Digital Commons Network^™

N-Acetyltransferase 2 Gene Polymorphisms And Susceptibility To Prostate Cancer: A Pilot Study In The Turkish Population, Buket Kosova, Vi̇ldan Bozok Çeti̇ntaş, Ahmet Çağ Çal, Asli Teti̇k, Ruki̇ye Özel, Çağdaş Aktan, Cumhur Gündüz, Nejat Topçuoğlu, İbrahi̇m Kadri̇ Cürekli̇batir, Fatma Zuhal Eroğlu

Turkish Journal of Medical Sciences

To investigate the association between the 3 most frequently observed single nucleotide polymorphisms of the NAT2 gene and the risk of developing prostate cancer in the Turkish population. Materials and methods: A total of 110 unrelated patients with prostate cancer were included in this case-control association study and constituted the study group. The control group also consisted of 150 unrelated but healthy men. Genomic DNA was isolated from peripheral blood leukocytes of all patients and analyzed with a sensitive real-time PCR method. After melting curve analysis genotypes were identified for the NAT2*5A, NAT2*6A, and NAT2*7A/B polymorphisms. Results: Prostate cancer patients …

Prediction Of Prostate Cancer Using Decision Tree Algorithm, Kemal Hakan Gülkesen, İsmai̇l Türker Köksal, Sebahat Özdem, Osman Saka

Turkish Journal of Medical Sciences

Serum Prostate Specific Antigen (PSA) level is used for prediction of cancer, but this approach suffers from weak sensitivity and specificity. We applied binary-split decision tree (DT) algorithm to prostate cancer prediction problem. Materials and methods: Quick, Unbiased and Efficient Statistical Tree (QUEST) algorithm was used in 750 patients who had a serum PSA levels between 0 and 10 ng/mL. Results: The analysis indicated that following five nodes had different levels of cancer possibility: (1) PSA > 5.98 ng/mL; (2) PSA 0.81; (4) PSA Keywords:

Serum Adenosine Deaminase Activity And The Total Antioxidant Capacity Of Plasma In Pulmonary Tuberculosis And Non-Tuberculosis Pulmonary Disease, Mohammad Naderi, Mohammad Hashemi, Ali Mehdizadeh, Hamid Mehrabifar, Hamid Reza Kouhpayeh, Hossein Ansari, Gholamreza Bahari, Saeid Ghavami

Turkish Journal of Medical Sciences

The aim of this study was to investigate the level of serum adenosine deaminase (ADA) and the total antioxidant capacity (TAC) in pulmonary tuberculosis (PTB), non-tuberculosis pulmonary disease (non-PTB) and healthy subjects. Materials and methods: Serum ADA activity was measured using the Giusti and Galanti method, and the total antioxidant capacity of plasma was determined by the ferric reducing ability of plasma (FRAP) test. Results: The serum ADA levels were significantly higher (P < 0.001) in pulmonary TB (PTB, 19.78 ± 7.09 U/L), as well as in non-PTB patients (14.78 ± 4.65 U/L) when compared to healthy controls (10.02 ± 1.99 U/L). The sensitivity and specificity were found to be 71.7% and 63.3%, respectively, in distinguishing PTB from non-PTB. In distinguishing PTB from healthy subjects, the sensitivity and specificity were 87% and 93.3%, respectively. The TAC was significantly lower in PTB (485.2 ± 190.0 µM) and non-PTB patients (588.3 ± 195.8 µM), when compared to the controls (784.3 ± 190.0 µM; P < 0.001). Plasma antioxidative activity decreased in PTB and non-PTB patients when compared to the controls. Conclusion: We concluded that serum ADA activity is not a useful test to differentiate pulmonary TB from other respiratory diseases. The TAC is low in pulmonary TB, therefore supplementation with a suitable anti-oxidant may be useful.

Chronic Pain And Depression: A Descriptive Survey Among Adult Primary Health Care Centre Patients, Nüket Paksoy Erbaydar, Nesri̇n Çi̇li̇ngi̇roğlu

Turkish Journal of Medical Sciences

Knowledge of chronic pain and its relationship to depression among primary health care patients in Turkey is inadequate. The aim of this study was to evaluate the frequency of chronic pain and its relationship to depression. Materials and methods: In this descriptive study, data was collected with a questionnaire based on sociodemographic and pain-related characteristics, which was administered to a study population (n = 259) of primary care patients, 18-64 years old. The Visual Analogue Scale (VAS) (min-max = 0-10) and Beck Depression Inventory (BDI) (min-max = 0-63) were used for the assessment of pain severity and depression. Results: Of …

Effects Of Vitamin A And C And Melatonin On 3-Nitrotyrosine Formation In Guinea Pig Heart Under Lipopolysaccharide-Induced Stress, Hali̇l Yaman, Tuncer Çayci, Meli̇k Seyrek, Emi̇n Özgür Akgül, Yasemi̇n Gülcan Kurt, İbrahi̇m Aydin, Hakan Yaren, Erdi̇nç Çakir, Ömer Özcan, Behzat Çi̇men, Nurten Türközkan, Mehmet Kemal Erbi̇l

Turkish Journal of Medical Sciences

Bacterial lipopolysaccharide (LPS) triggers synthesis of nitric oxide (NO) and superoxide (O_2^{.-}). O_2^{.-} can react with NO to produce the powerful oxidant peroxynitrite (ONOO-). The presence of 3-nitrotyrosine (3-NT) in tissues is often used as a marker of ONOO- production. Vitamin A, vitamin C, and melatonin are potent antioxidant molecules. We sought to clarify this issue by examining the effects of vitamin A (15,000 IU/kg/day), vitamin C (600 mg/kg/day), and melatonin (25 mg/kg) on 3-NT formation in heart tissue in a guinea pig model of LPS-induced endotoxemia. Materials and methods: A total of 75 animals were randomly divided into 5 …

Vitamin C Modulates Oxidative Stress-Induced Colitis In Rats, Mustafa Zeri̇n, Ali̇ Zi̇ya Karakilçik, Muharrem Bi̇ti̇ren, Davut Musa, Abdullah Özgönül, Şehabetti̇n Selek, Yaşar Nazligül, Ali̇ Uzunköy

Turkish Journal of Medical Sciences

Free radicals are an important factor in the etiopathogenesis of colitis and may increase oxidative damage. The antioxidant vitamin C efficiently scavenges free oxygen radicals. The present study aimed to investigate the probable protective effects of vitamin C on oxidative injury in rats in which colitis was experimentally induced with acetic acid. Materials and methods: This study was conducted with rats for a period of 7 days. Group 1 intrarectally received a placebo (0.9% NaCl) and group 2 intrarectally received 2 mL of 5% acetic acid (AA) and the placebo. Group 3 intrarectally received 2 mL of 5% AA and …

Evaluation Of Oxidant/Antioxidant Status And Ecp Levels In Asthma, Ömer Emecen, Berri̇n Berçi̇k İnal, Füsun Erdenen, Murat Usta, Hale Aral, Güvenç Güvenen

Turkish Journal of Medical Sciences

Inflammatory and immune cells, such as eosinophils, macrophages, and neutrophils, generate more reactive oxygen species in patients with asthma than they do in healthy individuals, and oxygen radicals contribute to tissue injury in asthma. We aimed to measure total oxidant status (TOS) and antioxidant status (TAS) in order to assess oxidative and antioxidative capacity. Eosinophil cationic protein (ECP), total IgE, and eosinophils (%) were measured to evaluate the level of inflammation. Materials and methods: The study included 56 non-smoking asthma patients that were followed-up at the respiratory disease and allergy outpatient clinics, where they received ongoing treatment for 5 months …

Effects Of Aqueous Garlic Extract On Oxidant/Antioxidant Status In 32d And 32dp210 Cell Lines, Aslihan Avci, Asuman Sunguroğlu, İmge B. Ergüder, Güvem Gümüş Akay, Erdi̇nç Devri̇m, Pinar Özkal Baydin, Nuray Varol, İlker Durak

Turkish Journal of Medical Sciences

To investigate the possible effects of aqueous garlic extract on the oxidant/antioxidant status and apoptosis in 32D (wild type mouse myeloid cell = normal) and 32Dp210 (BCR-ABL fusion gene (+) mouse myeloid cell = Chronic Myelocytic Leukemia cells) cell lines. Materials and methods: Aqueous garlic extract (10% w/v) was added into the cell line media with 2 different final concentrations (0.4% and 1%). At 0 h and at 24, 48, and 72 h later, the oxidant (malondialdehyde (MDA) level, and xanthine oxidase (XO) enzyme activity) and antioxidant (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) enzyme activities) parameters were …

Comparison Of In Vitro Cytotoxicity And Genotoxicity Of Mma-Based Polymeric Materials And Various Metallic Materials, Sultan Gülçe İz, Sai̇me İsmet Gürhan, Bi̇lge Hakan Şen, Tuğba Endoğan, Nesri̇n Hasirci

Turkish Journal of Medical Sciences

To determine the in vitro cytotoxicity and genotoxicity of some polymeric and metallic implant materials used as base materials in dentistry, based on ISO (International Organization for Standardization) and OECD (Organization for Economic Co-Operation and Development) test protocols. Materials and methods: Three different acrylate-based polymeric materials were tested for their in vitro cytotoxicity and genotoxicity (polymethylmethacrylate microspheres [PMMA], a solid cement prepared by mixing PMMA with its monomer methylmethacrylate [PMMA+MMA], a solid cement prepared by mixing PMMA, MMA, and hydroxyapatite [PMMA+MMA+HA], as wells as 4 different metallic materials (titanium [Ti grade 4], nickel alloy 625 [Ni-625], stainless steel alloy 304L …

Dermatoglyphics As Markers Of Prenatal Disturbances In Schizophrenia: A Case-Control Study, Bi̇rsen Özyurt, Ahmet Songur, Mustafa Sarsilmaz, Ömer Akyol, Mustafa Namli, Reha Demi̇rel

Turkish Journal of Medical Sciences

Several studies have reported the importance of dermatoglyphics as markers of a prenatal disturbance in patients with schizophrenia. Due to the fact that finger- and handprints are formed by the end of the second trimester, they may provide clues to disturbances in early development. The aim of this study was to determine specific dermatoglyphical frequencies in a sample of patients with schizophrenia and normal controls. Materials and methods: Fingerprints and palm prints were obtained from 45 schizophrenic patients as well as 45 healthy controls. The dermatoglyphic patterns on the fingers (total finger ridge count [TFRC]) and palms (a-b, b-c, and …

Assessment Of Dual Phase Remediation Sites In North Mississippi, Richard H. Crawford

Electronic Theses and Dissertations

No abstract provided.

Exploration Of The Relationship Of Trait And State Anxiety In The Chick Anxiety-Depression Model / Amy L. Salmeto, Amy L. Salmeto

Electronic Theses and Dissertations

No abstract provided.

Geg 3320 : Natural Resource Conservation, Geology/Geography

Approved Course Proposals

No abstract provided.

Geg 3310 : Introduction To Biogeography, Geology/Geography

Approved Course Proposals

No abstract provided.

In Search Of A Method: Charles Sanders Peirce’S Contribution To Theology, Donald Gelpi, Nate Hinerman

Reconstruction: Studies in Contemporary Culture

This article asserts that when one re-grounds the approach to the theological method of Catholic Theologian, Bernard Lonergan, S.J., in the pragmatistic logic and semiotic realism of Charles Sanders Peirce, then Lonergan's theory of functional specialties gives the promise of enabling one to describe how various types of theological inquiry relate to other scholarly disciplines through the criteria of agreement, convergence, complementarity, and disagreement.

Chm 4915 : Advanced Laboratory, Chemistry And Biochemistry

Approved Course Proposals

No abstract provided.

Preventing The Spread Of Hiv After Exposure, Jordan Gebil

A with Honors Projects

A biological breakdown and explanation of what could be done to stop the spread of HIV in the body.

Skeptical About Family Business: Advancing The Field Of Family Business In Its Scholarship, Relevance, And Academic Role, Alex Stewart

Management Faculty Research and Publications

Less polemical authors have published useful overviews of scholarship and institutional development in family business (Chrisman, Kellermanns, Chan, & Liano, 2010; Heck, Hoy, Poutziouris, & Steier, 2008; Schulze & Gedajlovic, 2010; Sharma, 2004). I take this as license for hyperbole. In such a vein, I am skeptical eight times over: that the field can be objective, that it can be defined, that “family business” is the right label, that it will find useful theories, that kinship exists, that if it does exist (all right, I do believe it does) we really observe it in action, that the field can progress …

Effects Of Cultural Practices On Weed Flora In Virginia (Flue-Cured) Organic Tobacco (Nicotiana Tabacum L.): Green Manure And Irrigation Systems, Anestis Karkanis, Dimitrios Bilalis, Aspasia Efthimiadou, Panagiotis Efthimiadis

Turkish Journal of Agriculture and Forestry

Organic tobacco is a new industrial crop. Field experiments were conducted, during 2005-2006, to determine the effects of irrigation system and green manure on weed flora in organic tobacco crops (Nicotiana tabacum cv. NC 71). The experiments were designed as a split plot design with 4 replicates, 2 main plots (drip and sprinkler irrigation), and 3 sub-plots (vetch and red clover as green manure, and control). The greatest number and dry weight of weeds was observed in sprinkler irrigation. Our results indicate that weed distribution under drip and sprinkler irrigation is related not only to the surface soil water content …

Floods, Famines, Or Feasts: Too Much, Too Little, Or Just Right, Sandra B. Zellmer

Faculty Law Review Articles

The United States has a passionate love-hate relationship with water. Americans love to live beside rivers and lakes and use them for drinking water, washing, fishing, generating power, navigating, and recreation. They also love to be able to use water from rivers, lakes, and the ground beneath their property to irrigate their crops. When it's too dry, they pray for rain. But when it's too wet, they beg for sunshine, because as much as they love living as close to the water as they can get, people hate having their homes, workplaces, and crops inundated by floodwater even more. Besides …

Elizabeth Cavalier, Elizabeth A. Cavalier

School of Art Graduate Exhibitions, Portfolios, and Theses

No abstract provided.

Deconstructing United States Sentencing Guidelines Section 3a1.4: Sentencing Failure In Cases Of Financial Support For Foreign Terrorist Organizations, James P. Mcloughlin Jr.

Minnesota Journal of Law & Inequality

No abstract provided.

Infertile Grounds: Feminist Interpretations Of Infertility Exclusions As Sex Discrimination, Jennifer L. Cornell

Minnesota Journal of Law & Inequality

No abstract provided.

Why Not Tell The Truth: Deceptive Practices And The Financial Meltdown., Charles W. Murdock

Faculty Publications & Other Works

No abstract provided.

Extractives And Lignin From Milled Corn Stover : A Comparison Of Soxhlet And Accelerated Solvent Methods, And Particle Size Effects / Ashwini Thakre, Ashwini Thakre

Electronic Theses and Dissertations

No abstract provided.

An Analytical Model For Rotator Cuff Repairs, A. Aurora, Jorge E. Gatica, Antonie J. Van Den Bogert, J. A. Mccarron, Kathleen A. Derwin

Mechanical Engineering Faculty Publications

Background

Currently, natural and synthetic scaffolds are being explored as augmentation devices for rotator cuff repair. When used in this manner, these devices are believed to offer some degree of load sharing; however, no studies have quantified this effect. Furthermore, the manner in which loads on an augmented rotator cuff repair are distributed among the various components of the repair is not known, nor is the relative biomechanical importance of each component. The objectives of this study are to (1) develop quasi-static analytical models of simplified rotator cuff repairs, (2) validate the models, and (3) predict the degree of load …

"There Must Be A Means" - The Backward Jurisprudence Of Baze V. Rees, Nadia N. Sawicki

Faculty Publications & Other Works

No abstract provided.

Ain't I A Parent?: Exclusion Of Kinship Caregivers From The Debate Over Expansions Of Parenthood., Sacha M. Coupet

Faculty Publications & Other Works

Kinship caregivers-a group disproportionately populated by persons of color, particularly black grandmothers -have historically assumed parental roles, often together with a legal parent. Yet even as kin have increasingly assumed substantial parental responsibilities over the past few decades, they continue to have limited opportunities to carry the title of legal parent. At the same time, in claims involving stepfamilies and same sex partners of parents, and cases involving assisted reproductive technology (ART), family courts have expanded their definition of parenthood to recognize the rights of other caregivers, including those whose parental claims extend beyond the so-called "rule of two."2 The …

Variables Of Health Reform And Their Impacts On The Elderly., John D. Blum

Faculty Publications & Other Works

No abstract provided.

Natural Law And The Rights Of The Family, Robert J. Araujo S.J.

Faculty Publications & Other Works

No abstract provided.