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2010

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When The Truth And The Story Collide: What Legal Writers Can Learn From The Experience Of Non-Fiction Writers About The Limits Of Legal Storytelling, Jeanne M. Kaiser Jan 2010

When The Truth And The Story Collide: What Legal Writers Can Learn From The Experience Of Non-Fiction Writers About The Limits Of Legal Storytelling, Jeanne M. Kaiser

Faculty Scholarship

This Article examines what can be gained and what can be lost by using storytelling in legal writing. After reviewing some basic principles of legal storytelling, the Article reviews some lessons that can be learned from the experience of the New Journalists who adopted literary techniques in their non-fiction work. In the end, the Author concludes that while there is much value in using the tools of fiction in legal writing, it is only with a blend of narrative and analysis that we most successfully do our jobs as lawyers.

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The Cross-Dressing Case For Bathroom Equality, Jennifer Levi, Daniel Redman Jan 2010

The Cross-Dressing Case For Bathroom Equality, Jennifer Levi, Daniel Redman

Faculty Scholarship

This Article offers a new set of arguments for transgender equality based on a little-known series of cases in which courts declined to enforce cross-dressing laws against transgender defendants. As shown below, the arguments brought by the defenders of these laws closely mirror the arguments brought today in favor of bathroom discrimination. The Authors discuss both the bathroom and cross-dressing debates in historical context, draw out the underlying reasoning in the two sets of cases,and argue that the reasoning that supports bathroom discrimination is as flawed as the reasoning behind criminal cross-dressing laws. The analysis also suggests that, just as …

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The Bacterial Community Of A Freshwater Sponge, Radiospongilla Cerebellata: A Comparison Of Terminal Restriction Fragment Length Polymorphisms (T -Rflp) And 16s Rrna Clone Library Methods, Andrew Stephen Mobley Jan 2010

The Bacterial Community Of A Freshwater Sponge, Radiospongilla Cerebellata: A Comparison Of Terminal Restriction Fragment Length Polymorphisms (T -Rflp) And 16s Rrna Clone Library Methods, Andrew Stephen Mobley

All ETDs from UAB

No abstract provided.

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Development Of Multi-Shot Parse Mri Techniques, Rajiv G. Menon Jan 2010

Development Of Multi-Shot Parse Mri Techniques, Rajiv G. Menon

All ETDs from UAB

Fast imaging Magnetic Resonance Imaging (MRI) techniques such as Echo Planar Imaging (EPI) often suffer from artifacts such as signal dropouts, geometric distortions and susceptibility artifacts due to background gradients. Parameter Assessment by Retrieval from Signal Encoding (PARSE) was introduced as a single shot, inverse estimation technique that models the MRI process more accurately and estimates the initial transverse magnetization, M0 and its phase, the decay rate R2* and local frequency at each pixel. This technique is devoid of the aforementioned artifacts seen in EPI techniques. The goal of this work is to develop multi-shot parameter assessment by retrieval from …

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Sexual Risk Behavior Among African-American Adolescents: Trajectories And Their Predictors, Maureen Muchimba Jan 2010

Sexual Risk Behavior Among African-American Adolescents: Trajectories And Their Predictors, Maureen Muchimba

All ETDs from UAB

Although adolescents in the United States are at high risk of sexually transmitted infections and HIV, research indicates that many do not use condoms consistently and have high numbers of lifetime multiple sexual partners. Among adolescents, different subgroups exhibit distinct patterns of sexual behavior over time. The purpose of this dissertation was to identify trajectories of sexual risk behavior among adolescents and to determine individual, family and community factors that are predictive of membership to trajectory groups. Data were collected on sexual risk behavior among low-income African-American adolescents in Mobile County, Alabama. Gender-balanced subsamples of risky sex (N = 1294) …

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Fiber Modification Of Adenoviral Vectors For Cancer Gene Therapy, Miho Murakami Jan 2010

Fiber Modification Of Adenoviral Vectors For Cancer Gene Therapy, Miho Murakami

All ETDs from UAB

Cancer still remains a major public health concern despite improvements in primary prevention, early detection and advanced treatments. Cancer gene therapy using human adenovirus serotype 5 (HAdV-5) as a vector has been explored as a new therapeutic approach. HAdV-5 infection is initiated by binding to the coxsackie virus and adenovirus receptor (CAR), its primary cellular receptor. However, the levels and patterns of expression of CAR vary greatly in clinical tumor tissue samples, and the expression lev-els tend to decrease as the tumors progress. The low level expression of CAR in target cancer cells diminishes the utility of HAdV-5 as a …

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Organizational Support, Perceived Social Support, And Intent To Turnover Among Psychiatric Nurses: A Mixed Methods Study., Beverly Jean Myers Jan 2010

Organizational Support, Perceived Social Support, And Intent To Turnover Among Psychiatric Nurses: A Mixed Methods Study., Beverly Jean Myers

All ETDs from UAB

Nurse turnover compromises the quality of patient care and leads to an increase in organizational costs. Nurse turnover is defined as the intent to leave one's current job position either to transfer to another unit within the organization or to terminate employment with the organization. Few studies have examined the role social support received at work as well as at home, personal characteristics and work factors play in guiding psychiatric nurses' decisions to leave a current nursing position (turnover). The overall purpose of this mixed-methods sequential explanatory study was to explore factors that contribute to psychiatric nurses' intent to turnover. …

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A Closer Look At Law: Human Rights As Multi-Level Sites Of Struggles Over Multi-Dimensional Equality, Susanne Baer Jan 2010

A Closer Look At Law: Human Rights As Multi-Level Sites Of Struggles Over Multi-Dimensional Equality, Susanne Baer

Articles

In many societies, deep conflicts arise around religious matters, and around equality. Often, religious collectives demand the right to self-determination of issues considered - by them - to be their own, and these demands collide with individual rights to, again, religious freedom. These are thus conflicts of religion v. religion. Then, collective religious freedom tends to become an obligation for all those who are defined as belonging to the collective, which carries the problem that mostly elites define its meaning and they silence dissent. Usually, such obligations are also unequal relating to gender, with different regimes for women and for …

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Medial Septal Beta-Amyloid 1-40 Injections Alter Septo-Hippocampal Anatomy And Function, Luis V. Colom, María Teresa Castañeda Licón, C. Banuelos, Gustavo Puras, Antonio García-Hernández, Sofia Hernandez, Suzanne Mounsey, Joy Benavidez, Claudia Lehker Jan 2010

Medial Septal Beta-Amyloid 1-40 Injections Alter Septo-Hippocampal Anatomy And Function, Luis V. Colom, María Teresa Castañeda Licón, C. Banuelos, Gustavo Puras, Antonio García-Hernández, Sofia Hernandez, Suzanne Mounsey, Joy Benavidez, Claudia Lehker

Health & Biomedical Sciences Faculty Publications

Degeneration of septal neurons in Alzheimer’s disease (AD) results in abnormal information processing at cortical circuits and consequent brain dysfunction. The septum modulates the activity of hippocampal and cortical circuits and is crucial to the initiation and occurrence of oscillatory activities such as the hippocampal theta rhythm. Previous studies suggest that amyloid β peptide (Aβ) accumulation may trigger degeneration in AD. This study evaluates the effects of single injections of Aβ 1–40 into the medial septum. Immunohistochemistry revealed a decrease in septal cholinergic (57%) and glutamatergic (53%) neurons in Aβ 1–40 treated tissue. Additionally, glutamatergic terminals were significantly less in …

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Third-Wave Feminism In Select Young Adult Literature, Colleen Mckinney Jan 2010

Third-Wave Feminism In Select Young Adult Literature, Colleen Mckinney

Honors Capstones

No abstract provided.

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Oral Lesions As Clinical Markers For Antiretroviral Therapy Failure In Hiv Patients, Irene M. Tamí-Maury Jan 2010

Oral Lesions As Clinical Markers For Antiretroviral Therapy Failure In Hiv Patients, Irene M. Tamí-Maury

All ETDs from UAB

The true nature of the association of oral lesions (OL) and gold standards of HIV progression, CD4+ T cell counts (CD4) and HIV-1 RNA viral load (VL), is not completely clear, especially when patients are on antiretroviral therapy (ART). Our aim was to assess the association between OL and virologic failure among HIV/AIDS patients on ART. We conducted a retrospective study of 744 HIV patients who entered care between 2000 and 2006 at the UAB 1917 Clinic. Data was collected for 2 years after enrollment. Prevalence of OL was 35.8%. Oropharyngeal candidiasis (OPC) was the most prevalent OL (74.9%). Among …

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Growth Of Chromium-Doped Zinc Selenide Thin Films By Pulsed Laser Deposition For Mid-Infrared Applications, Jonathan Ezekiel Williams Jan 2010

Growth Of Chromium-Doped Zinc Selenide Thin Films By Pulsed Laser Deposition For Mid-Infrared Applications, Jonathan Ezekiel Williams

All ETDs from UAB

Transition metal doped II-VI semiconductor materials features excellent spectroscopic and lasing characteristics in the middle infrared (mid-IR). Among this class of laser material, the most impressive results have been obtained from chromium-doped zinc selenide (Cr2+:ZnSe) crystals. To date, Cr2+:ZnSe materials are arguably the best choice of laser gain material for the advancements of high power mid-IR lasers broadly tunable over the 2-3 μm spectral range. The dissertation objectives are to demonstrate technological advancements in the development Cr2+:ZnSe thin films by pulsed laser deposition (PLD) thus establishing a viable route for the synthesis of mid-IR laser gain media based on Cr2+:ZnSe …

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Contributions Of The Atrial Natriuretic Peptide Gene System To The Relationship Between Pediatric Body Fat, Free Fatty Acids, And Blood Pressure, Amanda Willig Jan 2010

Contributions Of The Atrial Natriuretic Peptide Gene System To The Relationship Between Pediatric Body Fat, Free Fatty Acids, And Blood Pressure, Amanda Willig

All ETDs from UAB

Elevated blood pressure and nonesterified fatty acids (NEFA) in children can lead to increased chronic disease risk during adulthood. The atrial natriuretic peptide precursor A (NPPA) and natiuretic peptide receptor A (NPR1) genes encode for atrial natriuretic peptide (ANP) and its cell receptor, respectively, and may influence levels of blood pressure and NEFA. Additionally, it is unclear how body composition, physical activity, physical fitness, and racial genetic ancestry influence pediatric NEFA and blood pressure. In order to understand the associations among these factors, five investigations were performed. For experimental aim 1, the association between blood pressure and body composition measures …

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Small Molecule Inhibitors Of Acid Sensing Ion Channel-1, Yawar J. Qadri Jan 2010

Small Molecule Inhibitors Of Acid Sensing Ion Channel-1, Yawar J. Qadri

All ETDs from UAB

Acid Sensing Ion Channel 1 is one of the many proteins in the Epithelial Sodium Channel/Degenerin family. The proteins in this family interact to form cation channels with unique biophysical properties and can all be inhibited by the small molecule amiloride. Their expression in many different cell types underlies their involvement in a large variety of physiological and pathophysiological processes. ASIC-1 containing channels, specifically, are an important therapeutic target for ischemic stroke, nociception, the invasiveness of glioblastoma cells, and many other processes including anxiety and memory formation. Of the members of the ENaC/Deg family, chicken ASIC-1 is the only protein …

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Parental Separation Anxiety And Shared Responsibility For Diabetes-Related Tasks In Adolescents Diagnosed With Type 1 Diabetes Mellitus, Kathryn Anne Sheppard Jan 2010

Parental Separation Anxiety And Shared Responsibility For Diabetes-Related Tasks In Adolescents Diagnosed With Type 1 Diabetes Mellitus, Kathryn Anne Sheppard

All ETDs from UAB

Type 1 diabetes mellitus (T1D) is most commonly diagnosed in children and young adults, and complications may be life-long as well as life threatening. Management of T1D has proven to be very challenging during adolescence, and parental involvement in diabetes management has been shown to improve adherence and glycemic control in children and adolescents. Middle adolescents should become increasingly responsible for diabetes-related tasks under the supervision and guidance of parents (shared management). However, adolescents spend less time with their family as they get older, resulting in parents' being unable to validate effective self-management; this inability may lead to anxiety about …

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The Comparison Of Mitochondrial Functions Of 2 Drosophila Species: Drosophila Ananassae And Drosophila Subobscura, Hye J. Shin Jan 2010

The Comparison Of Mitochondrial Functions Of 2 Drosophila Species: Drosophila Ananassae And Drosophila Subobscura, Hye J. Shin

All ETDs from UAB

Recently, it has been suggested that differences in mitochondrial function enabled Homo sapiens to migrate out of Africa by enabling humans to adapt to colder environments as they migrated to higher latitude areas. Through mitochondrial mutations that partially uncoupled oxidative phosphorylation, humans that moved to colder areas were able to generate more heat for better survival, while producing less energy. However, due to challenges in working with human populations, no specific studies have been able to show the existence of such differences in mitochondrial function within healthy humans. Because of numerous advantages of Drosophila as a developmental model, such as …

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Association Between Birth Outcomes And Aflatoxin B1-Biomarker Levels Among Pregnant Women In Kumasi, Ghana, Faisal Mohammed Barbas Shuaib Jan 2010

Association Between Birth Outcomes And Aflatoxin B1-Biomarker Levels Among Pregnant Women In Kumasi, Ghana, Faisal Mohammed Barbas Shuaib

All ETDs from UAB

Aflatoxins are fungal metabolites that contaminate staple food crops in many developing countries. Although studies have linked these toxins to adverse health outcomes, few studies have investigated the association between birth outcomes and aflatoxin B1-lysine adduct levels among pregnant women. The objective of this dissertation was to investigate the association between birth outcomes and aflatoxin B1- lysine adduct levels among pregnant women in Kumasi, Ghana. In a cross-sectional study of 755 pregnant women, Aflatoxin B1-lysine adduct (AF-ALB) levels were determined by High Performance Liquid Chromatography. AF-ALB associations were assessed as both continuous and categorical values. Analysis of variance (ANOVA) was …

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Assessment Of Water Samples From The Cahaba River And Buck Creek For The Presence Of Estrogenic Compounds, Patricia Jackson Jan 2010

Assessment Of Water Samples From The Cahaba River And Buck Creek For The Presence Of Estrogenic Compounds, Patricia Jackson

All ETDs from UAB

No abstract provided.

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Arm Loss And Regenerative Capacity Of The Common Soft - Bottom Sea Star Luidia Clathrata Exposed To Near -Future Conditions Of Ocean Acidification, Julie B. Schram Jan 2010

Arm Loss And Regenerative Capacity Of The Common Soft - Bottom Sea Star Luidia Clathrata Exposed To Near -Future Conditions Of Ocean Acidification, Julie B. Schram

All ETDs from UAB

No abstract provided.

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Experimental Measurements During Combustion Of Moist Individual Foliage Samples, Brent M. Pickett, Carl Isackson, Rebecca Wunder, Thomas H. Fletcher, Bret Buitler, David R. Weise Jan 2010

Experimental Measurements During Combustion Of Moist Individual Foliage Samples, Brent M. Pickett, Carl Isackson, Rebecca Wunder, Thomas H. Fletcher, Bret Buitler, David R. Weise

Faculty Publications

Individual samples of high moisture fuels from the western and southern United States and humidified aspen excelsior were burned over a flat-flame burner at 987◦ ±12 C and 10±0.5 mol% O2. Time-dependent mass and temperature profiles of these samples were obtained and analysed. It was observed that significant amounts of moisture remained in the individual samples after ignition occurred. Temperature histories showed a plateau at 200◦–300 C at the leaf perimeter rather than at 100 C, with a plateau of 140 C for the leaf interior. Implications are that classical combustion models should be altered to reflect the behaviour of …

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The Effect Of Autopolymerizing Acrylic Resin Thickness On The Bond Strength Of A Repaired Denture Tooth, Wendy A. Auclair Jan 2010

The Effect Of Autopolymerizing Acrylic Resin Thickness On The Bond Strength Of A Repaired Denture Tooth, Wendy A. Auclair

All ETDs from UAB

No abstract provided.

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Validation Of Bioimpedance Spectroscopy By Assessing Precision And Accuracy Of In Vivo Body Composition In Mice, Matthew S. Carle Jan 2010

Validation Of Bioimpedance Spectroscopy By Assessing Precision And Accuracy Of In Vivo Body Composition In Mice, Matthew S. Carle

All ETDs from UAB

No abstract provided.

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Expansion And Differentiation Of Human Mesenchymal Stem Cells In A Perfusion And Surface Shear Stress Biore Actor For Engineered Tissue Cartilage, Carlos A. Carmona-Moran Jan 2010

Expansion And Differentiation Of Human Mesenchymal Stem Cells In A Perfusion And Surface Shear Stress Biore Actor For Engineered Tissue Cartilage, Carlos A. Carmona-Moran

All ETDs from UAB

No abstract provided.

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Characterization Of Btbd9 Knockout Mice: A Potential Model Of Restless Legs Syndrome, Mark P. Deandrade Jan 2010

Characterization Of Btbd9 Knockout Mice: A Potential Model Of Restless Legs Syndrome, Mark P. Deandrade

All ETDs from UAB

No abstract provided.

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Phocine Distemper Virus Induced Demyelination In The Spinal Cord Of Infected Harbor Seals (Phoca Vitulina), Thomas Siemens Jan 2010

Phocine Distemper Virus Induced Demyelination In The Spinal Cord Of Infected Harbor Seals (Phoca Vitulina), Thomas Siemens

All Theses And Dissertations

Phocine Distemper Virus (PDV) is a Morbillivirus that has been responsible for the death of approximately 40,000 phocid seals in the last three decades. The most commonly reported pathology is virally induced demyelination of the cerebrum and brainstem which leaves axons bare and limits their conductivity of action potentials. While these conditions have been studied at length, there is little mention of spinal cord involvement. This study aims to determine whether demyelination found in the brainstem continues into the cervical spinal cord. The results indicate that demyelination in the cervical spinal cord does not occur alongside the brainstem. It is …

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A Dual Protease Inhibitor/Receptor Antagonist With Therapeutic Implications For Chronic Inflammatory Lung Diseases, Matthew Thomas Hardison Jan 2010

A Dual Protease Inhibitor/Receptor Antagonist With Therapeutic Implications For Chronic Inflammatory Lung Diseases, Matthew Thomas Hardison

All ETDs from UAB

protein (CRP) and smoking, controlling for waist circumference (WC) and race, we find

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Investigation Of Residues Of The Vesicular Stomatitis Virus Nucleocapsid Protein That Affect Transcription And Rna Replication, Djamila Harouaka Jan 2010

Investigation Of Residues Of The Vesicular Stomatitis Virus Nucleocapsid Protein That Affect Transcription And Rna Replication, Djamila Harouaka

All ETDs from UAB

The template for transcription and RNA replication for vesicular stomatitis virus (VSV) and other negative-strand RNA viruses is a ribonucleoprotein (RNP) complex consisting of the viral RNA genome and associated nucleocapsid (N) protein. The structure of the RNP-like complex of VSV showed that the RNA is sequestered between two lobes of the N protein, and adjacent N monomers are linked by an extensive network of interactions. Long-range interactions mediated by the N-terminal arm and C-terminal loop of the N protein stabilize the side-to-side contacts between adjacent N monomers, and are required for RNA encapsidation. It is unclear how the polymerase …

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O-Glcnac Transferase Modulates Jnk1 And Foxo4 Transcription Factor To Resist Acute Oxidative Stress, Shiuh-Rong Ho Jan 2010

O-Glcnac Transferase Modulates Jnk1 And Foxo4 Transcription Factor To Resist Acute Oxidative Stress, Shiuh-Rong Ho

All ETDs from UAB

O-GlcNAcylation is an abundant and dynamic post-translational modification on serine and threonine residues of nuclear and cytoplasmic proteins. O-GlcNAc Transferase (OGT) and Nuclear Cytoplasmic O-GlcNAcase and Acetyltransferase (NCOAT) are the only two enzymes and major regulators in this process. In the past two decades, many studies have demonstrated its important modulation roles in nutrient sensing, protein turnover, cell cycle progression, transcription, translation as well as stress resistance. Among these biological functions, the understanding of O-GlcNAcylation dependent oxidative stress is relatively unknown. This study aims to examine the effects of O-GlcNAcylation on JNK1 and FOXO4 transcription factors under acute oxidative stress …

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Role Of Epithelial Sodium Channel And Acid Sensing Ion Channel In Glioblastoma Multiforme, Niren Kapoor Jan 2010

Role Of Epithelial Sodium Channel And Acid Sensing Ion Channel In Glioblastoma Multiforme, Niren Kapoor

All ETDs from UAB

Glioblastoma Multifrome is the most common and aggressive of the primary brain tumors. These tumors express multiple members of the Epithelial Sodium Channel (ENaC)/Degenerin (Deg) family, associated with a basally active amiloride sensitive cation current. We hypothesize that this glioma current is mediated by a hybrid channel composed of a mixture of Epithelial Sodium Channel (ENaC) and Acid Sensing Ion Channel (ASIC) subunits. To test this hypothesis we made dominant negative cDNAs for ASIC1, αENaC, and γENaC. D54-MG glioma cells transfected with the dominant negative constructs for ASIC1, αENaC, or γENaC showed reduced protein expression for each of the specific …

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An Investigation Of The Molecular Mechanisms Involved In The Generation Of Breast Cancer, Joseph Tyson Deangelis Jan 2010

An Investigation Of The Molecular Mechanisms Involved In The Generation Of Breast Cancer, Joseph Tyson Deangelis

All ETDs from UAB

Cell culture models of oncogenesis that use cellular reprogramming to generate a neoplastic cell from a normal cell provide one of the few opportunities to study the early stages of breast cancer development. Human mammary epithelial cells (HMECs) were induced to undergo a neoplastic transformation using defined genetic elements to generate transformed HMECs (THMECs). We conducted proteomic and transcriptomic analysis of three points in the neoplastic progression of breast cancer. First we monitored alterations in the proteome that revealed a progressive trend towards a metastatic state. Next, we identified a set of genes from transcriptomic analysis that displayed this same …

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