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Articles 59821 - 59850 of 59911
Full-Text Articles in Entire DC Network
The Relationship Among Couple Relationship Quality, Physical Functioning, And Depression In Multiple Sclerosis Patients And Partners, Justin K. Mcpheters, Jonathan G. Sandberg
The Relationship Among Couple Relationship Quality, Physical Functioning, And Depression In Multiple Sclerosis Patients And Partners, Justin K. Mcpheters, Jonathan G. Sandberg
Faculty Publications
Using Engel's biopsychosocial model and family systems theory, this study explored the associations between multiple sclerosis (MS) patient and partner reports of physical functioning, depression, and could relationship quality. Fifty-four couples recruited from the MS society completed self-reported questionnaires about couple relationship quality, demographic data, and physical functioning. In regression analyses, couple relationship quality positively related to MS patient physical functioning and depression negatively related to MS patient physical functioning. Both MS patient and partner reports of couple relationship quality negatively related to depression scores in partners. While MS patient reports of couple relationship quality negatively related to MS patient …
Older Couples’ Management Of Multiple-Chronic Illnesses: Individual And Shared Perceptions And Coping In Type 2 Diabetes And Osteoarthritis, Jeremy B. Yorgason, Susanne Olsen Roper, Brandan Wheeler, Kristen Crane, Rebekah Byron, Leslie Carpenter, Jonathan G. Sandberg, Rachel Sheffield, Dawn Higley
Older Couples’ Management Of Multiple-Chronic Illnesses: Individual And Shared Perceptions And Coping In Type 2 Diabetes And Osteoarthritis, Jeremy B. Yorgason, Susanne Olsen Roper, Brandan Wheeler, Kristen Crane, Rebekah Byron, Leslie Carpenter, Jonathan G. Sandberg, Rachel Sheffield, Dawn Higley
Faculty Publications
Using data from interviews with 28 older couples in which 1 spouse was diagnosed with diabetes and osteoarthritis, we examined illness perceptions and coping activities as they relate to illness management and relationship resilience. Qualitative analysis of interview transcripts revealed categories of data related to perceptions, coping, and cross category comparisons. Findings suggest that couples experience both negative and positive perceptions of their illnesses, indicating a balance between the reality of their illness challenges and an optimistic outlook of the future. Coping activities included a variety of tasks and were performed by individuals, by both spouses in a shared effort, …
Experimental Investigation Of Dielectric Barrier Impact On Breakdown Voltage Enhancement Of Copper Wire-Plane Electrode Systems, Elham Foruzan, M. Ziaee-Nezhad, A. A. Shayegani-Akmal, K. Niayesh
Experimental Investigation Of Dielectric Barrier Impact On Breakdown Voltage Enhancement Of Copper Wire-Plane Electrode Systems, Elham Foruzan, M. Ziaee-Nezhad, A. A. Shayegani-Akmal, K. Niayesh
Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research
Non-pressurized air is extensively used as basic insulation media in medium / high voltage equipments. An inherent property of air-insulated designs is that the systems tend to become physically large. Application of Dielectric barrier can increase the breakdown voltage and therefore decrease the size of the equipments.
In this paper, the impact of dielectric barrier on breakdown voltage enhancement of a copper wire-plane system is investigated. For this purpose, the copper wire is covered with different dielectric materials. Depending on the air gap and dielectric strength of the barrier the breakdown can be initiated in the solid or gas dielectric. …
The Need For Evidence-Based, Spiritually Oriented Psychotherapies, P. Scott Richards, Everett L. Worthington Jr.
The Need For Evidence-Based, Spiritually Oriented Psychotherapies, P. Scott Richards, Everett L. Worthington Jr.
Faculty Publications
Despite a proliferation of spiritually oriented psychotherapies during the past 2 decades in the mental health professions, outcome research is lacking. In this present article, 6 published outcome reviews that shed light on the efficacy of these psychotherapies are discussed. Although there is general support for the efficacy of spiritually oriented treatment approaches, the data base is relatively small and has methodological limitations. Spiritually oriented cognitive approaches for religious clients with depression and anxiety meet evidence- based standards of efficacy. Several other spiritually oriented approaches are probably efficacious but need additional investigation. Methodological recommendations for improving the quality of future …
The Role Of Inspiration In The Helping Professions, Kari A. O'Grady, P. Scott Richards
The Role Of Inspiration In The Helping Professions, Kari A. O'Grady, P. Scott Richards
Faculty Publications
This qualitative research study examined the ways that helping professionals experi- ence inspiration, as defined as divine guidance or influence, in their therapeutic work. It also explored their beliefs about how helping professionals can seek inspiration in their work. Open-ended survey questions from 333 respondents from a diverse range of religious and professional backgrounds were qualitatively analyzed. The themes ex- tracted give insight into the ways that these helping professionals have experienced inspiration in their work and about how helping professionals can facilitate a spiritual space in the therapeutic context.
Letter From The Editor, Christina Belcher
Letter From The Editor, Christina Belcher
International Christian Community of Teacher Educators Journal
As summer leans closer to the start of another school year, I invite you to put your feet up and read Volume 5, Issue 2 (Summer Issue) of the ICCTE e-journal. This publication includes papers from the recent ICCTE conference. The theme of the 2010 ICCTE conference in Longview, Texas was Igniting the Flames of Faith and Learning. Papers submitted probe this theme from different perspectives. In addition, this issue includes papers forthcoming since our last online publication.
Building A Community Of Shalom: What The Bible Says About Multicultural Education, Heekap Lee
Building A Community Of Shalom: What The Bible Says About Multicultural Education, Heekap Lee
International Christian Community of Teacher Educators Journal
Multicultural education is a highly controversial topic in which it has been the center of contentions and conflicts as it has evolved for the last couple of decades. Several concerns and problems existed in the field of multicultural education will be addressed in this article. In addition, a new framework of multicultural education, called the shalom model, which is drawn from the Bible is presented, along with the characteristics of the model. The goal of multicultural education, according to this model, is to build a community of shalom, an image that is clearly described in Isaiah 11:6. In order to …
Core Competencies And Christian Education: An Integrative Approach To Education In Marriage And Family Therapy Programs, Thomas V. Frederick Ph.D., Laura L. Steele
Core Competencies And Christian Education: An Integrative Approach To Education In Marriage And Family Therapy Programs, Thomas V. Frederick Ph.D., Laura L. Steele
International Christian Community of Teacher Educators Journal
For educating marriage and family therapy (MFT) students, there has been an increasing emphasis on their ability to demonstrate a series of core competencies as identified by the American Associate for Marriage and Family (AAMFT) (Nelson et al., 2007). This type of therapist education from outcome-based education (OBE) fosters the characteristics or worldview associated with educational institutions and the profession. At the most general level, OBE is education or socialization into the professional MFT worldview. As a corrective to this, there is a need to seek this moral character in a Christian worldview which emphasizes a metanarrative informed by the …
Faculty Perceptions Of Academic Freedom At A Private Religious University, James A. Swezey Ed.D., T. Christopher Ross Ed.S
Faculty Perceptions Of Academic Freedom At A Private Religious University, James A. Swezey Ed.D., T. Christopher Ross Ed.S
International Christian Community of Teacher Educators Journal
Academic freedom is viewed by many in higher education as an indispensible foundational principle offering protection to university faculty. University faculty working within schools of education rely on the protection of academic freedom to pursue and develop new knowledge, frameworks, and pedagogies with which they can train and equip the next generation of classroom teachers and school administrators. Private religious universities have been a part of the American education landscape since the founding of Harvard University, yet the perception exists that faculty at religious universities are de facto inhibited by the religious commitment of many of these institutions. This study …
The Role Of Controversial Issues In Moral Education: Approaches And Attitudes Of Christian School Educators, Samuel J. Smith
The Role Of Controversial Issues In Moral Education: Approaches And Attitudes Of Christian School Educators, Samuel J. Smith
International Christian Community of Teacher Educators Journal
This study investigated the approaches and attitudes of Christian school teachers as they addressed controversial issues in moral education. Thirteen teachers from four schools were interviewed extensively. A hermeneutic phenomenological methodology was implemented. Participants conveyed that they attempted to remain pedagogically neutral in matters relating to denominational differences among Christian churches. While acknowledging that indoctrinative techniques may alienate students, teachers chose to indoctrinate selectively, especially in matters critical to the Christian faith. Issues impacting the classrooms included abortion, sex, doctrine, homosexuality, evolution, etc. Teachers rarely chose to remain neutral on controversial issues unless by doing so they sensed that they …
Estimating The Prevalence And Frequency Of The Adolescent Drug Use: Do The Models Fit The Measures?, John P. Hoffmann, Stephen J. Bahr
Estimating The Prevalence And Frequency Of The Adolescent Drug Use: Do The Models Fit The Measures?, John P. Hoffmann, Stephen J. Bahr
Faculty Publications
We critically review recent studies to examine the measurement schemes and empirical models used to examine adolescent drug use, with a particular eye toward determining whether differences between the prevalence and frequency of use have been addressed. Several theoretical models suggest that there are differences but we find relatively few studies that have considered prevalence versus frequency, even though selection effects that dictations these processes affect conclusions about predictors of drug use. Using data from the 2004 U.S. National Survey of Drug Use and Health (NSDUH), (n=16,235), we provide an empirical example of why distinguishing prevalence and frequency of use …
Social Relationships And Mortality Risk: A Meta-Analytic Review, Julianne Holt-Lunstad
Social Relationships And Mortality Risk: A Meta-Analytic Review, Julianne Holt-Lunstad
Faculty Publications
Background
The quality and quantity of individuals' social relationships has been linked not only to mental health but also to both morbidity and mortality.
Objectives
This meta-analytic review was conducted to determine the extent to which social relationships influence risk for mortality, which aspects of social relationships are most highly predictive, and which factors may moderate the risk.
Data Extraction
Data were extracted on several participant characteristics, including cause of mortality, initial health status, and pre-existing health conditions, as well as on study characteristics, including length of follow-up and type of assessment of social relationships.
Results
Across 148 studies (308,849 …
Sōma Sēma: The Influence Of “The Body Is A Tomb” In Early Christi An Debates And The New Testament, Gaye Strathearn
Sōma Sēma: The Influence Of “The Body Is A Tomb” In Early Christi An Debates And The New Testament, Gaye Strathearn
Faculty Publications
As we study the second half of the New Testament, it becomes evident very quickly that the early Church struggled with doctrinal drift. One of the central responsibilities of having a Church with apostles and prophets, we learn in Ephesians, is so “that we henceforth be no more children, tossed to and fro, and carried about with every wind of doctrine, by the sleight of men, and cunning craftiness, whereby they lie in wait to deceive” (Ephesians 4:14). Therefore, most of Paul’s epistles were written to combat this doctrinal drift. But what happens when the people no longer listen to …
Self-Regulation As A Mediator Between Sibling Relationship Quality And Early Adolescents’ Positive And Negative Outcomes, Laura M. Padilla-Walker, James M. Harper, Alexander C. Jensen Phd
Self-Regulation As A Mediator Between Sibling Relationship Quality And Early Adolescents’ Positive And Negative Outcomes, Laura M. Padilla-Walker, James M. Harper, Alexander C. Jensen Phd
Faculty Publications
The current study examined the role of adolescents’ self-regulation as a mediator between sibling relationship quality and adolescent outcomes, after controlling for the quality of the parent-child relationship. Participants were 395 families (282 two parent; 113 single parent) with an adolescent child (M age of child at Time 1 = 11.15, SD = .96, 49% female) who took part in [project name masked for blind review] at both Time 1 and Time 2. Path analysis via structural equation modeling suggested that sibling affection was longitudinally and positively related to self-regulation and prosocial behaviors, and negatively related to externalizing behaviors; while …
Experimental Measurements During Combustion Of Moist Individual Foliage Samples, Brent M. Pickett, Carl Isackson, Rebecca Wunder, Thomas H. Fletcher, Bret Buitler, David R. Weise
Experimental Measurements During Combustion Of Moist Individual Foliage Samples, Brent M. Pickett, Carl Isackson, Rebecca Wunder, Thomas H. Fletcher, Bret Buitler, David R. Weise
Faculty Publications
Individual samples of high moisture fuels from the western and southern United States and humidified aspen excelsior were burned over a flat-flame burner at 987◦ ±12 C and 10±0.5 mol% O2. Time-dependent mass and temperature profiles of these samples were obtained and analysed. It was observed that significant amounts of moisture remained in the individual samples after ignition occurred. Temperature histories showed a plateau at 200◦–300 C at the leaf perimeter rather than at 100 C, with a plateau of 140 C for the leaf interior. Implications are that classical combustion models should be altered to reflect the behaviour of …
Tournament Incentives, League Policy, And Nba Team Performance Revisited, Joseph Price, Brian P. Soebbing, David Berri, Brad R. Humphreys
Tournament Incentives, League Policy, And Nba Team Performance Revisited, Joseph Price, Brian P. Soebbing, David Berri, Brad R. Humphreys
Faculty Publications
Taylor and Trogdon found evidence of shirking under some, but not all, draft lottery systems used in three different National Basketball Association (NBA) seasons. The authors use data from all NBA games played from 1977 to 2007 and a fixed effects model to control for unobservable team and season heterogeneity to extend this research. The authors find that NBA teams were more likely to intentionally lose games at the end of the regular season during the seasons where the incentives to finish last were the largest.
Louder Speech Leads To Greater Intelligibility Improvements Than Amplification Of Habitual Speech In Parkinson’S Disease, Christopher Dromey
Louder Speech Leads To Greater Intelligibility Improvements Than Amplification Of Habitual Speech In Parkinson’S Disease, Christopher Dromey
Faculty Publications
Effects of loud and amplified speech on sentence and word intelligibility in Parkinson disease.
Area Of Enigma: V. S. Naipaul And The East Indian Revival In Trinidad, Aaron Eastley
Area Of Enigma: V. S. Naipaul And The East Indian Revival In Trinidad, Aaron Eastley
Faculty Publications
On March 29, 1949, V.S. Naipaul was front-page news in the Trinidad Guardian. “Special ‘Schol’ Urged for QRC Student,” the headline stated, and beneath was a photo of a quietly smiling teenage Naipaul, looking studious and benign in a pair of large black-rimmed glasses (“Special”). Naipaul, the article reports, had earned marks of distinction in Spanish and French on the Cambridge Higher School Certificate Examination, but was not eligible for a Colonial Scholarship to study in England owing to a recently-introduced technicality. Through no fault of his own he had not completed all of the requisite course work to qualify …
Puebloan Sites In The Hidden Hills, James R. Allison
Puebloan Sites In The Hidden Hills, James R. Allison
Faculty Publications
In 2006 and 2007, the Brigham Young University Archaeological Field School worked in the Hidden Hills area of the Shivwits Plateau, in the western part of the Arizona Strip. The field school mapped, surface collected, and tested a number of Puebloan habitation sites dating from about A.D. 800 to the late 1200s. Architecture includes surface room blocks, stand-alone circular structures, and pit structures, including one deep masonry-lined pit structure that may be a kiva. Ceramic analysis shows that the Hidden Hills residents participated in ceramic exchange networks encompassing other parts of the Arizona Strip as well as more distant places.
The End Of Farming In The “Northern Periphery” Of The Southwest, James R. Allison
The End Of Farming In The “Northern Periphery” Of The Southwest, James R. Allison
Faculty Publications
Prehispanic farmers belonging to the Virgin and Fremont traditions once occupied most of Utah and adjacent parts of Arizona and Nevada. Through much of the twentieth century, these areas were called the "Northern Periphery'' of the Southwest, but in recent decades, both Fremont and Virgin have often been left out of syntheses of southwestern archaeology-even though they clearly had strong connections to the Southwest and represented, respectively, the northernmost and westernmost extensions of maize-based horticulture in western North America. This exclusion results from a combination of factors, the most important of which are geography and the territorial behavior of some …
Parent Involvement In End-Of-Life Care And Decision Making In The Newborn Intensive Care Unit: An Integrative Review, Lacey M. Eden, Lynn Clark Callister
Parent Involvement In End-Of-Life Care And Decision Making In The Newborn Intensive Care Unit: An Integrative Review, Lacey M. Eden, Lynn Clark Callister
Faculty Publications
Survival rates for very preterm and critically ill infants are increasing, raising complex ethical issues for health-care providers and parents who face the challenge of making end-of-life decisions for newborns. The purpose of this integrative literature review was to evaluate parental involvement in end-of-life care and decision making for their infant in the newborn intensive care unit. Findings revealed that establishing good relationships and clear communication between health-care providers and parents builds trust and eases stress placed on parents making decisions about the care of their infant. Palliative care programs provide support for parents and facilitate their decision making. Parents …
The Effects Of Direct And Indirect Speech On Native English And Esl Speakers’ Perception Of Teacher Written Feedback, Wendy Baker, Rachel Hansen Bricker
The Effects Of Direct And Indirect Speech On Native English And Esl Speakers’ Perception Of Teacher Written Feedback, Wendy Baker, Rachel Hansen Bricker
Faculty Publications
This study explores how second language (L2) learners perceive indirect (hedging or indirect speech acts) and direct written teacher feedback. Though research suggests that indirect speech acts may be more difficult to interpret than direct speech acts (Champagne, 2001; Holtgraves, 1999), using indirect speech acts is often encouraged in the learning process, with the idea that it helps students discover their own errors (Ferris, 2007; Riley and Mackiewitz, 2003;). However, it may not be effective with L2 learners who often need more explicit instruction to understand how to revise their writing (Ferris, 2002). To examine the effect of different directness …
Married With Children: The Influence Of Parental Status And Gender On Ambulatory Blood Pressure, Wendy C. Birmingham, Julianne Holt-Lunstad, Adam M. Howard, Dustin Thoman
Married With Children: The Influence Of Parental Status And Gender On Ambulatory Blood Pressure, Wendy C. Birmingham, Julianne Holt-Lunstad, Adam M. Howard, Dustin Thoman
Faculty Publications
Background Although there is substantial evidence that social relationships and marriage may influence both psychological and physical health, little is known about the influence of children. Purpose This study examined the competing predictions regarding the directional influence of parental status and its interaction with gender—given that mothers are typically disproportionately more responsible for everyday care of children—on cardiovascular functioning. Method We examined ambulatory blood pressure (ABP) over 24 hours among 198 married males and females. Results Couples without children had significantly higher ambulatory SBP and DBP than those with children. Moreover, we found a significant interaction between parental status and …
Use Of The Patient Care Monitor To Screen For Depressionin Adult Cancer Patients Interviewed With The Structuredclinical Interview For Dsm-Iv, Scott A. Baldwin, Arthur C. Houts, Damon Lipinski, James P. Olsen, Murad Hasan
Use Of The Patient Care Monitor To Screen For Depressionin Adult Cancer Patients Interviewed With The Structuredclinical Interview For Dsm-Iv, Scott A. Baldwin, Arthur C. Houts, Damon Lipinski, James P. Olsen, Murad Hasan
Faculty Publications
Objective: To evaluate the Patient Care Monitor (PCM1.0) Acute Distress and DespairnormalizedTscores as indicators of a diagnosis of Major Depression according to theStructured Clinical Interview for DSM-IV Axis I Disorders (SCID).Methods: Subjects were 21 adult cancer patients identified by treating communityoncologists as having significant emotional distress matched on age, cancer type, treatmenthistory, and sex to 21 patients not having significant distress. All completed e/tablet PCM 1.0and SCID administered by trained interviewers. Unweighted kappa and receiver operatingcharacteristics (ROC) analyses were used to assess scale properties.Results: Agreement between SCID Major Depression and Acute Distress and Despair(TX65) were kappa50.751 and 0.755, respectively. ROC …
Resisting Technological Gravity: Using Guiding Principles For Instructional Design, Jason K. Mcdonald
Resisting Technological Gravity: Using Guiding Principles For Instructional Design, Jason K. Mcdonald
Faculty Publications
Instructional designers face tremendous pressure to abandon the essential characteristics of educational approaches, and settle instead for routine practices that do not preserve the level of quality those approaches originally expressed. Because this pressure can be strong enough to affect designers almost as gravity affects objects in the physical world, the metaphor of technological gravity has been proposed to describe why designers choose one type of practice over another. In this essay, I discuss how designers can develop guiding principles to help them resist technological gravity. I describe three types of principles, in the areas of what instruction is, …
Empathy And Error Processing, Scott A. Baldwin, Michael J. Larson, Joseph E. Fair, Daniel A. Good
Empathy And Error Processing, Scott A. Baldwin, Michael J. Larson, Joseph E. Fair, Daniel A. Good
Faculty Publications
Recent research suggests a relationship between empathy and error processing. Error processing is an evaluativecontrol function that can be measured using post-error response time slowing and the error-related negativity (ERN)and post-error positivity (Pe) components of the event-related potential (ERP). Thirty healthy participants completedtwo measures of empathy, the Interpersonal Reactivity Index (IRI) and the Empathy Quotient (EQ), and a modifiedStroop task. Post-error slowing was associated with increased empathic personal distress on the IRI. ERN amplitudewas related to overall empathy score on the EQ and the fantasy subscale of the IRI. The Pe and measures of empathywere not related. Results remained consistent …
Multiple Pathways To Functional Impairment In Obsessive–Compulsive Disorder, Scott A. Baldwin, Yeraz Markarian, Michael J. Larson, Mirela A. Aldea, Daniel Good, Arjan Berkeljon, Tanya K. Murphy, Eric E. Storch, Dean Mckay
Multiple Pathways To Functional Impairment In Obsessive–Compulsive Disorder, Scott A. Baldwin, Yeraz Markarian, Michael J. Larson, Mirela A. Aldea, Daniel Good, Arjan Berkeljon, Tanya K. Murphy, Eric E. Storch, Dean Mckay
Faculty Publications
Obsessive–compulsive disorder (OCD) is a chronic and debilitating condition that is relatively common in both children and adults, and it is associated with a wide range of functional impairments. Mental health researchers and practitioners have placed considerable attention on OCD over the past two decades, with the goal of advancing treatment and understanding its etiology. Until recently, it was unknown to what extent this disorder was associated with functional impairment. However, recent research shows that the condition has significant social and occupational liabilities. This article discusses etiology, common symptom presentations (including comorbid and ancillary symptoms), basic OCD subtypes, neuropsychological functioning, …
5¢-O-B,G-Methylenetriphosphate Derivatives Of Nucleoside, Yousef Ahmadibeni, Chandravanu Dash, S. F. J. Le Grice, Keykavous Parang
5¢-O-B,G-Methylenetriphosphate Derivatives Of Nucleoside, Yousef Ahmadibeni, Chandravanu Dash, S. F. J. Le Grice, Keykavous Parang
Pharmacy Faculty Articles and Research
The solid-phase synthesis of 5¢-O-b,g-methylenetriphosphates of nucleosides 1–5 is described, where a 4-acetoxy-3-arylbenzyloxy group was used as a linker.
Synthesis, Antiviral And Contraceptive Activities Of Nucleoside-Sodium Cellulose Sulfate Acetate And Succinate Conjugates, Hitesh K. Agarwal, Anil Kumar, Gustavo F. Doncel, Keykavous Parang
Synthesis, Antiviral And Contraceptive Activities Of Nucleoside-Sodium Cellulose Sulfate Acetate And Succinate Conjugates, Hitesh K. Agarwal, Anil Kumar, Gustavo F. Doncel, Keykavous Parang
Pharmacy Faculty Articles and Research
Chemical conjugates between sodium cellulose sulfate (CS), displaying contraceptive and HIV-entry inhibiting properties, and nucleoside reverse transcriptase inhibitors (NRTIs) (3′-azido-2′,3′-dideoxythymidine (AZT), 3′-fluoro-2′,3′-dideoxythymidine (FLT), or 2',3'-dideoxy-3'-thiacytidine (3TC)) were designed to simultaneously provide contraceptive and anti-HIV activity. Two linkers, acetate and succinate, were used to conjugate the nucleoside analogs with CS. The conjugates containing cellulose sulfate-acetate (CSA) (e.g., AZT-CSA and FLT-CSA) were found to be more potent than CS and other conjugates (e.g., AZT-succinate-CS, and FLT-succinate-CS). The presence of both sulfate and the acetate groups on cellulose were critical for generating maximum anti-HIV activity. In addition to showing equal potency against wild-type …
Synthesis And Evaluation Of Conformationally Constrained Peptide Analogues As The Src Sh3 Domain Binding Ligands, Rakesh Tiwari, Alex Brown, Seetha Narramaneni, Gongqin Sun, Keykavous Parang
Synthesis And Evaluation Of Conformationally Constrained Peptide Analogues As The Src Sh3 Domain Binding Ligands, Rakesh Tiwari, Alex Brown, Seetha Narramaneni, Gongqin Sun, Keykavous Parang
Pharmacy Faculty Articles and Research
Src kinase activity is regulated by the interaction of SH3 domain with protein sequences that are rich in proline residues. Identification of more potent SH3 domain binding ligands that can regulate Src kinase activity is a subject of major interest. Conformationally constrained peptides have been previously used for improving the binding potency of the Src SH2 domain binding peptide ligands and peptide substrates of the substrate-binding site of Src. A series of peptide analogues of Ac-VSLARRPLPPLP (1, Ac-VSL-12, Kd = 0.34 M) were synthesized by introducing conformational constraints to improve the binding affinity towards the Src SH3 domain. Peptides synthesized …