Digital Commons Network^™

Early Detection Of Response To Hydroxyurea Therapy In Patients With Sickle Cell Anemia., Samir K. Ballas, William F. Mccarthy, Nan Guo, Carlo Brugnara, Gail Kling, Robert L. Bauserman, Myron A. Waclawiw

Department of Medicine Faculty Papers

Red blood cells (RBC) and reticulocyte parameters were determined on peripheral blood from a subset of patients enrolled in the multicenter study of hydroxyuea (HU) in sickle cell anemia. Multiple blood samples were obtained every 2 weeks. Cellular indices were measured by flow cytometry. Generalized linear models were used to determine the relationship between the longitudinal trajectories of RBC and reticulocyte indices and HU usage. There was a significant relationship between HU usage and most of the RBC and reticulocyte indices. Hydroxyurea produced higher value trajectories than those generated by placebo usage for the hemoglobin (Hb) content of both the …

Definitions Of The Phenotypic Manifestations Of Sickle Cell Disease., Samir K Ballas, Susan Lieff, Lennette J Benjamin, Carlton D Dampier, Matthew M Heeney, Carolyn Hoppe, Cage S Johnson, Zora R Rogers, Kim Smith-Whitley, Winfred C Wang, Marilyn J Telen

Department of Medicine Faculty Papers

Sickle cell disease (SCD) is a pleiotropic genetic disorder of hemoglobin that has profound multiorgan effects. The low prevalence of SCD ( approximately 100,000/US) has limited progress in clinical, basic, and translational research. Lack of a large, readily accessible population for clinical studies has contributed to the absence of standard definitions and diagnostic criteria for the numerous complications of SCD and inadequate understanding of SCD pathophysiology. In 2005, the Comprehensive Sickle Cell Centers initiated a project to establish consensus definitions of the most frequently occurring complications. A group of clinicians and scientists with extensive expertise in research and treatment of …

Book Review: The Hip Hop Church: Connecting With The Movement Shaping Our Culture By Efrem Smith And Phil Jackson, Robert W. Strong

Great Commission Research Journal

No abstract provided.

Resource Selection By Elk In An Agro-Forested Landscape Of Northwestern Nebraska, David M. Baasch, Justin W. Fischer, Scott E. Hygnstrom, Kurt C. Vercauteren, Andrew J. Tyre, Joshua J. Millspaugh, James W. Merchant, Jerry D. Volesky

School of Natural Resources: Faculty Publications

In recent years, elk have begun recolonizing areas east of the Rocky Mountains that are largely agroforested ecosystems composed of privately owned land where management of elk is an increasing concern due to crop and forage depredation and interspecific disease transmission. We used a Geographic Information System, elk use locations (n = 5013), random locations (n = 25,065), discrete-choice models, and information-theoretic methods to test hypotheses about elk resource selection in an agro-forested landscape located in the Pine Ridge region of northwestern Nebraska, USA. Our objectives were to determine landscape characteristics selected by female elk and identify publicly owned land …

Application Of Copper And Zinc Isotopes To Fingerprint Metal Sources And Identify Attenuation Mechanisms In The Abandoned Waldorf Mine Area, Clear Creek County, Colorado, Suzan Aranda Luna

Open Access Theses & Dissertations

Acid rock drainage (ARD) is caused by the oxidative weathering of sulfide minerals. Sulfur is oxidized by dissolved oxygen or Fe(III) and sulfate ions, metals, and protons are released into the environment. Hence, the pH of nearby water and soils often decreases in response to ARD while metal concentrations increase. Because a large part of the Rocky Mountains of Colorado are highly mineralized (i.e., the Colorado Mineral Belt), ARD is a serious problem in this region. Moreover, the many abandoned mining areas in the Rocky Mountains that include waste rock piles, tailings impoundments, and surface disturbances add to the problem …

Use Of The Cmaq And Wrf-Chem Models To Investigate Tropospheric Ozone And Particulate Matter In The El Paso-Juarez Airshed, Juan Gustavo Arias Ugarte

Open Access Theses & Dissertations

Ground level ozone pollution is a continuing environmental concern in several U.S cities. A necessary step towards understanding and quantifying the problem is the implementation of numerical models that can predict pollutant concentrations. Simulations were performed using the Community Multiscale Air Quality (CMAQ) and the (Weather Research Forecast/Chemical (WRF-Chem) models to study the tropospheric ozone and particulate matter concentrations in the El Paso-Juarez Airshed and to analyze the influence of U.S and Mexican cities as possible contributors to ground level ozone pollution in this region. This study involves the implementation and validation of both the CMAQ and WRF-Chem models for …

Rare's Implementation Strategies Of Environmental Conservation In Indonesia, Alvaro Arvizo

Open Access Theses & Dissertations

Like most developing nations, Indonesia is at a crucial stage in its modern political and economic history. Opposing forces are constantly at work, a government struggling to make Indonesia a modern nation and the economic demands of a growing population. This presents the country with a multitude of problems. One of several is that nature's resources are exploited for personal economic gain with no regard for the long-term effects. This is a major concern for environmental conservation and non-profit government organizations (NGOs) worldwide. The American NGO Rare is at the forefront of this issue. Its aim is to meet community …

Component Replacement Analysis For Electricity Distribution Systems Using Evolutionary Algorithms, Vasukumar Chenna

Open Access Theses & Dissertations

The main objective of the electric power grid is to supply economical and reliable electricity to industrial, commercial, household, transportation, and other end-users, including agricultural, educational institutions and hospitals. The power system is a very large and complex network consisting of generation, transmission, and distribution systems. The main focus of the present research is in the area of power distribution systems. Almost all the areas of the power grid uses simpler radial distribution systems to distribute electricity to the end consumer, it is the final and therefore vital link between the consumer and the rest of the power grid. Therefore …

Race, Gender, And Citizenship: The Removal Of Japanese And Japanese Mexicans From The United States/Mexico Borderlands, Selfa Alejandra Chew Smithart

Open Access Theses & Dissertations

This dissertation explores the uprooting of the Japanese Mexican community from the United States/Mexico borderlands region during World War II. I argue that the development of international relations and the global organization of the economy directly informed the management of Japanese immigrants and their descendants in the United States borderlands region. In compliance with the United States' request to control Japanese Mexicans, President Manuel Ávila Camacho ordered the dislocation of the entire Japanese Mexican community and approved the creation of concentration camps and zones of confinement. Under this order, a new pro-American nationalism developed, which scripted Japanese Mexicans as an …

The Composition Of Precipitation In El Paso, Texas, Sonny P. Emmert

Open Access Theses & Dissertations

The composition of precipitation reflects the transport of particles from varying air mass source regions as well as input from local environmental and anthropogenic activities. Air research in El Paso, TX, U.S.A/Ciudad Juarez, Chihuahua, Mexico has been traditionally limited to studies of local inputs of air pollution; no transition has been made to studying the scavenging, washout, and transport of pollutants by precipitation. The goal of this research project was to identify transported pollutants in precipitation, and determine if there were any health and ecological implications. The research investigated biological, chemical, and geological constituents in precipitation samples collected between September …

Computer-Aided Detection Of Sleep Apnea And Sleep Stage Classification Using Hrv And Eeg Signals, Edson F. Estrada

Open Access Theses & Dissertations

Sleep is a circadian rhythm essential for human life. Many events occur in the body during this state. In the past, significant efforts have been made to provide clinicians with reliable and less intrusive tools to automatically classify the sleep stages and detect apnea events. A few systems are available in the market to accomplish this task. However, sleep specialists may not have full confidence and trust in such systems due to issues related to their accuracy, sensitivity and specificity. The main objective of this work is to explore possible relationships among sleep stages and apneic events and improve on …

Development Of A Micro-Catbed For Miniature Thrusters, Chance Paul Garcia

Open Access Theses & Dissertations

The goal of this work is to develop a micro catalytic bed for miniature thrusters. A test bed was constructed for experimental testing to characterize several parts of the micro catalytic bed. The reactant fluid studied is 90% Hydrogen Peroxide (H2O2) by weight. Three different cross sectional area designs were tested to determine decomposition efficiency, temperature reaction propensity, optimum flow rate, and temperature distribution across each bed. The products of decomposition were condensed to measure the oxygen released from decomposition. The results will be used to develop the basis for a micro catalytic bed design to implement into future miniature …

Export Vs. Import - Led Growth In Mexico, Joseph Kababie

Open Access Theses & Dissertations

This study concentrates on the role of imports and the impact they have for economic growth in the country of Mexico. The investigation is conducted in a time series framework using an ordinary least square method, a vector autoregressive model, and a vector error correction model to test the trade variables of exports and imports for exogenous or endogenous induced growth. The results indicate through Granger causality tests that imports are having the significant impact for economic growth. These findings are in some ways in contradiction to previous literature that has focused on exports as being the sole engine for …

Low Impact Development (Lid) Structures For Groundwater Management And Watershed Protection In The Amrc10 Watershed, El Paso Texas, Ricardo Sabino Marmolejo

Open Access Theses & Dissertations

The AMRC10 watershed was modeled in HEC-HMS and in Green Values. Theoretical storm water conveyance and capture models were tested in these programs along with several Low environmental Impact Development features to determine their applicability and performance at this site. Lots should all be designed with all roof downspouts draining into raingardens, at least half of all lawns should be natural landscaping using local vegetation, porous pavement should be used for all driveways, sidewalks and non-street pavement and drainage to the stormwater conveyance structures should make use of drainage swales instead of storm water pipes. To manage runoff three detention …

Compressive Sensing With Prior Information Applied To Magnetic Resonance Imaging, Cristiano Jacques Miosso

Open Access Theses & Dissertations

This dissertation introduces the theory of compressive sensing with prior information about a signal's sparse representation. We show, mathematically and in numerical simulations, that prior information improves signal reconstruction, in terms of number of required measurements, computation time and signal-to-noise ratios. Following, we present a set of methods for enhanced magnetic resonance imaging and tomography that can be combined with prior information, for enhanced image quality.

In developing the theory of compressive sensing with prior information, we provide a mathematical proof of the required condition (in terms of number of linear measurements) for reconstruction using the ideal approach of l0-minimization, …

Identification Of A Novel Cytokine Inducible Stat5 Phosphoserine Site (Ps193) That Positively Regulates Its Transcriptional Activity And Is Found Constitutively Activated In Certain Hematopoietic Cancers, Abhisek Mitra

Open Access Theses & Dissertations

Hematological malignancies such as leukemia and lymphoma, can develop from aberrant changes in the cell signaling molecules to drive their uncontrolled cellular proliferation and differentiation. Activation, maturation, expansion and differentiation of T cells are critically regulated by the dynamics of various transcription factors activated by a variety of cytokines. Additionally, multiple effector molecules that mediate these T cells dependent signals include the JAK (Janus Kinase)-STAT (Signal transducer and activator of transcription) cascade. These signaling proteins are activated in response to a broad array of cytokines. Constitutively activated JAKs and STATs have been described in several T cell malignancies. A growing …

Coordination Directed Self Assembly Of Pt/Pd Mono-And Multinuclear Complexes, Robert Moreno

Open Access Theses & Dissertations

This research focuses on the development of mononuclear platinum complexes; multinuclear platinum complexes, both of which self assemble into micelles in the presence of water. This work also involved the synthesis of a reverse micelle that allows for detection of water nanocrystals within a defined size molecular envelope. The novel synthesis of these compounds allows for ligand substitution and the creation of a library of compounds.

Copper Isotope Fractionation During Surface Adsorption And Intracellular Incorporation By Bacteria, Jesica Urbina Navarrete

Open Access Theses & Dissertations

Copper isotopes may prove to be a useful tool for investigating bacteria-metal interactions recorded in natural waters, soils, and rocks. However, experimental data that constrain Cu isotope fractionation in biologic systems are limited and unclear. In this study we utilized Cu isotopes (65Cu) as a tool to investigate Cu-bacteria interactions, including surface adsorption and intracellular incorporation. Experiments were conducted with individual Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia coli) bacterial species as well as with bacterial consortia from several natural environments. Adsorption experiments were conducted with live or dead cells over the pH range 2.5 to 6. Surface adsorption of Cu …

Study Of Pbdes In Wastewater, Water And Sludge Of El Paso Del Norte Border Region Using Sbse Td/Gc-Ms, Beatriz Adriana Rocha-Gutierrez

Open Access Theses & Dissertations

Polybrominated diphenyl ethers (PBDEs) are a group of brominated compounds widely used as flame retardants. PBDEs are structurally similar to polychlorinated biphenyls (PCBs), and appear to act similarly in the environment. Due to their persistence and lipophilicity, PBDEs are found to be bioaccumulated and biomagnified in the food chain. Current research in PBDEs is focused on their occurrences, concentration, fate and transport in the environment, and the impact in the ecosystem and human health. Since PBDEs are not regulated in the USA, large amounts of these harmful chemicals are being dumped indiscriminately into the drainage system. As a result, these …

Granulometry And Geochemistry Of Dust Emission From Owens (Dry) Lake, California, Analila Rojo

Open Access Theses & Dissertations

Owens (dry) Lake, the terminus of Owens River, is located in the Basin and Range physiographic province in east–central California. The transformation of Owens Lake into a desiccated desert playa (approximately 280 km2) via diversion of the river into the Los Angeles Aqueduct (in 1913) led to extensive wind erosion, making the playa one of the most intense sources of airborne dust in the Western Hemisphere. The processes that direct the chemical and mineralogical composition of surface sediments at Owens (dry) Lake and the physical mechanisms of wind erosion, saltation and dust emission at Owens (dry) Lake are well–understood. However, …

The Effectiveness Of The University Interscholastic League One-Act Play Competition As An Extracurricular Activity, David Christopher Rout

Open Access Theses & Dissertations

In Texas the University Interscholastic League has had a significant impact in Theatre Education through their annual competitive One-Act Play Competition. In educational climates dominated by No Pass-No Play and TAKS Testing some schools may question the effectiveness of the UIL competition as an effective activity. This paper addresses this concern, a measurement of how effective UIL One Act Play is how FERPA is impacting research into UIL events.

The Effects Of Acculturation On Healthcare In The Mexican-Origin Community: El Paso County, Texas, Aurelio Saldana

Open Access Theses & Dissertations

This study was built around the understanding that there is complexity in the "Hispanic"¹ health care/acculturation phenomenon. The El Paso region provides an environment where an array of cultural influences produces an acculturation process whose dynamics appear to be unique but in fact are not dissimilar to other regions where cultures are coming into contact with each other. The way borderland acculturation manifests itself in local "Hispanic" healthcare behaviors contradicts the concept of the neat move from "traditional" to the "formal" biomedical paradigm. The actual behavior observed adds support to the more complex, segmented, multi-dimensional interpretations of healthcare behavior adaptation …

Disclosure Of Hiv Serostatus In Latinos As A Function Of Acculturation: The Role Of Attitudinal Components And The Theory Of Reasoned Action, John Andrew Sauceda

Open Access Theses & Dissertations

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School And Campus Characteristics Of Non-Graduating Seniors Due To Failure Of Taks Tests In The Western Independent School District, Patricia Silva

Open Access Theses & Dissertations

This study examined TAKS test scores of seniors that did not graduate with their cohort group due to failure of TAKS test. The data was for the 2007-2008, 2008-2009 and 2009-2010 school years and included students from ten traditional high schools. This researched focused on the relation between this senior cohort group and student and campus factors. The student characteristics included gender, ethnicity, at-risk status and students identified as economically disadvantaged and Limited English Proficient. The school characteristics included campus size, longevity of campus principal, teachers' classroom years of experience, and state and federal accountability factors. Through an observational and …

The Co-Existence Of Diabetes Mellitus Type 2 And Depression Symptoms In Mexican American Adults: Its Relation To Glucose Control, Perceived Stress And Physical Health, Guillermina Rincon Solis

Open Access Theses & Dissertations

Type 2 diabetes is a common chronic metabolic disease affecting 23.6 million people (7.8%) in the U.S. and is the 6th leading cause of death among adults (CDC, 2007). Mexican-Americans, the largest group within the Hispanic U.S population, have double the rate of type 2 diabetes. Long-term glucose control (HbA1C) is essential to lessen the risk of diabetes complications; self-care demands for diabetes management may be overwhelming and creates stress that predisposes individuals to depression and affects long-term glucose control (Anderson et al., 2000; Black, 1999; Black, Markides, & Ray, 2003). The purpose of this study was to evaluate the …

Development Of A Land Use Regression Model To Predict Nitrogen Dioxide Concentrations, Teresa Sosa

Open Access Theses & Dissertations

Air pollution is a major environmental concern in the El Paso-Juárez region. According to the Ministry of Environment and Natural Resources (Secretaría de Medio Ambiente y Recursos Naturales, SEMARNAT) the city of Juárez is one of the city's in México with the highest atmospheric levels of pollution because of its accelerated and unplanned urban growth. One air pollutant of concern is nitrogen dioxide (NO2) due to its detrimental health effects that have been associated with airway inflammation in healthy people and increased respiratory symptoms in people with asthma. Land use regression modeling is a GIS based approach that seeks to …

A Deadline-Driven Epidemic Data Collection Protocol Suitable For Tracking Interpersonnel Rendezvous, Avranil Tah

Open Access Theses & Dissertations

This thesis describes a peer-to-peer wireless data collection algorithm that uses epidemic communication to propagate time-sensitive sequentially sampled data records from sensors toward infrastructure connected upload stations via mobile data mules. These records are labeled with sequence numbers and delivery deadlines, and are transmitted in sequential order. Delivery deadlines enable transmission prioritization and trigger alarms warning of violations.

The sequential ordering of records simplifies the protocols transmission-control and garbage collection mechanisms: only two monotonically increasing scalar sequence indices associated with a particular sensor must be exchanged between peers prior to selecting which records need to be communicated. One of these …

The Impact Of Cartel Related Violence On Ongoing Traumatic Stress And Self-Medication In Young Adults Living Along The U.S./México Border, Thom J. Taylor

Open Access Theses & Dissertations

Ongoing Potentially Traumatic Stress (OPTS) as a result of violence and insecurity along the U.S./México border remains understudied. Many residents of the border may be both indirectly and directly exposed to potentially traumatic events on an ongoing basis, particularly in the city of Cd. Juárez, México. The present study examined the impact of the violence and insecurity on daily traumatic stress levels and the potential for self-medication via alcohol, cigarettes, and illicit drugs within Spanish speaking young adult residents and commuters to Cd. Juárez, Chihuahua, México. Participants (N = 121) completed multiple online reports of location in and travel to …

Using Soil-Borne Polycyclic Aromatic Hydrocarbons (Pahs) And Organic Carbon In Soil For Projecting Pollution States Of Pahs In Ambient Air, Chika Yamaguchi

Open Access Theses & Dissertations

Polycyclic Aromatic Hydrocarbons (PAHs) are of environmental concern due to their ubiquitous nature, long-range transport, long half-lives, and toxicity. PAHs enter the environment as a consequence of incomplete combustion and cause adverse health effects. Because they are omnipresent pollutants, PAH distribution is not only a local issue, but also a global issue. Therefore, monitoring PAHs in ambient air and identifying their sources and distribution patterns have tremendous importance in assessing public health. However, sampling and analyzing airborne PAHs with conventional methods is time consuming and costly. In addition, an active sampling method remains unfeasible in many cases because it requires …

The Use Of Social Marketing As A Means Of Promoting Enviornmental Conservation: A Case Study Of Indonesian Biodiversity Campaigns, Alesia Za Gara

Open Access Theses & Dissertations

As a means of preserving Indonesia's natural allure and resources it is evident that there must be a conscious shift made wherein environmental conservation becomes top priority among the people of Indonesia and the world. Traditionally dealt with through a country's governmental facets, a new tread of social marketing is now being employed ENGOs in various countries such as Indonesia as a way to promote biodiversity conservation. For example, one such ENGO is Rare Conservation, an international organization that teaches social marketing tools to classes or cohorts of individuals around the world as a means of improving a variety of …