergraduate Research Fund Award.