Digital Commons Network^™

Analysis Of Dna-Binding Proteins In Yeast Saccharomyces Cerevisiae, Su-Wen Ho

All Theses and Dissertations (ETDs)

Gene expression is an elaborate and finely tuned process involving the regulated interactions of multiple proteins with promoter and enhancer elements. A variety of approaches are currently used to study these interactions in vivo, in vitro as well as in silico. With the genome sequences of many organisms now readily available, a plethora of DNA functional elements have been predicted, but the process of identifying the proteins that bind to them in vivo remains a bottleneck. I developed two high-throughput assays to address this issue. The first is a modification of the yeast "one-hybrid" assay. The second is probing protein …

Physics Of Ultrasonic Wave Propagation In Bone And Heart Characterized Using Bayesian Parameter Estimation, Christian Anderson

All Theses and Dissertations (ETDs)

This Dissertation explores the physics underlying the propagation of ultrasonic waves in bone and in heart tissue through the use of Bayesian probability theory. Quantitative ultrasound is a noninvasive modality used for clinical detection, characterization, and evaluation of bone quality and cardiovascular disease. Approaches that extend the state of knowledge of the physics underpinning the interaction of ultrasound with inherently inhomogeneous and isotropic tissue have the potential to enhance its clinical utility. Simulations of fast and slow compressional wave propagation in cancellous bone were carried out to demonstrate the plausibility of a proposed explanation for the widely reported anomalous negative …

Unique Features Of Ptb Rrms: Insight Into Protein Motions And Rna Binding, Caroline Maynard

All Theses and Dissertations (ETDs)

Polypyrimidine tract binding protein: PTB) is a highly conserved RNA binding protein comprised of four RRMs: RNA recognition motifs). RRMs are extremely prevalent in all kingdoms of life, and have been very well characterized in terms of structure and RNA binding properties. However, all four RRMs of PTB exhibit unique features that can be exploited to learn more about the RNA selection and binding strategy of PTB, as well more general features involving structure/function relationships and protein unfolding mechanisms. PTB participates in a variety of functions in eukaryotic cells, including alternative splicing, mRNA stabilization, and internal ribosomal entry site: IRES) …

Quantitative Phosphoproteomics Through Β-Elimination And Michael Addition With Natural Abundance And Stable Isotope Labeled Thiocholine, Meng Chen

All Theses and Dissertations (ETDs)

The reversible covalent phosphorylation of cellular proteins is widely believed to be the most important mechanism for the regulation of multiple signal transduction pathways in cell growth, division, and death by acting as a molecular switch at multiple nodes in metabolic networks. In this dissertation, first, a novel mass spectrometric strategy is reported that exploited the unique chemical properties of thiocholine that was introduced into protein phosphosites through alkaline beta-elimination and Michael addition: BEMA), allowing the specific detection, identification and quantitation of phosphorylated serine/threonine containing peptides. Through replacement of the phosphate with thiocholine as the Michael donor, this strategy resulted …

Modeling Decision Making Related To Incident Delays During Hurricane Evacuations, Robert Michael Robinson

Computational Modeling & Simulation Engineering Theses & Dissertations

Successful evacuations from metropolitan areas require optimizing the transportation network, monitoring conditions, and adapting to changes. Evacuation plans seek to maximize the city's ability to evacuate traffic to flee the endangered region, but once an evacuation begins, real time events degrade even the best plans.

To better understand behavioral responses made during a hurricane evacuation, a survey of potential evacuees obtained data on demographics, driving characteristics, and the traffic information considered prior to and during an evacuation. Analysis showed significant levels of correlation between demographic factors (e.g., gender, age, social class, etc.) and self-assessed driver characteristics, but limited correlation with …

The Administration Of Community College Blogs: Considering Control And Adaptability In Loosely Coupled Systems, Troy A. Swanson

Educational Leadership & Workforce Development Theses & Dissertations

The purpose of this study using a multiple case study method is (1) to further the understanding of how community college administrators and blog authors strike a balance between organizational control and adaptability when implementing and using blog technologies and (2) to create a model that will help administrators better strike this balance within a loosely coupled system of college units and individuals. The rise of Web 2.0 technologies, which allows for direct publication to the Internet, presents two conundrums for community colleges: the conundrum of control and the conundrum of adaptability. As the oldest implementation of Web 2.0 technologies, …

Race, Colonialism, Gender And The Rwandan Genocide, Jessica Patrice Braccio

Dissertations and Theses @ UNI

In 1994 Rwanda erupted in a genocide, which targeted primarily the Tutsi and any of their sympathizers. At the end of the conflict an estimated 800,000 Rwandans were dead and some Hutu offenders still face prosecution today. Proponents of the genocide justified their violence by asserting that the Tutsi had privileged lot in life, compared with the Hutu. These ideas can be seen as a reaction against ideas of Tutsi racial superiority over the Hutu which originated in European, specifically German and Belgian, colonial thought about race and gender. Even though very little is known about Rwanda prior to European …

Identification Of Virulence Genes In The Corn Pathogen Fusarium Verticillioides, Divya Chouhan

Dissertations and Theses @ UNI

Fusarium verticillioides is a pathogenic fungus that causes infection of crops and vegetables such as corn, wheat, potato, cassava, banana, potato and sorghum. It causes various diseases in corn such as seedling blight, root, stalk, and ear rot. Pathogenic Fusarium species have caused billions of dollars of damage through reduced yield. F.verticillioides also produces mycotoxins such as fumonisin. Consumption of contaminated grain can cause various diseases in animals such as pulmonary oedema in pigs and leukoencephalomalacia in horses, and may be associated with esophageal cancer in humans. Identification of virulence genes in F. verticillioides will help in understanding its biology …

Adrift In The Wake Of Modernism: Music, Mind, And Meaning In The Works Of James Joyce, April E. Cook

Dissertations and Theses @ UNI

Since Joyce's rise to critical prominence over the course of the twentieth century, a diverse corpus of scholarship has emerged around the Joyce canon that is nearly as vast and as multifaceted as the works themselves. While many have explored Joyce's affinity for music and his unprecedented synthesis of musical and literary modes, relatively few have examined his works' musical properties in the context of the contemporaneous musical developments of the early avant-garde and jazz movements. This study explores the trajectory of Joyce's engagement with musical forms and techniques, ranging from the primarily allusive relations of his early works to …

Characterizing The Interaction Of P. Falciparum Eba-175 With Its Receptor Glycophorin A, Nichole Salinas

All Theses and Dissertations (ETDs)

No abstract provided.

Predictors Of Developmental Screenings For Young Children, Janice Chandler Ranne

Health Services Research Dissertations

This study examines the usefulness of the New Model of Children's Health and its Influences for the identification of predictors for health service effectiveness. Health service effectiveness is measured by probability estimations of whether young children receive formal or informal developmental screenings. Screenings lead to prevention of communication delays in later childhood. Formal screenings with standardized questions are preferred over informal screenings, which are knowledgeable observations. The theoretical framework is a child-centered socio-ecological theory that is untested for use in health service effectiveness studies until the present one. Four developmental concepts of the theoretical framework, social environment, physical environment, biological …

Cyber-Apocalypse Now: Securing The Internet Against Cyberterrorism And Using Universal Jurisdiction As A Deterrent, Kelly A. Gable

Vanderbilt Journal of Transnational Law

Cyberterrorism has become one of the most significant threats to the national and international security of the modern state, and cyberattacks are occurring with increased frequency. The Internet not only makes it easier for terrorists to communicate, organize terrorist cells, share information, plan attacks, and recruit others but also is increasingly being used to commit cyberterrorist acts. It is clear that the international community may only ignore cyberterrorism at its peril.

The primary security threat posed by the Internet is caused by an inherent weakness in the TCP/IP Protocol, which is the technology underlying the structure of the Internet and …

Superior Responsibility Of Civilians For International Crimes Committed In Civilian Settings, Yael Ronen

Vanderbilt Journal of Transnational Law

This Article examines the notion of superior responsibility of civilians for international crimes committed in civilian settings. The doctrine of superior responsibility grew out of the military doctrine of command responsibility, and its evolution is informed by this origin. Jurisprudence and academic writers emphasize that the doctrine is applicable to civilian superiors of military or paramilitary organizations, but there has never been a detailed analysis of the doctrine's relevance and applicability in civilian settings. The Article argues that the claim that customary international law extends the doctrine of superior responsibility to civilians, let alone in civilian settings, is inaccurate. In …

Standardizing The Principles Of International Election Observation, Jonathan Misk

Vanderbilt Journal of Transnational Law

On October 27, 2005, thirty-two international nongovernmental organizations (INGOs) and intergovernmental organizations (IGOs) signed the Declaration of Principles for International Election Observation, drafted with the assistance of the United Nations. For nearly four decades before the signing of the Declaration, international election observation rapidly gained acceptance as a legitimate method of guaranteeing free and fair elections and thus promoting lasting democratic institutions. Many INGOs and IGOs conducting observation missions--including the Organization for Security and Cooperation in Europe, the Organization of American States, the South African Development Community, and the Carter Center-independently developed standards for their observers to follow. As international …

Freeze-Outs: Transcontinental Analysis And Reform Proposals, Marco Ventoruzzo

Faculty Scholarship

One of the most crucial, but systematically neglected, comparative differences between corporate law systems in Europe and in the United States concerns the regulations governing freeze-out transactions in listed corporations. Freeze-outs can be defined as transactions in which the controlling shareholder exercises a legal right to buy out the shares of the minority, and consequently delists the corporation and brings it private. Beyond this essential definition, the systems diverge profoundly.

This gap exists despite the fact that minority freeze-outs are one of the most debated issues in corporate law, in the public media, in a vast body of scholarly work …

Copyright And The World's Most Popular Song, Robert Brauneis

GW Law Faculty Publications & Other Works

"Happy Birthday to You" is the best-known and most frequently sung song in the world. Many - including Justice Breyer in his dissent in Eldred v. Ashcroft - have portrayed it as an unoriginal work that is hardly worthy of copyright protection, but nonetheless remains under copyright. Yet close historical scrutiny reveals both of those assumptions to be false. The song that became "Happy Birthday to You," originally written with different lyrics as "Good Morning to All," was the product of intense creative labor, undertaken with copyright protection in mind. However, it is almost certainly no longer under copyright, due …

Healing Healthcare Through Tax Reform, Eleanor Marie Brown

GW Law Faculty Publications & Other Works

An economic crisis, sky-rocketing healthcare costs, and millions of Americans without health insurance combine to bring to the public square not only the possibility of a meaningful debate but the political perfect storm that might unearth entrenched partisans and bring about meaningful healthcare reform. The current taxation of expenditures for healthcare is a complex, unjust, uneconomical, and inefficient system. This article seeks to refute revisionist historians who might argue that healthcare in the workplace had no meaningful presence until World War II and to highlight the reasons for the development of employer-provided healthcare; to explain the fundamental inequities wrought by …

Gender, Masculinities And Transition In Conflicted Societies, Naomi R. Cahn, Fionnuala D. Ni Aolain

GW Law Faculty Publications & Other Works

This article uses a gender lens to explore how conflict affects men and women differently. It examines issues related to the emergence of certain kinds of “hyper” masculinity in situations of conflict and how such masculinities continue to function in subsequent peace-building attempts. The article argues that a failure to account for and be cognizant of these specific masculinities has a significant effect for women in particular, and, more generally, on the success of the conflict transition process. Finally, we show how using a gender lens could make a difference by considering the specific example of the impact of violent …

Embryo Fundamentalism, Naomi R. Cahn, June Caborne

GW Law Faculty Publications & Other Works

The battle for the future of assisted reproduction technologies (ART) has been joined. The tacit compromise underlying assisted reproduction - no laws are passed that even tangentially sanction embryo destruction and no laws are passed that intrude on the profitability of fertility treatments - may be coming to an end. As use of ART has increased, so have calls for supervision and oversight. In the wake of "Octomom" Nadya Suleman's use of in vitro fertilization (IVF) to give birth to octuplets, the calls to regulate assisted reproduction have become even more pressing. At the same time, religious communities ambivalent about …

Returning Home: Women In Post-Conflict Societies, Naomi R. Cahn, Dina Francesca Haynes, Fionnuala D. Ni Aolain

GW Law Faculty Publications & Other Works

This paper explores the situation of women returning to their homes and communities after their countries have experienced major conflicts. In that context, it assesses the range of barriers and challenges that women face and offers some thinking to addresses and remedy these complex issues. As countries face the transition process, they can begin to measure the conflict’s impact on the population and the civil infrastructure. Not only have people been displaced from their homes, but, typically, health clinics, schools, roads, businesses, and markets have deteriorated substantially. While the focus is on humanitarian aid in the midst of and during …

Integration Of Multi-Sensory Earth Observations For Characterization Of Air Quality Events, Erin Robinson

All Theses and Dissertations (ETDs)

In order to characterize air quality events, such as dust storms or smoke events from fires, a wide variety of Earth observations are needed from satellites, surface monitors and models. Traditionally, the burden of data access and processing was placed on the data user. These challenges of finding, accessing and merging data are overcome through the principles of Service Oriented Architecture. This thesis describes the collaborative, service-oriented approach now available for air quality event analysis, where datasets are turned into services that can be accessed by tools through standard queries. This thesis extends AQ event evidence to include photos, videos …

Characterization Of Scannable Leaky Wave Antennas Using An Extended Metamaterial Framework, Garrett Gilchrist

All Theses and Dissertations (ETDs)

No abstract provided.

Unbound By Law: Association And Autonomy In The Early American Republic, Kevin Butterfield

All Theses and Dissertations (ETDs)

This dissertation examines how the concept of voluntary membership evolved between the 1780s and the 1830s, a period in which men and women created thousands of groups seeking everything from fraternity to profit to social reform. Before observers foreign and domestic would begin to identify the voluntary association as a defining characteristic of post-Revolutionary American culture, Americans who organized and joined such groups had struggled for decades to determine what membership ought to look like, what rights and duties the act of joining should entail. By the time Alexis de Tocqueville famously noted in 1831 that Americans were "forever forming …

The Hematopoietic Compartment Regulates Osteoblast Differentiation And Apoptosis During Cytokine Treatment, Matthew Christopher

All Theses and Dissertations (ETDs)

Adult hematopoiesis normally occurs in bone marrow, where hematopoietic stem cells: HSC) reside within a specialized microenvironment. At steady state, hematopoiesis state is regulated such that immature hematopoietic stem and progenitor cells: HSPC) are restricted to the bone marrow and are rarely observed in peripheral blood. Under certain circumstances, however, this regulation is loosened and significant numbers of HSPC are released to the circulation, a process termed "mobilization." Mobilization can be induced pharmacologically by a wide range of agents. Of these, the best characterized and most widely used mobilizing agent is Granulocyte-colony stimulating factor: G-CSF). G-CSF is widely used clinically …

Hermann Hesse As Ambivalent Modernist, Theodore Jackson

All Theses and Dissertations (ETDs)

This dissertation asserts that the Hermann Hesse approaches the themes and techniques of literary Modernism with ambivalence. The first chapter outlines the role of philosophical and literary walking in Hesse's work in general as well as how these depictions differ from those produced by his predecessors. The second chapter takes Hesse's reinterpretation of Nietzsche and Rousseau and applies it to three of Hesse's early novels, Unterm Rad, Peter Camenzind, and Knulp. The third chapter examines Der Steppenwolf as an ambivalently Modernist autobiography, using Eugene Stelzig's notion of Seelenbiographie. The last chapter examines Hesse's two final novels, Die Morgenlandfahrt and Das …

Portland Roasting Company: Farm Friendly Direct, Madeleine E. Pullman, Brandon Arends, Mark Langston, Greg Price, Greg Stokes

Business Faculty Publications and Presentations

This case describes the issues and dilemmas facing a company in their efforts to differentiate their product through a social sustainability programme. Over the years, the company has built a strong reputation with their sustainability efforts, particularly amongst their peers in the specialty coffee industry. There is some question as to whether this reputation has been visible to consumers and if consumers see the value-proposition. The case covers the history of coffee, the specialty coffee industry, the supply chain and roles of different participants, and the competitive landscape.

Furthermore, most of the competitive eco-labels and certification schemes are discussed. The …

Importance Of Reader's Advisory Interview In Graphic Novel Promotion, Lori Petersen

Graduate Research Papers

Web sites, magazine articles, books, and even summer library programs are promoting graphic novels as an almost magic cure for those children who struggle with the written word or who may be simply lack interest in reading. Much of the appeal of the graphic novel for teachers and librarians is based on the pictures, and it is easy to assume this makes reading easier.

This research sought to explore the graphic novel reading experiences for young readers to ascertain (1) the nature of their understanding of the graphic novel; (2) their tendency to draw inference and interpretation from text and …

Notes On Contributors

Short Story

No abstract provided.

Mfa10 (Mfa 2010), Sam Fox School Of Design & Visual Arts, Mildred Lane Kemper Art Museum, Buzz Spector, Robert Gero, Patricia J. Olynyk, Clyde Ashby, Aaron Bos-Wahl, Andrew Cozzens, John Early, Ryan James Fabel, Joel Fullerton, Mary Beth Hassan, Wenting Hsu, John Nicholas Hutchings, Dani Kantrowitz, Larry Keaty, Mamie Korpela, Paola Laterza, Mad Mohre, Emily Moorhead, Jonathan Muehlke, Jessa Richardson, Nicolette Ross, Carlie Trosclair

Books and Monographs

Catalogue of a culminating student exhibition held at the Mildred Lane Kemper Art Museum in 2010. Content includes Foreword / Buzz Spector -- Thinking as making / Robert Gero -- A new set of conversations / Patricia Olynyk -- MFA 2010 graduates. Clyde Ashby / Aaron Bos-Wahl / Andrew Cozzens / John Early / Ryan James Fabel / Joel Fullerton / Mary Beth Hassan / Wenting Hsu / John Nicholas Hutchings/ Dani Kantrowitz / Larry Keaty / Mamie Korpela / Paola Laterza / Mad Mohre / Emily Moorhead / Jonathan Muehlke / Jessa Richardson / Nicolette Ross / Carlie Trosclair …

The Eminence Of Imminence And The Myopia Of Markets, Teneille R. Brown

Utah Law Faculty Scholarship

This article questions the privileging of disaster, or imminent threat, over more distant threats to public health. In many cases, this privileging makes sense as we do not have time to evaluate the threat under traditional frameworks. But in some cases, we privilege disaster in ways that may be ethically and legally unsound. Here I am interested in a particular type of public health threat – the negative consequences that stem from climate change. In this article I view the climate change discussion through the lens of distributive justice. I analyze the ethical as well as legal arguments for encouraging …