Digital Commons Network^™

Mechanism Of Catch Force: Tethering Of Thick And Thin Filaments By Twitchin., Thomas M Butler, Marion J Siegman

Department of Molecular Physiology and Biophysics Faculty Papers

Catch is a mechanical state occurring in some invertebrate smooth muscles characterized by high force maintenance and resistance to stretch during extremely slow relaxation. During catch, intracellular calcium is near basal concentration and myosin crossbridge cyctng rate is extremely slow. Catch force is relaxed by a protein kinase A-mediated phosphorylation of sites near the N- and C- temini of the minititin twitchin (approximately 526 kDa). Some catch force maintenance car also occur together with cycling myosin crossbridges at submaximal calcium concentrations, but not when the muscle is maximally activated. Additionally, the link responsible for catch can adjust during shortening of …

Real Three-Dimensional Objects Improve Performance For Both Genders On A Mental Rotation Task, Michael C. Felix

Undergraduate Honors Theses

Mental rotation (MR) tasks consistently show sex differences in performance. However, such tasks commonly present three-dimensional (3D) objects in two-dimensional paper-and-pencil forms (i.e., quasi-3D). The current experiment investigated the effect of real 3d objects on MR performance to determine if sex differences in MR are, in part, an artifact of using quasi-3D stimuli. Eighty undergraduates (40 men, 40 women) underwent training prior to alternating timed blocks of real-3D and quasi-3D MR trials. Sex differences were observed under both quasi-3D and real-3D conditions with real-3D stimuli resulting in higher accuracy for both sexes. Enrollment in science courses and self-reported map proficiency …

Differential Impact Of Tumor Suppressor Pathways On Dna Damage Response And Therapy-Induced Transformation In A Mouse Primary Cell Model., A Kathleen Mcclendon, Jeffry L Dean, Adam Ertel, Erik S Knudsen

Department of Cancer Biology Faculty Papers

The RB and p53 tumor suppressors are mediators of DNA damage response, and compound inactivation of RB and p53 is a common occurrence in human cancers. Surprisingly, their cooperation in DNA damage signaling in relation to tumorigenesis and therapeutic response remains enigmatic. In the context of individuals with heritable retinoblastoma, there is a predilection for secondary tumor development, which has been associated with the use of radiation-therapy to treat the primary tumor. Furthermore, while germline mutations of the p53 gene are critical drivers for cancer predisposition syndromes, it is postulated that extrinsic stresses play a major role in promoting varying …

Synthesis Of Novel Borinic Acids As Potential Hiv-1 Protease Inhibitors, Donald Ray Clayton Iii

Undergraduate Honors Theses

Implementation of antiretroviral treatment has drastically increased both the survival and quality of life of HIV/AIDS patients. While there has been significant success using these life saving drugs, several problems have arisen during their use. Among these major setbacks included the rising incidences of resistance, low bioavailability, and an unacceptable level of toxicity. Consequently, there is an urgent need for the development and production of new inhibitory compounds with increased resistance profiles, higher bioavailability, and decreased toxicity. Recent studies have demonstrated that boron modified peptides are effective inhibitors of aspartic proteases. Furthermore, these boronated compounds have exhibited dual-inhibition along with …

Building The Pandemic Influenza Digital Archive (Pida) At The National Institutes Of Health Library, James King

Sci-Tech News

A paper delivered at the Future of Science Librarianship Contributed Papers session at the 2010 Annual Conference of the Special Libraries Association.

Defining Future Roles For Science Librarians: One Publisher's Perspective, Karen Hunter

Sci-Tech News

A paper delivered at the Future of Science Librarianship Contributed Papers session at the 2010 Annual Conference of the Special Libraries Association.

Sci-Tech Book News Reviews, Susan Fingerman

Sci-Tech News

This section consists of 100 book reviews selected from Sci-Tech Book News, reprinted with the permission of Book News, Inc.

Regulation Of Medicine Patents By The Anti-Counterfeiting Trade Agreement To Broaden Access To Medicine, Daniel Lee

Intellectual Property Brief

No abstract provided.

A Call For A New Geoscience Education Research Agenda, Elizabeth B. Lewis, Dale R. Baker

Department of Teaching, Learning, and Teacher Education: Faculty Publications

A lack of qualified teachers and low enrollment in the geosciences exist at both secondary and tertiary levels in the United States. Consequently, it is unlikely that students will be able to achieve scientific literacy without an increase in both of these populations. To address these problems, we pose research questions, highlight sociocultural theories, and provide examples of other science education research as possible avenues by which to explore these related problems. We argue that such research studies are necessary to inform science education policy and advance national scientific literacy.

Mathematics & Statistics Newsletter January 2010, Rit Department Of Mathematics And Statistics

RIT Digital Archives

No abstract provided.

Department Of Economics Publication List 2010, Penny Stover

Economics Pamphlet Series (1985-2016)

This compilation lists published works authored by Department of Economics faculty members and other staff working on projects funded through the Department of Economics. Publications resulting from their research and academic activities are indexed by author at the end of this pamphlet for easy access by the public. The articles were published between January 1, 2009 and December 31, 2009.

Bo38-3-Web.Pdf, Bird Observer

Bird Observer

No abstract provided.

Commentary

The Journal of Law and Education

No abstract provided.

Bo38-1-Web.Pdf, Bird Observer

Bird Observer

No abstract provided.

Comparing Models Of Evolution For Ordered And Disordered Proteins, Celeste J. Brown, Audra K. Johnson, Gary W. Daughdrill

Molecular Biosciences Faculty Publications

Most models of protein evolution are based upon proteins that form relatively rigid 3D structures. A significant fraction of proteins, the so-called disordered proteins, do not form rigid 3D structures and sample a broad conformational ensemble. Disordered proteins do not typically maintain long-range interactions, so the constraints on their evolution should be different than ordered proteins. To test this hypothesis, we developed and compared models of evolution for disordered and ordered proteins. Substitution matrices were constructed using the sequences of putative homologs for sets of experimentally characterized disordered and ordered proteins. Separate matrices, at three levels of sequence similarity ( …

Status Of Credit For Prior Learning (Cpl) At The University Of Kentucky For 2008 & 2009 Official Cohorts, Randolph Hollingsworth

Undergraduate Education White Papers

This paper explores the college readiness levels of University of Kentucky's incoming first-year students, especially in preparation for success in UK's STEM majors.  Attention is paid to the statewide standards using ACT sub-scores in English, Reading and Mathematics, as well as the students’ scores from nationally recognized assessments (e.g., Advanced Placement scores). Evidence regarding a significant number of our entering cohorts for 2008 and 2009 (first time first-year, full-time, degree-seeking) who bring in credit for prior learning (CPL) is examined, and the paper discusses briefly how CPL affects their placement in their fall semester courses.

Mimosa 2010/2011, Jacksonville State University

JSU Yearbooks

The JSU Yearbook Collection spans the years from 1926 to the present. The publication began in 1926 as the Teacola (some volumes spelled "Teacoala") and continued under this title through 1933. The yearbook appears to have ceased printing after that year; the student newspaper took the name Teacola (later changed to the Collegian and finally the Chanticleer) and began publication in 1934. The yearbook started up again in 1947 under the name Mimosa. The Library holds all volume years that were printed: 1926-1933, 1947-1950, 1952-present.

The Role Of Cuticle, Fatty Acids, And Lipid Signaling In Plant Defense, Ye Xia

Theses and Dissertations--Plant Pathology

Systemic acquired resistance (SAR) is initiated upon recognition of specific microbial effectors by cognate plant resistance proteins and immunizes distal tissues of plants against secondary infections. SAR involves the generation of a mobile signal at the site of primary infection, which then translocates to and activates defense responses in the distal tissues via some unknown mechanism(s). This study shows that an ACYL CARRIER PROTEIN 4 (ACP4), GLABRA1 (GL1) and ACYL CARRIER BINDING PROTEINS (ACBP) are required for the processing of the mobile SAR signal in distal tissues of Arabidopsis. Although acp4, gl1 and acbp plants generate the mobile signal, …

Limiting Death: Maryland’S New Death Penalty Law, Michael Millemann

Maryland Law Review

In this Article, I describe and analyze the State of Maryland's 2009 death penalty law. This law adds three new death-eligibility criteria to the pre-existing law. These new evidentiary criteria supplement the pre-existing substantive death-eligibility criteria. As a result, Maryland now has one of the most restrictive death penalties in the country.

Identification Of A Nuclear Export Signal In The Catalytic Subunit Of Amp-Activated Protein Kinase, N. Kazgan, Tyisha Williams, L. J. Forsberg, J. E. Brenman

Biology Faculty Research

The metabolic regulator AMP-activated protein kinase (AMPK) maintains cellular homeostasis through regulation of proteins involved in energy-producing and -consuming pathways. Although AMPK phosphorylation targets include cytoplasmic and nuclear proteins, the precise mechanisms that regulate AMPK localization, and thus its access to these substrates, are unclear. We identify highly conserved carboxy-terminal hydrophobic amino acids that function as a leptomycin B–sensitive, CRM1-dependent nuclear export sequence (NES) in the AMPK catalytic subunit (AMPKα). When this sequence is modified AMPKα shows increased nuclear localization via a Ran-dependent import pathway. Cytoplasmic localization can be restored by substituting well-defined snurportin-1 or protein kinase A inhibitor (PKIA) …

2010 Commencement Program, Seattle University

Commencement Programs

No abstract provided.

Distillers Grains And Livestock Are Important To Ethanol Energy And Greenhouse Gas Balance, Virgil R. Bremer, Adam J. Liska, Haishun Yang, Daniel T. Walters, Galen E. Erickson, Terry J. Klopfenstein, Richard K. Koelsch, Kenneth G. Cassman

Nebraska Beef Cattle Reports

A life cycle assessment of the impact of distillers grains plus solubles (DGS) on mitigation of energy and greenhouse gas (GHG) emissions comparing corn ethanol to gasoline demonstrates the importanceof feeding wet DGS (WDGS) to feedlot cattle to optimize the environmental benefit of ethanol production relative to gasoline. Ethanol produced in Nebraska has a superior environmentalimpact compared to ethanol produced in Iowa or Texas.

Genetic And Phenotypic Parameter Estimates For Feed Intake And Other Traits In Growing Beef Cattle, Kelsey Rolfe, Merlyn K. Nielsen, Calvin L. Ferrell, Thomas G. Jenkins

Nebraska Beef Cattle Reports

The goal of this study was to estimate genetic and phenotypic parameters for growth, feed intake, feed efficiency, and temperament traits in a mixed-breed composite population of growing beef cattle. Intake and gain:feed (G:F) were moderately heritable; however, residual feed intake (RFI) was more heritable than other measures of feed efficiency. Adjusting RFI and G:F for carcass fatness had little effect on heritability and correlations with remaining traits. Flight speed was moderately heritable and highly repeatable. Flight speed was not highly correlated with measures of intake or feed efficiency. Some small breed effects were observed. High heritability estimates indicate that …

Wet Distillers Grains Diets Supplemented With Vitamin E Alter The Mineral Composition Of Beef M. Longissimus Lumborum And M. Psoas Major, Lasika S. Senaratne, Chris R. Calkins, Amilton S. De Mello Jr., Galen E. Erickson

Nebraska Beef Cattle Reports

Crossbred yearlings (n = 90) were allotted to one of 10 diets containing 0, 20 or 40% wet distillers grains (WDG) with or without vitamin E supplementation and distillers solubles (DS). Strip loin and tenderloin steaks were obtained and tested for their mineral (Ca, P, K, Mg, Zn, Fe, Mn, Cu, S, and Na) compositions using atomic absorption spectroscopy. Cattle fed DS diets had higher (P ≤ 0.05) levels of Ca, Fe, P, Mn, and S in strip loins than cattle fed non-DS diets. Feeding DS significantly reduced Mg and Na in tenderloins. Neither WDG nor vitamin E diets significantly …

Statistics Used In The Nebraska Beef Report And Their Purpose

Nebraska Beef Cattle Reports

The purpose of beef cattle and beef product research at UNL is to provide reference information that represents the various populations (cows, calves, heifers, feeders, carcasses, retail products, etc.) of beef production. Obviously, researchers cannot apply treatments to every member of a population; therefore, they must sample the population. The use of statistics allows researchers and readers of the Nebraska Beef Report the opportunity to evaluate separation of random (chance) occurrences and real biological effects of a treatment. Following is a brief description of the major statistics used in the beef report. For a more detailed description of the expectations …

Reduced Hamster Usage And Stress In Propagating Leishmania Chagasi Promastigotes Using Cryopreservation And Saphenous Vein Inoculation, Soi Meng Lei, Amanda E. Ramer-Tait, Rebecca R. Dahlin-Laborde, Kathleen Mullin, Jeffrey K. Beetham

Amanda Ramer-Tait Publications

Leishmania chagasi, a causal agent of visceral leishmaniasis, requires passage through lab animals such as hamsters to maintain its virulence. Hamster infection is typically accomplished via cardiac puncture or intraperitoneal injection, procedures accompanied by risks of increased animal stress and death. The use of the hamster model also necessitates a regular supply of infected animals, because L. chagasi parasites newly isolated from an infected hamster can be grown in culture for only several weeks before loss of function/phenotype occurs. In an effort to decrease animal usage and animal stress, experiments were performed to assess a more gentle inoculation …

Individuality In Gut Microbiota Composition Is A Complex Polygenic Trait Shaped By Multiple Environmental And Host Genetic Factors, Andrew K. Benson, Scott A. Kelly, Ryan Legge, Fangrui Ma, Soo Jen Low, Jaehyoung Kim, Min Zhang, Phaik Lyn Oh, Derrick Nehrenberg, Kunjie Huab, Stephen D. Kachman, Etsuko N. Moriyama, Jens Walter, Daniel A. Peterson, Daniel Pomp

Center for Plant Science Innovation: Faculty Publications

In vertebrates, including humans, individuals harbor gut microbial communities whose species composition and relative proportions of dominant microbial groups are tremendously varied. Although external and stochastic factors clearly contribute to the individuality of the microbiota, the fundamental principles dictating how environmental factors and host genetic factors combine to shape this complex ecosystem are largely unknown and require systematic study. Here we examined factors that affect microbiota composition in a large (n = 645) mouse advanced intercross line originating from a cross between C57BL/6J and an ICR-derived outbred line (HR). Quantitative pyrosequencing of the microbiota defined a core measurable microbiota …

Overview Of Surgical Management Of Infectious Non-Suppurative Brain Lesions (Part 2), Muhammad Shahzad Shamim, Ather Enam, Syed Faizan Ali, Rushna Pervez Ali, Mohammad Wasay

Section of Neurosurgery

No abstract provided.

Essential Medicines Management During Emergencies In Pakistan, S. K. S. Bukhari, J.A.R. H. Qureshi, Rashid Jooma, K.M. Bile, G. N. Kazi, W. A. Zaibi, A. Zafar

Section of Neurosurgery

This paper illustrates the experiences of essential medicine management in providing cure and care to victims of Pakistan's 2005 earthquake in a safe, rational and effective mode. The health interventions assured access to essential medicine, sustained supply, inventory control through a computerized logistic support system and rational use of medicines. World Health Organization Pakistan outlined modalities for acceptance of donated medicines, assisted in speedy procurement of medicines and designed customized kits. Proper storage of medicines at controlled temperature was ensured in warehousing facilities in 12 locations. A steady supply of medicines and their consumption without stock-outs in the 56 first-level …

An Inquiry Of The Lived Experiences And Contextual Understandings Of Early Childhood Special Educators Related To Children's Trauma, Alison Dubois

Electronic Theses and Dissertations

Secondary trauma stress, compassion fatigue, and vicarious trauma are terms rarely found in educational literature. Studies have shown the significant and lasting ramifications of these constructs within the realm of counseling and psychology. Professionals working in educational settings with high risk populations encounter multiple exposures to children experiencing traumatic events. Despite this phenomenon, teacher and counselor training programs do little to address the issue, thereby matriculating graduates who do not feel confident, well informed, and effective when dealing with trauma material on a daily basis.

This inquiry sought to examine the lived experiences and contextual understandings of early childhood special …