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2010

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An Analyses Of The Institution Of The Catholic Church From The Perspective Of New Institutional Economics And As A 'Carrier Of History' (David, 1994) In The Handling And Reporting Of Child Sexual Abuse, Given Its Role As A Social Institution Within Wider Irish Society, Elaine Mary Buckley Jan 2010

An Analyses Of The Institution Of The Catholic Church From The Perspective Of New Institutional Economics And As A 'Carrier Of History' (David, 1994) In The Handling And Reporting Of Child Sexual Abuse, Given Its Role As A Social Institution Within Wider Irish Society, Elaine Mary Buckley

Comparative Research in Law & Political Economy

This paper analyses the institution of the Catholic Church from the perspective of new institutional economics and as a “carrier of history” (David, 1994). This paper surveys the relevant body of literature and applies it directly to the problem of the lack of reporting of and the improper handling of child sexual abuse by the Catholic Church, given its role as a social institution within wider Irish society.

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The Future Of Legal Theory, Peer Zumbansen Jan 2010

The Future Of Legal Theory, Peer Zumbansen

Comparative Research in Law & Political Economy

This paper is part of a larger inquiry into “The Future of Law,” conducted by the Hague Institute for the Internationalisation of Law. The present paper addresses the prospects of development in the area of legal theory. It argues for a fundamental transformation of legal theory in the context of an increasingly interdisciplinary investigation into conceptualising legal argument and law’s role in regulating modern societies, inside and outside known parameters such as the state, normative hierarchy or ‘unity of law’. Instead, we must ask how and whether law at all can (or, should) reassert its place in a multi-vocal assessment …

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Making Space For Grandma: The Emancipation Of Traditional Knowledge And The Dominance Of Western-Style Intellectual Property Rights Regimes, Ikechi Mgbeoji Jan 2010

Making Space For Grandma: The Emancipation Of Traditional Knowledge And The Dominance Of Western-Style Intellectual Property Rights Regimes, Ikechi Mgbeoji

Comparative Research in Law & Political Economy

The question that this paper seeks to tackle is whether the patent system is of any relevance or pertinence to the search for mechanisms for the protection of traditional knowledge (TK) of the medicinal uses of biodiversity possessed by traditional knowledge practitioners across different parts of the world. Allegations of biopiracy have been made against researchers, bioprospectors and other entities actively scouring indigenous peoples’ cornucopia for the next miracle drug. The objective of this paper will be achieved through two main approaches. The first analyzes the historical and philosophical roots of the divide between dominant regimes of intellectual property rights …

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Jurisprudence And Psychology, Dan Priel Jan 2010

Jurisprudence And Psychology, Dan Priel

Comparative Research in Law & Political Economy

I argue that much of the work in analytic jurisprudence has been concerned with two questions that have not been adequately distinguished: (a) an inquiry about the concept of law, and (b) an explanation of the important features of the practice of law. It is often assumed that the two inquiries are the same. In this essay I distinguish the two and argue that work in psychology provides important insights about both. With regard to the first, I argue that much jurisprudential conceptual analysis is challenged by psychological work on concepts. With regard to the second, I argue that legal …

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First Amendment Protection Of Teachers' Instructional Speech: Extending Rust V. Sullivan To Ensure That Teachers Do Not Distort The Government Message, Emily White Kirsch Jan 2010

First Amendment Protection Of Teachers' Instructional Speech: Extending Rust V. Sullivan To Ensure That Teachers Do Not Distort The Government Message, Emily White Kirsch

Cleveland State Law Review

The emergence of political activism in the 2008 presidential election extended throughout the country and even to where partisan politics have no place: the public school classroom. In 2004, the New York City Board of Education enacted a regulation that prohibited teachers from wearing any material supporting political candidates or organizations. During the 2008 election, teachers who wanted to wear partisan political buttons in the classroom while teaching claimed that the regulation violated their First Amendment rights. Although the Southern District of New York ultimately held that the teachers had no First Amendment claim, the court's decision, which involved sorting …

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Two New Species Of Freshwater Crabs From Mt. Elgon, East Africa With A Redescription Of Potamonautes Niloticus And Notes On Their Natural History" , Neil Cumberlidge, Paul F. Clark Jan 2010

Two New Species Of Freshwater Crabs From Mt. Elgon, East Africa With A Redescription Of Potamonautes Niloticus And Notes On Their Natural History" , Neil Cumberlidge, Paul F. Clark

Journal Articles

No abstract provided.

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2010 Commencement Program, Morehead State University. Registrar's Office. Jan 2010

2010 Commencement Program, Morehead State University. Registrar's Office.

Morehead State Commencement Programs

2010 commencement programs of Morehead State University.

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The Case For Stewart Over Harlan On 24/7 Physical Surveillance, Afsheen John Radsan Jan 2010

The Case For Stewart Over Harlan On 24/7 Physical Surveillance, Afsheen John Radsan

Faculty Scholarship

This Article explains why the government’s physical surveillance can reach a point in terms of duration and intensity that it becomes a “search” under the Fourth Amendment. As references, Katz v. United States and Kyllo v. United States stand out from the canon. Katz, decided in 1967, swept away a prior emphasis on property rights and trespass laws to hold that the electronic monitoring of a phone booth was a search. Since then, the two-part test from Justice Harlan’s concurring opinion has received as much attention as the totality-of-the-circumstances test in Justice Stewart’s majority opinion. Kyllo, decided just months before …

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Introduction: Obstacles To The Development And Use Of Pharmacotherapies For Addiction, Richard C. Boldt Jan 2010

Introduction: Obstacles To The Development And Use Of Pharmacotherapies For Addiction, Richard C. Boldt

Journal of Health Care Law and Policy

No abstract provided.

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The Virtues Of Pragmatism In Drug Policy, Richard J. Bonnie Jan 2010

The Virtues Of Pragmatism In Drug Policy, Richard J. Bonnie

Journal of Health Care Law and Policy

No abstract provided.

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The Food And Drug Administration And The Pharmacy Profession: Partners To Ensure The Safety And Efficacy Of Pharmacogenomic Therapy, Jennifer E. Spreng Jan 2010

The Food And Drug Administration And The Pharmacy Profession: Partners To Ensure The Safety And Efficacy Of Pharmacogenomic Therapy, Jennifer E. Spreng

Journal of Health Care Law and Policy

No abstract provided.

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Symposium - Emerging Issues In Food And Drug Law: A National Conferencefor Lawyers, Policy-Makers, And Corproate Leaders - Table Of Contents Jan 2010

Symposium - Emerging Issues In Food And Drug Law: A National Conferencefor Lawyers, Policy-Makers, And Corproate Leaders - Table Of Contents

Journal of Health Care Law and Policy

No abstract provided.

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Thoughts On Preemption In The Wake Of The Levine Decision, Erika Fisher Lietzan, Sarah E. Pitlyk Jan 2010

Thoughts On Preemption In The Wake Of The Levine Decision, Erika Fisher Lietzan, Sarah E. Pitlyk

Journal of Health Care Law and Policy

No abstract provided.

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Follow-On Biologics: Legal, Scientific, And Policy Considerations, Jeremiah L. Kelly Jan 2010

Follow-On Biologics: Legal, Scientific, And Policy Considerations, Jeremiah L. Kelly

Journal of Health Care Law and Policy

No abstract provided.

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Life With A Rems: Challenges And Opportunities, Jennifer L. Bragg, Maya P. Florence Jan 2010

Life With A Rems: Challenges And Opportunities, Jennifer L. Bragg, Maya P. Florence

Journal of Health Care Law and Policy

No abstract provided.

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Shorebird Migration Ecology At Monomoy National Wildlife Refuge, Stephanie Lianne Koch Jan 2010

Shorebird Migration Ecology At Monomoy National Wildlife Refuge, Stephanie Lianne Koch

Open Access Dissertations

Many species of shorebirds (Charadrii) are long-distance migrants that rely on disturbance-free stopover sites with abundant food. Adequate protection of stopover sites requires knowledge of migration chronology, effects of anthropogenic disturbances, and factors affecting habitat selection. We studied shorebird migration ecology at Monomoy National Wildlife Refuge (Refuge), Cape Cod, Massachusetts, one of the most important shorebird stopover sites in eastern North America. Our findings can be implemented by land managers in the future to maintain the integrity of this stopover site. In the first manuscript, we studied seasonal variation in shorebird abundance during migration and determined peak periods of human …

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Effects Of Flight Speed Upon Muscle Activity In Hummingbirds, Bret W. Tobalske, Andrew A. Biewener, Douglas R. Warrick, Tyson L. Hedrick, Donald R. Powers Jan 2010

Effects Of Flight Speed Upon Muscle Activity In Hummingbirds, Bret W. Tobalske, Andrew A. Biewener, Douglas R. Warrick, Tyson L. Hedrick, Donald R. Powers

Faculty Publications - Department of Biological & Molecular Science

Hummingbirds have the smallest body size and highest wingbeat frequencies of all flying vertebrates, so they represent one endpoint for evaluating the effects of body size on sustained muscle function and flight performance. Other bird species vary neuromuscular recruitment and contractile behavior to accomplish flight over a wide range of speeds, typically exhibiting a Ushaped curve with maxima at the slowest and fastest flight speeds. To test whether the high wingbeat frequencies and aerodynamically active upstroke of hummingbirds lead to different patterns, we flew rufous hummingbirds (Selasphorus rufus, 3��g body mass, 42��Hz wingbeat frequency) in a variable-speed wind tunnel (0–10��m��s–1). …

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Erk Activation And Cell Growth Require Cam Kinases In Mcf-7 Breast Cancer Cells, John M. Schmitt, Ellen Abell, Andrea Wagner, Monika A. Davare Jan 2010

Erk Activation And Cell Growth Require Cam Kinases In Mcf-7 Breast Cancer Cells, John M. Schmitt, Ellen Abell, Andrea Wagner, Monika A. Davare

Faculty Publications - Department of Biological & Molecular Science

Previous studies on MCF-7 breast cancer cells have shown that the G-protein coupled receptor (GPCR) agonist carbachol increases intracellular calcium levels and the activation of extracellular signal-regulated kinase (ERK). Calcium and calmodulin regulate the calcium/calmodulin- dependent kinase (CaM kinase) family of proteins that have been proposed to regulate ERK and gene transcription. Our results suggest that both estrogen (E2) and carbachol treatment of MCF-7 breast cancer cells trigger phosphorylation of ERK I /2 and the transcription factor Elk-1. Carbachol and estrogen triggered nearly a four- to sixfold increase in MCF-7 cell proliferation by 96 h, respectively. Carbachol-stimulated ERK activation and …

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Arthropod Foraging By A Southeastern Arizona Hummingbird Guild, Don Powers, Jessamyn A. Van Hook, Elizabeth A. Sandlin, Todd J. Mcwhorter Jan 2010

Arthropod Foraging By A Southeastern Arizona Hummingbird Guild, Don Powers, Jessamyn A. Van Hook, Elizabeth A. Sandlin, Todd J. Mcwhorter

Faculty Publications - Department of Biological & Molecular Science

We tested the hypothesis that foraging for arthropods may be a viable source of energy when hummingbirds are competitively excluded from sources of nectar. We hypothesized that the Magnificent Hummingbird (Eugenes fulgens) relies more upon arthropods than the Blue-throated Hummingbird (Lampornis clemenciae) or Blackchinned Hummingbird (Archilochus alexandri) in southeastern Arizona. We were unable to quantify arthropod foraging by A. alexandri, but measured frequent arthropod foraging by both E. fulgens and L. clemenciae. E. fulgens engaged in more aerial flycatching than L. clemenciae, and their rate of flycatching attempts was higher than by L. clemenciae. Analysis of gut contents showed that …

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Inhibition Of Nonsense-Mediated Mrna Decay By Antisense Morpholino Oligonucleotides Restores Functional Expression Of Herg Nonsense And Frameshift Mutations In Long-Qt Syndrome, Qiuming Gong, Matthew R. Stump, Zhengfeng Zhou Jan 2010

Inhibition Of Nonsense-Mediated Mrna Decay By Antisense Morpholino Oligonucleotides Restores Functional Expression Of Herg Nonsense And Frameshift Mutations In Long-Qt Syndrome, Qiuming Gong, Matthew R. Stump, Zhengfeng Zhou

Faculty Publications - Department of Biological & Molecular Science

Mutations in the human ether-a-go-go-related gene (hERG) cause long-QT syndrome type 2 (LQT2). We previously described a homozygous LQT2 nonsense mutation Q1070X in which the mutant mRNA is degraded by nonsense-mediated mRNA decay (NMD) leading to a severe clinical phenotype. The degradation of the Q1070X transcript precludes the expression of truncated but functional mutant channels. In the present study, we tested the hypothesis that inhibition of NMD can restore functional expression of LQT2 mutations that are targeted by NMD. We showed that inhibition of NMD by RNA interference-mediated knockdown of UPF1 increased Q1070X mutant channel protein expression and hERG current …

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Mutational Studies Uncover Non-Native Structure In The Dimeric Kinetic Intermediate Of The H2a–H2b Heterodimer, Matthew R. Stump, Lisa M. Gloss Jan 2010

Mutational Studies Uncover Non-Native Structure In The Dimeric Kinetic Intermediate Of The H2a–H2b Heterodimer, Matthew R. Stump, Lisa M. Gloss

Faculty Publications - Department of Biological & Molecular Science

The folding pathway of the histone H2A–H2B heterodimer minimally includes an on-pathway, dimeric, burst-phase intermediate, I2. The partially folded H2A and H2B monomers populated at equilibrium were characterized as potential monomeric kinetic intermediates. Folding kinetics were compared for initiation from isolated, folded monomers and the heterodimer unfolded in 4 M urea. The observed rates were virtually identical above 0.4Murea, exhibiting a log-linear relationship on the final denaturant concentration. Below ∼0.4 M urea (concentrations inaccessible from the 4-M urea unfolded state), a rollover in the rates was observed; this suggests that a component of the I2 ensemble contains non-native structure that …

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Characterization Of Biofilms Formed By Mycobacterium Aviumn Subspecies Paratuberculosis In Psychologically Relevant Conditions, Richard Brunner Jan 2010

Characterization Of Biofilms Formed By Mycobacterium Aviumn Subspecies Paratuberculosis In Psychologically Relevant Conditions, Richard Brunner

All Graduate Theses, Dissertations, and Other Capstone Projects

Mycobacterium avium subspecies paratuberculosis (Mpt) is the cause of Johne's disease, a gastrointestinal disease that mainly affects ruminants. Despite being an obligate intracellular pathogen, Mpt can survive in the environment for months. How Mpt survives in the environment has yet to be determined, but one tactic Mpt may use is the formation of biofilms. Biofilms may provide sufficient protection and allow Mpt endure in the environment until a new host is encountered. The conditions affecting Mpt biofilm formation have not been investigated. Both in the host and in the environment, Mpt experiences physiological stresses that may induce biofilm formation including …

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Development Of A Preliminary Cost Estimation Method For Water Treatment Plants, Jwala Raj Sharma Jan 2010

Development Of A Preliminary Cost Estimation Method For Water Treatment Plants, Jwala Raj Sharma

Civil Engineering Theses - Archive

Reliable cost estimates for construction, and operation and maintenance (O&M) of water treatment plants are essential for their project planning and design. During the planning phases of the project, preliminary cost estimates are developed for major project components, and for screening of alternatives.Construction and O&M cost curves are widely used for developing preliminary cost estimates. This method is time consuming and there is possibility of human errors. Therefore, for this thesis, construction, and O&M cost equations were developed considering historical cost data for different unit operations and processes involved in a water treatment plant. These equations were developed from historical …

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Mitochondrial Physiology Of Diapausing And Developing Embryos Of The Annual Killifsh Austrofundulus Limnaeus: Implications For Extreme Anoxia Tolerance, Jeff Duerr, Jason E. Podrabsky Jan 2010

Mitochondrial Physiology Of Diapausing And Developing Embryos Of The Annual Killifsh Austrofundulus Limnaeus: Implications For Extreme Anoxia Tolerance, Jeff Duerr, Jason E. Podrabsky

Faculty Publications - Department of Biological & Molecular Science

Diapausing embryos of the annual killiWsh Austrofundulus limnaeus have the highest reported anoxia tolerance of any vertebrate and previous studies indicate modified mitochondrial physiology likely supports anoxic metabolism. Functional mitochondria isolated from diapausing and developing embryos of the annual killifish exhibited VO2, respiratory control ratios (RCR), and P:O ratios consistent with those obtained from other ectothermic vertebrate species. Reduced oxygen consumption associated with dormancy in whole animal respiration rates are correlated with maximal respiration rates of mitochondria isolated from diapausing versus developing embryos. P:O ratios for developing embryos were similar to those obtained from adult liver, but were diminished in …

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Estrogen Analysis By Liquid Chromatography - Mass Spectrometry, Hien P. Nguyen Jan 2010

Estrogen Analysis By Liquid Chromatography - Mass Spectrometry, Hien P. Nguyen

Chemistry & Biochemistry Dissertations - Archive

Estrogens are well known as female hormones associated with both health and disease. Although they have been reported as potential carcinogens, their use as therapy in the treatment of neurodegeneration has recently received a great deal of attention. The main goal of this work was to advance estrogen analysis using liquid chromatography - mass spectrometry (LC-MS) and associated techniques in order to support pre-clinical and clinical research on the neuroprotective effects of estrogens. Native estrogen analyses were performed in different types of biological samples, including human cerebrospinal fluid (CSF), horse serum, phosphate buffered saline - bovine serum albumin (PBS-BSA), mouse …

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Total Synthesis Of Cyclooroidin And Studies Towards Some Oroidin Dimers, Sabuj Mukherjee Jan 2010

Total Synthesis Of Cyclooroidin And Studies Towards Some Oroidin Dimers, Sabuj Mukherjee

Chemistry & Biochemistry Dissertations - Archive

This dissertation consists of two parts. The first part describes the synthesis of northern fragment of nagelamide R and the enantioselective total synthesis of cyclooroidin. The oroidin family of marine natural products is a growing group of marine sponge-derived alkaloids which contain 2-aminoimidazole and pyrrolecarboxamide fragments as their signature features. The structural complexity, and in many cases interesting biological profiles, of these compounds has rendered several of these natural products as targets of interest. In the context of nagelamide R, the key transformation involves the intramolecular cyclization of a pyrrolecarboxamide via the carbonyl oxygen leading to the formation of oxazoline, …

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Elucidation Of The Structure And Recognition Properties Of Antimony(Iii)-Tartrate Using Electrospray Ionization Mass Spectrometry, Aruna B. Wijeratne Jan 2010

Elucidation Of The Structure And Recognition Properties Of Antimony(Iii)-Tartrate Using Electrospray Ionization Mass Spectrometry, Aruna B. Wijeratne

Chemistry & Biochemistry Dissertations - Archive

Chirality of molecules is a major topic in the design, discovery and development of new drugs. Currently, analytical chemistry research divisions are challenged to find new methods to screen enantiospecific molecular recognition properties of potential chiral drug candidates with targeted biological molecules in a time-sensitive environment. Recently, mass spectrometry (MS) has received significant attention for its use in studying molecular recognition systems. Electrospray ionization mass spectrometry (ESI-MS) has received the most attention for the investigation of stereochemical association phenomena, due to its capacity to transfer solution phase chiral interactions into the gas phase for analysis in single-stage mass spectra. ESI-MS …

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Application Of Pd-Catalyzed Reactions In The Total Synthesis Of Oroidin-Derived Alkaloids, Manojkumar R. Bhandari Jan 2010

Application Of Pd-Catalyzed Reactions In The Total Synthesis Of Oroidin-Derived Alkaloids, Manojkumar R. Bhandari

Chemistry & Biochemistry Dissertations - Archive

The oroidin family of marine natural products is a growing group of sponge-derived alkaloids which contain 2-aminoimidazole and pyrrolecarboxamide fragments as their signature features. Due to their structural diversity and biological activity, many groups are interested in the total synthesis of these natural products. It has been proposed that many of the alkaloids in this family are produced in nature simply by dimerization and/or cyclization of the simplest member, oroidin. In this dissertation we have attempted to explore these biosynthetic relationships to complete the total synthesis of several oridin-derived natural products. This dissertation consists of two parts. The first part …

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Explorations Of Aspects Of Mixotrophy Using Mathematical Models, Kenneth W. Crane Jan 2010

Explorations Of Aspects Of Mixotrophy Using Mathematical Models, Kenneth W. Crane

Biology Dissertations - Archive

This work examined three theoretical aspects of mixotrophy, the simultaneous use of phototrophic and heterotrophic nutritional modes, and one practical application. The first study addressed the coexistence of microorganisms pursuing diverse nutritional strategies. It was found that in the range of model environments explored that all four types of organisms were predicted to persist for certain parameter combinations. The most successful mixotrophs were predicted to be primarily autotrophic, supplementing photosynthesis with bacterivory. The second study extended the first one by focusing on the effects of environmental parameters governing resource supplies and the responses of populations and ecosystem properties in relation …

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Quality Indicators For Engineering And Technology Education, Michael Dyrenfurth, Mike Murphy, Gary Bertoline Jan 2010

Quality Indicators For Engineering And Technology Education, Michael Dyrenfurth, Mike Murphy, Gary Bertoline

Conference papers

In recent years the development and use of university rankings, comparisons, and/or league tables has become popular and several methodologies are now frequently used to provide a comparative ranking of universities. These rankings are often based on research and publication activity and also not uncommonly focus on indicators that can be measured rather than those that should be measured. Further, the indicators are generally examined for the university as a whole rather than for university divisions, departments or programs. Implicit also is that placement in the rankings is indicative of quality. This paper provides an overview of the methodologies used …

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