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Hippocampal And Anterior Cingulate Cortex Volumes In Amnestic And Non-Amnestic Mild Cognitive Impairment, Elizabeth R. Tuminello

Master's Theses

Mild Cognitive Impairment (MCI) is a syndrome thought to fall between cognitively normal aging and dementia. Although much research has investigated the structural neuroimaging correlates of amnestic MCI, little research has been done on the imaging correlates of non-amnestic MCI. Even less research has examined the anterior cingulate cortex (ACC), a region important in executive functions (EFs), in these patients. This study attempted to address this gap by examining hippocampal and ACC volumes among amnestic and non-amnestic MCI patients and cognitively normal controls. Those with amnestic MCI were expected to have smaller hippocampal volumes than controls and those with non-amnestic …

The Distribution Of Gnrh And Erbeta In Pre- And Post-Pubertal Male Rats, Maysaa Nageeb

Master's Theses

The hypothalamic-pituitary- gonadal axis is intrinsic in regulating reproductive function. Each part orchestrates the synthesis and release of a key hormone. At the level of the hypothalamus, Gonadotropin- releasing hormone (GnRH) is released and it is the

most upstream regulator of sexual maturation. GnRH neurons express a type of estrogen receptor, ERbeta, which suggests that estradiol (E2) plays a direct role in modulating GnRH function (Herbison and Pape 2001). The objective of this study was to determine if gonadal steroid hormones regulate the expression of ERbeta and GnRH mRNA in the male brain during pubertal development. In-situ hybridization was used …

Dna Replication And Genome Maintenance Of Human Papillomavirus Type 16 In Mammalian Cells, Daraporn Pittayakhajonwut

School of Biological Sciences: Dissertations, Theses, and Student Research

Human papillomavirus (HPV) is a major causative agent of cervical cencer and a number of human cancers. The high‐risk types can be detected in more than 90% of cervical cancer, of which HPV16 is the most common found. The virus establishes a latent infection in basal epithelial cells in which the viral genomes can be stably maintained as extrachromosomal DNA for decades before the development of cancer. Several attempts have been made in bovine papillomavirus (BPV) to understand how the virus can maintain its genome at constant copy numbers in dividing cells. The viral protein E2 has been proposed to …

B Lymphocyte Development In Galt, Venkata Arunachalam Yeramilli

Dissertations

In rabbits, the primary antibody repertoire is generated in the gut-associated lymphoid tissues (GALT), where bone marrow (BM)-derived B cells undergo a proliferative expansion and somatically diversify the immunoglobulin genes. Unlike in other species, B lymphopoiesis in rabbit arrests a few months after birth, and it is unclear how the peripheral B cell compartment is maintained when there is no influx of newly-made B cells from the BM.

For my dissertation, I investigated how B cells develop in the GALT of rabbits, and how they are maintained in adults after the arrest of lymphopoiesis. To identify cellular signals that promote …

Ethanol Impairs Mechanisms Of Macrophage Phagocytosis And Cytokine Production, John Karavitis

Dissertations

Extensive evidence indicates that alcohol (ethanol) consumption affects human health by altering normal physiological functions of the immune system. This study investigated the effect of a single in vivo exposure of macrophages to clinically relevant levels of ethanol (1.2 and 2.2 g/kg). Following 3 hour exposure, both doses of ethanol decreased ex vivo TNFα production by splenic and alveolar macrophages (AMs). Interestingly, the higher dose of ethanol resulted in sustained suppression of LPS-induced TNFα production at 3 and 6 hours post ethanol administration, as well as decreased IL-6 and IL-12 production after 6 hours, compared control treated groups. LPS or …

Your Change Is Still Behind: Futurity In Early Modern Literature, Tripthi Pillai

Dissertations

A study of Renaissance literature's engagement with temporality, my project is a critical evaluation of the concept of early modern futurity, of which I propose three categories: "Material futurity"; "Biological futurity"; and "Political futurity." In the moments that I identify in texts composed during the Tudor and early Stuart reigns in England, I demonstrate that the future--as an idea--structures individuals' actions and ruptures social formations. Futurity, which I define as a play of multiple desires that exist simultaneously within our present beings, is a volatile agent of imagination in early modern literature. Futurity collides with the cultural sites of memory …

Characterization Of Tram, A Required Bacteroides Fragilis Conjugal Apparatus Protein That Interacts With The B. Fragilis Putative Coupling Protein Bcta And The B. Fragilis Relaxase Protein Bmph, Mai Thi Thanh Nguyen

Dissertations

Bacteroides spp. organisms, the most prominent bacteria of the human colon, are reservoirs of antibiotic resistance genes which promiscuously transfer within and from the genus via conjugation. The B. fragilis clinical isolate LV23 harbors a 37kb conjugative transposon, BTF-37. Two important conjugal apparatus proteins encoded by BTF-37 are BctA, a predicted coupling protein (CP) that powers DNA translocation, and ORF7 (TraM). In this study, we demonstrated that TraM exhibits characteristics of a required conjugal apparatus protein including 1) upregulated expression under conjugation conditions; 2) localization to the bacterial inner membrane; 3) interaction with the putative coupling protein BctA and the …

Morphogenesis Of The Bacillus Anthracis Spore, Michael Mallozzi

Dissertations

With the ability to shut down metabolism, survive exposure to high degrees of heat, ultra-violet and ionizing radiation, digestive enzymes, and antimicrobials, the bacterial spore is one of the most-resistant forms of life on earth. Although most spores are harmless, several species' spores cause serious diseases such as tetanus, anthrax, gas gangrene, botulism, and diarrhea. Spore-forming bacteria differentiate into spores in response to stresses (especially starvation) in a multi-stage developmental pathway involving the coordinated expression of hundreds of genes and the formation of specialized protective organelles which surround and protect the spore during dormancy. The Bacillus anthracis spore (the causative …

Involvement Of The Nmda Receptor In Moderate Ethanol Preconditioning-Dependent Neuroprotection From Amyloid-Beta In Vitro, Robert Matthew Mitchell

Dissertations

Alzheimer's disease (AD) is a progressive, mentally crippling, and eventually fatal form of dementia with growing prevalence in aging populations. In 2009 it was estimated that 5.3 million Americans have AD, with 5.1 million older than age 65 and 200,000 under 65. That accounts for 1 in 8 adults over 65. Furthermore, AD costs Americans 148 billion dollars in direct expenses, and is the leading cause of dementia and the 6th leading cause of death. Since improved medical care in general is increasing average life span and age is the primary risk factor for AD, there is need for basic …

Interpretive Teleology Without Eschatology: A Study Of The Hermeneutic Strategies Of Nietzsche's Genealogical Project, Darin Sean Mcginnis

Dissertations

In contemporary philosophy, there exists a vigorous debate between those thinkers who advocate the need for a truth that exists outside of historical forces and those who hold that all understanding must be historical in its basis. My research is focused on deciphering this problem by providing a description of how understanding and interpretation occur. More specifically, I have proposed a project that explores how the philosophical writings of Friedrich Nietzsche can give some insight into this problem of understanding truth. I argue that Nietzsche develops a method of interpretation - a hermeneutics - that focuses on the manner in …

Immigration As A "Theologizing Experience": Spiritual Well-Being As A Moderating Factor In Migratory Grief And Acculturation, Irma A. Sharp

Dissertations

The purpose of this study was to investigate the relationship of spiritual well-being to migratory grief and acculturation. The study employed a cross-sectional design and a convenience sampling method. Data were collected from 75 Mexican immigrant adult education students in the city of Chicago. Instruments used to collect data were a demographic form, Spiritual Well-Being Scale, Migratory Grief and Loss Questionnaire, and the Stephenson Multigroup Acculturation Scale. All instruments were translated into Spanish, the native language of the participants. Multiple regression analysis was used to test the moderator effects of existential well-being and religious well-being, the two sub-scales of the …

The Complexities Of Attachment, Peer Rejection And Gender Within A Middle School Dynamic - A Glimpse At Early Adolescents And Their Significant Relationships, Barbara Ann Mestling

Dissertations

This was a mixed method two phase explanatory study of attachment, peer rejection and gender in a non-clinical middle school population. The purpose of the study was to illustrate the relationship between these variables with the assumption that there would be differences in attachment style between rejected and non-rejected students and further differences by gender. The Behavioral Systems Questionnaire (BSQ) and the Children's Self-Experience Questionnaire-Self-Report (CSEQ-SR) were utilized to determine interview subjects. A Parent Demographic Form provided background, life experience and social functioning information. There were challenges in the use of both instruments for this study's purposes. Although there were …

The Relationship Among Adult Attachment Styles, Shame, Dissociation, And Abuse Characteristics In Women Survivors Of Intrafamilial Child Sexual Abuse Perpetrated By A Parental-Figure, Grace H. Tomas-Tolentino

Dissertations

The consequences of intrafamilial child sexual abuse (CSA) often evolve beyond the termination of abuse and pervade into adulthood, posing complex and enduring consequences for survivors (Courtois, 1999; Briere, 1992; Herman, 1981, 1991; van der Kolk & Kadish, 1987; Chu & Dill, 1990). The concepts of attachment, shame, and dissociation- in the context of childhood sexual abuse-are significant areas of study when working with adult survivors. The present study included 49 women with a history of childhood sexual abuse perpetrated by a parental-figure. The purpose of the study was to identify the relationships among adult attachment styles, shame, dissociation, and …

Roman Law And The Legal World Of The Romans, James G. Keenan

Classical Studies: Faculty Publications and Other Works

A review of Andrew. M Riggsby's book, Roman Law and the Legal World of the Romans.

The Impact Of Person-Centered Communications On Political Candidate Evaluation: An Experimental Investigation, Randall A. Renstrom

Dissertations

"Person-centeredness" refers to how empathetic and warm a person's communication style is. Although the role of person-centeredness has been documented in various areas concerning interpersonal relations, person-centeredness has not been explored in the political realm. This project investigated how person-centered communications can influence impressions and evaluations of political candidates. In the first study, person-centered (PC) messages were shown to impact candidate trait ratings. Candidates using low PC messages were associated with more instrumental traits but fewer socio-emotional traits, while high PC candidates were assumed to have more socio-emotional traits but fewer instrumental traits. Similar results were found when participants rated …

I Am Black And Beautiful: An Examiniaton Of The Black Coptic Church As The Manifestation Of Liberation Theology, Leonard Mckinnis

Dissertations

What does the Black Coptic Church have to offer the study of Black theology? This is the essential question this dissertation seeks to examine through a descriptive and constructive analysis. I submit the doctrinal formulation of black liberation theology is locatable within the Black Coptic Church, which was founded, and still boasts its largest membership in Chicago. This is the tradition that has informed my own faith background and has played a tremendous role in my earlier theological convictions. In fact, I was attracted to this tradition as a young child because it seemed to offer its adherents a sense …

Deconstructing Ihf-Mediated Inhibition Of The Complex Acs Promoter, David S. Thach

Dissertations

acs encodes a high affinity enzyme that permits survival during carbon starvation. As befits a survival gene, its transcription is subject to complex regulation. Previously, the Wolfe lab reported that CRP activates acs transcription by binding tandem DNA sites located upstream of the major acsP2 promoter and that the nucleoid protein IHF binds three specific sites located just upstream. The most proximal site (IHF III) exhibits reduced transcription compared to the full-length promoter or to a construct lacking all three IHF sites. The goal of my research was to understand how IHF III inhibits CRP-dependent acs transcription. First, I helped …

Altgeld Gardens: Evolution Of Culture And Educatiion In An Isolated African American Community, Beverly Anne Lesueur

Dissertations

Altgeld Gardens, a Chicago public housing project, was selected for this study because its unique attributes were designed as a model, self-contained complex located in a geographically and socially, isolated area of Chicago built to house African American war armament workers and their families beginning in the mid-1940’s. Oral testimonies from teachers and community members chronicle significant changes to the local culture and the primary school’s efforts to provide effective instructional services within the cultural context of this community. The most effective and frequently used modification of instruction was the incorporation of culturally relevant pedagogy. The goal was to effectively …

Developmental Characterization Of Cara Mitad: A Drosophila Nuclear Receptor Co-Regulator, Chhavi Chauhan

Dissertations

In insects and vertebrates, hormone titers drive cellular proliferation and differentiation events that guide proper development. Nuclear receptors (NR) respond to these hormone signals by activating cascades of gene expression, along with coregulator protein complexes. In Drosophila melanogaster, fluctuating titers of the steroid hormone ecdysone are responsible for coordinating the timing of organismal development. Despite major advances in our understanding of Drosophila NR activities, we lack essential knowledge of the coregulators that are required for their proper function.

We have recently identified the Drosophila cara mitad (cmi) (`dear half') gene. The deduced CMI protein is closely related to the N-terminal …

The Effects Of Uncontrollable Stress On Subjective Well-Being And Coping Behavior In Urban Adolescents, Laura Darr Coyle

Dissertations

The purpose of this dissertation was to determine whether uncontrollable and controllable stressors differentially affected levels of subjective well-being in a group of ethnically diverse urban adolescents. Additionally, the researcher examined what types of coping skills were utilized in the face of high levels of uncontrollable stress. Lastly, a moderational model was proposed, wherein active coping was hypothesized to strengthen the inverse relationship between uncontrollable stress and subjective well-being. Results revealed that higher levels of uncontrollable stress were related to higher levels of negative affect. Additionally, the use of active and adaptive coping strategies was associated with higher levels of …

Student Access To Advanced Placement (Ap) Coursework: Principals' Beliefs And Practices, Steve Wood

Dissertations

Advanced Placement® (AP®) courses provide high school students an opportunity to be exposed to the rigors of college while they are still in high school. Since school policies play a role in the opportunities for students to pursue these courses, educational leaders must be aware of the ways in which their personal beliefs and school practices influence the course-taking patterns in their students.

This study investigated the relationship between principals' personal beliefs and perceptions of school practices, and the opportunities for students to successfully complete rigorous Advanced Placement coursework. The study utilized a questionnaire distributed to eight-eight principals of schools …

First-Year College Students And Faculty: A Comparison Of Expectations For Success, Jodi Ellen Koslow Martin

Dissertations

The purpose of this qualitative study is to identify and explore academic, social, and career-related expectations that first-year college students believe lead to their collegiate success as defined by their perception of persisting in higher education. Further investigation determines how these expectations align with faculty expectations of student success. Eight first-year college students and eight college instructors were interviewed about their expectations at a small, private college. Criteria for first-year students include residing on campus and graduating from high school within the last year. Eligible faculty teach at least one class at the first-year level.

The data from student interviews …

Exploring The Relationship Between Teacher Personality Traits And Teachers' Attitudes And Practices Towards Family-School Partnerships, Anna Rawlings Hamilton

Dissertations

The primary purpose of this study is to determine if there is a relationship between teacher personality traits and teachers' reported attitudes and behaviors towards family-school partnerships. A secondary purpose of this study was to: 1) explore how various teacher demographic impacted attitudes and practices towards partnership, 2) examine if a cultural match between teachers' and students' backgrounds impacts teachers' reported attitudes and practices, and 3) to compare the personality profile of teachers as measured by the Five Factor Model (FFM) to that of the general population.

The participants were 243 practicing teachers in the state of Illinois who completed …

Uncovering Medical And Mental Health Professionals' Decision-Making In The Treatment Of Trans-Variant Patients, Jodie M. Dewey

Dissertations

This project is a study of medical and mental health professionals who treat trans-variant patients. Using in-depth interviews, I show how providers describe the process by which they make decisions with patients who desire, through formal means, to hormonally and/or surgically transition from one gender to the other. This work uncovers the ways professionals make decisions in the absence or limitation of formal knowledge while simulaneously attemping to ground their work in this same knoweldge to obtain respect and legitimacy. Professionals must also acknowledge that they relinquesh some power to patients to make decisions which involve high risk for them. …

Lysine Specific Demethylase-1 And The Brahma Chromatin Remodeling Complex Regulate Conserved Signaling Pathways During Drosophila Wing Development, Brenda Jean Curtis

Dissertations

The conserved SWI/SNF chromatin remodeling complex uses the energy from ATP hydrolysis to alter local chromatin environments by disrupting DNA-histone contacts. The Drosophila SWI/SNF counterpart, the Brahma complex, has been shown to have an essential role in regulating the proper expression of many developmentally important genes, including those required for eye and wing tissue morphogenesis. A temperature sensitive mutation in one of the core subunits, SNR1 (SNF5/Ini1/SMARC B1), results in reproducible wing patterning phenotypes that can be enhanced and suppressed by extragenic mutations. SNR1 functions as a regulatory subunit to modulate chromatin remodeling activities of the Brahma complex on target …

Courting And Consorting With The Global: The Local Politics Of An Emerging World Heritage Site In Sulawesi, Indonesia, Kathleen M. Adams

Anthropology: Faculty Publications and Other Works

I begin this chapter with a vignette concerning the events that led to the selection of a particular Toraja hamlet (known as Ke'te' Kesu') for tentative inclusion on UNESCO's List of World Heritage Sites. In this portion of the chapter I also unpack some of the local reactions to this selection and contrast these reactions with an analysis of UNESCO conception~ and assumptions pertaining to World Heritage Sites, many of which are entwined with romantic assumptions about ancient life-ways under siege by the contemporary world. I then turn to trace the historyofKe'te' Kesu', from its colonial roots to the present, …

Improved Detection Of Bartonella Dna In Mammalian Hosts And Arthropod Vectors By Real-Time Pcr Using The Nadh Dehydrogenase Gamma Subunit (Nuog), James M. Colborn, Michael Y. Kosoy, Vladimir L. Motin, Maxim V. Telepnev, Gustavo Valbuena, Khin S. Myint, Yuri Fofanov, Catherine Putonti, Chen Feng, Leonard Peruski

Bioinformatics Faculty Publications

We used a whole-genome scanning technique to identify the NADH dehydrogenase gamma subunit (nuoG) primer set that is sensitive and specific enough to detect a diverse number of Bartonella species in a wide range of environmental samples yet maintains minimal cross-reactivity to mammalian host and arthropod vector organisms.

Projected Loss Of A Salamander Diversity Hotspot As A Consequence Of Projected Global Climate Change, Joseph Milanovich, William E. Peterman, Nathan P. Nibbelink, John C. Maerz

Biology: Faculty Publications and Other Works

Significant shifts in climate are considered a threat to plants and animals with significant physiological limitations and limited dispersal abilities. The southern Appalachian Mountains are a global hotspot for plethodontid salamander diversity. Plethodontids are lungless ectotherms, so their ecology is strongly governed by temperature and precipitation. Many plethodontid species in southern Appalachia exist in high elevation habitats that may be at or near their thermal maxima, and may also have limited dispersal abilities across warmer valley bottoms.

Regeneration Of New Neurons Is Preserved In Aged Vomeronasal Epithelia, Jessica H. Brann, Stuart Firestein

Biology: Faculty Publications and Other Works

During normal and diseased aging, it is thought the capacity for tissue regeneration and repair in neuronal tissues diminishes. In the peripheral olfactory system, stem cell reservoirs permit regeneration of olfactory and vomeronasal sensory neurons, a unique capacity among neurons. Following injury, a large number of new neurons can be regenerated in a young animal. However, it is unknown whether this capacity for renewal exists in aged proliferative populations. Here, we report that neuronal replacement-associated proliferation continues in the vomeronasal organ of aged (18-24 months) mice. In addition, the potential for the aged stem cell to yield a mature neuron …

The Trpc2 Channel Forms Protein-Protein Interactions With Homer And Rtp In The Rat Vomeronasal Organ, Thomas G. Mast, Jessica H. Brann, Debra A. Fadool

Biology: Faculty Publications and Other Works

BACKGROUND: The signal transduction cascade operational in the vomeronasal organ (VNO) of the olfactory system detects odorants important for prey localization, mating, and social recognition. While the protein machinery transducing these external cues has been individually well characterized, little attention has been paid to the role of protein-protein interactions among these molecules. Development of an in vitro expression system for the transient receptor potential 2 channel (TRPC2), which establishes the first electrical signal in the pheromone transduction pathway, led to the discovery of two protein partners that couple with the channel in the native VNO. RESULTS: Homer family proteins were …