Digital Commons Network^™

Prognosis: A Wearable System For Health Monitoring Of People At Risk, Alexandros A. Pantelopoulos

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Wearable Health Monitoring Systems (WHMS) have drawn a lot of attention from the research community and the industry during the last decade. The development of such systems has been motivated mainly by increasing healthcare costs and by the fact that the world population is ageing. In addition to that, RandD in WHMS has been propelled by recent technological advances in miniature bio-sensing devices, smart textiles, microelectronics and wireless communications techniques. These portable health systems can comprise various types of small physiological sensors, which enable continuous monitoring of a variety of human vital signs and other physiological parameters such as heart …

Dosimetric Effects Near Implanted Vascular Access Ports Under External Electron Beam Radiation, David Coll Segarra

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Previous studies on dosimetry show important effects for metal vascular access ports for x-rays and electron beams and moderate to no effects for plastic ports for x-ray beams when ports are in the path of the beam. No previous studies exist regarding the effects of electron beams on vascular access ports other than for those made of metal although it has been suggested that electron beam attenuation through non-metal ports may be possible.

Measurements of relative ionization through the device and adjacent to the device anteriorly and laterally were taken. A clinical particle accelerator delivered typical clinical electron beams of …

Character Education: The Effects Of An After-School Music Program On At-Risk Youth Student Motivation And Academic Achievement, Sharon L. Koster

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This case study was designed to increase student motivation and improve academic achievement in at-risk students through participation in an after-school music program. The case study began in September 2007, as a part of Project Jericho's After-school Arts Program, a program that is a collaboration between the Clark State Community College Performing Arts Center and Job and Family Services of Clark County, in Springfield, Ohio. An analysis compared pre and post data that included field notes, personal observation, student journals, and SWIS data (School-wide Information System: official school behavioral tracking system for data), in order to measure changes in behavior, …

Tissue Specific Effects Of Adipose Stem Cells (Asc) In A Melanoma Tumor Environment, Drew Michael Nedderman

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This study determined the tissue-specific effect of adipose stem cells (ASC) within a melanoma environment for development of a cell-based melanoma therapy. Analysis included a subcutaneous B16-F1 melanoma model using thirty-one C57BL/6 wild-type mice. Melanoma xenografts were treated with cell-based therapies of CFDA-SE-labeled human fibroblasts HF20x (control), non-differentiated ndASC or hematopoietic-differentiated HdASC. No tumor regression was observed in presence of cell-based therapies, thus, the HdASC group demonstrated an increase in tumor growth accompanied with an up-regulated macrophage response, and increased angiogenesis. In addition, this group demonstrated a decrease in Melan-A tumor marker and interferon-γ expression suggesting that ASC-supported tumor angiogenesis …

Biodegradation Of Groundwater Pollutants (Chlorinated Hydrocarbons) In Vegetated Wetlands: Role Of Aerobic Microbes Naturally Associated With Roots Of Common Plants, Christina Lynn Powell

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Chlorinated aliphatic hydrocarbons (CAHs) are often found as groundwater contaminants because of past industrial activities and disposal practices. CAHs pose a threat to human health and thus, create a need to find both natural and engineered processes that can remove these chlorinated compounds from the environment. Natural attenuation by oxidative biodegradation is especially important because it can allow for mineralization to carbon dioxide, a nontoxic end-product. The goal of this research was to evaluate the potential oxidative biodegradation of CAHs by microorganisms that are naturally associated with wetland plant roots. The research was divided into field work and laboratory batch …

Charaterization Of Chlorpyrifos Toxicity On The Pancreatic Beta Cell Line Rinm5f, Zhongyu Yan

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Chlorpyrifos (CPF) is a well-known organophosphate (OP) insecticide that inhibits acetylcholinesterase (AChE). Organophosphates have been shown to induce hyperglycemia in both humans and animals that cannot be explained by AChE inhibition alone. Pancreatic β-cells are responsible for secreting insulin and playing a fundamental role in glucose homeostasis. The aim of this research was to investigate CPF toxicity on the insulin secreting β-cell line RINm5f (RIN). In the first part of this dissertation, we determined that cytotoxic concentrations of CPF between 50 µM and 200 µM induced a dose-dependent increase in RIN cell apoptotic and necrotic death (p<0.05). Lower doses, i.e., 5-25 µM did not induce apoptosis or necrosis. In further mechanistic studies, inhibitors of c-Jun N-terminal kinase (JNK) and P38 pathways, i.e., SP600125 and SB202190, successfully attenuated CPF-induced apoptosis (p<0.05), suggesting cell death is mediated by JNK and/or p38. In addition, N-Acetyl-L-cysteine (NAC), an antioxidant, inhibited apoptosis suggesting that oxidative stress is also involved in RIN cell death. In the second part of this dissertation, low dose CPF's effects on insulin synthesis and secretion was studied. Our results showed that RIN cells treated with CPF for 4 hr exhibited a dose-dependent decrease in insulin secretion in response to stimulation by 50 mM potassium (p<0.05). Insulin secretion stimulated by 25 mM glucose also showed significant decreases upon incubation with various doses of CPF (p<0.05). Insulin synthesis involves proteolytic cleavage of proinsulin at two specific sites. The enzymes responsible for promoting proinsulin cleavage, i.e, prohormone convertase (PC) 1/3 and 2 (PC2), contain a serine hydrolase catalytic triad, His-Asp-Ser, similar to AChE. CPF modification of PC enzymes similar to AChE, could potentially interrupt the conversion of proinsulin to insulin and disrupt insulin secretion. PC2 enzyme activity was significantly inhibited by CPF at concentrations as low as 10 µM (p<0.01). RIN cells, for the first time, were found to secrete proinsulin was through a constitutive instead of a regulated pathway. In summary, our results show that CPF not only exerts a direct cytotoxic effect at concentrations above 50 µM, but also significantly impairs insulin secretion at lower doses. Low dose CPF could potentially affect endocrine function in vivo by inhibiting the proinsulin processing enzyme PC2.

Inhibition Of Cell Invasion By Targeting Pld, Terry C. Farkaly

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Phospholipase D (PLD) is a crucial signaling enzyme involved in many cellular processes. The catalytic activity of PLD is essential for the production of Phosphatidic Acid (PA), a critical second messenger in cell signaling cascades downstream. Using the highly invasive rat mammary adenocarcinoma cell line mTLn3 as a metastatic model, we investigated the proficiency of these cells to invade using matrigels that mimic the basement membrane of the extracellular matrix (ECM), their activity through PLD enzymatic assays, as well as the potency of our potential inhibitors to inhibit PLD-mediated cell invasion and lipase activity. This study reveals that PLD-mediated cell …

Rev Interacts With Tubulin Heterodimers To Cause Cell Cycle Defects, Poornima Kotha Lakshmi Narayan

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Rev is a regulatory protein that plays an important role in the replication of HIV virus by post-transcriptionally promoting expression of viral proteins late in infection. Rev expression also slows cell growth, leads to an accumulation of cells in G2/M specifically before the spindle checkpoint, and can produce changes in ploidy. Because Rev is capable of depolymerizing microtubules (MTs) in vitro, possibly by a mechanism shared with Kinesin-13 proteins, themselves potent cellular MT depolymerases, I tested the hypothesis that these cellular defects were due to an interaction between Rev and tubulin.

To this end, Rev and select Rev mutants defective …

The Influence Of Stored Product Mites On The Function Of Skin Microvascular Endothelial Cells, Jennifer Graff Curp

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The prevalence of allergenic diseases and sensitization to stored product mites is increasing worldwide. Stored product mites are prevalent in homes, foods, and some work environments. Stored product mites need to be further studied so we can characterize their inflammatory properties to understand their role in skin disease, and provide proper treatment to patients with mite allergies. The purpose of the study was to show the role of stored product mites in modulating the inflammatory and immune response to human dermal endothelial cells in the skin. The epidermis serves as the first line of defense between the body and the …

Transport Through Georeservoirs: Spatial Entropy In Hydraulic Properties, And Temporal Entropy In Residence Time Distributions, Lumeng Huang

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The general principle of maximum entropy can be used to guide the construction of flow and transport models parameters when are uncertain. The principle states that the model which maximizes the entropy should be chosen so that the full multiplicity or uncertainty is represented in the model outcomes.

In models for flow and transport through georeservoirs, the principle would commonly be applicable to the uncertainty in the model outcome for the time of travel through the system, in order to represent the full range of multiplicity in the distribution of residence times. Importantly, the model which maximizes the entropy in …

Electrochemical Oxidation Of Ethanol In Ionic Liquids And Its Possible Use In Fuel Cells, Ashley M. Mason

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Electrochemical properties of EtOH in EMImBF4 ionic liquid were investigated and compared to the electrochemical properties of EtOH in 0.1M HClO4/H2O. As was shown earlier, oxidation of EtOH in HClO4/H2O involves formation of PtO on the electrode surface, which makes the electrode poisoned. We have found that the best procedure for removal of PtO from the Pt electrode is heating the electrode in concentrated H2SO4. Cyclic voltammograms obtained after cleaning several Pt electrodes conforms that this treatment gives clean Pt electrodes without any PtO. Electrochemical oxidation of EtOH in EMImBF4 ionic liquid show that is poisoning of Pt electrode by …

Uncertainty Quantification Of Residual Stresses Induced By Laser Peening Simulation, Hemanth Amarchinta

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Advanced mechanical surface enhancement techniques have been used successfully to increase the fatigue life of metallic components. These techniques impart deep compressive residual stresses into the component to counter potentially damage-inducing tensile stresses generated under service loading. Laser Peening (LP) is an advanced mechanical surface enhancement technique used predominantly in the aircraft industry. To reduce costs and make the technique available on a large-scale basis for industrial applications, simulation of the LP process is required. Accurate simulation of the LP process is a challenging task, because the process has many parameters such as laser spot size, pressure profile, and material …

Estimating Permeability From The Grain-Size Distributions Of Natural Sediment, Lawrence Mastera

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Permeability, k, can be estimated using the Kozeny-Carman equation, given a grain-size distribution with any number of grain-size categories and the porosity of a sediment. A recursive method was developed to calculate the effective grain-size parameter, d, for sediment mixtures with more than three grain sizes. The method was tested on four sediment models of sand, gravelly sand, sandy gravel, and open-framework gravel created from grain-size distributions. The k estimated from the recursive method were consistent with physical measurements of k.

Inferring Lake Depth Using Diatom Assemblages In The Shallow, Seasonally Variable Lakes Of The Nebraska Sand Hills (Usa): Calibration, Validation, And Application Of A 69-Lake Training Set, Avery L. C. Shinneman, Danuta M. Bennett, Sherilyn C. Fritz, Jens Schmieder, Daniel R. Engstrom, Aris Efting, John Holz

Department of Earth and Atmospheric Sciences: Faculty Publications

The Nebraska Sand Hills are a distinctive eco-region in the semi-arid Great Plains of the western United States. The water table underlying the Sand Hills is part of the High Plains/ Ogallala aquifer, an important water resource for the central Great Plains. Lake levels are affected directly by fluctuations in the water table, which is recharged primarily by local precipitation and responds quickly to climatically induced changes in regional water balance. Instrumental records are available for only 50–100 years, and paleolimnological data provide important insights into the extremes and variability in moisture balance over longer time scales. A set of …

Genetic Studies Of Genes Involved In The Initiation Of Dna Replication In The Fission Yeast Schizosaccharomyces Pombe, Zhuo Wang

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The initiation of DNA replication is a highly conserved process in all eukaryotes. However, the underlying mechanism is not well understood. Genetic studies in the fission yeast S. pombe have contributed greatly to and will continue to provide insights to our understanding of this important biological process.

In the first chapter, we have used a complementary method to test three recently identified human replication proteins DUE-B, Ticrr/Treslin, and GEMC1 as the candidate functional homologue of Sld3 in S. pombe. Sld3 is an essential replication initiation protein discovered in yeasts. Since no apparent sequence similarity can be found, its homologue in …

Characterization Of Three Mutations In Conserved Domain Of Subunit Iii Of Cytochrome C Oxidase From Rhodobacter Sphaeroides, Rachel Omolewu

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Cytochrome c oxidase (COX) is the final electron acceptor in mitochondrial respiratory chain and in many bacterial species including Rhodobacter sphaeroides. Electron transfer is coupled with the pumping of protons across the membrane. Previous work has shown that reaction of beef COX with dicyclohexylcarbodiimide (DCCD) resulted in an inhibition of proton translocation by covalently binding to the conserved amino acid residue E90 located in a nonpolar region of subunit III (SIII). E90 is involved in a bonding pair with another conserved residue H212, possibly connected by a salt bridge or a hydrogen bond in the three dimensional structure of SIII. …

Prospects For Change: Creating A Blended Learning Program Through A Culture Of Support, Bill Leach

Electronic Theses and Dissertations

Blended learning, a combination of traditional face to face (F2f) instruction and computer-mediated communication (CMC), is a popular trend in many universities and corporate settings today. Most universities provide faculty members course management systems, such as Blackboard, Angel, and others as a way to organize and transmit course materials to students. In order to assess the pedagogical value of blended learning in a university-level first year composition (FYC) environment, it is necessary to view the environment through a critical lens and adequately train faculty in the need for and use of the features of the learning management software (LMS). The …

Multi-Modal Reading For Low Level Readers, Jamie O'Neal

Electronic Theses and Dissertations

The value of this research hinges on the idea that exchanging illustrations for descriptive text can provide appropriate schemas for students with reading difficulties and thereby improve their comprehension and vocabulary acquisition. The research in this dissertation is based on theories and earlier research in the fields of psychology, education, reading, and narratology. A review of these fields offers a variety of perspectives on the processes involved in reading and comprehension. These processes range from the physical systems involved in reading (e.g., early childhood development, eye movement) to the psychological systems, which include cognitive load theory as well as image …

A Screen Of One's Own The Tpec And Feminist Technological Textuality In The 21st Century, Amy J. Barnickel

Electronic Theses and Dissertations

In this dissertation, I analyze the 20th century text, A Room of One's Own, by Virginia Woolf (2005), and I engage with Woolf's concept of a woman's need for a room of her own in which she can be free to think for herself, study, write, or pursue other interests away from the oppression of patriarchal societal expectations and demands. Through library-based research, I identify four screens in Woolf's work through which she viewed and critiqued culture, and I use these screens to reconceptualize "a room of one's own" in 21st Century terms. I determine that the new "room" is …

The Rhetoric Of The Regional Image Interpreting The Visual Products Of Regional Plannning, Alissa Barber Torres

Electronic Theses and Dissertations

The Rhetoric of the Regional Image: Interpreting the Visual Products of Regional Planning investigates the manner in which visual conventions and visual contexts of regional visioning scenarios affect their interpretation by urban and regional planners, who use visual communication to meet the technical and rhetorical demands of their professional practice. The research assesses Central Florida‘s ―How Shall We Grow?‖ regional land use scenario using focus groups and interviews with planning professionals, a corresponding survey of community values, and rhetorical analysis to explore the ―How Shall We Grow?‖ scenario as persuasive communication. The Rhetoric of the Regional Image proposes specific recommendations …

Race, Sex And Genes At Work: Uncovering The Lessons Of Norman-Bloodsaw, Elizabeth Pendo

Articles

The Genetic Information Nondiscrimination Act of 20081 ("GINA") is the first federal, uniform protection against the use of genetic information in both the workplace and health insurance. Signed into law on May 21, 2008, GINA prohibits an employer or health insurer from acquiring or using an individual's genetic information, with some exceptions.

One of the goals of GINA is to eradicate actual, or perceived, discrimination based on genetic information in the workplace and in health insurance. Although the threat of genetic discrimination is often discussed in universal terms - as something that could happen to any of us -the use …

Employee Benefit Plans With Conforming Changes As Of March 1, 2010; Audit And Accounting Guide, American Institute Of Certified Public Accountants. Employee Benefit Plans Committee Force Committee

Industry Guides (AAGs), Risk Alerts, and Checklists

No abstract provided.

Insurance Industry Developments - 2010/11; Audit Risk Alerts, American Institute Of Certified Public Accountants (Aicpa)

Industry Guides (AAGs), Risk Alerts, and Checklists

No abstract provided.

State And Local Governmental Developments - 2010; Audit Risk Alerts, American Institute Of Certified Public Accountants (Aicpa)

Industry Guides (AAGs), Risk Alerts, and Checklists

No abstract provided.

Of State, Market And Justice: Latcritical Challenges To Theory, Praxis And Policy, Francisco Valdes

American University Journal of Gender, Social Policy & the Law

No abstract provided.

Out Of Many, One People; E Pluribus Unum: An Analysis Of Self-Identity In The Context Of Race, Ethnicity, And Context Of Race, Kamille Wolff

American University Journal of Gender, Social Policy & the Law

No abstract provided.

Pennsylvania Superintendent-Preparation: How Has It Changed?, Sue A. King

Seton Hall University Dissertations and Theses (ETDs)

The purpose for this study was to add to the research on school administrator preparation programs by examining and describing the content, structure, and overall design of university preparation programs in Pennsylvania for school superintendents to determine the degree to which the programs of the 26 state-approved providers of superintendent certification are reflective of the current research and theory regarding effective school district leadership, particularly instructional leadership. At a time when public education is under fire from political leaders and the general public, school administrators are expected to design and manage education systems that meet the needs of all learners …

Predictors Of Success Of The National Council Licensure Examination For Registered Nurses Among Transfer Bsn Students, Mary E. Fortier

Seton Hall University Dissertations and Theses (ETDs)

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The Pulpit At The End Of The Rainbow: How Queer Clergy Enter Into And Maintain Religious Occupations, Brian Gregory Gerow

Dissertations and Theses

This study is a description of the ways queer clergy identify with and navigate their position in a traditionally heteronormative culture. Through twelve in-depth interviews, a set of codes and categories helped to assess the major barriers to access in contemporary Protestant clergy occupations in the United States. This research was conducted in Portland, Oregon, where a thriving queer religious community made it possible to access various different Protestant faiths and compare minister's experiences as professional clergy.

Participatory Action Research With Dignity Village: An Action Tool For Empowerment Within A Homeless Community, Heather Irene Mosher

Dissertations and Theses

With homelessness continuing to rise over the past two decades, disenfranchised unhoused people have sparked a national movement to build for themselves democratically governed communities of affordable housing. Dignity Village, in Portland Oregon, is one of the longest running and most organized self-help housing communities in the nation. This paper presents a theoretical systems-based model of a developmental pathway out of homelessness in the U.S. that has as one of its key steps membership and participation in humane and dignified "self-help micro-housing"; communities such as Dignity Village.

This research involved working collaboratively with Dignity Village on a participatory action research …