Digital Commons Network^™

Using Technology To Enhance Adult Learning In The Counselor Education Classroom, Edina Renfro-Michel, Kim C. O'Halloran, Megan E. Delaney

Department of Counseling Scholarship and Creative Works

The authors present a study that used a conceptual framework of adult learning and differentiated learning styles with graduate students in a counselor education classroom. Students in a hybrid course had higher midterm, group proposal, and posttest scores than did students in a face-to-face course taught by the same professor.

Nuchal Cord Management And Nurse-Midwifery Practice, Judith S. Mercer, Rebecca L. Skovgaard, Joann Peareara-Eaves, Tracey A. Bowman

College of Nursing Faculty Publications

Nuchal cord, or cord around the neck of an infant at birth, is a common finding that has implications for labor, management at birth, and subsequent neonatal status. A nuchal cord occurs in 20% to 30% of births. All obstetric providers need to learn management techniques to handle the birth of an infant with a nuchal cord. Management of a nuchal cord can vary from clamping the cord immediately after the birth of the head and before the shoulders to not clamping at all, depending on the provider's learned practices. Evidence for specific management techniques is lacking. Cutting the umbilical …

Transition Metal-Mediated Higher-Order Cycloaddition Reactions: Application To The Total Synthesis Of Complex Natural Products, Bilal Abou Aleiwi

Wayne State University Dissertations

ABSTRACT

TRANSITION METAL-MEDIATED HIGHER-ORDER CYCLOADDITION REACTIONS: APPLICATION TO THE TOTAL SYNTHESIS OF COMPLEX NATURAL PRODUCTS

by

BILAL ABOU ALEIWI

October 2010

Advisor: Dr. James H. Rigby

Major: Chemistry (Organic)

Degree: Doctor of Philosophy

Chromium (0)-mediated [6ð + 2ð] and [6ð + 2ð + 2ð] cycloaddition reactions between cyclic trienes and alkynes is reported. The development, investigation and the application of these reactions in the total synthesis of complex ring systems and natural products is described. Two natural products, namely, ∆ 9(12) -Capnellene and Echinopines A and B were targeted.

An investigation led to the successful development of a methodology to …

Measuring The Nanomechanics Of Nanoconfined Water Layers, Shah Haidar Khan

Wayne State University Dissertations

Nanoconfined water has been the subject of special interest due to its applications in various fields such as biology, geology, medicine, and engineering tribology. While there is a general agreement on the layering of water molecules along atomically smooth surfaces, the behavior and properties of nanoconfined water is still poorly understood. A significant controversy exists whether there is a phase transformation imposed by confinement. We have measured the stiffness and damping coefficient of nanoconfined water using a small amplitude (0.5-1 Å) atomic force microscope. The results were analyzed with the help of two viscoelastic models, the Kelvin model and the …

Meiotic Dna Re-Replication And The Recombination Checkpoint, Nicole Ann Najor

Wayne State University Dissertations

Progression through meiosis occurs through a strict sequence of events, so that one round of DNA replication precedes programmed recombination and two nuclear divisions. Cyclin dependent kinase 1 (Cdk1) is required for meiosis, and any disruption in its activity leads to meiotic defects. The Cdk1 inhibitor, Sic1, regulates the G1-S transition in the mitotic cell cycle and the analogous transition in meiosis. We have employed a form of Sic1, Sic1deltaP^HA, that is mutated at multiple phosphorylation sites and resistant to degradation. Meiosis specific expression of Sic1deltaP^HA disrupts Cdk1 activity and leads to significant accumulation of over replicated …

Single Molecule Studies Of Spliceosomal Snrnas U2-U6, Zhuojun Guo

Wayne State University Dissertations

Spliceosomes catalyze the maturation of precursor mRNAs in organisms ranging

from yeast to humans. Their catalytic core comprises three small nuclear RNAs (U2, U5

and U6) involved in substrate positioning and catalysis. It has been postulated, but never

shown experimentally, that the U2-U6 complex adopts at least two conformations that

reflect different activation states. We have used single-molecule fluorescence to probe the

structural dynamics of a protein-free RNA complex modeling U2-U6 from yeast and

mutants of highly conserved regions of U2-U6. Our data show the presence of at least

three distinct conformations in equilibrium. The minimal folding pathway consists of …

Development And Applications Of Thioacids In Peptide Chemistry And Exploration Of Methods Toward The Stereochemical Elucidation And Synthesis Of Virgineone, Kasinath Sana

Wayne State University Dissertations

ABSTRACT

DEVELOPMENT AND APPLICATIONS OF THIOACIDS IN PEPTIDE CHEMISTRY AND EXPLORATION OF METHODS TOWARD THE STEREOCHEMICAL ELUCIDATION AND SYNTHESIS OF VIRGINEONE

by

KASINATH SANA

December 2010

Advisor: David Crich

Major: Chemistry

Degree: Doctor of Philosophy

This dissertation describes investigations toward the development of methods for the synthesis of peptidyl thioacids and thioesters, with particular emphasis on applications in peptide chemistry, and the exploration of methods toward the assignment of the relative and absolute configuration of virgineone and its total synthesis.

The first part of chapter one introduces the general characteristics and reactivity of thioacids, and describes their potential for application …

Spirituality And Spiritual Self-Care: Expanding Self-Care Deficit Nursing Theory, Mary Louise White

Wayne State University Dissertations

The purpose of this study was to extend the theory of self-care deficit nursing by including specific constructs of religion, spirituality, and spiritual self-care practices within the structure suggested by Orem's self-care deficit nursing theory. Based on an extensive literature review, practice experience, and a discovery theory-building approach, a new mid-range theory called White's theory of spirituality and spiritual self-care (WTSSSC) was developed. To begin to test this mid-range theory, empirical indices of many of the main concepts were identified from prior studies and one new instrument (the Spiritual Self-Care Practice Scale) was developed. Hypothesized relationships among the main concepts …

Synthetic Levers Enabling Control Of Phase, Size And Morphology In Transition Metal Phosphide Nanoparticles (Fe, Ni), Elayaraja Muthuswamy

Wayne State University Dissertations

ABSTRACT

SYNTHETIC LEVERS ENABLING CONTROL OF PHASE, SIZE AND MORPHOLOGY IN TRANSITION METAL PHOSPHIDE NANOPARTICLES (FE, NI)

by

ELAYARAJA MUTHUSWAMY

May 2011

Advisor:Dr. Stephanie L. Brock

Major: Chemistry

Degree: Doctor of Philosophy

This dissertation study focuses on (1) development of a synthetic strategy to control phase in nanoscale iron phosphides; (2) extension of the developed phase control strategy to the nanoscale nickel phosphide system with simultaneous control on size and morphology and (3) illustration of the enhanced reactivity of nanoscale oxide systems.

A synthetic strategy to control phase in nanoscale iron phosphides was developed to prepare phase-pure samples of …

Regulation Of Neuronal Excitability: New Mechanisms For Slow Afterhyperpolarization Activation And Modulation, Claudio Alberto Villalobos

Wayne State University Dissertations

One of the most characteristic features of pyramidal cells in the prefrontal cortex (PFC) is that they present a slow afterhyperpolarizing current (I_sAHP) that plays a critical role in the regulation of neuronal excitability. This current is modulated by receptors acting via GΑ_q/11 G proteins, thus it is thought that neurotransmitters regulate neuronal excitability through the inhibition of this current. I_sAHP is known to be mediated by calcium-activated potassium channels, however, neither the identity of the channel underlying this current nor its mechanism of activation are yet well understood. Recent reports have questioned a direct role …

Design Of A Polysaccharide Derived Tissue Engineered Vascular Graft, Irina Robu

Wayne State University Dissertations

DESIGN OF A POLYSACCHARIDE DERIVED TISSUE ENGINEERED VASCULAR GRAFT

By

Irina Robu

November 2010

Advisor: Dr. Howard Matthew

Major: Chemical Engineering

Degree: Doctor of Philosophy

As the most frequent congenital anomaly and the leading cause of death, congenital heart disease is an attractive target for tissue engineering research. The challenging target to engineer a native blood vessel stems from the need to find substitutes for pediatric patients born with congenital defects. The tissue engineering graft functions to bring various cells of the vasculature in close proximity to one another to enable intercellular signaling which facilitates cell adhesion, migration and differentiation. …

Trajectories Of Emotion Regulation Into Middle Childhood: An Investigation Of Attachment, Temperament, And Language, Julie Elizabeth Braciszewski

Wayne State University Dissertations

The development of emotion regulation continues to be considered a cornerstone to adaptive child development. However, studies have yet to integrate early relationship, child-centered factors, and socio-demographic factors, from infancy through middle childhood, in an attempt to look at emotional regulation development over time. By utilizing latent growth curve modeling, the current study aimed to extend understanding of how child-centered factors (temperament and language skill) and socio-demographic factors (gender, ethnicity, and family resources) affect the development of emotion regulation from 3rd to 6th grades, within the context of early attachment relationships. Stability in emotion regulation in the general sample, as …

Molecular Mechanisms Of Pressure-Stimulated Cancer Cell Signaling, Christina Downey

Wayne State University Dissertations

ABSTRACT

MOLECULAR MECHANISMS OF PRESSURE-STIMULATED CANCER CELL SIGNALING

by

CHRISTINA DOWNEY

June 2010

Advisor: Dr. Marc Basson, MD, PhD

Major: Cancer Biology

Degree: Doctor of Philosophy

Increased extracellular pressure stimulates cancer cell adhesion by a mechanism that is dependent upon beta-1-integrin activation, an intact cytoskeleton, and FAK and Src activation. By a different mechanism, increased extracellular pressure modulates cancer cell proliferation in a manner that is regulated by protein kinase C, but not Src or an intact cytoskeleton. Previous studies from our laboratory have shown that paxillin is a necessary mediator in the pathway by which pressure stimulates adhesion; however, …

A Comparison Of Parental Self-Efficacy, Parenting Satisfaction, And Other Factors Between Single Mothers With And Without Children With Developmental Disabilities, Raymond Phillip Small

Wayne State University Dissertations

Depression and stress occur among single mothers and raising a child with a developmental disability can be a difficult burden. The purpose of this study was to determine if having a child with a developmental disability was a source of stress and depression among single mothers, and if this impinged on parental self-efficacy, parenting satisfaction, and social support. The moderating potential of having a child with a disability was examined on relationships between stress, depression, parental self-efficacy, parenting satisfaction, and social support. Understanding these relationships could be useful in the service delivery system to single mothers and families of children …

Adaptive Radiation Therapy Of Prostate Cancer, Ning Wen

Wayne State University Dissertations

ART is a close-loop feedback algorithm which evaluates the organ deformation and motion right before the treatment and takes into account dose delivery variation daily to compensate for the difference between planned and delivered dose. It also has potential to allow further dose escalation and margin reduction to improve the clinical outcome. This retrospective study evaluated ART for prostate cancer treatment and radiobiological consequences. An IRB approved protocol has been used to evaluate actual dose delivery of patients with prostate cancer undergoing treatment with daily CBCT.

The dose from CBCT was measured in phantom using TLD and ion chamber techniques …

Children's Adaptive Psychological Functioning In The Face Of Adversity, Rebecca Wiersma

Wayne State University Dissertations

This explanatory research study is a secondary data analysis of the restricted release version of the National Survey of Child and Adolescent Well-Being (NSCAW) data. Only children from the CPS sample were used and included only children who were 48 months or younger at the time of the initial survey (N=1,582). At the time of the initial survey, only the caregivers of 406 children were able to complete the Child Behavior Checklist (CBCL)/2-3 because of age restrictions for that particular measure. Therefore, a subsample of 406 children with CBCL scores at Wave 1 and Wave 4 was extracted from the …

Dechalcogenative Allylic Selenosulfide And Disulfide Rearrangements For Cysteine Modification And Glycoligation, Venkataraman Subramanian

Wayne State University Dissertations

This thesis describes investigations directed at the development of methods for the selenosulfide and disulfide rearrangements for the permanent functionalization of thiols, and in particular of cysteine and carbohydrate based thiols. Emphasis is placed on the newly invented silver mediated allylic desulfurative rearrangement for the primary modification of thiols and the synthesis of complex oligosaccharide mimics.

Chapter one introduces the concept of chemoselective ligations for the modification of macromolecules like carbohydrates and proteins. It overviews the native and non-native ligation techniques for their modification of such entities with a attention focusing on thiol based ligation techniques. The later part of …

Beyond The Dvh - Spatial And Biological Radiotherapy Treatment Planning, Bo Zhao

Wayne State University Dissertations

Purpose: Both spatial and biological information are necessary in order to perform true optimization of a treatment plan and for predicting clinical outcome. The goal of this work is to develop an enhanced treatment plan evaluation tool which incorporates biological parameters and retains spatial dose information.

Methods: A software system named SABER (Spatial And Biological Evaluation for Radiotherapy) is developed which provides biological plan evaluation with a novel combination of features. It incorporates hyperradiosensitivity using the induced-repair model and applies the new concept of Dose Convolution Filter (DCF) to simulate dose wash-out …

Metal Chalcogenide Nanocrystal Assembly: From Synthesis To Applications, Qinghong Yao

Wayne State University Dissertations

This dissertation study is focused on (1) the application of an oxidation-induced sol-gel assembly method to formation of CdTe aerogels; (2) extension of existing aerogel compositions and properties by an alternative synthetic approach: cation-exchange reactions; and (3) probing the functionality of CdSe aerogels as optical sensors of Lewis base analytes.

Highly porous CdTe aerogels were successfully synthesized by sol-gel assembly of CdTe nanocrystals with thiolate or nonthiolate (phosphine oxide) ligated surfaces by treatment with tetranitromethane. Both phosphine oxide-capped and the thiolate-capped aerogels exhibit similar structure, morphology and porosimetry properties, suggesting that precursor ligation does not have a no major effect …

The Effect Of Word Sociality On Word Recognition, Sean Seaman

Wayne State University Dissertations

While research into the role of semantic structure in the recognition of written and spoken words has grown, it has not looked specifically at the role of conversational context on the recognition of isolated words. This study was a corpus-based and behavioral exploration of a new semantic variable - sociality - and used on-line behavioral testing to obtain new word recognition data using the visual and auditory lexical decision tasks. The results consistently demonstrated that sociality is one of the most robust predictors of lexical decision performance. Overall, it appears that the visual lexical decision task is quite sensitive to …

Examining The Relationship Between Spiritual Resources, Self-Efficacy, Life Attidues, Cognition, And Personal Characteristics Of Homeless African American Women, Jean Gash

Wayne State University Dissertations

African Americans comprise 12% of the American population and 45% of the homeless sheltered population (United States Department of Housing and Urban Development [HUD], 2007). The fastest growing segment is African American women and African American women with children. The purpose of this study was to examine the relationship between spiritual resources, self-efficacy, life attitudes, cognition, and personal characteristics (e.g., physical and mental health, age, marital status, number of children, number and length of times homeless and perceptions of being at risk for serious illness) of homeless African American women from 30 years of age and older who were trying …

Raman Spectroscopic Modeling Of T- Lymphocyte Activation And Detection Of Acute Renal Allograft Rejection, Kristian L. Brown

Wayne State University Dissertations

ABSTRACT

RAMAN SPECTROSCOPIC MODELING OF T-LYMPHOCYTE ACTIVATION AND DETECTION OF ACUTE RENAL ALLOGRAFT REJECTION

By

KRISTIAN L. BROWN

2010

Advisor: Gregory Auner, PhD

Major: Biomedical Engineering

Degree: Doctor of Philosophy

Despite the advances made in the area of kidney transplantation, the disparity between the demand and available donated organs remains a dominant and unresolved issue. Given the paucity of available renal allografts the preservation of existing grafts is vital. One factor that has negatively impacted renal allograft survival is acute rejection (AR). Traditionally, kidney transplant centers have used elevations in serum creatinine as a screening tool for detecting AR. However, …

Perceptions Of Sexuality By African American Patients On Hemodialysis, Merry Ann Stewart

Wayne State University Dissertations

ABSTRACT

PERCEPTIONS OF SEXUALITY BY AFRICAN AMERCIAN PATIENTS ON HEMODIALYSIS

by

MERRY STEWART

May 2010

Advisor: Dr. Ramona Benkert

Major: Nursing

Degree: Doctor of Philosophy

Sexuality is central to who we are as sentient beings and transcends physical sex acts. Sexuality concerns are reported as common for individuals receiving hemodialysis; yet, sexuality-related research for this population has been limited to a focus on altered physical sexuality. Little is known about the effects of hemodialysis on perceptions of personal identity, family-social roles as men or women, and intimate relationships. African Americans make up a disproportionate percentage of chronic hemodialysis patients and …

Patent Reform And Damages Apportionment: Addressing The Concerns Of Industry-Scale Users Of The U.S. Patent System Without Legislatively Mandating A "Specific Contribution Over The Prior Art", Megan L. Wiggins

Seton Hall Law Review

No abstract provided.

A Social Ecological Perspective On Diabetes Care: Supporting Adolescents And Caregivers, April Marie Idalski Carcone

Wayne State University Dissertations

The diabetes illness management regimen is complex and demanding, requiring daily motivation and self-control. Adolescents with diabetes face unique risks for which social support may be one protective factor. The importance of social support from family and friends is well documented in the literature. Support for the caregiver and support from the health care provider, conversely, are understudied. These four sources of social support, considered together, span the adolescent's micro-, meso-, and exosystems constituting a social ecological model of social support for diabetes. The primary aim of this study was to test this model. The hypotheses were that each source …

C-Reactive Protein, Homocysteine, And Cognitive Performance In Healthy Adults, Cheryl Dahle

Wayne State University Dissertations

Elevated blood levels of C-reactive protein (CRP) and homocysteine (Hcy) have received a great deal of attention as biomarkers for the development of cardiovascular disease. Their utility in predicting cognitive function has also been assessed, though the findings are equivocal. The current study examined the relationship between elevated blood levels of CRP and Hcy and their effect on cognition across several cognitive domains. As baseline blood levels of CRP and Hcy and cognition are in part regulated by genetic factors, the impact of T carrier status for variants in the CRP -286 C>T>A and the MTHFR 677C>T …

Identification Of Neuroblastoma And Its Prognostic Markers Using Raman Spectroscopy, Rachel Kast

Wayne State University Dissertations

Introduction: Neuroblastoma is the most common cancer of infancy. It is one of several peripheral nervous system tumors, including ganglioneuroma, peripheral nerve sheath tumor, and pheochromocytoma. It is commonly situated on the adrenal gland. It displays similar histology to other small round blue cell tumors, including non-Hodgkin lymphoma, rhabdomyosarcoma, and Ewing sarcoma. One method of judging neuroblastoma aggressiveness uses tumor histology factors, including mitosis-karyorrhexis index, Schwannian stromal development, degree of differentiation, and patient age. Tumor aggressiveness can also be judged based on the amplification of certain genes, including MYCN. Raman spectroscopy is a physics-based method which identifies the biochemical …

Values And Problem Behaviors In Hong Kong Adolescents, Phebe Karen Lam

Wayne State University Dissertations

The present study examined sensation seeking, psychological problem behaviors, values orientation, and problem behaviors of smoking, alcohol use, and delinquency among Hong Kong adolescents studying in high school of two different ability levels. Adolescents (N = 1385) from a band one and band three level high school in Hong Kong were assessed using the Sensation Seeking Scale Form-V (SSS-V), Youth Self Report (YSR), Portrait Values Questionnaire (PVQ), and the Adolescent Health and Development Questionnaire (AHDQ), along with several demographic variables (e.g., age, gender, grade level, employment).

Regression analyses were employed to determine the contribution of the significantly correlated variables in …

College Students' Perceptions Of An Uncomfortable Sexual Experience, Sandra Lee Parent

Wayne State University Dissertations

The purpose of this study was to investigate college students' perception of an uncomfortable sexual experience and identify factors that may reinforce revictimization of rape victims. An additional purpose was to compare perceptions of rape victims to perceptions of those who have never been raped, but because the sample size of rape victims was too small, and the data could not be analyzed and data from rape victims were eliminated from further analyses. In the final sample, data were collected from 296 college students attending a large commuter campus university. Participants were randomly assigned to read one of four scenarios …

Cyberbullying: The Role Of Family And School, Jennifer Taiariol

Wayne State University Dissertations

The purpose of this study was to examine family and school variables in relation to different types of perpetration, victimization and witnessing experiences (physical, social, verbal and cyber). Students (n=253) in grades 7 to 8 from two middle schools located in a suburb in southeastern Michigan participated in the study. Data were collected during the 2008-2009 school year.

Statistically significant differences were found for perpetration and victimization by gender and perpetration and witnessing by grade. No gender and grade interaction results were significant. All types of bullying experiences were positively correlated with cyberbullying and cyber victimization. Bullying experiences were significant …