Digital Commons Network^™

Apoptosis Initiation And Angiogenesis Inhibition: Melanoma Targets For Nanosecond Pulsed Electric Fields, Xinhua Chen, Juergen F. Kolb, R. James Swanson, Karl H. Schoenbach, Stephen J. Beebe

Bioelectrics Publications

Many effective anti-cancer strategies target apoptosis and angiogenesis mechanisms. Applications of non-ionizing, nanosecond pulsed electric fields (nsPEFs) induce apoptosis in vitro and eliminate cancer in vivo; however in vivo mechanisms require closer analysis. These studies investigate nsPEF-induced apoptosis and anti-angiogenesis examined by fluorescent microscopy, immunoblots, and morphology. Six hours after treatment with one hundred 300 ns pulses at 40 kV/cm, cells transiently expressed active caspases indicating that caspase-mediated mechanisms. Three hours after treatment transient peaks in Histone 2AX phosphorylation coincided with terminal deoxynucleotidyl transferase dUTP nick end labeling positive cells and pyknotic nuclei, suggesting caspase-independent mechanisms on nuclei/DNA. Large …

Developing Performance Indicators To Evaluate The Management Effectiveness Of The Massachusetts Ocean Management Plan, Jack Wiggin, Dan Hellin, Kristin Uiterwyk, Robert E. Bowen, Prassede Vella, John Weber, Stephanie Moura, Nicholas Napoli, Kim Starbuck, Howard Krum

Urban Harbors Institute Publications

In June 2009, the Massachusetts Executive Office of Energy and Environmental Affairs (EEA) released its draft Massachusetts Ocean Management Plan (draft plan) for public comment. The plan is required by the Oceans Act of 2008 to, among other things, be adaptive to evolving knowledge and understanding of the ocean environment. The plan’s Science Framework establishes a blueprint for future research and data acquisition and ensuring that the plan evolves and its management measures adapt to this new and enhanced information. As stated in Chapter 5 of the draft plan, an important part of the science framework is the development and …

Disrupted But Not Destroyed: Fictive-Kinship Networks Among Black Educators In Post-Katrina New Orleans, Daniella Ann Cook

Faculty Publications

Drawing on Adkins’ (1997) notion of reform as colonization and using ethnographic data from African American teachers in New Orleans after Hurricane Katrina, this article discusses how black educators’ fictive-kinship (Fordham 1996, Chatters, Taylor, and Jayadoky 1994, Stack 1976) networks have been altered in the changing landscape of reform. I argue that the importance of fictive-kinship relationships among educators and students was ignored in school-reform efforts in post-Katrina New Orleans. Post-Katrina school reforms disrupted, but did not destroy, these fictive-kinship networks. I discuss three themes: (1) fictive-kinship networks created before Katrina cultivated an environment centered on cooperation, collaboration, and solidarity, …

Protecting Water Resources And Managing Stormwater: A Bird's Eye View For New Hampshire Communities, Julia Peterson, Amanda Stone, James J. Houle

UNH Stormwater Center

No abstract provided.

Fungi-Derived Natural Products With Binding Affinities For Human Opioid Or Cannabinoid Receptors, Jiangtao Gao

Electronic Theses and Dissertations

Both opioid and cannabinoid receptors belong to the large superfamily of GPCRs and play an important role in a variety of processes including pain, craving, neurodegeneration, metabolic regulation, anxiety and immune function. Therefore, recent advances and discoveries in opioid and cannabinoid receptors have paved the way for a very exciting future for opioid and cannabinoid receptors-based therapies to potentially treat a variety of conditions. However, the growing realizations of the complexity of these two receptors regulation in physiological and pathological conditions have discouraged the development of new therapeutics. So, it is important for us to identify new chemical scaffolds which …

Pharmacological Reversal Of Cognitive Bias In The Chick Anxiety-Depression Continuum Model, Kristen Anne Hymel

Electronic Theses and Dissertations

Cognitive bias is a phenomenon that presents in clinical populations where anxious individuals tend to adopt a more pessimistic interpretation of ambiguous aversive stimuli and depressed individuals not only tend to adopt a more pessimistic interpretation of ambiguous aversive stimuli, but also a less optimistic interpretation of ambiguous appetitive stimuli. Such biases have also been pharmacologically reversed in clinical trials. To measure cognitive bias in the chick anxiety-depression continuum model, chicks exposed to an isolation stressor of 5 min to induce an anxiety-like or 60 min to induce a depressive-like state were then tested in a straight alley maze to …

Missouri County Profiles: Tobacco-Related Disparities In Missouri, Center For Public Health Systems Science, Amy Sorg, Sarah Shelton, Jenine Harris

Center for Public Health Systems Science

This report identified tobacco-related disparities in Missouri through examining tobacco use, secondhand smoke exposure, and smoking cessation based on demographic, socioeconomic and personal characteristics. Findings from this report can be used to better understand differences in tobacco use among specific populations across the state. Addressing groups that are bearing a disproportionate burden from tobacco use will contribute to comprehensive tobacco control efforts, reducing overall tobacco use and making Missouri a healthier place to live.

Public School District: Baseline Policy Assessment, Center For Public Health Systems Science, Sarah Moreland-Russell, Bobbi Carothers, Laura Brossart

Center for Public Health Systems Science

This report from the CPPW project presents the findings from a baseline assessment of tobacco policies in all St. Louis County public school districts. These findings are provided to stakeholders to help inform intervention efforts for strengthening school tobacco policies.

The Oregon Profile: Advancing The Best Practices, Center For Public Health Systems Science, Max Bryant, Stephanie Herbers, Lana Wald

Center for Public Health Systems Science

This Oregon case study/profile presents findings from an evaluation that aimed to understand how evidence-based guidelines were disseminated, adopted, and used within state tobacco control programs.

Core Data Set, Center For Public Health Systems Science, Julianne Cyr

Center for Public Health Systems Science

This core data set is based on the evaluation questions identified by the Center for Tobacco Policy Research (CTPR), MFH, and grantees. Each grantee was responsible for submitting these data to CTPR through their web-based data collection system, the Tobacco Initiative Evaluation System (TIES), on a monthly and quarterly basis.

Model Pratice Building: Baseline Evaluation Findings, Center For Public Health Systems Science, Virginia Houmes, Nicole Leacock, Nancy Mueller

Center for Public Health Systems Science

This report presents the key findings based on data from baseline qualitative interviews and retrospective data collected from December 2007 to September 2009. The evaluation found grantees reported much success implementing their project. In particular, increasing project visibility and buy-in within their communities were areas where grantees felt they made significant progress.

Point Of Sale Advertising: Baseline Policy Assessment, Center For Public Health Systems Science, Sarah Moreland-Russell, Julianne Cyr, Doneisha Snider

Center for Public Health Systems Science

This report provides an overview of the retail environment and point of sale advertising in a sample of St. Louis County tobacco retailers. These findings were provided to the St. Louis County Department of Health and other CPPW stakeholders, including the Leadership Team, to help inform intervention efforts for strengthening point of sale policies.

Best Practices User Guide: Youth Engagement, Center For Public Health Systems Science, Sarah Moreland-Russell, Laura Brossart, Sarah Schell, Erin K. Black, Anneke Mohr, Kendre E. Israel, Nancy B. Mueller, Douglas A. Luke

Center for Public Health Systems Science

This user guide, funded by the Centers for Disease Control and Prevention, focuses on the role youth play in advancing policy as part of a comprehensive tobacco control program. This guide will provide tobacco control program managers with information on the best practices for engaging youth as a part of a comprehensive program. Youth involvement can lead to important policy and social norm changes, and advance the fight against pro-tobacco influences.

Annual Report 2009, Dexia

Documents

No abstract provided.

Athletic Trainers' Comfort And Competence In Addressing Psychological Issues Of Athletes, Gina Marie Biviano

Master's Theses

The purpose of this descriptive study was to determine the frequency with which athletic trainers address certain psychological issues related to injury and non-injury-related psychological issues with their student-athletes, their comfort and competence level with these discussions, and referral patterns to other mental health professionals. An electronic survey was adapted from Mann, Grana, Indelicato, O'Neill, and George (2007) and administered through www.surveymonkey.com ®. A random sample of 1,000 athletic trainers (ATs) who were members of the NATA were invited to participate, which yielded a response rate of 31.1%. More than half (n=170, 55.7%) of all subjects had completed 1-2 psychology …

An Investigation Of Co-Rumination On Stress Levels And Mood, Anthony Thomas Holguin

Master's Theses

A recently defined type of social support known as co-rumination, the process of sharing negative thoughts, feelings, or ideas with a supporter that triggers the supporter to share similar thoughts and feelings of negativity, is believed to generate both a sense of bonding and an exacerbated stress response. The present study examined the impact of co-rumination on stress levels and mood states in men and women. Participants were assigned to one of three conditions (a control condition, a stress condition without a co-ruminator, or a stress condition with a co-ruminator), which depended on both the timeslot for which a participant …

A Qualitative Study Of The Motivations Of Runners In A Cause-Based Marathon-Training Program, Karin Ann Jeffery

Master's Theses

In the late 1980s, the nonprofit sector within the United States introduced a new philanthropic paradigm, the cause-based fundraising endurance-training program. Participants in such programs raise funds for a charitable cause and, in return, are coached to complete a marathon or other endurance event.

Cause-based training programs frequently use recruitment messages implying that the cause provides a guaranteed motivation to exercise. However, little research has examined this assumption. Therefore, the purpose of this study was to qualitatively research the motivations of runners in a charitable cause-based marathon-training program, particularly the relationship between the cause and the participants' motivations to train …

Phenomenological Examination Of Depression In Female Collegiate Athletes, Alyson Jones

Master's Theses

Collegiate athletes may be at an increased risk of depression due to the pressure and stress they face. This risk is of great concern because their health, safety, and sport performance may all be affected. In addition, collegiate athletes are more likely to turn to maladaptive coping behaviors and less likely to seek help for mental health struggles than other populations. It has been suggested that a greater understanding of personal experiences would be helpful in increasing awareness and improving treatment. Therefore, the purpose of the current study was to explore the lived experience of depression in female collegiate athletes. …

Stress And Coping Due To Global Virtual Teamwork, Irina Alexandra Shargo

Master's Theses

Global virtual teams (GVTs), project teams composed of individuals working across time and space via electronic platforms, are becoming increasingly commonplace in most organizations today and in global organizations specifically. The aim of this study was to explore issues employees experienced when working virtually in GVTs in order to develop recommendations for addressing those issues and encouraging solutions to benefit the employees, teams, and organizations as a whole. This paper presents findings from 27 interviews on coping and strain reactions to participation in intercultural computer-mediated communication (CMC). Analyses of the qualitative data suggest that intercultural training were helpful in reducing …

A Qualitative Analysis Of Motivation Of Elite Female Triathletes, Alexis Smith

Master's Theses

The multidimensional theoretical framework of Self-Determination

Theory (SDT) has gained prominence in the sport and exercise field to assist in

understanding human motivation. While there is extensive research on motivation

of recreational athletes, no study has qualitatively examined the motivation of elite

female triathletes. The primary purpose of this research was to determine how

motivation to train and compete is maintained at the elite level using the Basic

Needs Theory. The participants were eight elite female triathletes who competed

in International Triathlon Union (ITU) draft-legal Olympic distance, Half-

Ironman, and Ironman triathlons. Results from the semi-structured interviews

revealed that challenges, …

The Effects Of Bordetella Pertussis On Dendritic Cell Imprinting Of Cd4+ T Cells, Sana Waheed

Master's Theses

Bordetella pertussis is an aerobic gram-negative bacterial pathogen that causes the human respiratory disease whooping cough. Despite widespread vaccination, whooping cough is reemerging due to decreased vaccine efficacy. One of the hallmarks of infection is lymphocytosis, which is induced by the pertussis toxin. Lymphocytes such as CD4+ T cells navigate to infected tissues through surface-trafficking molecules, which are imprinted during their interaction with tissue-associated dendritic cells. We hypothesized that the pertussis toxin affects the imprinting process resulting in altered expression of trafficking molecules on CD4+ T cells. We tested this hypothesis using a mouse model of infection. Imprinting levels on …

Planet Building: A Case Study Of Corporate Sustainability For A Globalized World, Darci L. Arnold

Master's Theses

With the increasing complexities of a globalized 21st-century world, the growing power of industry clusters makes corporations important actors in designing sustainable development strategies. This thesis presents an applied case study at CB Richard Ellis (CBRE) as the company designed and launched its award-winning Sensible Sustainability platform. The research was conducted to determine how a large multinational company could create a business case for sustainability, and the results illustrate that value exists for firms engaged in sustainability initiatives.

CBRE's initial no-cost and low-cost activities resulted in increased operational efficiencies and lower costs. Over the course of the research period, the …

Uncultivated Environmental Tm7 Model To Study Human Disease-Associated Tm7 Bacteria, David Barton

Master's Theses

The TM7 bacterial phylum has no cultivated species and includes members that span a broad range of environmental and human habitats, some of which are associated with human periodontitis. In this project, activated wastewater TM7 bacteria were analyzed and their relatedness compared to human-associated TM7 bacteria for the long-term goal of using an environmental TM7 to better understand TM7 pathogenesis in humans. DNA was extracted from activated wastewater and PCR amplified using TM7 16S rRNA gene- specific primers. The ~1,170 base pair PCR products were then cloned and sequenced. DNA sequencing and phylogenetic analysis identified environmental TM7 clones with high …

Nature And Culture Of Strawberry Farmers On California's Central Coast: A Case Study, James D'Albora

Master's Theses

As United States (US) agriculture continues to experience declines in farms and farmers, the organic sector steadily increases in size. Furthermore, survey data show that almost half of the new organic farmers are not conventional farmers who are transitioning to organic, but urban dwellers who have migrated to a new rural setting. Migration theory is used to look at non-economic influences that may be driving these new organic farmers. Through in-depth interviews with 11 organic and conventional small-to-larger strawberry farmers on California's central coast, this study identifies two distinct cultures that now inhabit the agricultural industry of this area. Two …

Implementation Of Risk Management In The Medical Device Industry, Rachelo Dumbrique

Master's Theses

This study looks at the implementation and effectiveness of risk management (RM) activities in the medical device industry. An online survey was distributed to medical device professionals who were asked to identify RM-related activities performed during the device life cycle. RM activities and techniques included Establishing Risk Acceptance Criteria, Hazard Identification, Human Factors/Usability, Fault Tree Analysis (FTA), Design Failure Mode and Effects Analysis (DFMEA), Process Failure Mode and Effects Analysis (PFMEA), Hazard and Operability Study (HAZOP), Hazard Analysis and Critical Control Point (HACCP), Risk Benefit Analysis, and Risk Assessment of Customer Complaint. Devices were identified by type (therapeutic, surgical/clinical tools, …

Learning Financial Literacy In The Family, Maria Paula Calamato

Master's Theses

This thesis examines the relationship between parental involvement and student level of financial literacy. Past studies have established that children's financial behavior and attitudes are shaped by their parents who pass on norms and social values to them. Using a convenience sample of 108 undergraduate students at a local state university, the present research tested whether children who had higher levels of financial literacy had parents who had taught them financial knowledge. The results of the test show that students' level of financial literacy is not significantly related to parental involvement.

Native Americans In The San Francisco Bay Area: Patterns In Ancient Teeth, Palimpsests Of Behavior, Dave Grant

Master's Theses

NATIVE AMERICANS IN THE SAN FRANCISCO BAY AREA:

PATTERNS IN ANCIENT TEETH; PALIMPSESTS OF BEHAVIOR

by Dave Grant

In analyzing burial populations from seven sites in the Santa Clara Valley, patterns on teeth were found that did not conform to the flat normative wear explanation. This study attempts to expand upon the seminal work of Molnar (1968), Hinton (1981), and Keiser (2001a, 2001b) and to propose a definitional refinement of wear patterns found on teeth from populations in Central California. Flat normative wear was present. In addition, four additional distinct wear patterns were found. Wear patterns include slants and scoops …

Establishing Community And Research Trust In Public Health Using Service-Oriented Architecture (Soa), Juanita Hun Mah

Master's Theses

One of the major challenges of community-based research is recruitment of community members who will participate in clinical trials, continue for the duration of the trial, and provide accurate sensitive personal information. This challenge can be overcome by establishing greater trust between researchers and communities.

This study focuses on a system to address trust issues between the San Jose Hispanic community and clinical researchers. It describes a methodology for translating non-functional wants and needs into technical requirements that are used as input to a Service-Oriented Architecture (SOA) approach to design a solution. Unlike a typical SOA that is derived from …

Psychological And Behavioral Correlates Of Freshman Bmi Change, Rebecca Kathleen Jackl

Master's Theses

This observational research examines body-mass-index (BMI) changes in multicultural freshmen attending a large public urban university. It explores psychological and behavioral factors associated with gains and loss in BMI. The study utilizes an online survey distributed in September 2008 and again in December 2008. All3,509 freshmen were eligible to participate. Initial survey response rate was 29%; in December, 40% of initial respondents completed both surveys (n = 355). A subset of respondents (n = 65) had height, weight, and body composition measured to compare to self-reported data. Mean BMI change was a gain of 0.23 units, but those who gained …

Absence Of Keratin 8 Is Associated With Marked Colon Mast Cell Infiltration, Diana El Bezri Nasser

Master's Theses

Patients with inflammatory bowel disease (IBD) have increased numbers of numbers of intestinal mast cells (MCs). Chymases and tryptases are mast-cell-specific proteases (MCPs) that are reliable indicators of MC degranulation. The role of MCs in the pathophysiology of IBD is poorly understood, and it is unclear whether MCs play a role in patients or in experimental models of IBD. Furthermore, MCs have been characterized only in chemically induced models of colitis. In this study, we characterize MCs in inflamed colons of keratin 8 knock-out mice (K8-/-), a spontaneous model of colitis with primarily an epithelial cell defect. We used histologic, …