Digital Commons Network^™

Medical School Watercooler Newsletter - October 31, 2010, Lindsey Lyle

Watercooler Newsletter

This is the October 31, 2010 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• November Med School Café: Maintaining a Healthy Heart - Separating Fact from Fiction
• Snapshot: USA's 6th Annual Benefits Fair
• Mitochondrial Focus Group Holds First Meeting
• Next Week's DSS - Dr. Zbigniew Darzynkiewicz
• Dr. Jeffrey Brandon Appointed Chair of Radiology

Combat Lifesaver Course, Telemedicine And Advanced Technology Research Center

Telemedicine & Advanced Technology Research Center

No abstract provided.

Gender And The Indonesian Pronouns, Hein Steinhauer

Wacana, Journal of the Humanities of Indonesia

The absence of a gender opposition in the Indonesian pronominal system requires special strategies in the translation from languages which do have such an opposition illustrated in the first part opf this article. In the second part the lexical and morphological means are discussed with which Indonesian expresses gender, culminating in a description of the use of perempuan and wanita, pria and laki-laki.

Data For Lexicography; The Central Role Of The Corpus, Allan F. Lauder

Wacana, Journal of the Humanities of Indonesia

This paper looks at the nature of data for lexicography and in particular on the central role that electronic corpora can play in providing it. Data has traditionally come from existing dictionaries, citations, and from the lexicographer's own knowledge of words, through introspection. Each of these is examined and evaluated. Then the electronic corpus is considered. Different kinds of corpora are described and key design criteria are explained, in particular the size of corpus needed for lexicography as well as the issue of representativeness and sampling. The advantages and disadvantages of corpora are weighed and compared against the other types …

The Bible In Danger? An Appreciation And Criticism., Rev. Gabriel Oussani

The Open Court

No abstract provided.

Gains In Power From Structured Two-Sample Tests Of Means On Graphs, Laurent Jacob, Pierre Neuvial, Sandrine Dudoit

U.C. Berkeley Division of Biostatistics Working Paper Series

We consider multivariate two-sample tests of means, where the location shift between the two populations is expected to be related to a known graph structure. An important application of such tests is the detection of differentially expressed genes between two patient populations, as shifts in expression levels are expected to be coherent with the structure of graphs reflecting gene properties such as biological process, molecular function, regulation, or metabolism. For a fixed graph of interest, we demonstrate that accounting for graph structure can yield more powerful tests under the assumption of smooth distribution shift on the graph. We also investigate …

Molecular Mono-Dikaryon Discrimination Of Fungi “Pleurotus Sajor-Caju”, F.A. Avin, S. Bhassu, S. Vikineswary

Research Publications (2006 to 2010)

All 62 single spore isolates of Pleurotus sajor-caju (monokaryons) could be clearly discriminated from their parents (dikaryons) by amplification of the partial sequence of nuclear ribosomal DNA. Moreover, by using the sequence data, two different types of monospore were identified that will provide very useful background for further breeding and fusion purpose.

2010 Warbonnet Ranch Botanical Survey, Robert F. Steinauer

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

The Nebraska Natural Legacy Project (Schneider et al, 2005), a statewide comprehensive wildlife conservation strategy developed by the Nebraska Game and Parks Commission (NGPC), identified the Pine Ridge and Oglala Grasslands of northwestern Nebraska as “Biologically Unique Landscapes” (BULs). Native plant community and rare plant surveys were conducted on the approximately 8,000-acre privately-owned Warbonnet Ranch. The Ranch occurs within both of the above mentioned BULs and is topographically and geologically diverse. The primary goal of this survey was to document the botanical resources of a well-managed, privately-owned, western Nebraska range and determine its potential for conservation of Nebraska’s biological diversity. …

Conference Program

Steroid Use, Abuse and Policy Symposium (2010)

No abstract provided.

Back Where They Once Belonged? Local Response To Afforestation In County Kerry, Ireland, Matthew S. Carroll, Áine Ní Dhubháin, Courtney G. Flint

Sociology, Social Work and Anthropology Faculty Publications

Afforestation has many benefits at the local regional and global scale. The local social impacts of planting new forests, however, depend on a variety of contextual factors and other details including who is doing the planting, which species are being planted, the location of the planting and, perhaps most importantly, existing land uses and their linkage to social and economic circumstances. This article presents case study research into these issues in two places in County Kerry Ireland. Utilising the concept of the differentiated landscape, we examine the somewhat varying social responses to afforestation in the two study sites in light …

Reporter - October 29th 2010, Rit Reporter Staff

University Publications

No abstract provided.

V. 78, Issue 6, October 29, 2010

Archway (1946-2020)

No abstract provided.

Neural Coding And Decoding, Alexander Dimitrov

Systems Science Friday Noon Seminar Series

Methods based on Rate Distortion theory have been successfully used to cluster stimuli and neural responses in order to study neural codes at a level of detail supported by the amount of available data. They approximate the joint stimulus-response distribution by quantizing paired stimulus-response observations into smaller reproductions of the stimulus and response spaces. An optimal quantization is found by maximizing an information-theoretic cost function subject to both equality and inequality constraints, in hundreds to thousands of dimensions. This analytical approach has several advantages over other current approaches:

• it yields the most informative approximation of the encoding scheme given the …

A Taxonomic Revision Of Camptocerus Dejean (Coleoptera: Curculionidae: Scolytinae), Sarah M. Smith, Anthony I. Cognato

Insecta Mundi

The Neotropical ambrosia beetle genus Camptocerus Dejean was revised. Monophyly of the genus was tested using 66 morphological characters in a cladistic analysis. Camptocerus was recovered as monophyletic and 31 species were recognized. Six new synonyms were discovered: C. auricomus Blandford 1896 (= C. striatulus Hagedorn 1905), C. inoblitus (Schedl) 1939 (= C. morio (Schedl) 1952), C. niger (Fabricius) 1801 (= C. tectus Eggers 1943), C. opacicollis (Eggers) 1929 (= C. infidelis Wood 1969; = C. uniseriatus Schedl 1972), C. suturalis (Fabricius) 1801 (= C. cinctus Chapuis 1869). Two species were removed from synonymy: C. charpentierae Schedl and C. hirtipennis …

Genome Dynamics Are Influenced By Food Source In Allogromia Laticollaris Strain Csh (Foraminifera), Laura Wegener Parfrey, Laura A. Katz

Biological Sciences: Faculty Publications

Across the eukaryotic tree of life, genomes vary within populations and within individuals during their life cycle. Understanding intraspecific genome variation in diverse eukaryotes is key to elucidating the factors that underlie this variation. Here, we characterize genome dynamics during the life cycle of Allogromia laticollaris strain CSH, a member of the Foraminifera, using fluorescence microscopy and reveal extensive variation in nuclear size and DNA content. Both nuclear size and DNA content are tightly correlated across a 700-fold range in cell volume. In contrast to models in yeast where nuclear size is determined solely by cell size, the relationship in …

Filtering Of Visual Information In The Tectum By An Identified Neural Circuit, Filippo Del Bene, Claire Wyart, Estuardo Robles, Amanda Tran, Loren Looger, Ethan K. Scott, Ehud Y. Isacoff, Herwig Baier

Neuroscience: Faculty Publications

The optic tectum of zebrafish is involved in behavioral responses that require the detection of small objects. The superficial layers of the tectal neuropil receive input from retinal axons, while its deeper layers convey the processed information to premotor areas. Imaging with a genetically encoded calcium indicator revealed that the deep layers, as well as the dendrites of single tectal neurons, are preferentially activated by small visual stimuli. This spatial filtering relies on GABAergic interneurons (using the neurotransmitter γ-aminobutyric acid) that are located in the superficial input layer and respond only to large visual stimuli. Photo-ablation of these cells with …

Neural Activity Patterns In Response To Interspecific And Intraspecific Variation In Mating Calls In The Túngara Frog, Mukta Chakraborty, Lisa A. Mangiamele, Sabrina S. Burmeister

Biological Sciences: Faculty Publications

Background: During mate choice, individuals must classify potential mates according to species identity and relative attractiveness. In many species, females do so by evaluating variation in the signals produced by males. Male túngara frogs (Physalaemus pustulosus) can produce single note calls (whines) and multi-note calls (whine-chucks). While the whine alone is sufficient for species recognition, females greatly prefer the whine-chuck when given a choice. Methodology/Principal Findings: To better understand how the brain responds to variation in male mating signals, we mapped neural activity patterns evoked by interspecific and intraspecific variation in mating calls in túngara frogs by measuring expression of …

Crusader, October 29, 2010, College Of The Holy Cross

Student Newspapers

The student newspaper for the College of the Holy Cross in Worcester, Massachusetts. Articles include coverage of campus events and issues, sports, editorials and special features.

Cyanidin-3-Glucoside Inhibits Ethanol-Induced Invasion Of Breast Cancer Cells Overexpressing Erbb2, Mei Xu, Kimberly A. Bower, Siying Wang, Jacqueline A. Frank, Gang Chen, Min Ding, Shiow Wang, Xianglin Shi, Zunji Ke, Jia Luo

Internal Medicine Faculty Publications

BACKGROUND: Ethanol is a tumor promoter. Both epidemiological and experimental studies suggest that ethanol may enhance the metastasis of breast cancer cells. We have previously demonstrated that ethanol increased the migration/invasion of breast cancer cells expressing high levels of ErbB2. Amplification of ErbB2 is found in 20-30% of breast cancer patients and is associated with poor prognosis. We sought to identify agents that can prevent or ameliorate ethanol-induced invasion of breast cancer cells. Cyanidin-3-glucoside (C3G), an anthocyanin present in many vegetables and fruits, is a potent natural antioxidant. Ethanol exposure causes the accumulation of intracellular reactive oxygen species (ROS). This …

Widespread Transcriptional Autosomal Dosage Compensation In Drosophila Correlates With Gene Expression Level, Ashley A. Mcanally, Lev Y. Yampolsky

ETSU Faculty Works

Little is known about dosage compensation in autosomal genes. Transcription-level compensation of deletions and other loss-of-function mutations may be a mechanism of dominance of wild-type alleles, a ubiquitous phenomenon whose nature has been a subject of a long debate. We measured gene expression in two isogenic Drosophila lines heterozygous for long deletions and compared our results with previously published gene expression data in a line heterozygous for a long duplication. We find that a majority of genes are at least partially compensated at transcription, both for 1/2-fold dosage (in heterozygotes for deletions) and for 1.5-fold dosage (in heterozygotes for a …

Finite Element Analysis Of Thermoelectric Systems With Applications In Self Assembly And Haptics, Patrick T. Mcknight

USF Tampa Graduate Theses and Dissertations

Micro-scale self assembly is an attractive method for manufacturing sub-millimeter sized thermoelectric device parts. Challenges controlling assembly yield rates, however, have caused research to find novel ways to implement the process while still resulting in a working device. While a typical system uses single n-type and p-type material elements in series, one method used to increase the probability of a working device involves adding redundant parallel elements in clusters. The drawback to this technique is that thermal performance is affected in clusters which have missing elements. While one-dimensional modeling sufficiently describes overall performance in terms of average junction temperatures and …

Plasma Mediated Molecular Delivery, Richard J. Connolly

USF Tampa Graduate Theses and Dissertations

Non-viral delivery of plasmid DNA has traditionally relied upon physical forces applied directly to target tissues. These physical methods typically involve contact between an applicator and the target tissue and often cause transient patient discomfort. To overcome the contact-dependent limitations of such delivery methodologies, an atmospheric direct current plasma source was developed to deposit ionized gas molecules onto localized treatment sites. The deposition of charged species onto a treatment site can lead to the establishment of an electric field with strengths similar to those used for traditional electroporation. In vitro experiments proved that this technology could transiently permeabilize cell membranes …

Endothelial Cell Capture Of Heparin-Binding Growth Factors Under Flow, Bing Zhao, Changjiang Zhang, Kimberly Forsten-Williams, Jun Zhang, Michael Fannon

Ophthalmology and Visual Science Faculty Publications

Circulation is an important delivery method for both natural and synthetic molecules, but microenvironment interactions, regulated by endothelial cells and critical to the molecule's fate, are difficult to interpret using traditional approaches. In this work, we analyzed and predicted growth factor capture under flow using computer modeling and a three-dimensional experimental approach that includes pertinent circulation characteristics such as pulsatile flow, competing binding interactions, and limited bioavailability. An understanding of the controlling features of this process was desired. The experimental module consisted of a bioreactor with synthetic endothelial-lined hollow fibers under flow. The physical design of the system was incorporated …

Spartan Daily October 28, 2010, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 135, Issue 33

The Carroll News- Vol. 87, No. 7, John Carroll University

The Carroll News

No abstract provided.

Conserved Genes Act As Modifiers Of Invertebrate Smn Loss Of Function Defects, Maria Dimitriadi, James N. Sleigh, Amy Walker, Howard C. Chang, Anindya Sen, Geetika Kalloo, Jevede Harris, Tom Barsby, Melissa B. Walsh, John S. Satterlee, Chris Li, David Van Vactor, Spyros Artavanis-Tsakonas, Anne C. Hart

Publications and Research

Spinal Muscular Atrophy (SMA) is caused by diminished function of the Survival of Motor Neuron (SMN) protein, but the molecular pathways critical for SMA pathology remain elusive. We have used genetic approaches in invertebrate models to identify conserved SMN loss of function modifier genes. Drosophila melanogaster and Caenorhabditis elegans each have a single gene encoding a protein orthologous to human SMN; diminished function of these invertebrate genes causes lethality and neuromuscular defects. To find genes that modulate SMN function defects across species, two approaches were used. First, a genome-wide RNAi screen for C. elegans SMN modifier genes was undertaken, yielding …

Spectrum, Volume 27, Issue 6, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights Include: Make Your Vote Count for Midterm Elections -- Volunteers Help Bridgeport 'Feel the Warmth' -- Seattle University Strives to Save Environment -- Editorials -- Dance Team 'Jumps on It' -- A Day in the Life: Sacred Heart Ice Hockey

The Comment, October 28, 2010, Bridgewater State University

The Comment

No abstract provided.

Exponent, Vol. 42, Iss. 8, 2010-10-28, University Of Alabama In Huntsville

2010

No abstract provided.

A Map Of Human Genome Variation From Population-Scale Sequencing, David L. Altshuler, Richard M. Durbin, Gonçalo R. Abecasis, David R. Bentley, Aravinda Chakravarti, Andrew G. Clark, Francis S. Collins, Francisco M. De La Vega, Peter Donnelly, Michael Egholm, Paul Flicek, Stacey B. Gabriel, Richard A. Gibbs, Bartha M. Knoppers, Eric S. Lander, Hans Lehrach, Elaine R. Mardis, Gil A. Mcvean, Debbie A. Nickerson, Leena Peltonen, Alan J. Schafer, Stephen T. Sherry, Jun Wang, Richard K. Wilson, David Deiros, Mike Metzker, Donna Muzny, Jeff Reid, David Wheeler, Shenzhen Jun Wang, Jingxiang Li, Min Jian, Guoqing Li, Ruiqiang Li

Faculty Publications

The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and phenotype. Here we present results of the pilot phase of the project, designed to develop and compare different strategies for genome-wide sequencing with high-throughput platforms. We undertook three projects: low-coverage whole-genome sequencing of 179 individuals from four populations; high-coverage sequencing of two mother-father-child trios; and exon-targeted sequencing of 697 individuals from seven populations. We describe the location, allele frequency and local haplotype structure of approximately 15 million single nucleotide polymorphisms, 1 million short insertions and …