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2010

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Dynamic Remodeling Of The Stressed Heart: Role Of Protein Degradation Pathways, Deborah Vela Dec 2010

Dynamic Remodeling Of The Stressed Heart: Role Of Protein Degradation Pathways, Deborah Vela

Dissertations and Theses (Open Access)

The heart is a remarkable organ. In order to maintain its function, it remodels in response to a variety of environmental stresses, including pressure overload, volume overload, mechanical or pharmacological unloading and hormonal or metabolic disturbances. All these responses are linked to the inherent capacity of the heart to rebuild itself. Particularly, cardiac pressure overload activates signaling pathways of both protein synthesis and degradation. While much is known about regulators of protein synthesis, little is known about regulators of protein degradation in hypertrophy. The ubiquitin-proteasome system (UPS) selectively degrades unused and abnormal intracellular proteins. I speculated that the UPS may …

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Effects Of Combined Bevacizumab And Paclitaxel On Tumor Interstitial Fluid Pressure In A Preclinical Breast Cancer Model, Ricardo Hugo Alvarez Dec 2010

Effects Of Combined Bevacizumab And Paclitaxel On Tumor Interstitial Fluid Pressure In A Preclinical Breast Cancer Model, Ricardo Hugo Alvarez

Dissertations and Theses (Open Access)

Effects of Combined Bevacizumab and Paclitaxel on Tumor Interstitial Fluid Pressure in a Preclinical Breast Cancer Model by Ricardo H. Alvarez Several mechanisms of cell resistance are often accountable for unsuccessful chemotherapy against cancer. Another reason, which has received increased attention, is the inefficient transport of anticancer drugs into tumor tissue. These impaired transports of chemotherapy into the tumor have been attributed to abnormal microvasculature and to pathologically increased tumor hypertension also called: interstitial fluid pressure (IFP). The pathophysiological processes leading to elevated tumor IFP are poorly understood. Here, in a preclinical breast cancer model, it is argued that a …

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Temozolomide And Bevacizumab Therapy In Advanced Hemangiopericytoma/ Solitary Fibrous Tumor, Min S. Park Dec 2010

Temozolomide And Bevacizumab Therapy In Advanced Hemangiopericytoma/ Solitary Fibrous Tumor, Min S. Park

Dissertations and Theses (Open Access)

Tumors comprising the spectrum of hemangiopericytoma/ malignant solitary fibrous tumor (HPC/SFT) are thought to arise from fibroblasts and represent a small subset of soft tissue sarcomas. Surgery is typically the treatment of choice for localized disease, with reported 10-year overall survival rates of 54-89% after complete surgical resection. However, for the approximately 20% of HPC/SFT patients who eventually develop local recurrences and/or distant metastases, options for effective treatment are limited and are poorly defined. Alternative therapeutic options are therefore needed for improved palliation and disease control. We hypothesize that HPC/SFT are a spectrum of soft tissue tumors with unique clinical, …

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Mcam/Muc18 Regulates Melanoma Progression By Modulating The Expression Of Id-1, Maya Zigler Dec 2010

Mcam/Muc18 Regulates Melanoma Progression By Modulating The Expression Of Id-1, Maya Zigler

Dissertations and Theses (Open Access)

The acquisition of the metastatic melanoma phenotype is associated with increased expression of the melanoma cell adhesion molecule MCAM/MUC18 (CD146). However, the mechanism by which MUC18 contributes to melanoma metastasis remains unclear. Herein, we stably silenced MUC18 expression utilizing lentivirus-incorporated small hairpin RNA, in two metastatic melanoma cell lines, A375SM and C8161, and conducted cDNA microarray analysis. We identified and validated that the transcriptional regulator, Inhibitor of DNA Binding-1 (Id-1), previously shown to function as an oncogene in several malignancies, was downregulated by 5.6-fold following MUC18 silencing. Additionally, we found that MUC18 regulated Id-1 expression at the transcriptional level via …

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Response Of Warm Season Turfgrasses To Reduced Light Environments, Jeffrey Atkinson Dec 2010

Response Of Warm Season Turfgrasses To Reduced Light Environments, Jeffrey Atkinson

All Theses

Shade or low light tolerance is an increasingly important issue to turf managers as they are often expected to grow turf in less than ideal agronomic conditions. As permanent structures such as residential buildings add to already problematic shade caused by trees, and other barriers, new solutions are needed to help turf managers provide acceptable turf conditions. The plant growth regulator trinexapac-ethyl (TE) can lessen negative responses of turfgrass to shade.
Two experiments were conducted during the summers of 2008 and 2009 to evaluate various grasses under a reduced light environment (RLE). In the first study, performance of `Diamond' zoysiagrass …

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Vena Cava As An Alternative To Pericardium In Bioprosthetic Percutaneous Heart Valves, Amy Munnelly Dec 2010

Vena Cava As An Alternative To Pericardium In Bioprosthetic Percutaneous Heart Valves, Amy Munnelly

All Theses

Valve disease is a specialized form of cardiovascular disease that specifically affects the heart valves. Heart valves serve the vital function of maintaining unidirectional blood flow through the chambers of the heart during the cardiac cycle; however, as valve disease progresses, this function can become severely compromised [1]. Currently, the only cure for valve disease is to replace the defective valve with an engineered substitute. Each year, over 300,000 heart valve replacement surgeries are performed worldwide [2], and this number is expected to continue growing as life expectancies increase [3].
In the United States, the most common form of valve …

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Modeling Greenhouse Gas Emissions From Conventional Wastewater Treatment Plants In South Carolina, Andrea Hicks Dec 2010

Modeling Greenhouse Gas Emissions From Conventional Wastewater Treatment Plants In South Carolina, Andrea Hicks

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Wastewater treatment is an essential part of life in the urbanized world. As global climate change becomes a more pressing issue, the greenhouse gas emissions created through wastewater treatment will become a more prominent concern. Tertiary treatment will likely be standard for wastewater treatment plants in the near future, and therefore must be included in a model of greenhouse gas emissions. Also, the geographic location of a WWTP will change the mix of power types (e.g., coal, nuclear, biomass) used to run the plant. Although GHG emissions from the waste sector are small compared to the emissions of the United …

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Chemical Composition And Antioxidant Properties Of Maya Nut (Brosimum Alicastrum), Hatice Kubra Tokpunar Dec 2010

Chemical Composition And Antioxidant Properties Of Maya Nut (Brosimum Alicastrum), Hatice Kubra Tokpunar

All Theses

ABSTRACT
Maya nut was investigated in term of its moisture, ash content, antioxidant activities, phenolic components by high pressure liquid chromatography-ultraviolet detector (HPLC-UV) and fatty acid composition by gas chromatography-flame ionization detector (GC-FID). The results showed that Maya nut was mainly composed of 55.06% linoleic acid (C18:2 n6), 27.2% palmitic acid (C16:0), 6.26% stearic acid (C18:0), 9.9% linolenic acid (C18:3 n3), and 3.36% Cis-11-Eicosenoic (C20:1). Maya nut possesses a higher content of polyunsaturated fatty acids (PUFAs) (linoleic and linolenic acid), but lower content of monounsaturated fatty acids (MUFAs) than canola oil and olive oil. The antioxidant capacities and total phenolic …

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Using Nestling Bald Eagles To Assess Spatial And Temporal Trends Of Environmental Contaminants, Voyageurs National Park, Minnesota, Henry Pittman Dec 2010

Using Nestling Bald Eagles To Assess Spatial And Temporal Trends Of Environmental Contaminants, Voyageurs National Park, Minnesota, Henry Pittman

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Bald eagles (Haliaeetus leucocephalus) are a avian species used to monitor environmental contaminants such as mercury (Hg), methylmercury (MeHg), polychlorinated biphenyls (PCBs), and organochlorine pesticides (OCs) in North America. Populations of bald eagles nesting along the Great Lakes were very slow to recover after the ban of PCBs and OCs because these compounds were very persistent. Bald eagles at Voyageurs National Park (VNP) have been monitored since 1973 and provide an opportunity to assess temporal and spatial trends of persistent environmental contaminants. Nestling bald eagle feathers were analyzed for Hg concentrations for the past 12 years. Nestling bald …

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Evaluation Of Spotlight Surveys For Monitoring Mink Populations In Coastal South Carolina, Michael Waller Dec 2010

Evaluation Of Spotlight Surveys For Monitoring Mink Populations In Coastal South Carolina, Michael Waller

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Annual commercial fur harvest data suggests a decline in South Carolina's mink (Mustela vison) populations over the past century (Butfiloski and Baker 2005). In 1990, DNR began conducting assessments of South Carolina's coastal marshes, revealing mink populations to be scarce to absent in the northern coastal regions (Baker 1999). Since 1999, restoration efforts have re-established mink populations in the Cape Romain National Wildlife Refuge and additional areas in the northern coastal marshes of South Carolina. Because mink are a species of high conservation priority throughout the coastal zone of South Carolina, it is important to develop and implement a reliable …

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The Synthesis, Characterization, And Electrochemical Study Of Tris(Pyrazolyl)-Type Iron(Ii) Complexes, Iron(Ii) Sulfur- And Selenium-Containing Complexes, And Tris(Pyrazolyl)-Type Ruthenium(Ii) Complexes, Christopher Underwood Dec 2010

The Synthesis, Characterization, And Electrochemical Study Of Tris(Pyrazolyl)-Type Iron(Ii) Complexes, Iron(Ii) Sulfur- And Selenium-Containing Complexes, And Tris(Pyrazolyl)-Type Ruthenium(Ii) Complexes, Christopher Underwood

All Theses

Highly reactive radical species such as hydroxyl radical cause oxidative stress, resulting in chronic or degenerative diseases. In the biological Fenton reaction, iron(II) generates hydroxyl radical, OH, but only within a specific electrochemical potential window (-324 mV to 640 mV). Selenium and sulfur compounds have been extensively studied for their antioxidant properties, and they may exert their effects by binding iron(II) and shifting its electrochemical potential out of this window. This work has investigated the synthesis and electrochemical characterization of iron(II) chalcogenate complexes and iron(II) chalcogenone complexes. Cyclic voltammetry (CV) of [Fe(EPh)4][(PPh4)2] (E = S, Se) complexes shows Fe2+/3+ redox …

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Femoral Loading Mechanics In Virginia Opossums (Didelphis Virginiana): Torsion And Mediolateral Bending In Mammalian Parasagittal Locomotion, William Gosnell Dec 2010

Femoral Loading Mechanics In Virginia Opossums (Didelphis Virginiana): Torsion And Mediolateral Bending In Mammalian Parasagittal Locomotion, William Gosnell

All Theses

Studies of limb bone loading in terrestrial mammals have typically found anteroposterior bending to be the primary loading regime, with torsion contributing minimally. However, previous studies have focused on large, cursorial eutherian species in which the limbs are held essentially upright. Recent in vivo strain data from the Virginia opossum Didelphis virginiana, a marsupial that uses a crouched rather than upright limb posture, have indicated that its femur experiences moderate torsion during locomotion as well as strong mediolateral bending. The elevated femoral torsion and strong mediolateral bending observed in opossums (compared to other mammals) might result from external forces such …

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Characterization Of Transgenic Plum Lines Expressing Gastrodia Antifungal Protein (Gafp)-1, Hetalben Kalariya Dec 2010

Characterization Of Transgenic Plum Lines Expressing Gastrodia Antifungal Protein (Gafp)-1, Hetalben Kalariya

All Theses

The Gastrodia antifungal protein (GAFP-1) is a mannose-binding lectin originating from the Asiatic orchid Gastrodia elata. It has potential for conferring resistance to fungal and non-fungal pathogens in other plants which is currently being investigated. The goals of this research project were to determine (i) the potential movement of GAFP-1 protein from transgenic rootstocks into the non-transgenic scion of chimeric-grafted trees (ii) the levels of GAFP-1 protein in lines of the cultivar Bluebyrd expressing the gene gafp-1 under the control of the polyubiquitin promoter bul409, and (iii) the susceptibility of selected lines to the root pathogens Phytophthora cinnamomi Rands and …

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Development Of A Carbohydrate Microarray System And A Microcantilever-Based Biosensor For Detection Of Target Bacteria, Yunyan Cheng Dec 2010

Development Of A Carbohydrate Microarray System And A Microcantilever-Based Biosensor For Detection Of Target Bacteria, Yunyan Cheng

All Theses

The increasing number of disease outbreaks results in a demand for novel pathogen detectors. Carbohydrates serving as receptors for pathogen lectins have become the focus of such research. Two primary sugars, ‡-D-mannose and ‡-L-fucose, as receptors for Escherichia coli and Pseudomonas aeruginosa, respectively, are of great interest to researchers due to their high affinity. These interactions can be studied using carbohydrate microarrays, which are also suitable platforms for detecting bacterial pathogens. In addition, carbohydrates have the potential to act as sensing molecules in microcantilever-based biosensors. The goal of this research was to design a carbohydrate microarray system to study the …

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Development, Characterization, And Technical Applications Of An Atlantic Killifish Ahr-2 Specific Monoclonal Antibody (Mab 5b6), Josephine Wojdylo Dec 2010

Development, Characterization, And Technical Applications Of An Atlantic Killifish Ahr-2 Specific Monoclonal Antibody (Mab 5b6), Josephine Wojdylo

All Theses

The aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor normally found in the cytoplasmic compartment of cells held by chaperones and immunophilin-like proteins. Ligand binding dissociates the AhR/ligand from chaperone proteins, allowing translocation to the nucleus with subsequent transcription of a suite of responsive genes, most notably Phase I, II, and III drug metabolism genes. Select environmental contaminants such as co-planar PCBs, planar polyaromatic hydrocarbons (PAHs), and halogenated aromatic hydrocarbons (HAHs) are potent AhR agonists, with 2,3,7,8 -tetrachlorodibenzodioxin (TCDD) being one of the most potent. Adverse effects of exposure to these potent environmental AhR ligands include immune suppression, …

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Isolation, Characterization And Application Of Bacteriophage To Treat Hydrogen Sulfide Producing Bacteria In Raw Animal Materials Destined For The Rendering Process, Chao Gong Dec 2010

Isolation, Characterization And Application Of Bacteriophage To Treat Hydrogen Sulfide Producing Bacteria In Raw Animal Materials Destined For The Rendering Process, Chao Gong

All Theses

In the United States, billions of pounds of animal by-products are generated by the food processing industry every year. Hydrogen sulfide producing bacteria (SPB) can utilize the sulfur-containing proteins and amino acids in the raw animal materials destined for the rendering process to produce harmful hydrogen sulfide (H2S) gas rapidly under the ambient conditions, resulting in hazardous working environments and inferior quality of finished products. In this study, the application of bacteriophage was explored as an effective solution for the elimination of H2S production in the rendering industry. The objectives of this study were to: 1) isolate and characterize strains …

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Circuit Modules For Cmos High-Power Short Pulse Generators, Yongtao Geng Dec 2010

Circuit Modules For Cmos High-Power Short Pulse Generators, Yongtao Geng

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High-power short electrical pulses are important for high-performance functionality integration, such as the development of microelectromechanical/nanoelectromechanical systems (MEMS/NEMS), system on chip (SoC) and lab on chip (LoC). Many of these applications need high-power (low impedance load) short electrical pulses, in addition to CMOS digital intelligence. Therefore, it is of great interest to develop new circuit techniques to generate high-power high-voltage short electrical pulses on-chip.
Results on pulse forming line (PFL) based CMOS pulse generator studies are reported. Through simulations, the effects of PFL length, switch speed and switch resistance on the output pulses are clarified. CMOS pulse generators are modeled …

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Understanding Gafp, A Plant Lectin With Broad Spectrum Inhibitory Activity, Alexis Nagel Dec 2010

Understanding Gafp, A Plant Lectin With Broad Spectrum Inhibitory Activity, Alexis Nagel

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South Carolina and Georgia are the largest peach producing regions in the Southeastern United States, generating about $60 million worth (~90,000 tons) of fruit per year on average. Peaches and other stone-fruits (Prunus sp.) can be afflicted by a variety of root-associated diseases which negatively impact annual yield and long-term tree mortality. An engineered Prunus rootstock with enhanced resistance to soil-borne pathogens would therefore be of great benefit to the Southeastern peach industry. The Gastrodia anti-fungal protein (GAFP) is a monocot mannose-binding lectin which is able to inhibit the growth of multiple species of plant pathogenic fungi. Previous findings from …

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The Genetics Of Metal Uptake In Caulobacter Crescentus: Characterization Of Regulators And Identification Of Receptors, Leah Howell Dec 2010

The Genetics Of Metal Uptake In Caulobacter Crescentus: Characterization Of Regulators And Identification Of Receptors, Leah Howell

All Dissertations

Caulobacter crescentus is an oligotrophic, Gram negative bacterium with a dimorphic lifecycle. It is a model system for cell cycle regulation and cellular development. Since C. crescentus resides primarily in freshwater, this microorganism can also serve as a model system for nutrient uptake by oligotrophic freshwater species. This study focused on TonB-dependent receptors and metal-dependent regulators in C. crescentus.
To maintain appropriate levels of iron within the cell, bacteria have evolved mechanisms to control iron uptake, storage, and use. In microbes, there are two protein families possessing members that accomplish this: Fur and Rrf2. In the C. crescentus genome, there …

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Identification And Characterization Of Micrornas In Porcine Gametes And Pre-Implantation Embryos, Erin Curry Dec 2010

Identification And Characterization Of Micrornas In Porcine Gametes And Pre-Implantation Embryos, Erin Curry

All Dissertations

MicroRNAs (miRNAs) are short ribonucleic acids that ultimately affect the production of proteins. Although miRNAs are involved in nearly every biological process examined to date, little is known of the identity or function of miRNA in porcine reproductive tissues or their potential involvement in reproductive processes in pigs or other species. The objective of this dissertation research was to determine the presence of miRNAs in porcine gametes and both in vivo- and in vitro- produced pre-implantation embryos and to identify differences in miRNA expression between normal and aberrant samples. Using a heterologous RT-PCR approach, we demonstrated the presence of a …

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Novel Neomycin Conjugates For Multi-Recognition Of Nucleic Acids, Albert Willis Dec 2010

Novel Neomycin Conjugates For Multi-Recognition Of Nucleic Acids, Albert Willis

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Neomycin is an aminoglycoside antibiotic known for its high affinity for RNA duplex structures. Recent developments from our labs have indicated that aminoglycoside binding is not limited to RNA, but to nucleic acids that, like RNA, adopt conformations similar to A-form. Our group sought to further expand the utility of aminoglycoside binding to B-DNA structures by conjugating neomycin, an aminoglycoside antibiotic, with the B-DNA minor groove binding ligand Hoechst 33258. Envisioning a dual groove-binding mode, we have extended the potential recognition process to include a third, intercalative moiety. Furthermore, we observe remarkable recognition of such conjugates with RNA duplex. Spectroscopic …

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Pulsed-Laser Direct Writing Of Biological Materials, Yafu Lin Dec 2010

Pulsed-Laser Direct Writing Of Biological Materials, Yafu Lin

All Dissertations

Laser direct writing, developed based on modified laser-induced forward transfer (LIFT), has been emerging as one of the most promising biofabrication techniques. While some studies have been conducted to investigate laser direct writing of biological materials, there are some key challenges such as mechanisms of bubble formation, droplet formation and process-induced cell injury that have not been well elucidated. The objective of this dissertation is to study laser-induced droplet formation dynamics and process-induced cell injury in pulsed-laser direct writing of biological materials, and improve the existing laser direct-write techniques.
Phase explosion is identified as the dominant bubble formation mechanism in …

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Modulated Properties Of Fully Absorbable Bicomponent Meshes, Shawn Peniston Dec 2010

Modulated Properties Of Fully Absorbable Bicomponent Meshes, Shawn Peniston

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Current meshes used for soft-tissue repair are mostly composed of single component, nonabsorbable yarn constructions, limiting the ability to modulate their properties. This situation has left the majority of soft tissue repair load-bearing applications to suffer distinctly from undesirable features associated, in part, with mesh inability to (1) possess short-term stiffness to facilitate tissue stability during the development of wound strength; (2) gradually transfer the perceived mechanical load as the wound builds mechanical integrity; and (3) provide compliance with load transfer to the remodeling and maturing mesh/tissue complex. The likelihood of long-term complications is reduced for fully absorbable systems with …

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Successional Vegetation In The Jocassee Gorges, South Carolina, Maxwell Boyle Dec 2010

Successional Vegetation In The Jocassee Gorges, South Carolina, Maxwell Boyle

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Multifactor ecosystem classification systems provide a three-pronged approach to identifying site units across the landscape based on repeating patterns of vegetation, soil, and geomorphology. Ecosystem classification models have been developed for a diversity of forest landscapes throughout North America, and are beneficial as an ecosystem management tool because the outcome yields data models that can be utilized by scientists and natural resource managers alike. In contrast to the enormous amount of classification studies undertaken in relatively stable, older-aged forests in eastern North America, there have been few studies that have employed multifactor classification techniques across a successional gradient, or heavily …

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Spidroin N-Terminal Domain: A Ph Sensor In The Spider Silk Assembly Process, William Gaines Dec 2010

Spidroin N-Terminal Domain: A Ph Sensor In The Spider Silk Assembly Process, William Gaines

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Spider silks are protein-based fibers with remarkable mechanical qualities. Perhaps even more impressive is the spinning process in which the spider silk proteins (spidroins) are assembled from a highly soluble storage state into a well-ordered and insoluble fiber. Indeed, the ordered arrangement of spidroins, which is endowed by the spinning process, is the basis of fiber strength. However, the forces driving fiber assembly and the mechanisms by which spidroins respond those forces are only poorly understood. Spidroins have a tripartite domain architecture consisting of a large and repetitive central domain flanked by small, non-repetitive N- and C-terminal domains. Both terminal …

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Resistance And Dna Repair Mechanisms Under Nitrosative Stress In Mammalian And Microbial Systems, Hyun-Wook Lee Dec 2010

Resistance And Dna Repair Mechanisms Under Nitrosative Stress In Mammalian And Microbial Systems, Hyun-Wook Lee

All Dissertations

Living organisms are exposed a nitrosative stress mediated by reactive nitrogen species (RNS) that can cause DNA damage and mutation. DNA base deamination is a typical damage occurred under nitrosative stress, which results in conversion of cytosine (C) to uracil (U), adenine (A) to hypoxanthine (I), and guanine (G) to xanthine (X) or oxanine (O). Base excision repair (BER) is an important pathway to remove deaminated DNA lesions in mammalian and microbial systems. My dissertation work concerns with genes and enzymes involved in resistance to nitrosative stress and DNA glycosylases in the BER pathway. In chapter one, I will briefly …

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A Study Of African American Forest Landowners In South Carolina: Implications For Land Ethic And Forest Stewardship, Keenan Adams Dec 2010

A Study Of African American Forest Landowners In South Carolina: Implications For Land Ethic And Forest Stewardship, Keenan Adams

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African Americans account for a significant proportion of South Carolina`s
population but reportedly own a disproportionally smaller amount of land. Research indicates that landowners who hold significant sources of sustainable wealth and power can dramatically increase their quality of life and ultimately that of their communities. Current land loss trends for African Americans are increasing at an alarming rate, which may have larger social implications for this traditionally underserved population. The remaining African American landowners are a rapidly declining group, due to an assortment of factors (e.g., age, heirs property). Understanding the experiences of the residual African American forest landowners …

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A Structural Equation Model Of Leader Attributes In The Principalship, Amy Young Dec 2010

A Structural Equation Model Of Leader Attributes In The Principalship, Amy Young

All Dissertations

To become a principal in South Carolina, one must have teaching experience, a master's degree, and certification in the area of primary responsibility. Beyond what is learned through coursework, internships, and certification tests, what intangible factors critically influence a principal's actions and decisions, and (ultimately) success? Trait theory begs the question of whether any of these criteria truly influences the decisions and actions of the principalship. Are there interactive traits of leadership that describe the behaviors of school principals? This study revisits trait theory by examining leader attributes relative to the principalship of South Carolina public schools. This study replicates, …

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Preparation And Studies Of Fluorescent Carbon Nanomaterials, Xin Wang Dec 2010

Preparation And Studies Of Fluorescent Carbon Nanomaterials, Xin Wang

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There have been rapid advances in the development and applications of semiconductor quantum dots (QDs) represented by CdSe/ZnS. However, a serious limitation of these QDs is the necessary use of toxic heavy metals. Fluorescent 'carbon dots' (surface passivated carbon nanoparticles) are developed as alternative to classical semiconductor QDs.
The carbon dots could be made to be highly fluorescence, with emission quantum yields close to 60%. Their optical properties resemble bandgap transitions found in nanoscale semiconductors, suggesting that carbon particles at the nanoscale acquire essentially semiconductor-like characteristics.
The fluorescence in carbon dots could be quenched efficiently by electron acceptor or donor …

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Utilizing Copper(I) Catalyzed Azide-Alkyne Huisgen 1,3-Dipolar Cycloaddition For The Surface Modification Of Colloidal Particles With Electroactive And Emissive Moieties, Parul Rungta Dec 2010

Utilizing Copper(I) Catalyzed Azide-Alkyne Huisgen 1,3-Dipolar Cycloaddition For The Surface Modification Of Colloidal Particles With Electroactive And Emissive Moieties, Parul Rungta

All Dissertations

The development of charge–transporting and fluorescing colloidal particles that can be directly printed into electroluminescent devices may result in a broad impact on the use of electrical energy for illumination. The objective of this work was to design and synthesize electroactive & fluorescing colloidal particles; establish their optical, electronic, and thermodynamic properties; and transition them into a device format for potential applications. The original intended application of this work was to build “better” colloidally–based organic light emitting devices (OLEDs) by creating functional particles with superior electrical and optical performance relative to commercially available technologies, but through the course of the …

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