Digital Commons Network^™

Predictors Of Survival For Patients With Non-Small Cell Lung Cancer And Synchronous Brain Metastases With Fdg-Pet/Ct Staging, N. Ohri, Y. Xiao, M. Werner-Wasik

Bodine Journal

Purpose: The clinical course of patients diagnosed with non-small cell lung cancer (NSCLC) with brain metastases (BM) at presentation is variable. Here we seek to identify predictors of survival in patients staged with FDG-PET/CT.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Feasibility Of Improving Cone Beam Ct Number Consistency With A Scatter-Correction Algorithm, J. Li, W. Yao, Y. Xiao, Y. Yu

Bodine Journal

Purpose: To explore the feasibility of improving Elekta cone beam CT (CBCT) number consistency using a scatter-correction algorithm, with the aim of using CBCT images for treatment planning with heterogeneity correction.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Quantitative Analysis Of Dose Enhancement Contributed By Different Photon Interactions In X-Ray Irradiation With The Presence Of Hz Materials With Geant4 Monte Carlo Simulation, K. Huang, Y. Yu

Bodine Journal

Purpose: To study the overall dose enhancements and those contributed by different processes quantitatively in the presence of HZ materials and X-ray with different energies with Monte Carlo method.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Performance Study Of Novel Accelerationenhanced Filters In The Prediction Of Normal And Irregular Respiration Motion, K. Huang, I. Buzurovic, M. Werner-Wasik, T. Biswas, A. Dicker, J. Galvin, Y. Yu, T. Podder

Bodine Journal

Purpose: To study the performance of the novel acceleration-enhanced (AE) filters in the prediction of normal and irregular respiration motion and compare them with those of traditional adaptive normalized least mean squares (nLMS) and adaptive neuron network (ANN) filters. This facilitates the real-time tumor tracking and dynamic delivery of radiation dose to the tumor.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Optical Guidance System Vs. Cbct For Phantom And Patient Setup, L. Fu, H. Perera, H. Liu, Y. Xiao, Y. Yu

Bodine Journal

Purpose: To quantify the discrepancy between Varian optical guidance (OG) frameless localization system and Varian Trilogy on board imaging (OBI) system for setting up phantom and SRS patient.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Motion Control Consistency With Abdominal Compression Device From Daily 4d Cbct, Y. Cui, A. S. Harrison, Y. Xiao

Bodine Journal

Purpose: To investigate the effectiveness of abdominal compression in tumor motion control for lung cancer radiotherapy. To study the motion control consistency during radiation treatment course through 4D reconstruction of daily cone beam computed tomography (CBCT) images.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA

Dosimetric Advantages Of Active Tracking And Dynamic Dose Delivery, I. Buzurovic, K. Huang, M. Werner-Wasik, T. Biswas, J. M. Galvin, A. Dicker, Y. Yu, T. Podder

Bodine Journal

Purpose: To investigate dosimetric effect of tumor tracking. To evaluate changes of treatment volumes when tracking is applied.

American Association of Physicists in Medicine (AAPM) 52nd Annual Meeting July 18-22, Philadelphia, PA.

Combination Of Vorinostat With Whole-Brain Radiotherapy In The Treatment Of Brain Metastases, Y. R. Lawrence, R. M. Pfeffer, M. Werner-Wasik, H. Choy, A. Dicker

Bodine Journal

Background: A third of patients with solid malignancies develop brain metastases. Expected overall survival is 4-7 months depending on age, performance status, and extracranial disease. Standard treatment is controversial; however, the majority of patients receive wholebrain radiation therapy at some point. Vorinostat (suberoylanilide hydroxamic acid, SAHA), an FDA-approved HDAC inhibitor, has been demonstrated to radiosensitize tumor cells in vitro, as assessed by both radiation-induced DNA damage and clonogenic cell survival (Munshi et al. Molecular Cancer Therapeutics 5, 1967-1974, 2006). We have shown that vorinostat downregulates key genes involved in double-strand DNA repair (Rad50, Rad51, XRCC2, XRCC3, XRCC6), as assessed by …

Accuracy Of Cancer Information On The Internet: A Comparison Of A Wiki With A Professionally Maintained Database, M. S. Rajagopalan, V. Khanna, M. Stott, Y. Leiter, T. N. Showalter, A. Dicker, Y. L. Lawrence

Bodine Journal

Background: A Wiki is a website which can be directly, openly edited; Wikipedia, a collaborative encyclopedia, is a well-known example. Due to Wiki’s lack of editorial control and formal structure, we hypothesized that the content would be less complete and less accurate than that presented on a formal, peer-reviewed web site. Our goal was to compare the coverage, accuracy, and readability of cancer information from a Wiki (Wikipedia) with a peer-reviewed web site, the patientoriented National Cancer Institute’s Physician Data Query (PDQ) comprehensive cancer database.

American Society of Clinical Oncology (ASCO) 46th Annual Meeting June 4-8, Chicago, IL.

Acute Neurological Toxicity (Nt) And Long-Term Outcomes In High-Grade Glioma Rtog Trials, Y. R. Lawrence, M. Wang, A. P. Dicker, D. W. Andrews, W. J. Curran, J. M. Michalski, L. Souhami, W. A. Yung, M. Mehta

Bodine Journal

Background: Treatment of high-grade glioma consists of fractionated radiation therapy (RT) ± chemotherapy. The incidence/significance of neurological toxicity (NT) in this disease is not known. We evaluated the relationship between acute and chronic NT, and ultimate outcome, as well as risk factors for NT from the RTOG database.

American Society of Clinical Oncology (ASCO) 46th Annual Meeting June 4-8, Chicago, IL.

Potential For Thermal Enhancement By Quercetin Mediated Mechanisms Targeting P53 Antagonists In Human Melanoma Cells, T. Thangasamy, K. Limesand, D. B. Leeper, R. Burd

Bodine Journal

Introduction: Recently Temozolomide (TMZ) has become the more commonly used analog of DTIC-related oral agents. Although the response rates achieved by TMZ alone are less than satisfactory, there is great interest in identifying compounds that could be used in combination therapy. We have previously demonstrated that the bioflavonoid quercetin (Qct) promotes a p53-mediated response in melanoma and sensitizes melanoma to DTIC. Here we demonstrate that Qct also sensitizes cells to TMZ by a mechanism that involves the modulation of a truncated p53 family member, ΔNp73.

Society for Thermal Medicine Annual Meeting April 23-26, Clearwater Beach, FL.

Control Of Glycolytic Flux By Ampk And P53-Mediated Signaling Pathways In Tumor Cells Adapted To Grow At Low Ph, E. E. Mendoza, J. Caro, D. B. Leeper, R. Burd

Bodine Journal

Introduction: Tumor cells grow in nutrient and oxygen deprived microenvironments and adapt to the suboptimal growth conditions by altering metabolic pathways. This adaptation process characteristically results in a tumor phenotype that displays anaerobic glycolysis, chronic acidification and aggressive tumor characteristics. Understanding the tumor cell reaction to the microenvironment is a critical factor in predicting the tumor response to hyperthermia. The glucose regulatory molecule, 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase Isoform-3 (PFKFB3), is a bifunctional enzyme central to glycolytic flux and downstream of the metabolic stress sensor AMP-activated protein kinase (AMPK), which has been shown to activate an isoform of Phosphofructokinase (PFK-2).

Society for Thermal Medicine …

Effects Of Egfr Expression On Anti-Tumor Efficacy Of Vandetanib Or Cediranib Combined With Radiotherapy (Rt) In U87 Human Glioblastoma (Gbm) Xenografts, P. Wachsberger, Y. R. Lawrence, Y. Liu, A. P. Dicker

Bodine Journal

Introduction: Vandetanib is a receptor tyrosine kinase inhibitor (RTKI) with activity against vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR). Cediranib is a highly potent VEGF RTKI that inhibits all three VEGF receptors. In this study we investigated the effect of exogenous overexpression of EGFR on sensitivity of human GBM U87 xenografts to vandetanib or cediranib, alone or in combination with RT.

American Association for Cancer Research (AACR) 101st Annual Meeting April 17-21, Washington, DC.

Functional Antagonism Between Vorinostat And Temozolomide When Combined With Ionizing Radiation (Ir) In Glioblastoma, Y. R. Lawrence, Y. Liu, B. Andersen, X. Xia, A. P. Dicker, P. Wachsberger

Bodine Journal

Background: Glioblastoma is the most common primary adult brain tumor. Surgery followed by radiation therapy in combination with temozolomide (Tmz) produces a median survival of 14.6 months. Tmz is a DNA akylating agent that leads to the mispairing of guanine residues with thymine. An intact mismatch-repair mechanism (MMR) converts the mispaired thymine into a lethal double-strand DNA break. Vorinostat (SAHA), an HDAC inhibitor, has been shown to act as a radiosensitizer, possibly through inhibition of DNA repair. SAHA has successfully been combined with a number of cytotoxic agents. We hypothesized that SAHA would further potentiate the radiosensitizing properties of Tmz …

Bodine Journal, Table Of Contents, Volume 3, Issue 1, Fall 2010

Bodine Journal

Table of Contents for Fall 2010 issue of Bodine Journal.

Action Research: Can It Be A Means For Helping Teacher Candidates Learn About Student Diversity?, Alisa Bates, Laura S. Pardo

i.e.: inquiry in education

This paper describes the use of action research in a teacher education course as a way to support novice teachers in meeting the learning needs of a diverse student population. Our experiences as instructors in teacher education courses led us to look for strategies that could support novices’ attempts to meet students’ diverse needs because students viewed this as one of their greatest challenges as beginning teachers. We explore action research as one such strategy to respond to this learning need. We examine this practice for supporting novice teachers and consider three cases of student learning as examples. Our findings …

Universal Design For Learning: A Collaborative Framework For Designing Inclusive Curriculum, Xiuwen Wu

i.e.: inquiry in education

The purpose of this article is twofold: 1) to introduce the concept of Universal Design for Learning (UDL) by going to its origination in the field of architecture—the Universal Design, in order to illustrate the inclusive nature of UDL, 2) to shed light on one of the most important aspects of UDL—collaboration. The UDL framework provides teachers with a unified framework to collaborate on the development of an accessible and inclusive curriculum through flexible pedagogy and tool use. Developed for all students, the UDL framework aims to expand all teachers’ expertise in teaching diverse learners and depends on collaboration for …

The Critical Friends Group: A Strategy For Developing Intellectual Community In Doctoral Education, Tracie Costantino

i.e.: inquiry in education

A key recommendation from the Carnegie Initiative on the Doctorate project is for doctoral programs to focus on developing intellectual communities that are knowledge-centered and multigenerational. In this article I describe a graduate art education course, Writing Critique in Art Education, which uses the Critical Friends discussion protocol to facilitate a heterogeneous intellectual community for doctoral and master’s level students. Using a practitioner inquiry methodology, I investigated how the use of a Critical Friends protocol influenced the development of an intellectual community in this course, and how the intellectual community supported students’ growth as educational researchers, future teacher educators, and …

Quintessential Acts Of Inquiry In Educational Practice: Delineating Inquiry And Interpretation In The Pursuit Of Teacher Professionalization, Ted Purinton

i.e.: inquiry in education

Sociological and political theories on the professions indicate that established professions utilize unique forms of inquiry and interpretation to guide practice. This essay argues that for teaching to become professionalized, unique forms of inquiry and interpretation need to be emphasized. Utilizing the concept of professional jurisdiction, the essay argues that other professions' forms of inquiry, while not detrimental to the purpose of teacher professionalization, do not establish the distinctive skills upon which teachers can lay claim.

Advocating For Practitioner Research, Arlene Borthwick, Wendy Gardiner, Linnea Rademaker

i.e.: inquiry in education

No abstract provided.

The Concept Of Value In Design Practice - An Interview Study, Katarina Wetter Edman

ServDes Conference Series

Use and the value thereof are implicit in the design discourse and therefore rarely explicitly spoken of; although they are at the core of design practice. With the recent turn to a service dominant logic perspective; the service marketing discourse opens up for understanding value as value-in-use and value-in-context. This paper empirically explores and describes ways in which professional designers themselves express “value-in-use”. The findings suggest that professional designers do not focus explicitly on value as a standalone concept; but conceptualize value-in-use through contextualization and an extensive use of emotions.

Creating Scenarios For Regional Projects: Service Design For Multifunctional And Collaborative Food Networks, Daria Cantù, Giulia Simeone

ServDes Conference Series

This paper presents a strategic and service design approach to create scenarios for regional projects through an action-research strategy. The intent is to reflect on the basis of an on-going project; insisting on the Agricultural Park South Milano; lightening the actions taken and their contributions to the scenario building process.

This paper presents a strategic and service design approach to create scenarios for regional projects through an action-research strategy. The intent is to reflect on the basis of an on-going project; insisting on the Agricultural Park South Milano; lightening the actions taken and their contributions to the scenario building process.

Service Innovation Through Touch-Points: The At-One Touch-Point Cards, Simon Clatworthy

ServDes Conference Series

In this paper we review the area of touch-point innovation in services and specifically describe the development and use of a card-based toolkit developed in the AT-ONE project - the AT-ONE touch-point cards. These cards have been developed to assist cross functional teams during the first phases of the new service development (NSD) process. This paper describes the development of the tools; their intended use and their evaluation. The results show that the toolkit assists the innovation process and helps develop team cohesiveness. The card-based approach offers a tangibility that teams find useful; and that offers multiple usage alternatives. Discussion …

Exploring Networked Innovation; Results Of An Exploration And The Setup Of An Empirical Study, Katinka Bergema, Rianne Valkenburg, Maaike Kleinsmann, Cees De Bont

ServDes Conference Series

The growing complexity of societal problems and the increasing need to co-design contexts together with the service or product; force companies to collaborate in innovation. This networked innovation requires people to design together; who not only come from different disciplines; but also come from different organisations and companies. The collaboration in networked innovation therefore adds another level of complexity in addition to the (better known) collaboration in mono- and multidisciplinary teams and introduces new issues.

The growing complexity of societal problems and the increasing need to co-design contexts together with the service or product; force companies to collaborate in innovation. …

Health And Social Care Services For People With Complex Needs: The Importance Of Context In The Design Process, Eva-Maria Hempe, Terry Dickerson, P John Clarkson, Anthony Holland

ServDes Conference Series

No abstract provided.

Service Design And Healthcare Innovation: Fr0m Consumption To Co-Production And Co-Creation, Karine Freire, Daniela Sangiorgi

ServDes Conference Series

In the last decades the economy saw two significant changes in the way value has been conceived and created: the introduction of the value-constellation model and the advent of the open innovation movement. This paper will report on how these paradigmatic changes are mirrored in public services reform; with a focus on healthcare services; and on how Design practice and research are contributing to this shift. The authors will use four case studies of healthcare design-driven service innovation as a way to reflect on which models and approaches designers have been using and to evaluate the actual results and impacts …

Service Design For Tourism Smes - The Concept Of Service Design And Its Application On The Alpine Zoo In Innsbruck; Austria, Marc Stickdorn, Anita Zehrer

ServDes Conference Series

No abstract provided.

Characteristics Of Value Co-Creation In A Learning Environment By Service Design And Service-Dominant Logic Frameworks, Jussi Haukkamaa, Pia Yliräisänen-Seppänen, Eija Timonen

ServDes Conference Series

Presently; educational institutions exist as complex networks of expertise that fulfil the needs of their stakeholders and respond to the challenges of a transforming society. Therefore; educational services are subject to a constant design process in co-operation with the customers and other stakeholders. Co-operation between parties is strongly related to the value co-creation; since the customer is the co-producer of the value according to the concept of service-dominant logic.

Service design research has paid little attention to the value of co-creation in networked education services. This paper focuses on value co-creation in service-dominant logic and service design frameworks using a …

The Design Value Of Business, Stefan Holmlid

ServDes Conference Series

In this small essay I will explore the notion of the design value of business. Interpreted as merely a play with words; such a statement may be regarded as a bearer of little value. But; taken as seriously as the more common question; what the business value of design is; it turns into a critical examination of basic conceptions of what design is for. It also paves the way for the critical claim that design value precedes business value.

Service Prototyping According To Service Design Practitioners, Johan Blomkvist, Stefan Holmlid

ServDes Conference Series

Current trends in service design research include case studies and similar approaches that aspire to reveal what the practice of service design looks like. The understanding of how service design is performed can serve as a base for future research into more specific research endeavours. One area where knowledge is said to be lacking is service prototyping; part of which knowledge this paper attempts to contribute. The main data source for the paper is findings from in-depth interviews with six practicing service designers from some of the more well-known design agencies. The informants consider service prototyping to be a very …