Digital Commons Network^™

Climate Change And Globalization In The Americas: Case Studies Of Mitigation And Adaptation, Mary Finley-Brook, Melissa Haeffner, Charmaine Heslop-Thomas, Elma Montaña, Leah Sprain

Environmental Science and Management Faculty Publications and Presentations

Robin Leichenko and Karen O‘Brien have proposed ―double exposure‖ as a conceptual framework to demonstrate how processes of globalization and global environmental change (GEC) redefine risk and encourage new, interrelated responses to social and ecological transitions (O‘Brien and Leichenko, 2000; Leichenko and O'Brien, 2008). In particular, the concept encourages researchers and policy makers to consider interplay between global climate change and globalization and how this is expressed unevenly across space. After reviewing the ways double exposure has been used in the literature, we consider four case studies to investigate the utility of the framework for analyzing and understanding climate change …

Ecology: A Prerequisite For Malaria Elimination And Eradication, Heather M. Ferguson, Anna Dornhaus, Arlyne Beeche, Christian Borgemeister, Michael Gottlieb, Mir S. Mulla, John E. Gimnig, Durland Fish, Gerry F. Killeen

All Peer-Reviewed Publications

Existing front-line vector control measures, such as insecticide-treated nets and residual sprays, cannot break the transmission cycle of Plasmodium falciparum in the most intensely endemic parts of Africa and the Pacific. The goal of malaria eradication will require urgent strategic investment into understanding the ecology and evolution of the mosquito vectors that transmit malaria. Priority areas will include understanding aspects of the mosquito life cycle beyond the blood feeding processes which directly mediate malaria transmission. Global commitment to malaria eradication necessitates a corresponding longterm commitment to vector ecology.

July 31, 2010 (Pages 4233-4374), Pennsylvania Legislative Reference Bureau

Volume 40 (2010)

No abstract provided.

Poxa, Yjek And Elongation Factor P Coordinately Modulate Virulence And Drug Resistance In Salmonella Enterica, William Wiley Navarre, Shicong Zou, Hervé Roy, Jinglin Lucy Xie, Alexei Savchenko, Alexander Singer, Elena Edvokimova, Lynne R. Prost, Runjun Kumar, Michael Ibba, Ferric C. Fang

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

We report an interaction between poxA, encoding a paralog of lysyl tRNA-synthetase, and the closely linked yjeK gene, encoding a putative 2,3-β-lysine aminomutase, that is critical for virulence and stress resistance in Salmonella enterica. Salmonella poxA and yjeK mutants share extensive phenotypic pleiotropy, including attenuated virulence in mice, an increased ability to respire under nutrient-limiting conditions, hypersusceptibility to a variety of diverse growth inhibitors, and altered expression of multiple proteins, including several encoded on the SPI-1 pathogenicity island. PoxA mediates posttranslational modification of bacterial elongation factor P (EF-P), analogous to the modification of the eukaryotic EF-P homolog, eIF5A, with …

Characterization And Crystallization Of The Mycobacterium Tuberculosis Trmd, Zohal Hamidi

Theses and Dissertations

One third of the world’s population is affected by Tuberculosis (TB), a disease caused by infection with Mycobacterium tuberculosis (MtB). The emergence of multidrug-resistant MtB makes this disease a major public health concern. New agents are needed to treat TB infections in a manner that circumvents existing pathways of resistance. One strategy is to target the organism at the translational level by inhibiting vital modifications of RNA. One gene responsible for these modifications is the tRNA (guanosine-1)-methyltransferase, trmD, which has been shown to be essential in several bacteria. The eukaryotic and bacterial m1G methyltransferases are structurally dissimilar, making this enzyme …

Interactions Of Burkholderia Pseudomallei And Acanthamoeba Castellanii And Their Effects On Virulence In Human Monocytes, Emily Ann Moore

Theses and Dissertations

Burkholderia pseudomallei, the etiological agent of melioidosis, is a saprophytic bacterium existing endemically in the water and soil of SE Asia and Northern Australia. This organism has shown the ability to remain dormant in its host for decades. B. thailandensis is a closely related non-pathogenic near neighbor that is also found in these soils. It has been suggested that free-living amoeba could be natural reservoirs for these organisms. The interactions of Burkholderia species and Acanthamoeba castellanii, a species of free-living amoeba, were studied to better understand the natural ecology of these organisms and to determine the effects amoeba …

Genetic Polymorphisms Of Cyp2e1, Gstp1, Nqo1 And Mpo And The Risk Of Nasopharyngeal Carcinoma In A Han Chinese Population Of Southern China, Xiuchan Guo, Yi Zeng, Hong Deng, Jian Liao, Yuming Zheng, Ji Li, Bailey Kessing, Stephen J. O'Brien

Biology Faculty Articles

Background

Southern China is a major area for endemic nasopharyngeal carcinoma (NPC). Genetic factors as well as environmental factors play a role in development of NPC. To investigate the roles of previously described carcinogen metabolism gene variants for NPC susceptibility in a Han Chinese population, we conducted a case-control study in two independent study population groups afflicted with NPC in Guangdong and Guangxi Provinces of southern China.

Methods

Five single nucleotide polymorphisms (SNPs) of CYP2E1-rs2031920, CYP2E1-rs6413432, GSTP1-rs947894, MPO-rs2333227 and NQO1-rs1800566 were genotyped by PCR-based RFLP, sequencing and TaqMan assay in 358 NPC cases and 629 …

Research News: 2010, No. 1, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

Grants, publications, technology transfer, special announcements

July 26, 2010 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Stem V. Prouty Clerk's Record V. 3 Dckt. 37641

Idaho Supreme Court Records & Briefs, All

No abstract provided.

2010 Uab Summer Research Expo, University Of Alabama At Birmingham

Expo Programs

Catalog of undergrauate student research poster presentations with abstracts.

Case Fatality Rates Based On Population Estimates Of Influenza-Like Illness Due To Novel H1n1 Influenza: New York City, May–June 2009, James L. Hadler, Kevin Konty, Katharine H. Mcveigh, Anne Fine, Donna Eisenhower, Bonnie Kerker, Lorna Thorpe

Publications and Research

Background The public health response to pandemic influenza is contingent on the pandemic strain's severity. In late April 2009, a potentially pandemic novel H1N1 influenza strain (nH1N1) was recognized. New York City (NYC) experienced an intensive initial outbreak that peaked in late May, providing the need and opportunity to rapidly quantify the severity of nH1N1. Methods and Findings Telephone surveys using rapid polling methods of approximately 1,000 households each were conducted May 20–27 and June 15–19, 2009. Respondents were asked about the occurrence of influenza-like illness (ILI, fever with either cough or sore throat) for each household member from May …

Enteroaggregative Escherichia Coli: An Emerging Enteric Food Borne Pathogen, A. Asea, P. Kaur, A. Chakraborti

ETSU Faculty Works

Enteroaggregative Escherichia coli (EAEC) are quite heterogeneous category of an emerging enteric pathogen associated with cases of acute or persistent diarrhea worldwide in children and adults, and over the past decade has received increasing attention as a cause of watery diarrhea, which is often persistent. EAEC infection is an important cause of diarrhea in outbreak and non-outbreak settings in developing and developed countries. Recently, EAEC has been implicated in the development of irritable bowel syndrome, but this remains to be confirmed. EAEC is defined as a diarrheal pathogen based on its characteristic aggregative adherence (AA) to HEp-2 cells in culture …

07-16-2010 Hubin Presents And Cannon Wins Award At Nisbre, Southwestern Oklahoma State University

THE BARK ARCHIVE 2010

Dr. Tim Hubin, associate professor in the Southwestern Oklahoma State University Chemistry and Physics Department, and his research student Desiray Cannon of McAlester recently presented their research at the 3rd Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE) in Bethesda, Maryland.

The Identification And Resolution Of Ethical Issues In Health Care: Theoretical And Practical Viewpoints, Sherryl Whearry Johnson Ph.D.

Journal of Health Ethics

This paper provides an overview of ethical issues facing the health care industry – along with strategies for resolution. The issues were prioritized using the practical perspectives of twenty-six health professionals, employed in various setting in the health care field. The insight of these professionals was deemed most valuable based on the combination of professional experience and ethical training. The responses of the health professionals were compared with theoretical viewpoints of twenty-four healthcare management students enrolled in ethical / legal issues in health care class. The findings from each group were ranked in individual charts. A final chart was used …

Characterization Of Unidentified Viruses From Florida, Jessie L. Dyer

USF Tampa Graduate Theses and Dissertations

Public Health and clinical laboratories occasionally obtain viral isolates that cannot be typed by routine methods. Therefore, the sequence-independent, single primer amplification (SISPA) technique was adapted to rapidly identify and characterize viral isolates of unknown etiology. A panel of known (West Nile virus and St. Louis encephalitis virus) and unknown viral isolates (environmental samples collected in Florida) were used to develop and refine the SISPA technique. Selectivity for viral genomic sequences was obtained through enriching viral particles by centrifugation, removal of cellular debris by filtration and removal of host genomic material by benzonase application. The SISPA method successfully amplified the …

Molecular Mechanisms Involved Involved In The Interaction Effects Of Hcv And Ethanol On Liver Cirrhosis, Ryan Fassnacht

Theses and Dissertations

The leading causes of liver disease are Hepatitis C virus infection and chronic alcohol abuse. Alcohol accelerates liver disease in HCV but the mechanisms are poorly understood. The identification of molecular gene expression profiles on human liver tissue was performed using microarrays. Samples were obtained from alcoholic-cirrhotic, HCV-cirrhotic, HCV/alcohol-cirrhotic and control non-cirrhotic liver tissue. Probe set expression summaries were calculated using RMA. Probe set level linear models were fit where probe set expression was modeled by HCV status, alcohol status, and the interaction between HCV and Alcohol. HCV cirrhosis was associated with up-regulation of genes related to viral and immune …

Humor As A Moderating Variable Of The Relationship Between Family Conflict And Self-Regulation In Children: A Two-Year Panel Study, Kristiane Madsen

Theses and Dissertations

Conflict is a common problem among families, and children may be negatively affected by this family dynamic. Some family characteristics may protect children from negative effects, even in the midst of conflict. Though little research has been conducted addressing familial effects of humor, the current longitudinal study examined the moderating effect of humor on the relationship between family conflict and child self regulation. Two hundred ninety six two-parent families from the Seattle area were surveyed and observed as a party of Brigham Young University's Flourishing Family Project. Family conflict and coded humor from an observation task were assessed at time …

China Healthcare Ict: Reinventing China’S National Healthcare System Through Electronic Medical Records, Telecom Networks And Advanced It Services, Ken Zita

Journal of Emerging Knowledge on Emerging Markets

In January 2009 China announced a RMB 850 billion ($124 billion) stimulus package over three years to fundamentally reshape the nation's healthcare sector. A key element of the plan is to modernize healthcare services with digital hospitalization, electronic medical records, and next-generation information networks. The goal is to dramatically improve healthcare service quality and, importantly, to enable virtual healthcare services that can overcome service disparities between rich areas and poor. But the lack of technical standardization complicates take-up and adoption of unified e-healthcare solutions. The stakes are high for the government and for international technology companies seeking position in this …

Avirulent Uracil Auxotrophs Based On Disruption Of Orotidine-5′-Monophosphate Decarboxylase Elicit Protective Immunity To Toxoplasma Gondii, Barbara A. Fox, David J. Bzik

Dartmouth Scholarship

The orotidine-5'-monophosphate decarboxylase (OMPDC) gene, encoding the final enzyme of the de novo pyrimidine biosynthesis pathway, was deleted using Toxoplasma gondii KU80 knockouts to develop an avirulent nonreverting pyrimidine auxotroph strain. Additionally, to functionally address the role of the pyrimidine salvage pathway, the uridine phosphorylase (UP) salvage activity was knocked out and a double knockout of UP and OMPDC was also constructed. The nonreverting DeltaOMPDC, DeltaUP, and DeltaOMPDC DeltaUP knockout strains were evaluated for pyrimidine auxotrophy, for attenuation of virulence, and for their ability to elicit potent immunity to reinfection. The DeltaUP knockout strain was replication competent and virulent. In …

Interleukin-10 Mediated Autoregulation Of Murine B-1 B-Cells And Its Role In Borrelia Hermsii Infection, Vishal Sindhava, Michael E Woodman, Brian Stevenson, Subbarao Bondada

Microbiology, Immunology, and Molecular Genetics Faculty Publications

B cells are typically characterized as positive regulators of the immune response, primarily by producing antibodies. However, recent studies indicate that various subsets of B cells can perform regulatory functions mainly through IL-10 secretion. Here we discovered that peritoneal B-1 (B-1P) cells produce high levels of IL-10 upon stimulation with several Toll-like receptor (TLR) ligands. High levels of IL-10 suppressed B-1P cell proliferation and differentiation response to all TLR ligands studied in an autocrine manner in vitro and in vivo. IL-10 that accumulated in cultures inhibited B-1P cells at second and subsequent cell divisions mainly at the G1/S interphase. …

Bjc Today

BJC Today

No abstract provided.

Galactoxylomannans From Cryptococcus Neoformans Varieties Neoformans And Grubii Are Structurally And Antigenically Variable, Magdia De Jesus

Biomedical Sciences Faculty Scholarship

No abstract provided.

Modeling And Support Tools For Studying Disease Spread In Livestock Using Networks, Joel Francis, Greg Klotz, Neil Harvey, Deborah Stacey

International Congress on Environmental Modelling and Software

The natural occurrence or intentional release of highly contagious agents of livestock disease can have serious consequences for any country’s agricultural economy. Successful control and management of animal disease outbreaks require that adequate response strategies be developed beforehand. Disease spread simulation models are being used by veterinary epidemiologists to evaluate strategies for the control of disease spread. These models enable decision-makers and emergency preparedness personnel to explore many different scenarios to determine the effects of control measures such as vaccination, and study the likely size, duration and cost of outbreaks. This paper presents an overview of livestock disease spread modeling …

Healthy You, Lehigh Valley Health Network

Healthy You

No abstract provided.

Checkup, Lehigh Valley Health Network

Checkup

No abstract provided.

Infection Connection, Lehigh Valley Health Network

Infection Connection

No abstract provided.

Benchmarks 2010, July 2, The Rockefeller University

BenchMarks 2010

BenchMarks. Friday, July 2, 2010

The community newsletter of The Rockefeller University

BenchMarks is published monthly and is distributed on the campus of The Rockefeller University. It produced by the Office of Communications and Public Affairs

A Geosimulation Tool To Assess Intervention Scenarios In Relation To The Spread Of Infectious Disease And Environmental Factors, Mondher Bouden, Bernard Moulin, Pierre Gosselin

International Congress on Environmental Modelling and Software

Several approaches have been proposed to model and simulate the spread ofinfectious diseases such as the West Nile virus (WNV). However, these approaches such asmathematical modeling and cellular automata have some weaknesses when trying to modeland simulate the influence of geographic and climatic features on the disease spread and thespatio-temporal interactions of various kinds of actors (e.g. mosquitoes, birds, mammalsand humans in the WNV case). In this context, we propose to apply a geosimulationapproach to remedy some shortcomings of current methods. Using such an approach wedeveloped WNV-MAGS, a tool allowing public health decision policy makers to assessseveral intervention scenarios in …

Evaluating The Impact Of Climate Change On Global Hpai H5n1 Outbreaks, Zhijie Zhang, Dongmei Chen, Wenbao Liu, Lei Wang

International Congress on Environmental Modelling and Software

Highly pathogenic avian influenza viruses H5N1 have spread throughout Asia, Europe, and Africa in the past decade, raising serious worldwide concerns about a potential new pandemic. Many studies have investigated the spread of the HPAI H5N1 virus and discussed its possible risk factors. However, the climate factor, which can affect the whole process of H5N1 outbreaks, has been greatly ignored. The objective of this preliminary study is to use a GIS-based approach to explore the potential impacts of temperature change on H5N1 outbreaks. We have divided the outbreaks into five epidemic waves. Although the temperature ranges of different epidemic waves …