Digital Commons Network^™

Host Preference Profile In An Area Of Eastern Equine Encephalitis (Eee) Virus Transmission In Alabama, Ana Lucia Oliveira

All ETDs from UAB

osteoporosis susceptibility, perceived osteoporosis severity, perceived barriers to

A Nucleolar Specificity Factor For E2f1 Induced Cell Death, Jason Chang Paik

All ETDs from UAB

The E2F family of transcription factors are important regulators of cell proliferation, and are often dysregulated in cancers. One member of the E2F family, E2F1, also has the ability to induce apoptosis; therefore, uncovering how E2F1-induced apoptosis is controlled is of interest in understanding tumorigenesis. To this end, we identified RRP1B as a novel target specifically induced by E2F1. RRP1B expression is specifically upregulated by E2F1 overexpression, but not other E2F family members. RRP1B expression is correlated with E2F1 expression during the cell cycle, and is significantly induced after DNA damage. The minimal RRP1B promoter region responsive to E2F1 was …

The Impact Of Ehr Systems On Physician Productivity And Performance, Anantachai Panjamapirom

All ETDs from UAB

This study examines the relationship between electronic health record (EHR) adoption and physicians' operational productivity and financial performance. The resource-based view of the firm (RBV) was utilized as a theoretical framework to develop and address four hypotheses. Specifically, the first two hypotheses address the impact of EHR adoption status (i.e., electronic- vs. paper-based medical records), and the other two hypotheses focus on the length of EHR adoption (i.e., years of EHR adoption). This cross- sectional study used secondary data from the 2008 physician compensation and production survey conducted by the Medical Group Management Association (MGMA). Multiple linear regression analysis was …

Pneumococcal Vaccine Response And Aging In Human, Saeyoung Park

All ETDs from UAB

Streptococcus pneumoniae is a major human pathogen, especially for young children and older adults. To protect from pneumococcal diseases, 23-valent pneumococcal polysaccharide vaccine (PPV23) has been used clinically since 1983. However, PPV23 is not so effective among old adults with its protective efficacy diminishing with age. We confirmed that young and old adults, who were immunized with PPV23, have comparable pneumococcal polysaccharide (PS) specific IgG levels. Interestingly, we found that old adults had lower IgA and IgM antibody levels than young adults for three serotypes (serotype 14, 18C and 23F). Consistent with the previous results, opsonic capacities of immune sera …

Regulation Of Vascular Smooth Muscle Cell Signaling And Metabolism By Platelet-Derived Growth Factor, Jessica Perez

All ETDs from UAB

Growth factors are important inducers of vascular cell growth whose regulation is altered during the pathogenesis of atherosclerosis. An increase in growth factor and cytokine production, as well as lipid oxidation is observed in cardiovascular disease (CVD) and contributes to altered vascular cell signaling, exacerbated atherosclerotic lesions and heart failure. A change in cellular bioenergetic status due to mitochondrial dysfunction or damage has also been noted in CVD. In this thesis, we first examine cell signaling pathways in vascular smooth muscle cells (VSMC) which are activated in response to platelet-derived growth factor (PDGF) and regulate the cell cycle protein changes …

Dna Replication And Cytokinesis In Drosophila Melanogaster, Anton Svitin

All ETDs from UAB

DNA replication and cytokinesis are two important parts of the cell division process. Our studies address different aspects of both of these processes and potential links between them. One of the best approaches for studying DNA replication in eukaryotes has been an analysis in cell free in vitro systems. The existing cell free replication systems for Drosophila are relatively ineffective. In the first part of this work, we have developed an optimized in vitro system to study DNA replication using early egg extracts of Drosophila. Our studies indicate that this system proves to be an extremely useful tool for a …

The Structural And Functional Studies Of Yeast Nucleotide Exchange Factor Sil1p And Its Complex With Bip, Ming Yan

All ETDs from UAB

Sil1 is an Endoplasmic Reticulum (ER) localized protein. SIL1 was initially identified as a UPR-regulated gene. Later studies show Sil1 functions as the nucleotide exchange factor of ER lumenal Hsp70--Bip by directly interacting with the ATPase domain of Bip. Currently, the molecular mechanism how Sil1 catalyzes nucleotide exchange of Bip is still elusive. In this study we determine the complex structure of yeast S.cerevisia Sil1 and Bip (also called Kar2) ATPase domain at 2.3Å resolution by Single-anomalous dispersion (SAD) methods. The Sil1-Bip complex structure reveals that one sil1 molecule interacts with one Bip ATPase domain molecule to form the complex. …

A Timp2-Armed Conditionally-Replicating Adenovirus For The Treatment Of Ovarian Cancer, Sherry Wei Yang

All ETDs from UAB

Ovarian cancer remains the most lethal gynecological malignancy in the U.S. Conventional therapies have limited therapeutic value due to advanced stage of the disease at diagnosis. Conditionally-replicating adenoviruses (CRAds) are promising, novel anti-cancer agents that are designed to selectively replicate in and lyse tumor cells. In clinical trials, CRAds exhibited limited efficacy thus far. Second generation CRAds are being developed to express a therapeutic protein to further enhance antitumor efficacy. One attractive target in ovarian tumor microenvironment is the matrix metalloproteinases (MMPs) that degrade the extracellular matrix. Thus, tissue inhibitor of metalloproteinase 2 (TIMP2), an endogenous inhibitor of MMPs, is …

Cross-Talk Between Marginal Zone B Cells And Marginal Zone Macrophages, Yuying You

All ETDs from UAB

the test of group differences and the test of covariate. When we force the predictors in the

Radiographic Damage And Functional Disability In African American Patients With Recent-Onset Rheumatoid Arthritis, Jie Zhang

All ETDs from UAB

we adjust for heterskedasticity using a HCCM estimator, we find no significant evidence

Roles Of Nr4a3 In Insulin Sensitivity In Skeletal Muscle, Xiaolin Zhu

All ETDs from UAB

For the past several decades, the prevalence of Type 2 Diabetes and the metabolic syndrome has been increasing. Insulin resistance is the central pathogenic event for these diseases. We previously reported that the NR4A family of orphan nuclear receptors augments insulin sensitivity in adipocytes. We now found that lentiviral mediated NR4A3 hyper-expression increased insulin stimulated glucose transport (ISGT) in C2C12 myocytes while NR4A3 knock-down exhibited opposite effect. We also examined the effects of prostaglandin A2 (PGA2) on insulin action and NR4A3 trans-activation in C2C12 myocytes. PGA2 augmented ISGT and insulin stimulated AKT phosphorylation in C2C12 myocytes. Importantly, PGA2 treatment led …

Weapon Brandishment Among Impoverished Adolescents: A Longitudinal Approach, Alexis Magdalene Inabinet

All ETDs from UAB

Violence has become increasingly more difficult to ignore in the United States, with homicide and suicide rates among American adolescents being the highest in the world. Firearm deaths have skyrocketed, including unintentional injuries, homicides and suicides; American adolescents are more likely to die from gunshot wounds than all natural causes combined. With homicide continuing to rank as the second leading cause of death among youth, research must focus on diminishing weapon brandishment. Based on prior research and a developmental systems approach to violent behavior, this study explores individual influences on adolescent weapon carrying, including perception of danger, hopelessness, and conflict …

The Buffering Effects Of Job Embeddedness On Negative Shocks., James P. Burton, Brooks C. Holtom, Chris J. Sablynski, Terence R. Mitchell, Thomas W. Lee

Faculty Articles, Papers, and Other Scholarship

Unpleasant events are a fact of organizational life. The way in which people respond to such events, however, varies. In the present study, we hypothesized and found that some individuals choose to respond to negative events in ways that helped the organization. Instead of withdrawing in an attempt to “get even” by reducing work outputs, these individuals improved their in-role and extra-role performance. The study examined the role that job embeddedness plays in creating this work enhancement reaction. Specifically, we discovered that on-the-job embeddedness helps reduce the impact of negative shocks on organizational citizenship and overall job performance. The findings …

The Land Use Jurisprudence Of Chief Justice Rehnquist And Justice Stevens: Two Views On Balancing Public And Private Interests In Property, Mark W. Cordes

Faculty Articles, Papers, and Other Scholarship

This three-part article examines the separate and combined legacies of Chief Justice William H. Rehnquist and Justice John Paul Stevens in the area of regulatory takings jurisprudence as applied to land use controls. Part one of the article examines the U.S. Supreme Court’s takings jurisprudence during the tenure of Chief Justice Rehnquist and Justice Stevens, with special attention to their own contributions to regulatory takings analysis. Special focus is given to the 1978 decision in Penn Central Transportation Co. v. New York City. Part two of the article outlines the land use visions presented by Rehnquist and Stevens. In its …

Birmingham's Jewish Women And Social Reform 1880-1980, Kaye Cochran Nail

All ETDs from UAB

Many historians and scholars have argued that Jewish women kept a low profile during periods of southern social reform since the late nineteenth century. This thesis reveals a little known pattern of activism among some Birmingham Jewish women, encompassing many trends of social change over one hundred years, from 1880 to 1980. Nineteenth century Jewish women immigrants and migrants brought to the South a social conscience rooted in the traditions of their Jewish faith. They mentored their daughters, sisters, and neighbors in the ways of community goodwill. During the Progressive Era, their numbers and voices grew in the public sphere, …

Evolution And Genetic Diversity In Streptococcus Pneumoniae, Diana Lee Dupraw

All ETDs from UAB

The relative contributions of point mutations and intergenomic recombination via lateral gene transfer (LGT) determine the population structure and evolutionary style for a given bacterial species. Streptococcus pneumoniae has a weakly clonal population structure; adaptive clonal complexes can be detected; however, these can also be rapidly lost due to the high rate of recombination. To characterize the diversity of pneumococcal isolates in clonal complex, and to elucidate possible mechanisms for the long-term stability of such complexes, 35 serotype 6B strains belonging to a previously identified clonal complex, CC14, were assayed by Comparative Genome Hybridization (CGH) and Multi Locus Sequence Typing …

Traditional Knowlege: Is Perpetual Protection A Good Idea?, J. Janewa Oseitutu

Faculty Publications

Most of the international dialogue about traditional knowledge has taken place within the context of an intellectual property framework with the World Intellectual Property Organization (WIPO) as the primary facilitator of the discussion. Following more than a decade of dialogue, the WIPO Intergovernmental Committee on Intellectual Property and Genetic Resources, Traditional Knowledge and Folklore (WIPO IGC) has been given until the Fall of 2011 to come up with something concrete. Due to the intersection between traditional knowledge and intellectual property, the resulting text is likely to be a significant development for international intellectual property law.

Developing countries have long advocated …

Commercial Space, Diane Howard

Publications

This chapter assesses trends and developments in the commercial space sector, which includes manufacturers of space hardware such as rockets and satellite components, providers of space-based information such as telecommunications and remote sensing, and service operators for space launches. Also covered in this chapter are the developments related to the nascent space tourism industry, as well as the relationship between commercial operators and the public sector.

Assessing The Oral Proficiency Of Adult Learners, “Heritage” And “Native” Speakers Using The Ilr Descriptions And Actfl Proficiency Guidelines: Considering The Challenges, Cynthia L. Martin

Russian Language Journal

The ILR Descriptions – Speaking and the ACTFL Proficiency Guidelines – Speaking trace their genesis to an oral proficiency assessment system first developed at the Foreign Service Institute in the 1950s to assess “foreign language users’ abilities according to a consistent scale.” The original purpose was clearly aimed at assessing the abilities of non-­‐‑native, non-­‐‑heritage adult foreign language learners, and this genesis is still reflected in the current ILR Descriptions and the ACTFL Guidelines. However, tools based on these descriptions/guidelines are increasingly being used to assess the abilities of language users who are not what we would consider to be …

Heritage Is Not Enough: The Changing Demographics Of The Chinese Language Field In The United States, Scott Mcginnis

Russian Language Journal

In a series of articles beginning in 1994, Richard Brecht and the late A. Ronald Walton first identified four sectors in the United States as sources for providing national capacity in the Less Commonly Taught Languages (LCTLs).

Nonlinear Analysis Of Ambulatory Activity Patterns In Community-Dwelling Older Adults, James T. Cavanaugh, Naomi Kochi, Nikolaos Stergiou

Journal Articles

Background The natural ambulatory activity patterns of older adults are not well understood. User-worn monitors illuminate patterns of ambulatory activity and generate data suitable for analysis using measures derived from nonlinear dynamics.

MethodsAmbulatory activity data were collected continuously from 157 community-dwelling older adults for 2 weeks. Participants were separated post hoc into groups based on the mean number of steps per day: highly active (steps ≥ 10,000), moderately active (5,000 ≤ steps < 10,000 steps), and inactive (steps

Results All groups displayed patterns of fluctuating step count values containing complex temporal structure. DFA, ER, and ApEn parameter values increased monotonically and significantly with increasing activity …

Anterior Cruciate Ligament Reconstruction Results In Alterations In Gait Variability, Constantina O. Moraiti, Nikolaos Stergiou, Haris S. Vasiliadis, Eustathios Motsis, Anastasios D. Georgoulis

Journal Articles

Introduction: The temporal structure of gait variability has shown that healthy human gait exhibits long- range correlations and deterministic properties which allow the neuromuscular system to be flexible and adaptable to stresses. Pathology results in deterioration of these properties. We examined structure of gait variability after ACL reconstruction with either BPTB or quadrupled ST/G tendon autografts.

Methods: Six patients with BPTB reconstruction, six with ST/G reconstruction and six healthy controls walked on a treadmill at their self-selected pace. Two minutes of continuous kinematic data were recorded with a 6-camera optoelectronic system. The nonlinear measure of the largest Lyapunov …

Lyapunov Exponent And Surrogation Analysis Of Patterns Of Variability: Profiles In New Walkers With And Without Down Syndrome, Beth A. Smith, Nikolaos Stergiou, Beverly D. Ulrich

Journal Articles

In previous studies we found that preadolescents with Down syndrome (DS) produce higher amounts of variability (Smith et al., 2007) and larger Lyapunov exponent (LyE) values (indicating more instability) during walking than their peers with typical development (TD) (Buzzi & Ulrich, 2004). Here we use nonlinear methods to examine the patterns that characterize gait variability as it emerges, in toddlers with TD and with DS, rather than after years of practice. We calculated Lyapunov exponent (LyE) values to assess stability of leg trajectories. We also tested the use of 3 algorithms for surrogation analysis to investigate mathematical periodicity of toddlers’ …

Patient Attitudes Regarding Consent For Emergency Department Computed Tomography Scans, Michael Weigner Md, Hilary Basham Do, Kate M. Dewar Do, Valerie A. Rupp Rn, Bsn, Marna R. Greenburg Do, Mph

Department of Emergency Medicine

No abstract provided.

Cancer In Louisiana: 2002-2006, Volume 24, Louisiana Tumor Registry, Patricia A. Andrews, Mei-Chin Hsieh, Brent Mumphrey, Lisa Pareti, Mary Namiak, Beth A. Schmidt, Edward S. Peters, Xiao-Cheng Wu, Vivien W. Chen

Policy & Position Papers

Mission:

To collect and report complete, high-quality, and timely population-based cancer data in Louisiana to support cancer research, control, and prevention.

Vision:

To reduce suffering and death from cancer using information collected by the Louisiana Tumor Registry.

History:

Cancer registration in Louisiana began in 1947 at the Charity Hospital Tumor Registry in New Orleans. In 1974, as part of its Surveillance, Epidemiology and End Results (SEER) Program, the National Cancer Institute provided funds for a population-based cancer incidence and survival registry covering Jefferson, Orleans, and St. Bernard parishes. Five years later, the Louisiana Tumor Registry (LTR) was transferred to the …

Lsuhsc Facilities Biweekly Update: January 2010, Lsuhsc Property And Facilities Management

LSUHSC Facilities Biweekly Updates: 2010

LSUHSC Facilities Biweekly Updates from January 15 and 29, 2010.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Faculty Publications 2009, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 806 publications.

Fraternity Member's Perceptions Of The Benefits And Limitations Of On-Campus, University-Owned Fraternity Housing And Off-Campus, Chapter-Owned Fraternity Housing, Erin Therese Morettes

Masters Theses

This purpose of this qualitative study was to explore the perceptions of fraternity members in relation to their experience living in off-campus, chapter-owned fraternity housing and on-campus, university-owned fraternity housing. The fraternity resided in an off-campus chapter house for several decades and recently relocated to a housing facility provided by the university. General theme emerging from participants' responses were critically evaluated based on prior research. The findings of this study suggested that the participant's perceived on-campus housing to be an overall better living environment than off-campus housing in the areas of academic success, residential community, and student persistence and engagement. …

Technical Efficiency Of Farmers In Ethiopia: A Stochastic Production Frontier Approach, Askal Ayalew Ali

Masters Theses

This study is to investigate the farmer's efficiency in Ethiopia. The stochastic production function is applied to estimate the technical efficiency of farmers. Using 2006 survey data conducted by the World Bank in collaboration with Ethiopian Economic Policy Research Institute, shows that farmers produce under the production frontier, and the average technical efficiency of the farmers is 62.4 percent. Variation in efficiency comes from many factors, however, this study focuses on extension program participation, education, and land ownership. Lack of extension program and education cause inefficiencies of 59.8 percent and 60.21 percent respectively. Land ownership is found to have mixed …

Frederick Douglass: The Man, His Words And His Legacy As A Master Rhetorician, Tameka Lashean Johnson

Masters Theses

This thesis offers a synthesis of existing research regarding not only Frederick Douglass· literacy in the slave narrative genre. but also an Aristotelian analysis of his Narrative of the Life of Frederick Douglass, An American Slave, Written by Himself (1845). Dougiass' challenge is to reach an audience not only of abolitionists, but also of free blacks who are more grounded in the vernacular tradition than equal to his own considerable skills in rhetorical literary construction.

My research addresses the problem that existing research inadequately considers the degree to which Douglass uses his awareness of the audience and employs rhetoric in …