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2010

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On The Legal Validation Of Sexual Relationships, Richard Stith Jan 2010

On The Legal Validation Of Sexual Relationships, Richard Stith

Law Faculty Publications

No abstract provided.

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Methods In Environmental Biotechnology For Environmentalists, Florentin Smarandache, W.B. Vasantha Kandasamy, S.R. Kannan, S. Ramathilagam Jan 2010

Methods In Environmental Biotechnology For Environmentalists, Florentin Smarandache, W.B. Vasantha Kandasamy, S.R. Kannan, S. Ramathilagam

Branch Mathematics and Statistics Faculty and Staff Publications

The study of environmental pollution by chemicals used in agriculture as pesticide or as fertilizers or pollution caused by industries and chemical plants which use chemicals have not been analysed systematically. This book has five chapters. First chapter is introductory in nature. Here we just study chemical pollution caused by garment industries in chapter two of this book using fuzzy associative memories. In chapter three we give ways to control pollution by improving the system performance using hierarchical genetic fuzzy control algorithm. This study is carried out using the past data reported by Shimada et al (1995). Health hazards suffered …

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Conservation Status And Habitat Use Of The West Virginia Spring Salamander (Gyrinophilus Subterraneus) And Spring Salamander (G. Porphyriticus) In General Davis Cave, Greenbrier Co., West Virginia, Matthew L. Niemiller, Michael S. Osbourn, Dante B. Fenolio, Thomas K. Pauley, Brian T. Miller, John R. Holsinger Jan 2010

Conservation Status And Habitat Use Of The West Virginia Spring Salamander (Gyrinophilus Subterraneus) And Spring Salamander (G. Porphyriticus) In General Davis Cave, Greenbrier Co., West Virginia, Matthew L. Niemiller, Michael S. Osbourn, Dante B. Fenolio, Thomas K. Pauley, Brian T. Miller, John R. Holsinger

Biological Sciences Faculty Publications

The West Virginia Spring Salamander (Gyrinophilus subterraneus) is one of four obligate cave-dwelling species of plethodontid salamanders found east of the Mississippi River in the United States. This species is endemic to a single cave system; General Davis Cave, in Greenbrier Co., West Virginia, where it is syntopic with the closely-related Spring Salamander (G. porphyriticus). Accordingly, the West Virginia Spring Salamander is a species of critical conservation concern. Because of it's conservation status and lack of data regarding the ecology and life history, particularly about population trends, we present data on relative abundance of and habitat …

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Ancient Dna Analyses Exclude Humans As The Driving Force Behind Late Pleistocene Musk Ox (Ovibos Moschatus) Population Dynamics, Paula F. Campos, Eske Willerslev, Andrei Sher, Ludovic Orlando, Erik Axelsson, Alexei Tikhonov, Kim Aaris-Sorensen, Alex D. Greenwood, Ralf-Dietrich Kahlke, Pavel Kosintsev Jan 2010

Ancient Dna Analyses Exclude Humans As The Driving Force Behind Late Pleistocene Musk Ox (Ovibos Moschatus) Population Dynamics, Paula F. Campos, Eske Willerslev, Andrei Sher, Ludovic Orlando, Erik Axelsson, Alexei Tikhonov, Kim Aaris-Sorensen, Alex D. Greenwood, Ralf-Dietrich Kahlke, Pavel Kosintsev

Biological Sciences Faculty Publications

The causes of the late Pleistocene megafaunal extinctions are poorly understood. Different lines of evidence point to climate change, the arrival of humans, or a combination of these events as the trigger. Although many species went extinct, others, such as caribou and bison, survived to the present. The musk ox has an intermediate story: relatively abundant during the Pleistocene, it is now restricted to Greenland and the Arctic Archipelago. In this study, we use ancient DNA sequences, temporally unbiased summary statistics, and Bayesian analytical techniques to infer musk ox population dynamics throughout the late Pleistocene and Holocene. Our results reveal …

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Chloroquine Susceptibility And Reversibility In A Plasmodium Falciparum Genetic Cross, Jigar J. Patel, Drew Thacker, John C. Tan, Perri Pleeter, Lisa Checkley, Joseph M. Gonzales, Bingbing Deng, Paul D. Roepe, Roland A. Cooper, Michael T. Ferdig Jan 2010

Chloroquine Susceptibility And Reversibility In A Plasmodium Falciparum Genetic Cross, Jigar J. Patel, Drew Thacker, John C. Tan, Perri Pleeter, Lisa Checkley, Joseph M. Gonzales, Bingbing Deng, Paul D. Roepe, Roland A. Cooper, Michael T. Ferdig

Biological Sciences Faculty Publications

Mutations in the Plasmodium falciparum chloroquine (CQ) resistance transporter (PfCRT) are major determinants of verapamil (VP)-reversible CQ resistance (CQR). In the presence of mutant PfCRT, additional genes contribute to the wide range of CQ susceptibilities observed. It is not known if these genes influence mechanisms of chemosensitization by CQR reversal agents. Using quantitative trait locus (QTL) mapping of progeny clones from the HB3 x Dd2 cross, we show that the P. falciparum multidrug resistance gene 1 (pfmdr1) interacts with the South-East Asia-derived mutant pfcrt haplotype to modulate CQR levels. A novel chromosome 7 locus is predicted to contribute …

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Impact Of Soil Drought Stress On Photochemical Efficiency Of Photosystem Ii And Antioxidant Enzyme Activities Of Phaseolus Vulgaris Cultivars, Rabi̇ye Terzi̇, Aykut Sağlam, Ni̇hal Kutlu, Hati̇ce Nar, Asim Kadioğlu Jan 2010

Impact Of Soil Drought Stress On Photochemical Efficiency Of Photosystem Ii And Antioxidant Enzyme Activities Of Phaseolus Vulgaris Cultivars, Rabi̇ye Terzi̇, Aykut Sağlam, Ni̇hal Kutlu, Hati̇ce Nar, Asim Kadioğlu

Turkish Journal of Botany

Common bean (Phaseolus vulgaris L.) cultivars (cvs) (Göynük 98, Karacaşehir 90, Şehirali 90, ES 855, and Yunus 90) were subjected to drought stress in order to assess the levels of drought tolerance through the analysis of growth parameters, leaf water potential (\psi_{leaf}), stomatal conductance (g_s), chlorophyll (chl) content, and lipid peroxidation. Significant differences were recorded among cultivars in most traits. Yunus 90 was identified as the most tolerant, and Karacaşehir 90 was the most sensitive. Furthermore, the changes in antioxidant enzyme activities, H_2O_2 content, and Photosystem II were investigated under drought stress, where Antioxidant enzyme activities increased while H_2O_2 contents …

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Enhanced Adventitious Shoot Regeneration From Aerial Stem Explants Of Ginger Using Tdz And Its Histological Studies, Adinkudikuyyal Lincy, Bhaskaran Sasikumar Jan 2010

Enhanced Adventitious Shoot Regeneration From Aerial Stem Explants Of Ginger Using Tdz And Its Histological Studies, Adinkudikuyyal Lincy, Bhaskaran Sasikumar

Turkish Journal of Botany

A protocol for direct plantlet regeneration from aerial stem explants of ginger (Zingiber officinale Rosc.) has been developed. Adventitious shoots and roots were regenerated from in planta aerial stem explants of 2 ginger varieties viz. var. 'Jamaica' and var. 'Varada'. Maximum shoot and root regeneration were observed in the cultures containing TDZ and IBA (1:1; 1:0.1 mg L-1) in both varieties. Cultures containing TDZ alone showed poor shoot and root formation. Histological studies revealed that the shoot initials originated from the primary thickening meristem and apical meristem, while the root primordial originated from the primary thickening meristem present in the …

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The Genotoxic Potential Of Two Heavy Metals In Inbred Lines Of Maize (Zea Mays L.), Girjesh Kumar, Prashant Kumar Rai Jan 2010

The Genotoxic Potential Of Two Heavy Metals In Inbred Lines Of Maize (Zea Mays L.), Girjesh Kumar, Prashant Kumar Rai

Turkish Journal of Botany

The genotoxic effects of 2 heavy metals (mercury chloride and cadmium chloride) on the gametic cells of 6 inbred lines of maize were tested in terms of cytological abnormalities. Meiosis was normal under control conditions. During the treatments with mercury and cadmium there was a concentration-dependent increase in meiotic abnormalities in all the inbred lines. A wide spectrum of chromosomal aberrations in the treated sets was stickiness, followed by laggards, bridges, scattering, precocious movement, fragments, etc. Maximum chromosomal anomalies were observed in inbred line CM-142 in both the treatment sets of heavy metals. Compared to CdCl_2, HgCl_2 induced more chromosomal …

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A New Species Of Onosma (Boraginaceae) From Eastern Turkey, Ali̇ Kandemi̇r, Zafer Türkmen Jan 2010

A New Species Of Onosma (Boraginaceae) From Eastern Turkey, Ali̇ Kandemi̇r, Zafer Türkmen

Turkish Journal of Botany

Onosma beyazoglui Kandemir & Z. Türkmen sp. nov. (Boraginaceae) is described as a new species from the province of Erzincan in Turkey. Diagnostic morphological characters of this new species from the related species are discussed.

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Nitrogen And Phosphorus Resorption In A Salt Marsh In Northern Turkey, Yasemi̇n Çakir, Tuğba Özbucak, Hamdi̇ Güray Kutbay, Dudu Duygu Kiliç, Ali̇ Bi̇lgi̇n, Rena Huseyinova Jan 2010

Nitrogen And Phosphorus Resorption In A Salt Marsh In Northern Turkey, Yasemi̇n Çakir, Tuğba Özbucak, Hamdi̇ Güray Kutbay, Dudu Duygu Kiliç, Ali̇ Bi̇lgi̇n, Rena Huseyinova

Turkish Journal of Botany

This study was conducted to investigate foliar nitrogen and phosphorus dynamics, nitrogen and phosphorus resorption, and some leaf traits (i.e. SLA=specific leaf area) in some coastal salt marsh plants located in northern Turkey. The study area is located on the east bank of the Kızılırmak River in the central Black Sea Region. There were statistically significant differences among months (from June to October) in terms of SLA in all species except for Artemisia santonicum. However, no significant differences were found with respect to P in all species. The highest N and P resorption efficiencies were found in Salicornia prostrata, whereas …

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Development Of A Highly Responsive Leaf-Based Regeneration System For Peperomia Species, Mohammad Ahmadabadi, Ralph Bock Jan 2010

Development Of A Highly Responsive Leaf-Based Regeneration System For Peperomia Species, Mohammad Ahmadabadi, Ralph Bock

Turkish Journal of Botany

Several species in the genus Peperomia Ruiz & Pav. have giant chloroplasts in the palisade parenchyma of their leaves. Because of this unique feature, Peperomia metallica L. Linden & Rodigas has become a valuable model plant for studying plastid biology. However, the use of Peperomia for molecular studies has been limited by the lack of efficient regeneration and transformation protocols. In this work, we aimed to develop a reliable regeneration system for Peperomia from leaf explants. Using MS medium complemented with different combinations of phytohormones, a highly efficient in vitro regeneration protocol was developed for P. metallica and P. peduncularis, …

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Macrofungi Of Derebucak District (Konya, Turkey), Si̇nan Alkan, Giyasetti̇n Kaşik, Si̇nan Aktaş Jan 2010

Macrofungi Of Derebucak District (Konya, Turkey), Si̇nan Alkan, Giyasetti̇n Kaşik, Si̇nan Aktaş

Turkish Journal of Botany

Macrofungi specimens were collected from different localities in Derebucak district (Konya province) between 2005 and 2007, particularly during the autumn and spring. As a result 134 species were identified. Thirteen of them belong to Ascomycota, and the other 121 belong to the division Basidiomycota. According to the present literature about the macrofungi of Turkey, 6 taxa are new records for Turkey. These are Lachnellula calyciformis (Willd.) Dharne of the division Ascomycota, and Hebeloma stenocystis J.Favre, Cortinarius calochrous var. coniferarum (M.M.Moser) Nezdojm., Cortinarius cupreorufus Brandrud, Inocybe ayeri Furrer-Ziogas, and Calocera pallidospathulata D.A.Reid of the division Basidiomycota.

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Male Individuals In Cultivated Fritillaria Persica L. (Liliaceae): Real Androdioecy Or Gender Disphasy?, Elisa Mancuso, Lorenzo Peruzzi Jan 2010

Male Individuals In Cultivated Fritillaria Persica L. (Liliaceae): Real Androdioecy Or Gender Disphasy?, Elisa Mancuso, Lorenzo Peruzzi

Turkish Journal of Botany

In the last twenty years the growing number of studies about the reproductive biology in angiosperms has brought to light new cases of andromonoecy and androdioecy, the rarest sexual models among flowering plants. Female-sterile sexual systems, especially within order Liliales and family Liliaceae, often seem to occur in the particular form of size/age dependent sex allocation, known as "gender disphasy". The presence of male individuals of Fritillaria persica (Liliaceae) is here documented. Comparative morphological and functional sexual expression of this species, among males and hermaphrodites, was investigated by means of flowers counting, morphometric measurements of plants and pollen-grains, pollen viability …

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A New Species Of Echinops (Asteraceae) From Turkey, Cem Vural, Mustafa Kemal Bi̇ter, Mehmet Yaşar Dadandi Jan 2010

A New Species Of Echinops (Asteraceae) From Turkey, Cem Vural, Mustafa Kemal Bi̇ter, Mehmet Yaşar Dadandi

Turkish Journal of Botany

Echinops dumanii C.Vural is described and illustrated from Adana province, South Anatolia, Turkey. It is considered to be endemic to Turkey. The morphological differences from the closely related species Echinops phaeocephalus Hand.-Mazz. are discussed. The International Union for Conservation of Nature (IUCN) threat category and observations on the ecology of the populations are noted. The geographical distribution of the new species is mapped.

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An Analysis Of Anchitherine Equids Across The Eocene–Oligocene Boundary In The White River Group Of The Western Great Plains, David M. Masciale Jan 2010

An Analysis Of Anchitherine Equids Across The Eocene–Oligocene Boundary In The White River Group Of The Western Great Plains, David M. Masciale

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

Anchitherine horses are a subfamily of equids that are abundantly represented in the late Eocene and early Oligocene of North America. This group has been heavily studied in the past, but important questions still remain. Some studies have focused on the Eocene-Oligocene boundary and have used these equids along with other taxa to study mammalian diet and climate change through this interval. I reexamine two anchitherine genera, Mesohippus and Miohippus, from stratigraphic sequences of the White River Group in western Nebraska and southwestern South Dakota. These sequences span the Chadronian (late Eocene), Orellan (early Oligocene), and Whitneyan (early Oligocene) …

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Methionine-R-Sulfoxide Reductases And Biological Importance Of Free Methionine Sulfoxide Reduction, Byung Cheon Lee Jan 2010

Methionine-R-Sulfoxide Reductases And Biological Importance Of Free Methionine Sulfoxide Reduction, Byung Cheon Lee

Department of Biochemistry: Dissertations, Theses, and Student Research

We identified and functionally characterized yeast fRMsr homolog which showed specificity for reduction of free Met-R-SO and contributed to oxidative stress resistance of yeast cells. We further identified three conserved Cys which participate in catalysis through disulfide exchange. Evolutionary analyses revealed that the occurrence of fRMSr is restricted to unicellular organisms. We further found that mammalian MsrA can reduce free Met-S-SO, whereas MsrBs do not reduce free Met-R-SO. Consistent with these findings and the lack of fRMsr, mammalian cells could not grow in media that replaced Met with Met-R-SO. However, they grew in the presence of free Met-S-SO, which was …

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Feasibility Study Of Solar Driven Underground Cooling System, Michel E. Shafik Jan 2010

Feasibility Study Of Solar Driven Underground Cooling System, Michel E. Shafik

Durham School of Architectural Engineering and Construction: Dissertations, Theses, and Student Research

In the United States the peak electrical use occurs during the summer. In addition, the building sector consumes a major portion of the annual electrical energy consumption. One of the main energy consuming components in the building sector is the Heating, Ventilation, and Air-Conditioning (HVAC) systems. This research studies the feasibility of implementing a solar driven underground cooling system that could contribute to reducing building cooling loads. The developed system consists of an Earth-to-Air Heat Exchanger (EAHE) coupled with a solar chimney that provides a natural cool draft to the test facility building at the Solar Energy Research Test Facility …

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Niche Specialization And Conservation Biology Of Cicindela Nevadica Lincolniana, Tierney R. Brosius Jan 2010

Niche Specialization And Conservation Biology Of Cicindela Nevadica Lincolniana, Tierney R. Brosius

Department of Entomology: Dissertations, Theses, and Student Research

As with many organisms across the globe, Cicindela nevadica lincolniana is threatened with extinction. Understanding ecological factors that contribute to extinction vulnerability and what methods aid in the recovery of those species is essential in developing successful conservation programs. Here we examine behavioral mechanisms for niche partitioning along with improving techniques for captive rearing protocol and increasing public awareness about the conservation of this local insect. Ovipositional selectivity was examined for Cicindela nevadica lincolniana, Cicindela circumpicta, Cicindela togata, Cicindela punctulata, and Cicindela fulgida. Models reflect that these species of co-occurring tiger beetles select different ranges of salinity in which to …

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The Railroads Must Have Ties: A Legal History Of Forest Conservation And The Oregon And California Railroad Land Grant, 1887–1916, Sean M. Kammer Jan 2010

The Railroads Must Have Ties: A Legal History Of Forest Conservation And The Oregon And California Railroad Land Grant, 1887–1916, Sean M. Kammer

Department of History: Dissertations, Theses, and Student Research

Historians have! for the most part! left unchallenged a similar negative view of Edward H. Harriman, who headed both the Union Pacific and the Southern Pacific and was perhaps the most powerful of the railroad tycoons during the first decade of the twentieth century.4 Prior to Harriman's takeover of the Southern Pacific in 1901, that railroad's long-standing policy had been to subdivide and sell lands to farmers, miners, and loggers, the purpose being lito encourage long-term settlement, economic growth, and rail traffic," but Harriman questioned and ultimately rejected this policy.s In January 1903, he ordered the termination of sales of …

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Carbon Dynamics In A Phragmites Australis Invaded Riparian Wetland, Steven Walters Jan 2010

Carbon Dynamics In A Phragmites Australis Invaded Riparian Wetland, Steven Walters

School of Natural Resources: Dissertations, Theses, and Student Research

Invasive plant species are widely recognized as a major threat to biodiversity and ecosystem stability. Wetland ecosystems tend to be much more susceptible to invasions because of their location on the landscape where water, nutrients, and the impacts of disturbances accumulate. Invasive plants have the ability to alter ecosystem processes and community/population dynamics. The ability of invasive plants to alter these processes can have profound economic consequences. In the United States, control of invasive wetland species alone costs approximately 155 million dollars annually. The state of Nebraska spends 2 million dollars annually controlling invasive plant species in the Platte River …

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Retention, Movement, And The Biotic Response To Large Woody Debris In The Channelized Missouri River, Michael W. Archer Jan 2010

Retention, Movement, And The Biotic Response To Large Woody Debris In The Channelized Missouri River, Michael W. Archer

School of Natural Resources: Dissertations, Theses, and Student Research

Large woody debris (LWD) is an important component of a healthy aquatic ecosystem. However, little is known about the dynamics of LWD in a large, channelized river such as the Missouri River. My objectives were to first, assess the abundance of LWD found along the channelized portion of the Missouri River. Second, I documented movement of LWD that entered the river. Lastly, using PRIMER software I analyzed what effect, if any, river segments, bend types, and LWD had on the community composition of the macroinvertebrate and fish that inhabit the river. Abundance of LWD was greater along bends that have …

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Multiple Determinants Of Sexualized Behavior In Middle Childhood: A Developmental Psychopathology Perspective, Natasha Elkovitch Jan 2010

Multiple Determinants Of Sexualized Behavior In Middle Childhood: A Developmental Psychopathology Perspective, Natasha Elkovitch

Department of Psychology: Dissertations, Theses, and Student Research

In order to adequately and appropriately intervene with children exhibiting problematic sexual behaviors, a comprehensive understanding of etiology is imperative. Although sexually abused children are observed engaging in more problematic sexual behaviors than their normative or psychiatric counterparts, it is clear that such behaviors may be the result of factors other than, or in addition to, sexual abuse. The goal of the present study was utilize a developmental psychopathology perspective in broadening our understanding of mechanisms associated with the development of problematic sexual behaviors in childhood. Participants for the study include 1, 149 children (51.8% female) drawn from the Longitudinal …

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The Experience And Expression Of Emotion Within Stepsibling Relationships: Politeness Of Expression And Stepfamily Functioning, Emily Lamb Normand Jan 2010

The Experience And Expression Of Emotion Within Stepsibling Relationships: Politeness Of Expression And Stepfamily Functioning, Emily Lamb Normand

Department of Communication Studies: Dissertations, Theses, and Student Research

While scholars agree there are emotional challenges associated with the divorce and remarriage process, little is known about how stepsiblings interact and manage the experience and expression of emotion within their stepfamily. The current investigation examined the frequency of experience, intensity, and expression of positive, strong negative, and weak negative emotion within stepsibling relationships over time. Using Politeness Theory as a framework, the study also investigated if an association existed between stepsiblings’ use of politeness strategies during the expression of emotion and stepsiblings’ perception of the quality of their relationship and their perception of the entire stepfamily. Participants were 187 …

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Yield Potential And Resource-Use Efficiency Of Maize Systems In The Western U. S. Corn Belt, Patricio Grassini Jan 2010

Yield Potential And Resource-Use Efficiency Of Maize Systems In The Western U. S. Corn Belt, Patricio Grassini

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Maize demand for food, livestock feed, and biofuel is expected to increase substantially. The Western U.S. Corn Belt accounts for 23% of U.S. maize production, and irrigated maize accounts for 43 and 58% of maize land area and total production, respectively, in this region. The most sensitive parameters (yield potential [YP], water-limited yield potential [YP-W], yield gap between actual yield and YP, and resource-use efficiency) governing performance of maize systems in the region are lacking. A simulation model was used to quantify YP under irrigated and rainfed conditions based on weather data, soil properties, and crop management at 18 locations. …

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Molecular Dynamics Studies Of Simple Model Fluids And Water Confined In Carbon Nanotube, Jun Wang Jan 2010

Molecular Dynamics Studies Of Simple Model Fluids And Water Confined In Carbon Nanotube, Jun Wang

Department of Chemistry: Dissertations, Theses, and Student Research

Molecular Dynamics (MD) simulation is one of the most important computational techniques with broad applications in physics, chemistry, chemical engineering, materials design and biological science. Traditional computational chemistry refers to quantum calculations based on solving Schrodinger equations. Later developed Density Functional Theory (DFT) based on solving Kohn-Sham equations became the more popular ab initio calculation technique which could deal with ~1000 atoms by explicitly considering electron interactions. In contrast, MD simulation based on solving classical mechanics equations of motion is a totally different technique in the field of computational chemistry. Electron interactions were implicitly included in the empirical atom-based potential …

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Examining The Impact Of Student Involvement And Intercultural Experiences On Perceptions Of Institutional Commitment To Diversity, Aaron Klein Haight Jan 2010

Examining The Impact Of Student Involvement And Intercultural Experiences On Perceptions Of Institutional Commitment To Diversity, Aaron Klein Haight

Master's Theses and Doctoral Dissertations

The purpose of this study was to examine the impact of involvement in student organizations as it relates to perceptions of campus climate. The researcher conducted a crosssectional, ex-post facto secondary data analysis of a 2005 institutional survey on diversity at Great Falls State University. The researcher utilized a Chi Square Test for Independence, as well as a Forward Thinking Logistic Regression Model to analyze the data. Although the main emphasis of the research was student involvement in student organizations, the researcher also analyzed data pertaining to background demographics and campus climate. The data results demonstrated differences in perception in …

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The Impact Of Wyeth V. Levine On Fda Regulation Of Prescription Drugs, Richard C. Ausness Jan 2010

The Impact Of Wyeth V. Levine On Fda Regulation Of Prescription Drugs, Richard C. Ausness

Law Faculty Scholarly Articles

On March 4, 2009, the United States Supreme Court decided Wyeth v. Levine. In that case, the Court concluded that the plaintiff's failure to warn claim against the makers of the drug Phenergan was not impliedly preempted by the Food, Drug and Cosmetic Act (FDCA). In doing so, the Court rejected the argument of the U.S. Food and Drug Administration (FDA) that tort claims of this nature stand as an obstacle to federal regulatory objectives. This article evaluates the Court's opinion in Wyeth and examines that decision's impact on subsequent litigation in the area of prescription drug labeling. In …

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Theoretical And Experimental Study Of The Gem-Dimethyl (Thorpe-Ingold) Effect On The Rate Of The Bergman Cyclization Of The Eleven-Carbon Monocyclic Enediyne, Olga Lavinda Jan 2010

Theoretical And Experimental Study Of The Gem-Dimethyl (Thorpe-Ingold) Effect On The Rate Of The Bergman Cyclization Of The Eleven-Carbon Monocyclic Enediyne, Olga Lavinda

Student Theses and Dissertations

No abstract provided.

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Major Challenges For The Modern Chemistry In Particular And Science In General, Vuk Uskoković Jan 2010

Major Challenges For The Modern Chemistry In Particular And Science In General, Vuk Uskoković

Pharmacy Faculty Articles and Research

In the past few hundred years, science has exerted an enormous influence on the way the world appears to human observers. Despite phenomenal accomplishments of science, science nowadays faces numerous challenges that threaten its continued success. As scientific inventions become embedded within human societies, the challenges are further multiplied. In this critical review, some of the critical challenges for the field of modern chemistry are discussed, including: (a) interlinking theoretical knowledge and experimental approaches; (b) implementing the principles of sustainability at the roots of the chemical design; (c) defining science from a philosophical perspective that acknowledges both pragmatic and realistic …

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Hcmv Pus28 Initiates Pro-Migratory Signaling Via Activation Of Pyk2 Kinase, Jennifer Totonchy, Susan Varnum, Ryan Melnychuk, Patricia Smith, Ljiliana Pasa-Tolic, Janani I. Shutthanadan, Daniel N. Streblow Jan 2010

Hcmv Pus28 Initiates Pro-Migratory Signaling Via Activation Of Pyk2 Kinase, Jennifer Totonchy, Susan Varnum, Ryan Melnychuk, Patricia Smith, Ljiliana Pasa-Tolic, Janani I. Shutthanadan, Daniel N. Streblow

Pharmacy Faculty Articles and Research

Background: Human Cytomegalovirus (HCMV) has been implicated in the acceleration of vascular disease and chronic allograft rejection. Recently, the virus has been associated with glioblastoma and other tumors. We have previously shown that the HCMV-encoded chemokine receptor pUS28 mediates smooth muscle cell (SMC) and macrophage motility and this activity has been implicated in the acceleration of vascular disease. pUS28 induced SMC migration involves the activation of the protein tyrosine kinases (PTKs) Src and Focal adhesion kinase as well as the small GTPase RhoA. The PTK Pyk2 has been shown to play a role in cellular migration and formation of cancer, …

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