Digital Commons Network^™

Exogenous Fms-Like Tyrosine Kinase 3 Ligand Overrides Brain Immune Privilege And Facilitates Recognition Of A Neo-Antigen Without Causing Autoimmune Neuropathology, Daniel Larocque, Nicholas S. R. Sanderson, Josée Bergeron, James Curtin, Joe Girton, Mia Wibowo, Niyati Bondale, Kurt M. Kroeger, Jieping Yang, Liliana M. Lacayo, Kevin C. Reyes, Catherine Farrokhi, Robert N. Pechnick, Maria G. Castro, Pedro R. Lowenstein

Articles

Soluble antigens diffuse out of the brain and can thus stimulate a systemic immune response, whereas particulate antigens (from infectious agents or tumor cells) remain within brain tissue, thus failing to stimulate a systemic immune response. Immune privilege describes how the immune system responds to particulate antigens localized selectively within the brain parenchyma. We believe this immune privilege is caused by the absence of antigen presenting dendritic cells from the brain. We tested the prediction that expression of fms-like tyrosine kinase ligand 3 (Flt3L) in the brain will recruit dendritic cells and induce a systemic immune response against exogenous influenza …

It Takes A Village: Considering The Other Interests At Stake When Extending Inheritance Rights To Posthumously Conceived Children, Morgan K. Wood

Georgia Law Review

The advent of assisted reproductive technologies has brought into existence a new class of children: those not conceived until after the death of one biological parent, or posthumously conceived children. Such a child may be born after a parent dies from a terminal illness or is killed in military action. Is the child legally recognized as the child of the deceased parent,and may the child inherit from that parent's estate? Not surprisingly, the law has been slow to evolve to deal with this relatively new concept. Only twelve states to date have enacted statutes specifically addressing posthumously conceived children, so …

What Is It Like To Be Funny? The Spontaneous Humor Producer’S Subjective Experience, Lisa Goldstein Graham

Antioch University Dissertations & Theses

The purpose of this study is to explore the experience of the individual who spontaneously produces humor during conversation. Although a broad humor literature exists, very little research addresses the experience of the spontaneous humor producer. This study represents an early step toward filling this gap in the literature. I gathered data by videotaping organizational meetings and conducting subsequent Interpersonal Process Recall (IPR) interviews with individuals who produced humor during the course of the meetings. I analyzed data from the IPR interviews using an emergent thematic analysis. Most humor producers in this sample were consciously aware of specific external cues, …

Cross-Race Relationships As Sites Of Transformation: Navigating The Protective Shell And The Insular Bubble, Karen Audrey Geiger

Antioch University Dissertations & Theses

The context of leadership has evolved to incorporate greater social identity differences. Therefore, learning ways to navigate differences in social identity becomes important work leaders must now do. Because these differences surface in relationship with others, examining a relational framework helps us understand the nature of what happens between people (Ely & Roberts, 2008). This study explored the processes by which Black African American and White European American women enact leadership by creating and sustaining cross-race relationships as they work to change unjust systems around them. Using grounded theory methodology (Charmaz, 2006; Strauss & Corbin, 1990), a model was developed …

The Art Of Caring: Woman And Restorative Justice, Peggy Lobb

Antioch University Dissertations & Theses

The process of restorative justice involves the caring compassion of others by providing support for the peaceful resolution of the conflict. The term restorative justice is used to describe a justice practice that has been in existence for hundreds of years in many indigenous communities. Recently, it is emerging in modern criminal justice systems as a way to obtain fair reparation for the victim and to offer an opportunity for the victim and the offender to mediate and reconcile after the offense to restore balance and peace to the community. The process involves the participation of the victim, offender, and …

An Analysis Of Factors That Influence The Success Of Women Engineering Leaders In Corporate America, Letha Joye Jepson

Antioch University Dissertations & Theses

"One in 4 women entering the engineering profession leaves after age 30, while only 1 in 10 of their male counterparts does" (Perusek, 2008, p. 20). I was interested in analyzing the factors supporting women engineers’ leadership development and success. My particular focus was on women engineers in corporate environments—the personal characteristics needed for a successful career and the impacts of social support, career development, and the corporate culture on their career progression. The aspects of social support included the factors of family, friends, and significant others and the levels of supports during the woman’s career. The features of corporation …

The Phenomenology Of Obsessive Compulsive Disorder From The Perspective Of The Adult Support Group Attendee, Richard R. Thomas Jr.

Antioch University Dissertations & Theses

This qualitative phenomenological dissertation utilizes the empirical descriptive phenomenological method, a modified Husserlian (1931) approach developed by A. P. Giorgi (1975, 1985, 1997) in order to lend voice to a vulnerable population of eight (four men and four women) adult Obsessive-Compulsive Disorder (OCD) sufferers while also gleaning a greater understanding of their in vivo (or lived) experience. Though extensive quantitative research into the disorder exists, this study utilizes the words of the participants and searches for emergent themes amongst their collective experience. This study addresses the treatment gap of this crippling disorder, increases community awareness, and allows for emergence of …

Participatory Planning For A Promised Land: Citizen-Led, Comprehensive Land Use Planning In New York’S Adirondack Park, Ann Hope Ruzow Holland

Antioch University Dissertations & Theses

New York’s Adirondack Park is internationally recognized for its biological diversity. Greater in size than Yellowstone, Everglades, Glacier, and Grand Canyon National Park combined, the Adirondacks are the largest protected area within the Northern Appalachian/Acadian Eco-Region and within the contiguous United States. Ecologists, residents of the Park, and others are concerned about rapid land use change occurring within the borders of the Park. Almost half of the six million acres encompassed by the Park boundary is privately-owned, where 80% of land use decisions fall within the jurisdiction of local governments. The comprehensive planning process of one such local government, the …

Spring 2010

University of Richmond Magazine

No abstract provided.

Fall 2010

University of Richmond Magazine

No abstract provided.

Summer 2010

University of Richmond Magazine

No abstract provided.

Phase Six Pandemic: A Call To Re-Evaluate Federal Quarantine Authority Before The Next Catastrophic Outbreak, John T. Clarkson

Georgia Law Review

At some point in the future, the United States will confront a deadly pandemic. One potential response to blunt the impact of an outbreak may be the use of a large-scale quarantine. The current statutory framework governing federal quarantine authority, however, is outdated and in need of revision. Any reform must acknowledge that the federal government may be best positioned to respond to national health threats and must simultaneously create limits on federal power to ensure a proper balance of power remains between the states and the federal government. This Note proposes that Congress focus its reform efforts on adding …

Philanthropy, Evaluation, Accountability, And Social Change, John Bare

The Foundation Review

· Many foundations have substituted process accountability for accountability for contributing to social change.

· While process accountability is important, it sets a floor, not an aspirational ceiling.

· There are tools—such as risk analysis, systems approaches, and game theory—that can help philanthropy engage in work on complex social problems that cannot be deconstructed into a series of small, linear projects.

· Seeking to extend basic human rights to more individuals around the world, seeking to reduce racism in a given city, or seeking to change publichealth norms in small town—all of these aspirations require first a willingness to take …

A Post-Race Equal Protection?, Mario L. Barnes, Erwin Chemerinsky, Trina Jones

Articles

No abstract provided.

From Chevron To Massachusetts: Justice Stevens's Approach To Securing The Public Interest, Kathryn A. Watts

Articles

During the past three decades, one Supreme Court justice— John Paul Stevens—has authored two of the most significant administrative law decisions that speak to the judiciary’s role in checking agency interpretations of the statutes that they administer. In Chevron U.S.A. Inc. v. Natural Resources Defense Council, Inc., Justice Stevens’s landmark 1984 decision unanimously upheld the EPA’s construction of a term found in the Clean Air Act. Subsequently, in Massachusetts v. EPA, Justice Stevens’s 2007 opinion for a five-justice majority handed a major win to global environmental security by ordering the EPA to reconsider its refusal to regulate greenhouse …

Oregon's Fish And Wildlife In A Changing Climate, Mark A. Hixon, Stanley V. Gregory, W. Douglas Robinson, C. Scott Baker, Harold P. Batchelder, Clinton Epps, Tiffany S. Garcia, Susan M. Haig, Ricardo M. Letelier, David A. Lytle, Bruce A. Menge, Jeffery C. Miller, David L.G. Noakes, William T. Peterson, James M. Rice, Steven S. Rumrill, Carl B. Schreck, Robert M. Suryan, Mark D. Sytsma, Angelicque E. White

Center for Lakes and Reservoirs Publications and Presentations

Chapter 7 in: The Oregon Climate Change Assessment Report

Oregon's fish and wildlife include animals on land, fish and other species in rivers and lakes, and various kinds of sea life in estuaries and coastal ocean. Oregon is one of the most ecologically diverse states in the country. The state’s robust biodiversity, some of which is already threatened or endangered -- inhabits complex and dynamic ecosystems that we have only begun to understand, let alone examine in terms of climate change.It is clear that the abundance and distribution of species are shifting already and will shift more rapidly as habitats …

Peeping Hals: Making Sense Of Artificial Intelligence And Privacy, Ryan Calo

Articles

The field of artificial intelligence, broadly defined as the study and practice of designing intelligent agents, is at least six decades into its existence as a formal discipline. Sometimes called “computational” or “synthetic” intelligence, AI borrows from and informs a wide variety of subjects, including philosophy, psychology, linguistics, neuroscience, statistics, economics, and law. Techniques of AI underpin all manner of industrial and consumer applications - from the complex neural nets used in data mining, down to the ‘fuzzy logic’ used by commercial washers and driers.

Insofar as “the issues of AI are directly related to [the] self-image of human beings”, …

Clean Tech Reality Check: Nine International Green Technology Transfer Deals Unhindered By Intellectual Property Rights, Eric Lane

Santa Clara High Technology Law Journal

No abstract provided.

Contributions Of Family Leisure To Family Functioning Among Single-Parent Families, Laurel B. Hornberger, Ramon Zabriskie, Patti Freeman

Faculty Publications

The purpose of this study was to examine the contribution of family leisure involvement to the family functioning of single-parent families and to compare family functioning and family leisure between large samples of dual and single-parent families. Data were collected from a dependent child and custodial parent in 362 U.S. single-parent households. Core and balance family leisure involvement were related to both family cohesion and family adaptability, with core family leisure explaining more variance in family functioning variables from parent, youth, and family perspectives. Family functioning among single-parent families was similar to that of dual-parent families. Family leisure involvement among …

Richmond Law Magazine: Winter 2010

Richmond Law Magazine

Features:

From Classroom to Courtroom

Civil City

Reinventing Fire

The New Jobs Landscape

Mass Privatisation And The Post-Communist Mortality Crisis: Is There Really A Relationship?, John S. Earle, Scott G. Gehlbach

Upjohn Institute Working Papers

We reexamine the recent, well-publicized claim that "rapid mass privatisation [of state-owned enterprises]...was a crucial determinant of differences in adult mortality trends in postcommunist countries" (Stuckler, King and McKee, 2009). Our analysis shows that the estimated correlation of privatization and mortality in country-level data is not robust to recomputing the mass-privatization measure, to assuming a short lag for economic policies to affect mortality, and to controlling for country-specific mortality trends. Further, in an analysis of the determinants of mortality in Russian regions, we find no evidence that privatization increased mortality during the early 1990s. Finally, we reanalyze the relationship between …

Temporal And Biochemical Aspects Of Sindbis Virus Dissemination In The Mosquito Host, Kristen A. Ciano

UNF Graduate Theses and Dissertations

The prototype Alphavirus, Sindbis virus (SIN), relies on cyclic transmission between the mosquito and vertebrate hosts in order to be maintained in nature. This broad host range suggests that alphaviruses use a universally expressed molecule for attachment. Heparan sulfate proteoglycan (HSPG), a ubiquitous SIN receptor present on the cell surface of most eukaryotic cells, has been reported in the salivary glands and midguts of mosquitoes. These organs are essential for virus transmission from this hematophageous invertebrate. Variable host cell response in the mosquito following intrathoracic inoculation with SIN has been documented. In this study, per os infection of Aedine …

Seeking Generalities In Salt Stress Effects On Herbivores: A Multi-Species Approach, Christy Marie Foust

UNF Graduate Theses and Dissertations

Stress has been identified as one of the primary factors influencing the structure of food webs, but few conclusions about the effects of stress on community dynamics have emerged. This study examined generalities that exist between salt stress and insect herbivore responses. Ambient salinity was artificially increased by adding 1.3 kg/m2 of salt to six different plant species: Avicennia germinans, Baccharis halimifolia, Batis maritima, Borrichia frutescens, Iva frutescens, and Spartina alterniflora. By performing a multiple species examination, stress responses were examined to determine if consistencies within and between plant type, ambient salinity conditions, and host plant species (among other criteria) …

Structure Prediction For The Helical Skeletons Detected From The Low Resolution Protein Density Map, Kamal Al Nasr, Weitao Sun, Jing He

Computer Science Faculty Publications

Background: The current advances in electron cryo-microscopy technique have made it possible to obtain protein density maps at about 6-10 Å resolution. Although it is hard to derive the protein chain directly from such a low resolution map, the location of the secondary structures such as helices and strands can be computationally detected. It has been demonstrated that such low-resolution map can be used during the protein structure prediction process to enhance the structure prediction.

Results: We have developed an approach to predict the 3-dimensional structure for the helical skeletons that can be detected from the low resolution protein density …

Improving Predicted Protein Loop Structure Ranking Using A Pareto-Optimality Consensus Method, Yaohang Li, Ionel Rata, See-Wing Chiu, Erik Jakobsson

Computer Science Faculty Publications

Background

Accurate protein loop structure models are important to understand functions of many proteins. Identifying the native or near-native models by distinguishing them from the misfolded ones is a critical step in protein loop structure prediction.

Results

We have developed a Pareto Optimal Consensus (POC) method, which is a consensus model ranking approach to integrate multiple knowledge- or physics-based scoring functions. The procedure of identifying the models of best quality in a model set includes: 1) identifying the models at the Pareto optimal front with respect to a set of scoring functions, and 2) ranking them based on the fuzzy …

The 3rd Computational Structural Bioinformatics Workshop, Jing He, Di Wu

Computer Science Faculty Publications

As many other domains in biology, molecular structures have proposed challenging but interesting computational problems. The unique challenge of the 3-dimensional molecular structures comes from the combination of the fundamental concepts of physics, chemistry, biology and geometry, and it is often computationally intensive to search for the correct structure. The Computational Structural Bioinformatics Workshop (CSBW) is a workshop that focuses on the fundamental computational work that is related to 3-dimensional molecular structures. This workshop aims to bring together researchers with expertise in bioinformatics, computational biology, structural biology, data mining, optimization and high performance computing to discuss recent results, new techniques, …

Synthesis And Reactivity Of Alpha-Azido Acylals, Gretchen Bell

Honors Theses

alpha-Azido -Azido acylals are a novel combination of azide (N3) and acylal [R-C(OOCR)2] functional groups. Since these compounds are new chemical entities, little is known in the chemical literature about their physical, chemical, and biological properties. This synthetic methodology investigation sought to (1) develop a one-pot, two reaction method for preparing alpha-azido acylals and (2) investigate the chemical reactivity of alpha-azido acylals with phosphine reagents. Progress has been made and will be discussed regarding both the synthesis and reactivity of alpha-azido acylals. This work developed methods and processes that will have significant impact in our broader objective of exploring the …

From Placebo To Self-Help: Investigating Retention, Outcome And Mechanisms In Self-Directed Gratitude Interventions, Adam William Alfred Geraghty

School of Psychology Theses

The research presented in this thesis explored unguided self-help therapy, primarily using a gratitude technique. Psychological mechanisms that underlie the placebo response may also play a primary role in beneficial response to unguided selfhelp therapy. Retention (whether participants completed the intervention), outcome (whether the technique effectively reduced symptoms), and mechanisms (the psychological processes which antecede outcome and retention), were investigated with participants engaging in procedures to improve a diverse range of symptoms, namely, mood, sleep disturbance, body dissatisfaction, depression and anxiety. Studies one and two investigated the role of two placebo mechanisms, response expectancy and motivational concordance, as predictors of …

A Strategy To Mobilize Seventh-Day Adventists In Lusaka In Response To The Hiv/Aids Crisis, Harrington Simui Akombwa

Doctor of Ministry Projects

Problem

While Zambia is rated the 7th country worst affected by HIV/AIDS worldwide, the Seventh-day Adventist (SDA) Church, an Faith Based Organization (FBO) well respected nationwide for its concern about people’s physical health because of its hospitals and clinics around the nation, is seemingly standing by doing close to nothing. What could be the problem?

Method

To uncover the possible causes of Adventists’ perceived noncommittal stance on the AIDS issue, a survey designed around a descriptive and exploratory social research model utilizing quantitative research techniques for data collection and analysis was conducted. The survey was conducted in 2 of the …

Physical Activity As A Treatment For Depression: The Tread Randomised Trial Protocol, Helen Baxter, Rachel Winder, Melanie Chalder, Christine Wright, Sofie Sherlock, Anne Haase, Nicola J. Wiles, Alan A. Montgomery, Adrian H. Taylor, Ken R. Fox, Debbie A. Lawlor, Tim J. Peters, Deborah J. Sharp, John Campbell, Glyn Lewis

Peninsula Medical School

No abstract provided.