Digital Commons Network^™

1,2,3,4-Tetrahydroacridones As Potential Inhibitors Of Atovaquone-Resistant And Atovaquone- Susceptible P. Falciparum Isolates Tm90-C2b And W2, Lisa Luong

Honors Thesis and Capstone Projects

Malaria is one of the most significant parasitic diseases affecting mankind today, exceeding 200 million annual cases worldwide1. This disease has been a serious issue due to developed resistance to commonly available antimalarial drugs including atovaquone and artemisinin2, the most relevant modern treatment (figure 1.1). This project focuses on the preparation of 1,2,3,4- tetrahydroacridones (figure 1.2) that can be tested for their activity against P. falciparum isolates TM90-C2B (an atovaquone-resistant parasitic strain) and W2 (an atovaquone-susceptible parasite). In the past, studies have shown that endochins (4(1H)-quinolones) 3 and acridines (figure 1.1) have been found to exhibit antimalarial activity4. The research …

The Daily Egyptian, December 10, 2010, Daily Egyptian Staff

December 2010

No abstract provided.

A Space Acquisition Leading Indicator Based On System Interoperation Maturity, Jason T. Shibata

Theses and Dissertations

The Department of Defense‘s space acquisition enterprise has experienced numerous challenges since the advent of space power. Space borne capabilities are needed more than ever, but space acquisition frequently fails to meet its goals. The decades of space acquisition experience form a rich history that can be used to build a leading indicator of success to enable effective program execution. First, the space acquisition areas of greatest concern were determined to be cost, schedule and requirements. These areas are considered as systems composed of the people, processes and products that execute the program. Second, the vital interoperation characteristics, or attributes …

Flyer News, Vol. 58, No. 20 (Dec. 10, 2010), University Of Dayton

Flyer News

Student-run newspaper of the University of Dayton.

Stevenson Center Compass, Vol. 4, Iss. 1, December 10, 2010, Illinois State University, Stevenson Center For Community And Economic Development

Stevenson Center Compass

Newsletter for the Stevenson Center for Community and Economic Development

Ua3/4/1 President's Office-Downing Subject/Correspondence File, Wku Archives

WKU Archives Collection Inventories

Subject file regarding the Dero Downing administration.

Coupling Sediment Transport And Water Quality Models, Yi Xiong

Theses and Dissertations

Sediment has profound effects on water quality. Correspondingly, water quality modeling often needs sediment transport modeling. However, simplified descriptive sediment transport was originally employed for water quality modeling, and the linkage between sediment transport models and water quality models is less developed. Therefore, the main purposes of this study were to develop general methods of coupling sediment transport and water quality models and to improve sediment transport modeling for water quality modeling. Linkage of sediment transport and water quality was discussed and a comprehensive sediment transport literature review was conducted. SEDDEER (Sediment Deposition and Erosion), a stand-alone sediment and contaminant …

A Revision Of The New World Species Of Donacaula Meyrick And A Phylogenetic Analysis Of Related Schoenobiinae (Lepidoptera: Crambidae), Edda Lis Martinez Calez

Theses and Dissertations

Phylogenetic relationships of 13 genera of Schoenobiinae (Lepidoptera: Crambidae) are postulated based on traditional characters of genitalia and wing venation and new characters of the descaled whole body. The phylogenetic analysis yielded one most-parsimonius tree (length 287 steps, CI= .36, RI= .62) that resulted in a monophyletic clade of all genera of Schoenobiinae examined. The monophyly of the Schoenobiinae is supported by a Bremer support value of five. Donacaula is not congeneric with the type-species of Schoenobius, S. gigantellus. The analysis confirms Lewvanich‘s hypothesis that Scirpophaga, Donacaula, Schoenobius, Catagela, and Helonastes are closely related. Based on this analysis, the New …

A Meta-Analysis Of School-Based Childhood Obesity Prevention Programs, Ling Shen Hung

Theses and Dissertations

The prevalence rate of childhood obesity has increased rapidly worldwide. The childhood obesity epidemic is associated with many adverse health consequences in children as well as a financial burden for a nation’s economy. A meta-analysis was conducted to investigate the effectiveness of school-based childhood obesity prevention programs in preventing childhood obesity. The objectives of this study were to 1) identify the most effective childhood obesity prevention programs through effect size comparison, and 2) identify important program components that affect the effectiveness of the intervention through subgroup analysis. The Comprehensive Meta-Analysis (CMA) program was used for all statistical analyses. Results of …

Detection And Characterization Of A Volatile Compound As A Response To Fall Armyworm (Spodoptera Frugiperda) Feeding In Maize (Zea Mays), Whitney Elizabeth Crow Smith

Theses and Dissertations

Maize (Zea mays) is an important agricultural crop frequently targeted by pests that pose a threat to plant development and survival. To deal with this problem, maize generates a wide variety of responses to attack by pests, from activation of woundresponse pathways to the release of volatile compounds. Several maize lines have been developed that show resistance to one common pest, the larvae of the fall armyworm (Spodoptera frugiperda). Analysis of the volatiles released by the resistant and susceptible lines in the presence and absence of the fall armyworm was conducted using SPME coupled to GC/MS. Caryophyllene, a commonly released …

Clarifying The Effects Of Neighborhood Context On Violence “Behind Closed Doors”, Emily M. Wright, Michael L. Benson

Criminology and Criminal Justice Faculty Publications

Research on neighborhood-level effects on intimate partner violence (IPV) has expanded significantly in the past two decades. However, to date, studies have been unable to disentangle compositional and contextual effects on IPV and have rarely considered the social mechanisms that might link neighborhood conditions to IPV. Using data from the Project on Human Development in Chicago Neighborhoods, this study considers individual and contextual influences on violence between partners, and examines the effects of disadvantage and collective efficacy on this type of behavior. Results indicate that neighborhood disadvantage significantly increases and collective efficacy significantly decreases IPV after controlling for individual-level correlates. …

A Comparative Study Of Embedded And Anesthetized Zebrafish In Vivo On Myocardiac Calcium Oscillation And Heart Muscle Contraction, Brian S. Muntean, Christine M. Horvat, James H. Behler, Wissam A. Aboualaiwi, Andromeda M. Nauli, Frederick E. Williams, Surya M. Nauli

Pharmacy Faculty Articles and Research

The zebrafish (Danio rerio) has been used as a model for studying vertebrate development in the cardiovascular system. In order to monitor heart contraction and cytosolic calcium oscillations, fish were either embedded in methylcellulose or anesthetized with tricaine. Using high-resolution differential interference contrast and calcium imaging microscopy, we here show that dopamine and verapamil alter calcium signaling and muscle contraction in anesthetized zebrafish, but not in embedded zebrafish. In anesthetized fish, dopamine increases the amplitude of cytosolic calcium oscillation with a subsequent increase in heart contraction, whereas verapamil decreases the frequency of calcium oscillation and heart rate. Interestingly, verapamil also …

The Beacon - Vol 9 No. 7 - December 10, 2010, Merrimack College

The Beacon

The Beacon - the student newspaper of Merrimack College. Volume 9, Number 7 - December 10, 2010. 12 pages

Modeling Heat Transfer During Cooling Of Ready-To-Eat Meat And Poultry Products Using Three-Dimensional Finite Element Analysis And Web-Based Simulation, Jihan F. Cepeda Jimenez

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

The meat industry is required to comply with processing performance standards for preventing the growth of foodborne pathogens in products. These performance standards, established by the United States Department of Agriculture - Food Safety and Inspection Service (USDA-FSIS) require a reduction of Salmonella spp (lethality standard) and limit the growth of sporeforming bacteria (stabilization standard) in certain processed meat products. In general, strategies used to comply with these standards are associated with thermal processing. Meat processors have difficulties complying with these performance standards. Moreover, thermal processing deviations are an issue in the meat industry that generate uncertainty regarding the safety …

Organizational, Job, And Supervisory Antecedents And Consequence Of Job Embeddedness: The Case Of Vietnam, Vinh Q. Nguyen

Theses and Dissertations

A recent major development in the turnover literature is the introduction of the Job Embeddedness (JE) construct. JE is a multidimensional construct conceptualized as the combined forces that tend to keep an employee from leaving his or her job. Research has demonstrated that JE predicts voluntary turnover above and beyond the variables used in traditional turnover models. However, since it is a relatively new construct, JE has received very limited study, especially across cultures. Further research is needed in order to understand both antecedents and consequences of JE. This dissertation, therefore, investigates a range of presumed organizational, job, and supervisory …

Production Of Second Generation Biofuels From Woody Biomass, Sanjeev Kumar Gajjela

Theses and Dissertations

Increased research efforts have recently been accelerated to develop liquid transportation fuels from bio-oil produced by fast pyrolysis. However, these bio-oils contain high levels of oxygenated compounds that require removal to produce viable transportation fuels. A variety of upgrading technologies have been proposed, of which catalytic hydroprocessing of the raw bio-oil has appears to have the best potential due to the fact that no fractionation of the bio-oil is required prior to treatment. The objective of this research was to apply two-stage catalytic hydroprocessing to bio-oil with heterogeneous catalysts to produce hydrocarbon fuels. To achieve this objective seven catalysts were …

Screening Of New Commercial And Experimental Gossypium Hirsutum Cultivars For Tolerance To The Reniform Nematode (Rotylenchulus Reniformis), Julie Anna Blessitt

Theses and Dissertations

The reniform nematode is a major pest affecting common upland cotton in the United States. Management of this pest in cotton fields only gives partial control and is sometimes neither economical nor profitable. Past research has shown no resistance to the reniform nematode in currently available commercial cotton cultivars. Screenings of several currently available cotton cultivars for tolerance to the reniform nematode were conducted in the growing seasons of 2006 and 2007 at the Delta Branch Experiment Station in Stoneville MS. Several cultivars were identified as tolerant and productive including ‘Croplan Genetics 3520 B2RF,’ ‘DynaGrow 2520 B2RF,’ and ‘Stoneville 5242 …

Gene Network Inference And Expression Prediction Using Recurrent Neural Networks And Evolutionary Algorithms, Heather Y. Chan

Theses and Dissertations

We demonstrate the success of recurrent neural networks in gene network inference and expression prediction using a hybrid of particle swarm optimization and differential evolution to overcome the classic obstacle of local minima in training recurrent neural networks. We also provide an improved validation framework for the evaluation of genetic network modeling systems that will result in better generalization and long-term prediction capability. Success in the modeling of gene regulation and prediction of gene expression will lead to more rapid discovery and development of therapeutic medicine, earlier diagnosis and treatment of adverse conditions, and vast advancements in life science research.

Relations Of Depression, Social Support, And Socio-Demographic Factors On Health Behaviors Of Mothers With Premature Infants Hospitalized In A Neonatal Intensive Care Unit (Nicu), Surbhi Kanotra

Theses and Dissertations

The present study examined the relationships of depression, social support, and socio-demographic factors on health behaviors of mothers with preterm infants hospitalized in the neonatal intensive care unit (NICU). In addition, the study also assessed the moderation effect of social support on the relationship between depression and health behaviors. Eighty-nine mothers with hospitalized infants in the central Richmond area participated in the study. Analyses found that mother’s education level and her marital status to be significantly associated with her health behaviors. Mothers with a higher level of education and those who were married, were less likely to smoke and more …

Factors Influencing Macroinvertebrate Diversity And Community Composition In Riverine Freshwater Rock Pools, Chtaura Jackson

Theses and Dissertations

I examined a system of 378-riverine rock pools situated along the James River in Richmond, Virginia, to uncover the factors influencing their macroinvertebrate diversity and community composition. I characterized (total = 60) the physical characteristics, water quality, hydrology, and community assemblages in July 2009 for a subset of pools. I examined whether selected environmental factors (pH, nearest neighbor distance, depth, surface area and inundation height) were related to macroinvertebrate diversity and community composition. Species richness and total abundance of all taxa increased with pool pH and surface area. Ordination indicates that nearest neighbor distance (NND) and pH varied significantly among …

Chimes: December 10, 2010, Calvin College

Chimes

'Wednesday' hits stage by Jasmine Wilson

Calvin gets new land for Christmas by Amanda Elliott

Foreign students face mistreatment by Rachel Hekman

Humans are a species unlike any other on the planet by Matthew Koh

Make, bake, share Christmas chear by Kendra Haan

Hope slashed and iced in Knight victory by Tim Clover

Swim and dive teams host annual Calvin Winter Invitational by Luke Leisman

Economic Impact Of On-Board Module-Building Cotton Harvesters On Replacement Schedule And Harvest Costs, Matthew Alan Farrell

Theses and Dissertations

The purpose of this study is to further understand the economic impact of the new on-board module-building cotton harvesters that both John Deere and Case IH have introduced to the market. This study will examine two different areas, the optimal asset replacement schedule and a machine’s performance rate’s effect on harvest costs due to rainfall loss. Using data collected from Willcut (2008), USDA crop progress reports, and a USDA weather station, models will be used to study the areas in question. The findings are that, the age of the associated assets begin replaced with the conventional harvester and the number …

Fall Commencement Ceremonies, University Of North Florida

Commencement Printed Materials

Program for the Fall Commencement ceremonies.

Decay And Environmental Studies On Southern Pine, Joseph Martin Dahlen

Theses and Dissertations

This work focused on decay and dimensional stability of southern pine lumber and environmental issues associated with emissions released during kiln drying of southern pine. In one study decking boards were treated with a 3% resin acid solution to increase the dimensional stability. The boards were placed on a roof and weathered for two years. The increased water repellency reduced moisture gain following summer rainstorms by one-third compared to untreated matched samples, this significantly reduced splitting by half and cupping by one-third. In one study decking boards from matched samples were weathered for two years in the roof setup described …

Gasoline-Range Hydrocarbons Produced From Three Types Of Synthesis Gas Using A Mo/Hzsm-5 Catalyst, Jason Tyler Street

Theses and Dissertations

Biomass-derived hydrocarbons that include gasoline, diesel, and jet fuel will help replace finite fossil fuel hydrocarbons of the same range. This study showed that temperature could be controlled in a scaled-up reactor system using three types of syngas. The CO conversion, selectivity and amount of product created from each type of syngas were examined. Clean syngas composed of 40% H2, 20% CO, 12% CO2, 2% CH4, and 26 % N2 was used to test ideal stoichiometric molar values. Clean syngas composed of 19% H2, 20% CO, 12% CO2, 2% CH4, and 47 % N2 was used to test an ideal …

Evolution Of The Protein-Coding Genes In The Genomes Of The Mycoplasmatales, Dipaloke Mukherjee

Theses and Dissertations

The bacterial species belonging to the order Mycoplasmatales have highly truncated genomes, and are thus ideal for studying genome evolution patterns. Fourteen members (twelve species) of this order were selected for study of genome evolution based on gene function and phylogeny. A database was constructed that consisting of the set of genes that are common to all of these species, and these genes were further subdivided based on their functions. A Bayesian phylogenetic tree was also constructed from the 16 S ribosomal DNA sequences from these species and robust clades were identified for testing the influence of selection on gene …

Effects Of Prescribed Fire And Selective Herbicide (Imazapyr) On Biodiversity In Intensively Managed Pine Stands Of Mississippi, Raymond Bruce Iglay

Theses and Dissertations

Prescribed fire and imazapyr are two silviculture tools used to control hardwood midstory competition in intensively managed, mid-rotation pine (Pinus spp.) stands but also may support conservation of biodiversity in the southeastern United States. Therefore, I investigated select measures of biodiversity response, small mammals, reptiles, amphibians, carabid beetles, songbirds, and vegetation communities, to fire and imazapyr treatments in intensively managed, mid-rotation pine stands of east-central Mississippi. I used a randomized complete block design of 6 stands (blocks) with 4, 10- ha treatment plots assigned randomly a treatment of burn only, herbicide only, burn + herbicide, or control. I applied dormant …

Enhanced Lipid Production And Biodiesel Yields From Activated Sludge Via Fermentation Of Lignocellulose Hydrolyzate, Andro Hernandez Mondala

Theses and Dissertations

The potential of enhancing lipid accumulation in municipal sewage activated sludge via fermentation of lignocellulose biomass hydrolyzate was investigated. The overall objective was to increase the levels of feedstock lipids in the activated sludge biomass and increase its biodiesel yield via in situ or ex situ transesterification; and improve its cost competitiveness as an abundant feedstock source for biofuels production. To reduce production costs and maintain environmental sustainability, influent wastewater and waste lignocellulose biomass hydrolyzate were used as cultivation media and substrate, respectively. However, lignocellulose hydrolyzates also contain degradation by-products such as furfural and acetic acid that are known to …

Fiber Loop Ringdown Evanescent Field Sensors, Chamini Saumya Herath

Theses and Dissertations

We combine the evanescent field (EF) sensing mechanism with the fiber loop ringdown (FLRD) sensing scheme to create FLRD-EF sensors. The EF sensor heads are fabricated by etching the cladding of a single-mode fiber (SMF), while monitoring the etching process by the FLRD technique in real-time, on-line with high control precision. The effect of the sensor head dimensions on the sensors' detection sensitivity and response time are investigated. The EF scattering (EFS) sensing mechanism is combined with the FLRD detection scheme to create a new type of fiber optic index sensor. The detection limit for an optical index change is …

Biomass-To-Biofuels' Supply Chain Design And Management, Ambarish Madhukar Acharya

Theses and Dissertations

The goal of this dissertation is to study optimization models that integrate location, production, inventory and transportation decisions for industrial products and apply the knowledge gained to develop supply chains for agricultural products (biomass). We estimate unit cost for the whole biomass-to-biofuels’ supply chain which is the per gallon cost for biofuels up till it reaches the markets. The unit cost estimated is the summation of location, production, inventory holding, and transportation costs. In this dissertation, we focus on building mathematical models for designing and managing the biomass-to-biofuels’ supply chains. The computational complexity of the developed models makes it advisable …