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Carcinosarcoma Of The Esophagus, Ziaur Rehman, Inam Pal, Zubair Ahmad, Asim Qureshi

Section of General Surgery

Carcinosarcoma of the esophagus is a rare neoplasm characterized histologically by presence of carcinomatous and sarcomatous elements. Case report of carcinosarcoma of the esophagogastric junction whose morphological and immunohistochemical features makes it quite distinctive from other tumours is presented. It was an ulcerated lesion diagnosed in an elderly Afghan lady located 34 cms from the incisor teeth. The patient was a smoker.

Enhancing Green Tax Measures In Hong Kong : A Means Of Addressing The City's Environmental Problems, Yuzhu Lu

Lingnan Theses

Nowadays, pressures on the environment are increasing around the world. In particular, Hong Kong, a compact city with a population of nearly seven million, one which has undergone remarkable economic growth over the past few decades, has developed severe environmental problems. It also has deficiencies in its taxation system: a small tax base, for example. In today’s world, “green” taxes have been accepted and applied by more and more countries, especially those in the OECD. However, Hong Kong still has not adequately used the tax tool as an integral part of the government’s anti-pollution strategy. Accordingly, the major objective of …

Consequences Of Increased Cd45ra And Rc Isoforms For Tcr Signaling And Peripheral T Cell Deficiency Resulting From Heterogeneous Nuclear Ribonucleoprotein L-Like Mutation, Zuopeng Wu, Adele L. Yates, Gerard F. Hoyne, Christopher C. Goodnow

Health Sciences Papers and Journal Articles

CD45 is the most abundant protein tyrosine phosphatase in the plasma membrane of T cells and serves a critical role in TCR signaling. Different CD45 isoforms are made by alternative mRNA splicing depending on the stage of T cell development and activation, yet their role remains unclear. Expression of CD45RA and RC isoforms is increased 20- to 200-fold on T cells from thunder mice with a loss-of-function mutation in the RNA-binding protein, heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL), although total CD45 expression is unaltered. In this study, we test the hypothesis that this shift in CD45 isoform expression alters TCR signaling, …

Magnetic Nanosensors For Multiplexed Bacterial Pathogenesis Identification, Charalambos Kaittanis

Electronic Theses and Dissertations

Developing diagnostic modalities that utilize nanomaterials and miniaturized detectors can have an impact in point-of-care diagnostics. Diagnostic systems that (i) are sensitive, robust, and portable, (ii) allow detection in clinical samples, (iii) require minimal sample preparation yielding results quickly, and (iv) can simultaneously quantify multiple targets, would have a great potential in biomedical research and public healthcare. Bacterial infections still cause pathogenesis throughout the world (Chapter I). The emergence of multi-drug resistant strains, the potential appearance of bacterial pandemics, the increased occurrence of bacterial nosocomial infections, the wide-scale food poisoning incidents and the use of bacteria in biowarfare highlight the …

An Assessment Of Sea Turtle Nesting Behavior In Relation To Hurricane- And Restoration-Induced Beach Morphodynamics, Tonya Michele Long

Electronic Theses and Dissertations

Coastal habitats are highly dynamic and vulnerable to landscape-level disturbances such as storms and restoration projects. Along the east coast of Florida these areas are particularly valuable as they provide significant nesting habitat for two sea turtle species, the threatened loggerhead (Caretta caretta) and the endangered green turtle (Chelonia mydas). This coast was heavily impacted by three major hurricanes in 2004 and in some areas by large restoration projects in 2005. Recent remote sensing methods allow for broad evaluation of the shoreline and thus the ability to assess sea turtle nesting habitat at a landscape scale. I collected nesting data …

Assessing The Psychometric Properties Of The Counseling Competencies Scale A Measure Of Counseling Skills, Dispositions, And Behaviors, Jacqueline Melissa Swank

Electronic Theses and Dissertations

Ethical and competent professional counselors are needed to provide quality counseling services to the public. Counselor educators and supervisors have the responsibility of training competent counselors. Furthermore, counselors and counselors-in-training have the responsibility of continually assessing their own development and implementing measures to increase their competency. Assessment instruments have sought to measure counseling competencies through evaluating counseling skills. However, a paucity of research exists that examines counseling competencies in a comprehensive manner using a psychometrically sound approach. Therefore, a need exists for a psychometrically sound assessment instrument that measures the construct of counseling competencies in a holistic manner. Thus, the …

Electroconvulsive Shock Ameliorates Disease Processes And Extends Survival In Huntington Mutant Mice, Akanksha Baharani

Electronic Theses and Dissertations

Huntington's disease (HD) is a devastating autosomal dominantly inherited neurological disorder caused by an abnormal expansion of CAG trinucleotide repeats in the gene coding for the Nterminal region of the huntingtin (Htt) protein, which leads to the formation of a polyglutamine stretch. The greater the CAG repeats, the earlier the onset of the disease. The polyglutamine stretch destabilizes the Htt protein leading to misfolding, abnormal processing, aggregation, and inclusion formation. Mutant Htt protein is believed to damage and kill neurons in the striatum by a mechanism involving increased oxidative and metabolic stress, and impaired adaptive cellular stress responses. A large …

Job Satisfaction And Values Of Counselors In Private Practice And Agency Settings, Laura Cunningham

Electronic Theses and Dissertations

Counselors can work at a variety of locations (Vacc & Loesch, 2000). Yet very little is known about each setting (King, 2007) and what type of counselors would have an optimum fit. Burnout is a pervasive issue in counseling (Lawson, 2007) and providing good-fit information could lessen turnover and burnout from the counseling field. The primary purpose of this study included investigating the differences between job satisfaction and value priorities of counselors in private practice and agency settings. The overarching theoretical framework included Frank Parsons‘ counselors, with seventy-two agency counselors and sixty-three private practitioners. Counselors completed two assessments and a …

Acetazolamide-Induced Decrease Of Apical Fluid Flow In Choroid Plexus Is Independent Of The Concomitant Changes In Aquaporin-1 Expression, Pouya Alexander Ameli

Electronic Theses and Dissertations

Acetazolamide (AZA), the only drug approved for treatment of hydrocephalus, is effective in only 25-30% of patients while its effect on fluid flow in the choroid plexus (CP) is unknown. The drug reversibly inhibits Aquaporin 4 (AQP4), the most highly expressed „water pore‟ in the brain, and it is postulated that it reduces cerebrospinal fluid (CSF) production by modulating AQP1 (mostly found in the apical membrane of the CP). In this study, we sought to elucidate the effect of AZA on AQP1 and fluid flow in CP. Primary CP culture from p10 Sprague-Dawley rats and TRCSF-B cell line were grown …

Clinical Practice Guidelines For Emerging Ultrasound Applications Drafting For Validity And Usability, Kathi Keaton Borok

Electronic Theses and Dissertations

Clinical practice guidelines (CPGs) are viewed by many people with interests in health care as valuable tools for reducing practice variations that undermine patient outcomes and increase medical costs. However, guidelines themselves vary in quality. Assessment tools generally base quality measures on strength of guidelines' evidence base, but particularly for newly emerging applications of ultrasound, standards for measuring guideline quality are controversial. The validity of a guideline is considered likely when strong research-based evidence supports its recommendations, but for newer medical procedures such as emerging ultrasound applications, available evidence is sparse. Existing assessment tools must be modified if they are …

Estimating Diet And Food Selectivity Of The Lower Keys Marsh Rabbit Using Stable Isotope Analysis, Matthew James Gordon

Electronic Theses and Dissertations

Understanding the effect of food abundance on feeding behavior can benefit conservation efforts in many ways, such as to determine whether impacted environments need food supplementation, whether different locations of threatened species contain different food abundances, or whether reintroduction sites are missing key components of a species’ diet. I studied the relationship between feeding behavior and food abundance in the Lower Keys marsh rabbit (Sylvilagus palustris hefneri), an endangered subspecies endemic to the lower Florida Keys. Specifically, my study set out to measure the relative abundance of the primary plants within the natural habitat of the Lower Keys marsh rabbit …

Evaluation Of A Simulation-Enhanced Obstetric Clinical Experience On Learning Outcomes For Knowledge, Self-Efficacy, And Transfer, Mary Elizabeth Guimond

Electronic Theses and Dissertations

Simulation using computerized patient mannequins may be a useful mechanism to teach safe and effective nursing care, thus improving the quality of education for nurses. As nursing program enrollments grow, clinical placement is becoming more difficult and may not offer consistent learning opportunities that reinforce safe and effective nursing practice. This study applied Ford, Smith, Weissbein, Gully, and Salas’ (1998) model of learning transfer as the theoretical framework to design a simulated obstetric clinical learning experience to augment the current clinical practice model, an approach that may lead to an improved educational experience. The purpose of this study was to …

Social Comparison, Self-Objectification, And Objectification Of Others Investigating The Vicious Cycle That Leads To Body Dissatisfaction And Disordered Eating, Danielle M. Lindner

Electronic Theses and Dissertations

The purpose of this study was to test a new theoretical model that integrates self-objectification, objectification of others, and social comparison as contributors to the development and maintenance of body image disturbance and disordered eating behavior. Within the new theoretical model, self-objectification, objectification of others, and social comparison are conceptualized as a self-perpetuating cycle, rather than as processes that occur independently of one another. Four hundred fifty-nine female college students between the ages of 18 and 32 completed measures of self-objectification, objectification of others, social comparison, body shame, body dissatisfaction, and eating disorder symptomatology. Structural equation modeling with nested model …

Dialectical Tensions Between Glocalization And Grobalization For Wal-Mart In The United States, Laura Lord

Electronic Theses and Dissertations

This qualitative analysis examines Wal-Mart managers‟ perspectives of the strategies that the U.S. corporation has implemented in order to increase its sales and profits at more than 4,000 stores in local U.S. communities. Two theoretical paradigms are specifically used: glocalization and grobalization. The former refers to cultural adaptation; the latter means standardization. The ultimate goal of the researcher is to identify the dialectical tensions between those two current forms of globalization. In-depth, face-to-face, qualitative interviewing of ten Wal-Mart managers in Central Florida allowed the researcher to actually comprehend managers‟ perspectives, gather fresh data, and construct a final product to enlighten …

Transplantation Of Ips Cells Reduces Apoptosis And Fibrosis And Improves Cardiac Function In Streptozotocin-Induced Diabetic Rats, Sarah Elizabeth Neel

Electronic Theses and Dissertations

Background: Streptozotocin (STZ) induced diabetes leads to various complications including cardiomyopathy. Recent data suggests transplanted bone marrow stem cells improve cardiac function in diabetic cardiomyopathy. However, whether modified ES, iPS cells, or factors released from these cells can inhibit apoptosis and fibrosis remains completely unknown. The present study was designed to determine the effects of transplanted ES cells overexpressing pancreatic transcription factor 1 a (Ptf1a), a propancreatic endodermal transcription factor, iPS cells, or their respective conditioned media (CM) on diabetic cardiomyopathy. Methods: Experimental diabetes was induced in male Sprague Dawley rats (8-10 weeks old) by intraperitoneal STZ injections (65 mg/kg …

A Model Of Flow And Play In Game-Based Learning The Impact Of Game Characteristics, Player Traits, And Player States, Davin Pavlas

Electronic Theses and Dissertations

In this dissertation, the relationship between flow state, serious games, and learning was examined. Serious games, which are games that convey something other than enjoyment (e.g., learning), are increasingly popular platforms for research, training, and advertisement. The elements that make serious games useful to researchers, trainers, and practitioners are closely linked to those that make up the positive psychology construct of flow state. Flow state describes an optimum experience that is encountered when a variety of factors are met, and is characterized by high focus, engagement, motivation, and immersion. While flow state is often discussed in the serious games literature, …

Water Resources, Health, And The Sustainability Of Interventions To Achieve Water And Sanitation Targets Of The Millennium Development Goals In A Changing World, Lauren M. Fry

Dissertations, Master's Theses and Master's Reports - Open

This dissertation addresses sustainability of rapid provision of safe water and sanitation required to meet the Millennium Development Goals. Review of health-related literature and global statistics demonstrates engineers' role in achieving the MDGs. This review is followed by analyses relating to social, environmental, and health aspects of meeting MDG targets.

Analysis of national indicators showed that inadequate investment, poor or nonexistent policies and governance are challenges to global sanitation coverage in addition to lack of financial resources and gender disparity. Although water availability was not found to be a challenge globally, geospatial analysis demonstrated that water availability is a potentially …

Male Remating Success And The Frequency Of Copulatory Plugs In The Green Lynx Spider Peucetia Viridans (Araneae, Oxyopidae), Martina G. Ramirez, Angelik C. Achekian, Catherine R. Coverley, Rachel M. Pierce, Sarah S. Eiman, Melissa M. Wetkowski

Biology Faculty Works

Peucetia viridans males were allowed to mate with three virgin females and most matings resulted in live spiderlings, even when males lacked palpal paracymbial processes. Among females, the presence of copulatory plugs was inconsistent, and when present, their condition was not uniform; broken-off male paracymbia were often found in epigynal orifices. There was no size effect in a male’s ability to completely plug a female’s genital orifices, as well as no significant change in the pattern of plug production over consecutive mating trials. Among mated, field-collected females, the presence of plugs and paracymbia was variable, with females from some sites …

Substrate Specificity Of The Tim22 Mitochondrial Import Pathway Revealed With Small Molecule Inhibitor Of Protein Translocation, Deepa V. Dabir

Biology Faculty Works

The TIM22 protein import pathway mediates the import of membrane proteins into the mitochondrial inner membrane and consists of two intermembrane space chaperone complexes, the Tim9-Tim10 and Tim8-Tim13 complexes. To facilitate mechanistic studies, we developed a chemical-genetic approach to identify small molecule agonists that caused lethality to a tim10-1 yeast mutant at the permissive temperature. One molecule, MitoBloCK-1, attenuated the import of the carrier proteins including the ADP/ATP and phosphate carriers, but not proteins that used the TIM23 or the Mia40/ Erv1 translocation pathways. MitoBloCK-1 impeded binding of the Tim9-Tim10 complex to the substrate during an early stage of translocation, …

Patch Selection By Wintering White-Tailed Deer : Consequences For Eastern Hemlock Regeneration At Local And Landscape Scales, Jill Christine Witt

Dissertations, Master's Theses and Master's Reports - Open

Tsuga canadensis (eastern hemlock) is a highly shade-tolerant, late-successional, and long-lived conifer species found throughout eastern North America. It is most often found in pure or nearly pure stands, because highly acidic and nutrient poor forest floor conditions are thought to favor T. canadensis regeneration while simultaneously limiting the establishment of some hardwood species with greater nutrient requirements. Once a common species, T. canadensis is currently experiencing widescale declines across its range. The hemlock woolly adelgid (Adelges tsugae) is decimating the population across its eastern distribution. Across the Upper Great Lakes region, where the adelgid is currently being …

Use Of A 3d Perfusion Bioreactor With Osteoblasts And Osteoblast/Endothelial Cell Co-Cultures To Improve Tissue-Engineered Bone, Matthew J. Barron

Dissertations, Master's Theses and Master's Reports - Open

The delivery of oxygen, nutrients, and the removal of waste are essential for cellular survival. Culture systems for 3D bone tissue engineering have addressed this issue by utilizing perfusion flow bioreactors that stimulate osteogenic activity through the delivery of oxygen and nutrients by low-shear fluid flow. It is also well established that bone responds to mechanical stimulation, but may desensitize under continuous loading. While perfusion flow and mechanical stimulation are used to increase cellular survival in vitro, 3D tissue-engineered constructs face additional limitations upon in vivo implantation. As it requires significant amounts of time for vascular infiltration by the host, …

Influence Of Traumatic Impaction And Pathological Loading On Knee Menisci, Megan Leigh Killian

Dissertations, Master's Theses and Master's Reports - Open

Nearly half of the US population faces the risk of developing knee osteoarthritis (OA). Both in vitro and in vivo studies can aid in a better understanding of the etiology, progression, and advancement of this debilitating disorder. The knee menisci are fibrocartilagenous structures that aid in the distribution of load, attenuation of shock, alignment and lubrication of the knee. Little is known about the biochemical and morphological changes associated with knee menisci following altered loading and traumatic impaction, and investigations are needed to further elucidate how degradation of this soft tissue advances over time. The biochemical response of porcine meniscal …

Simulating Dioxane Transport In A Heterogeneous Glacial Aquifer System (Washtenaw County, Michigan) Using Publicly Available Models And Data, Rungroj Benjakul

Dissertations, Master's Theses and Master's Reports - Open

The primary challenge in groundwater and contaminant transport modeling is obtaining the data needed for constructing, calibrating and testing the models. Large amounts of data are necessary for describing the hydrostratigraphy in areas with complex geology. Increasingly states are making spatial data available that can be used for input to groundwater flow models. The appropriateness of this data for large-scale flow systems has not been tested. This study focuses on modeling a plume of 1,4-dioxane in a heterogeneous aquifer system in Scio Township, Washtenaw County, Michigan. The analysis consisted of: (1) characterization of hydrogeology of the area and construction of …

Clean Water In The Classroom : Understanding The Importance Of Water Quality , Emily Curry

Dissertations, Master's Theses and Master's Reports - Open

This study’s objective was to answer three research questions related to students’ knowledge and attitudes about water quality and availability issues. It is important to understand what knowledge students have about environmental problems such as these, because today’s students will become the problem solvers of the future. If environmental problems, such as those related to water quality, are ever going to be solved, students must be environmentally literate.

Several methods of data collection were used. Surveys were given to both Bolivian and Jackson High School students in order to comparison their initial knowledge and attitudes about water quality issues. To …

Mse News 2010, Department Of Materials Science And Engineering, Michigan Technological University

Department of Materials Science and Engineering Annual Reports

Table of Contents

• MSE Welcomes New Professors
• Professor Emeritus Passes
• Alumni Achieves Milestone
• Hydrogen Storage Research
• Student Accomplishments
• Staff News
• Alumni News

2009-2010 Che Newsletter, Department Of Chemical Engineering, Michigan Technological University

Department of Chemical Engineering Newsletters

Table of Contents

• Department
• Students
• Alumni and Friends
• Faculty and Staff
• Industrial Advisory Board

The Relationship Between Energy Balance Understanding And Measures Of Wellness, Stephanie Fishel-Brown

All Dissertations

Much emphasis on the fight against obesity is placed on education and food labeling, yet very little research has been performed to measure how much people know about energy balance and the relationship of this knowledge to measures of wellness. The primary objective of this study was to determine if college students' (N = 262) performance on an energy balance questionnaire is associated with measures of wellness. Performance on the questionnaire as a whole was not significantly correlated (p > .05) with body mass index (BMI; r_s = .04), percent body fat (r_s = .05), waist to hip ratio …

Carnosine Content And Antioxidant Activity From Poultry Co-Products, Protein Meal And Stressed Poultry Tissues, Paljinder Manhiani

All Dissertations

Four separate studies were conducted to examine carnosine levels and associated antioxidant activity in poultry co-products, in rendered poultry protein meal, in tissues from stressed or non-stressed chickens. In the first study, carnosine was extracted from poultry co-products (head, liver, lungs, tail, gizzard, brain and heart). Liver contained the highest (102.29 mg/gm) level, while brain contained the lowest level of carnosine (0.95 mg/gm). Except brain, all tissue ultrafiltrates (20.87-39.57%) and reconstituted dry powders (5.66- 14.47%) showed thiobarbituric reactive acid species (TBARS) inhibition. Head ultrafiltrate and reconstituted dry powder showed maximum while gizzard showed the minimum metal chelating activity. Free radical …

Production And Characterization Of Novel Air Filtration Media, Elizabeth Skomra

All Dissertations

HEPA and ULPA filtration systems have proven to be an advantageous instrument in removing common contaminants from the air. However, an increased pressure drop due to the build-up of particulates on the filters results in its inevitable decrease in performance. Improving current filtration systems would include increasing collection efficiency all the while either maintaining or reducing the differential pressure drop in order to extend the life of the filter. One method of improving collection efficiency would be viable by increasing the amount of surface area within the filter media by glass fibers because of their inherent quality of being smaller …

The Development Of A Mesenchymal Stem Cell Based Biphasic Osteochondral Tissue Engineered Construct, Scott Maxson

All Dissertations

The ability of human articular cartilage to respond to injury is poor. Once cartilage damage has occurred, an irreversible degenerative process can occur and will often lead to osteoarthritis (OA). An estimated 26.9 million of U.S. adults are affected by OA. Osteochondral grafting is currently used to treat OA and osteochondral defects; however, complications can develop at the donor site and defect area. Osteochondral tissue engineering provides a potential treatment option and alternative to osteochondral grafting. The long term goal of this work is to develop a tissue engineered mesenchymal stem cell (MSC) based osteochondral construct to repair cartilage damage. …