Digital Commons Network^™

Characterizing Ancylostoma Caninum Transcriptome And Exploring Nematode Parasitic Adaptation, Zhengyuan Wang, Sahar Abubucker, John Martin, Richard K. Wilson, John Hawdon, Makedonka Mitreva

Open Access Publications

No abstract provided.

Cd4+ Lymphocyte Adenosine Triphosphate Determination In Sepsis: A Cohort Study, Kevin L. Lawrence, Patrick H. White, Gerald P. Morris, Jody Jennemann, Donna L. Phelan, Richard S. Hotchkiss, Marin H. Kollef

Open Access Publications

No abstract provided.

Depression Symptoms And Cognitive Function Among Individuals With Advanced Hiv Infection Initiating Haart In Uganda, Noeline Nakasujja, Richard L. Skolasky, Seggane Musisi, Peter Allebeck, Kevin Robertson, Allan Ronald, Elly Katabira, David B. Clifford, Ned Sacktor

Open Access Publications

No abstract provided.

Cost And Mortality Prediction Using Polymerase Chain Reaction Pathogen Detection In Sepsis: Evidence From Three Observational Trials, Lutz E. Lehmann, Bernd Herpichboehm, Gerald J. Kost, Marin H. Kollef, Frank Stuber

Open Access Publications

No abstract provided.

Enhancement Of Anti-Diii Antibodies By The C3d Derivative P28 Results In Lower Viral Titers And Augments Protection In Mice, Matthew D. Dunn, Shannon L. Rossi, Donald M. Carter, Matthew R. Vogt, Erin Mehlhop, Michael S. Diamond, Ted M. Ross

Open Access Publications

No abstract provided.

Vipr: A Probabilistic Algorithm For Analysis Of Microbial Detection Microarrays, Adam F. Allred, Guang Wu, Tuya Wulan, Kael F. Fischer, Michael R. Holbrook, Robert B. Tesh, David Wang

Open Access Publications

No abstract provided.

Inappropriate Empiric Antifungal Therapy For Candidemia In The Icu And Hospital Resource Utilization: A Retrospective Cohort Study, Marya D. Zilberberg, Marin H. Kollef, Heather Arnold, Andrew Labelle, Scott T. Micek, Smita Kothari, Andrew F. Shorr

Open Access Publications

No abstract provided.

The Epidemiology Of Hematogenous Vertebral Osteomyelitis: A Cohort Study In A Tertiary Care Hospital, Kavita P. Bhavan, Jonas Marschall, Margaret A. Olsen, Victoria J. Fraser, Neill M. Wright, David K. Warren

Open Access Publications

No abstract provided.

A Practical, Bioinformatic Workflow System For Large Data Sets Generated By Next-Generation Sequencing, Cinzia Cantacessi, Aaron R. Jex, Neil D. Young, Bronwyn E. Campbell, Anja Joachim, Matthew J. Nolan, Sahar Abubucker, Paul W. Sternberg, Shoba Ranganathan, Makedonka Mitreva, Robin B. Gasser

Open Access Publications

No abstract provided.

The Interplay Of Sociodemographic Factors On Virologic Suppression Among A U.S. Outpatient Hiv Clinic Population, Enbal Shacham, Diana Nurutdinova, Nur Onen, Katelin Stamm, E. Turner Overton

Open Access Publications

No abstract provided.

Detection Of Wuchereria Bancrofti L3 Larvae In Mosquitoes: A Reverse Transcriptase Pcr Assay Evaluating Infection And Infectivity, Sandra J. Laney, Reda M. R. Ramzy, Hanan H. Helmy, Hoda A. Farid, Ameen A. Ashour, Gary J. Weil, Steven A. Williams

Open Access Publications

No abstract provided.

Ips-1 Is Essential For The Control Of West Nile Virus Infection And Immunity, Mehul S. Suthar, Daphne Y. Ma, Sunil Thomas, Jennifer M. Lund, Nu Zhang, Stephane Daffis, Alexander Y. Rudensky, Michael J. Bevan, Edward A. Clark, Murali-Krishna Kaja, Michael S. Diamond, Michael Gale Jr.

Open Access Publications

No abstract provided.

Identification Of Hookworm Daf-16/Foxo Response Elements And Direct Gene Targets, Xin Gao, Zhengyuan Wang, John Martin, Sahar Abubucker, Xu Zhang, Makedonka Mitreva, John M. Hawdon

Open Access Publications

No abstract provided.

Leishmania Major Survival In Selective Phlebotomus Papatasi Sand Fly Vector Requires A Specific Scg-Encoded Lipophosphoglycan Galactosylation Pattern, Deborah E. Dobson, Shaden Kamhawi, Phillip Lawyer, Salvatore J. Turco, Stephen M. Beverley, David L. Sacks

Open Access Publications

No abstract provided.

Six Rna Viruses And Forty-One Hosts: Viral Small Rnas And Modulation Of Small Rna Repertoires In Vertebrate And Invertebrate Systems, Poornima Parameswaran, Ella Sklan, Courtney Wilkins, Trever Burgon, Melanie A. Samuel, Rui Lu, K. Mark Ansel, Vigo Heissmeyer, Shirit Einav, William Jackson, Tammy Doukas, Suman Paranjape, Charlotta Polacek, Flavia Barreto Dos Santos, Roxana Jalili, Farbod Babrzadeh, Baback Gharizadeh, Dirk Grimm, Mark Kay, Satoshi Koike, Peter Sarnow, Mostafa Ronaghi, Shou-Wei Ding, Eva Harris, Marie Chow, Michael S. Diamond, Karla Kirkegaard, Jeffrey S. Glenn, Andrew Z. Fire

Open Access Publications

No abstract provided.

Endosymbiont Dna In Endobacteria-Free Filarial Nematodes Indicates Ancient Horizontal Genetic Transfer, Samantha N. Mcnulty, Jeremy M. Foster, Makedonka Mitreva, Julie C. Dunning Hotopp, John Martin, Kerstin Fischer, Bo Wu, Paul J. Davis, Sanjay Kumar, Norbert W. Brattig, Barton E. Slatko, Gary J. Weil, Peter U. Fischer

Open Access Publications

No abstract provided.

Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells, Marielle C. Gold, Stefanie Cerri, Susan Smyk-Pearson, Meghan E. Cansler, Todd M. Vogt, Jacob Delepine, Ervina Winata, Gwendolyn M. Swarbrick, Wei-Jen Chua, Yik Y. L. Yu, Olivier Lantz, Matthew S. Cook, Megan D. Null, David B. Jacoby, Melanie J. Harriff, Deborah A. Lewinsohn, Ted H. Hansen, David M. Lewinsohn

Open Access Publications

No abstract provided.

Evaluating A Wellness Program For Uni Faculty And Staff: Preparing For A Cost-Benefit Analysis, Michelle M. Breen

Honors Program Theses

The University of Northern Iowa (UNI) paid total annual employer medical premiums of $17,967,000 for 2008, an increase of 7.37% from 2007. If medical premiums continue to increase at this rate, UNI will pay $29,556,720 in annual medical premiums in 2015. UNI is not alone in facing rising healthcare costs. Healthcare costs were identified as the "most serious challenge to their bottom line" by 41. 7 percent of the employers in a survey by the National Association of Professional Employer Organizations (Kumar 2009). The Business Roundtable Fourth Quarter 2007 CEO Economic Outlook Survey confirms these results with CEO's ranking the …

Emerging Vaccine Informatics, Yongqun He, Rino Rappuoli, Anne S. De Groot, Robert T. Chen

Institute for Immunology and Informatics Faculty Publications

Vaccine informatics is an emerging research area that focuses on development and applications of bioinformatics methods that can be used to facilitate every aspect of the preclinical, clinical, and postlicensure vaccine enterprises. Many immunoinformatics algorithms and resources have been developed to predict T- and B-cell immune epitopes for epitope vaccine development and protective immunity analysis. Vaccine protein candidates are predictable in silico from genome sequences using reverse vaccinology. Systematic transcriptomics and proteomics gene expression analyses facilitate rational vaccine design and identification of gene responses that are correlates of protection in vivo. Mathematical simulations have been used to model host-pathogen interactions …

World Of Viruses: The Frozen Horror, Martin Powell, Tom Floyd, Angie Fox, Anisa Angeletti, Peter Angeletti, Judy Diamond, Kristin Watkins, Charles Wood

Books: College of Public Health

No abstract provided.

The Role Of Socioeconomic Factors In Racial And Ethnic Disparities Among Child And Adult Tuberculosis Cases, Spatial And Non-Spatial Analysis: Alabama 1993-2007, Sharada Adolph

All ETDs from UAB

This study aimed to evaluate the role of individual and community/population level socioeconomic factors on racial/ethnic disparities among children and adults with TB, and used area-based socioeconomic measures (ABSMs) for the identification of high-risk geographic areas for populations-at-risk. Joinpoint, multivariable and Poisson regression, and spatial methods were used to determine the trends and risks of disease in a low TB incidence state. General disease trends declined significantly by factors of -0.044838 from 1993-1998, and -0.061821 from 2001-2007; but, were disparate and increased for the foreign-born, African Americans (AA) and Latinos, and in long-term care settings. The average annual percentage change …

The Role Of Toll-Like Receptors 2 And 4 In Helicobacter Felis Infections And Asthma, Carolyn Durham

All ETDs from UAB

The inverse correlation between the industrialization and disease prevalence is termed the "hygiene hypothesis." Supporting this, immunological studies show Th1 cytokines modulate Th2 immune responses. Because the mucosa is essential in antigenic exposure, understanding bacterial sensing here is critical to addressing three foundations of this hypothesis: the role of bacterial exposure, relevance of noninvasive bacterial exposure, and influence of these exposures on immune responses. Key components of antigen sensing in the mucosa are toll-like receptors (TLRs) 2 and 4, which have been implicated in disease. The hypothesis of this thesis is, by globally knocking out one or both of these …

An Assessment Of The Factors That Affect The Self-Care Behaviors Of Diabetics, Gregory Ellis

All ETDs from UAB

various heteroskedastic analysis of covariance (ANCOVA) models with orthogonal

Cellular Mechanisms Involved In Host Responses To Porphyromonas Gingivalis And Its Virulence Factor Hemagglutinin B, Dalia Emil Gaddis

All ETDs from UAB

Porphyromonas gingivalis is a main causative agent for adult chronic periodontitis and immunization with its virulence factor Hemagglutinin B (HagB) provides protection against infection. Toll-like receptors (TLRs) recognize various microbial products and are crucial in eliciting and regulating the innate and adaptive immune responses to infections. The objective of this dissertation was to investigate the cellular mechanisms that influence the innate and adaptive immune response to HagB and P. gingivalis, focusing on the role of TLR signaling in the response. We started with investigating the ability of HagB to activate dendritic cells (DC), the most efficient antigen-presenting cell in priming …

Characterization Of The Oligosaccharides Of B. Anthracis Exosporium, Shengli Dong

All ETDs from UAB

Fatal systemic anthrax is caused by exposure to spores of Bacillus anthracis. The outermost layer of the B. anthracis spore is called the exosporium. It consists of a paracrystalline basal layer and an external hair-like nap. The filaments of the hair-like nap are primarily composed of the glycoprotein BclA. Our previous studies showed that a 715-Da tetrasaccharide and a 324-Da disaccharide are attached to BclA through GalNAc. We named the novel nonreducing terminal sugar of the 715-Da tetrasaccharide anthrose. We subsequently proposed a plausible anthrose biosynthetic pathway and identified a gene cluster of four continuous genes that appeared to encode …

Exosomal Curcumin: Its Bioavailability And Potential Anti-Inflammation Activity, Dongmei Sun

All ETDs from UAB

Curcumin, a pleiotropic polyphenol derived from turmeric plants Curcuma Longa with rhizome, exhibits strong evidence as an anti-inflammation, anti-oxidant and anti-cancer reagent both in vitro and in vivo. Due to its low stability and systemic bioavailability, a large amount of curcumin has to be administrated to achieve therapeutic effects both in animal and in human. The major effort to overcome this barrier is making by encapsulation of curcumin into nanoparticles such as polymers and liposomes; some promising data have demonstrated the effectiveness of such method. Exosomes are vesicle-like nanoparticles secreted by living cells. Exosomes contain both cell surface molecules and …

Genotyping Of Streptococcus Mutans Using Multilocus Sequence Typing, Stephanie Momeni

All ETDs from UAB

ABSTRACT The role of Streptococcus mutans has been extensively studied using a variety of genotyping techniques. Repetitive extragenic palindromic polymerase chain reaction (rep-PCR) is an effective tool for screening large-scale epidemiological studies with high discriminatory power and reproducibility. For this study, multilocus sequence typing (MLST) analysis is used to evaluate genotypes previously identified as unique using rep-PCR. Twenty-two unique S. mutans rep- PCR genotypes were selected from a longitudinal study. Four additional isolates were selected from each genotype group of the 6 most commonly occurring genotypes (n=30) for further analysis. Real-time PCR was performed using eight housekeeping S. mutans gene …

Assessing North American Influenza Dynamics With Hierarchical Spatio-Temporal Models, Jessica Anderson

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

We present a general statistical modeling framework to characterize continental-level influenza dynamics in the United States for the purposes of examining state-level epidemiological sources and sinks. The methods we describe depend directly on state-level influenza data that are updated weekly and available on the internet. Advances in search engine query analysis have provided powerful new tools for collecting epidemiological data and, when used in conjunction with sophisticated statistical models, allow for the identification and quantification of the flow of influenza across the continental United States. Our proposed methods, when conditioned on this comprehensive search query product, can provide unprecedented scientific …

An Evaluation Of Health Behavior Change During A General Education Health Course, Lynn M. Merklin

Dissertations

Problem. There have been no studies as to the effectiveness of the one-credit general education health course at Andrews University, Fit for Life, in promoting the adoption of healthy lifestyle behaviors. Because behavior change is a process that occurs over time, any measurement of student health behaviors must be sensitive enough to detect the early stages of behavior change as well as the behaviors themselves.

Method. The purpose of this study was to determine the degree to which students enrolled in Fit for Life adopted the health behaviors promoted in the course, evidenced by progress through the stages …

Fabrication Of Miniature Drug Screening Platform Using Low Cost Bioprinting Technology, Jorge Ivan Rodriguez

Open Access Theses & Dissertations

In the pharmaceutical industry, new chemicals and substances are being tested to find appropriate compounds or mix for treating a specific disease. The demand for screening large compound collections against and increasing number of therapeutic targets has stimulated technology development in the areas of assay automation and miniaturization. Current methods for evaluating the reactions of cells use a volume in the range of microliters. We have developed a new and low-cost deposition method to fabricate miniature drug screening platform that can realistically and inexpensively evaluate biochemical reactions up to 4 substances per trial in a picoliter-scale volume. This paper describes …