Digital Commons Network^™

Temozolomide And Bevacizumab Therapy In Advanced Hemangiopericytoma/ Solitary Fibrous Tumor, Min S. Park

Dissertations and Theses (Open Access)

Tumors comprising the spectrum of hemangiopericytoma/ malignant solitary fibrous tumor (HPC/SFT) are thought to arise from fibroblasts and represent a small subset of soft tissue sarcomas. Surgery is typically the treatment of choice for localized disease, with reported 10-year overall survival rates of 54-89% after complete surgical resection. However, for the approximately 20% of HPC/SFT patients who eventually develop local recurrences and/or distant metastases, options for effective treatment are limited and are poorly defined. Alternative therapeutic options are therefore needed for improved palliation and disease control. We hypothesize that HPC/SFT are a spectrum of soft tissue tumors with unique clinical, …

Mcam/Muc18 Regulates Melanoma Progression By Modulating The Expression Of Id-1, Maya Zigler

Dissertations and Theses (Open Access)

The acquisition of the metastatic melanoma phenotype is associated with increased expression of the melanoma cell adhesion molecule MCAM/MUC18 (CD146). However, the mechanism by which MUC18 contributes to melanoma metastasis remains unclear. Herein, we stably silenced MUC18 expression utilizing lentivirus-incorporated small hairpin RNA, in two metastatic melanoma cell lines, A375SM and C8161, and conducted cDNA microarray analysis. We identified and validated that the transcriptional regulator, Inhibitor of DNA Binding-1 (Id-1), previously shown to function as an oncogene in several malignancies, was downregulated by 5.6-fold following MUC18 silencing. Additionally, we found that MUC18 regulated Id-1 expression at the transcriptional level via …

Is Punishment Relevant After All? A Prescription For Informing Juries Of The Consequences Of Conviction, Jeffrey Bellin

Vanderbilt Law School Faculty Publications

The American jury, once heralded as "the great corrective of law in its actual administration," has suffered numerous setbacks in the modern era. As a result, jurors have largely become bystanders in a criminal justice system that relies on increasingly severe punishments to incarcerate tens of thousands of offenders each year. The overwhelming majority of cases are resolved short of trial and, even when trials occur, jurors are instructed to find only the facts necessary for legal guilt. Apart from this narrow task, jurors need not, in the eyes of the law, concern themselves with whether a conviction and subsequent …

4-H Leaders: Factors That Affect Their Persistence In The 4-H Youth Development Program, Regina Schinker

Dissertations

For over one hundred years, the 4-H youth development program has educated millions of children across the country in a variety of programs; from livestock husbandry to leadership skills. Like all programs that have endured, 4-H has had to adjust its focus as society has changed. One area in the 4-H program that has not changed is the heavy reliance on adult volunteer leaders to deliver the educational programs to 4-H youth. Because of the reliance on volunteer 4-H leaders, 4-H professionals and extension office staff are concerned about issues of retention.

The case study examines two related issues: First, …

The Effects Of A Course On Statistical Literacy Upon Students' Challenges To Statistical Claims Made In The Media, Rose Martinez-Dawson

All Dissertations

Statistical literacy involves critically evaluating and questioning statistics encountered in everyday life. The purpose of this study was to evaluate students' questions (challenges) concerning statistics encountered in everyday life and how these challenges differed before and after taking an undergraduate statistics course, entitled Statistics in Everyday Life 200 (SIEL), which focused on statistical literacy. One hundred forty-four students were given three media articles to indicate questions they had concerning statistics cited in the articles and explain why these questions were important to ask. Students' responses were categorized based on the topic and were assessed using the Statistics Literacy Components Rubric …

Debugging Techniques For Locating Defects In Software Architectures, Kyungsoo Im

All Dissertations

The explicit design of the architecture for a software product is a well established part of development projects. As the software architecture descriptions are becoming larger and more complex, there is more likelihood of defects being present in the software architecture. Studies have shown that a defect in the software architecture that has propagated to the development phase is very expensive to fix. To prevent such propagation of defects, this research proposes to provide debugging support for software architecture design.
Debugging is commonly used in programming languages to effectively find the cause of a failure and locate the error to …

An Investigation Of Metaheuristics Using Path- Relinking On The Quadratic Assignment Problem, Thashika Rupasinghe

All Dissertations

The Quadratic Assignment Problem (QAP) is a widely researched, yet complex, combinatorial optimization problem that is applicable in modeling many real-world problems. Specifically, many optimization problems are formulated as QAPs. To resolve QAPs, the recent trends have been to use metaheuristics rather than exact or heuristic methods, and many researchers have found that the use of hybrid metaheuristics is actually more effective. A newly proposed hybrid metaheuristic is path relinking (PR), which is used to generate solutions by combining two or more reference solutions. In this dissertation, we investigated these diversification and intensification mechanisms using QAP. To satisfy the extensive …

Packet Error Rate Predictive Model For Sensor Radios On Fast Rotating Structures, Lei Tang

All Dissertations

Wireless sensing technologies have raised widespread interests in the applications for monitoring fast rotating or moving machinery structures in manufacturing environments. Over the past five years, a few wireless sensor systems have been implemented and proven to feasibly work under fast rotation conditions. However, few of these studies evaluated data transmission performance of the wireless communication systems. Although the manufacturing environments are known to be harsh for wireless communication, in many cases, an excellent data throughput is critical for such systems. Conventional statistical methods for studying wireless communication channels are not sufficient in this specific field.
This dissertation presents systematic …

Deadly Discourse: Negotiating Bureaucratic Consensus For The Final Solution Through Organizational And Technical Communication, Mark Ward Sr

All Dissertations

The Final Solution was largely accomplished in eleven months; its executors, the Nazi SS, faced the constant problem that as killing and plunder escalated so did internal competition and corruption; and the SS deliberately cultivated an intensely competitive and polycratic organizational culture that fit the Nazi worldview of life-as-struggle. By tying these three observations together—that the Final Solution was punctuated, entropic, and polycratic—the problem arises: How did SS organizational communications manage, just barely long enough, to create a temporary social reality that regulated the internal contradictions of its genocidal project and fragmented bureaucracy? This study contends that through its organizational …

Approximation Algorithms For Network Interdiction And Fortification Problems, Adam Whitley

All Dissertations

This dissertation discusses algorithms and results on several NP–hard graph problems which can all be classified as network interdiction and network fortification problems.
The first problem studied, the multiway cut problem, is a generalization of the well–studied s–t min–cut problem, in which we must remove a minimum–cost subset of edges from a graph so that r > 2 designated terminals become disconnected from each other. We investigate an approximation algorithm for general r with a relatively simple analysis guaranteeing an approximation ratio ≤ 1.4647 − epsilon_r, where epsilon_r is a small constant related to the number of terminals …

Predictive Energy Management In Connected Vehicles: Utilizing Route Information Preview For Energy Saving, Chen Zhang

All Dissertations

This dissertation formulates algorithms that use preview information of road terrain and traffic flow for reducing energy use and emissions of modern vehicles with conventional or hybrid powertrains. Energy crisis, long term energy deficit, and more restrictive environmental protection policies require developing more efficient and cleaner vehicle powertrain systems. An alternative to making advanced technology engines or electrifying the vehicle powertrain is utilizing ambient terrain and traffic information in the energy management of vehicles, a topic which has not been emphasized in the past. Today's advances in vehicular telematics and advances in GIS (Geographic Information System), GPS (Global Positioning Systems), …

A Study Of African American Forest Landowners In South Carolina: Implications For Land Ethic And Forest Stewardship, Keenan Adams

All Dissertations

African Americans account for a significant proportion of South Carolina`s
population but reportedly own a disproportionally smaller amount of land. Research indicates that landowners who hold significant sources of sustainable wealth and power can dramatically increase their quality of life and ultimately that of their communities. Current land loss trends for African Americans are increasing at an alarming rate, which may have larger social implications for this traditionally underserved population. The remaining African American landowners are a rapidly declining group, due to an assortment of factors (e.g., age, heirs property). Understanding the experiences of the residual African American forest landowners …

A Structural Equation Model Of Leader Attributes In The Principalship, Amy Young

All Dissertations

To become a principal in South Carolina, one must have teaching experience, a master's degree, and certification in the area of primary responsibility. Beyond what is learned through coursework, internships, and certification tests, what intangible factors critically influence a principal's actions and decisions, and (ultimately) success? Trait theory begs the question of whether any of these criteria truly influences the decisions and actions of the principalship. Are there interactive traits of leadership that describe the behaviors of school principals? This study revisits trait theory by examining leader attributes relative to the principalship of South Carolina public schools. This study replicates, …

Utilizing Copper(I) Catalyzed Azide-Alkyne Huisgen 1,3-Dipolar Cycloaddition For The Surface Modification Of Colloidal Particles With Electroactive And Emissive Moieties, Parul Rungta

All Dissertations

The development of charge–transporting and fluorescing colloidal particles that can be directly printed into electroluminescent devices may result in a broad impact on the use of electrical energy for illumination. The objective of this work was to design and synthesize electroactive & fluorescing colloidal particles; establish their optical, electronic, and thermodynamic properties; and transition them into a device format for potential applications. The original intended application of this work was to build “better” colloidally–based organic light emitting devices (OLEDs) by creating functional particles with superior electrical and optical performance relative to commercially available technologies, but through the course of the …

The Impact Of University Housing Construction Type On Psychosocial Development Of First-Year Students, Justin Owens

All Dissertations

The purpose of this study was to explore the impact of university housing construction type on psychosocial development of first-year students. Data were collected at a large, four-year, public, research university in the Southeast using the Student Development Task and Lifestyle Assessment. The population considered for this study consisted of first-year, traditionally-aged students living on campus within university housing at the research site for the spring of 2010. The study only considered students within three residential living environments: (a) modified-traditional residence halls, (b) adjoining suite style residence halls, and (c) super-suite style residence halls.
Multivariate analysis of covariance and analysis …

Development And Characterization Of Novel Sub-Coatings With Polymorphic Brookite Titania Nanoparticles: Enhanced Uv/Vis Photocatalytic Antibacterial And Anticancer Properties, Donna Weinbrenner

All Dissertations

ABSTRACT
Nosocomial and community infections and biofilm formation from bacteria has increased significantly through adaptation combined with overuse of broad spectrum antibiotics. Because the world population continues to escalate, hospitals and long-term managed care will also escalate, thereby increasing transmission of infections, lowering patients' quality of health. Another disease on the rise throughout the world is skin cancer. A treatment modality that would cause less deleterious effects on the patient would be ideal. These two seemingly different issues could be solved with one product. First an inexpensive, safe, and non-selective antimicrobial surface coating would enhance the hospital arena and a …

Simulating The Evolution Of Recruitment Behavior In Foraging Ants, Kenneth Letendre

Computer Science ETDs

Spatial heterogeneity in the distribution of food is an important determinant of species' optimal foraging strategies, and of the dynamics of populations and communities. In order to explore the interaction of food heterogeneity and colony size in their effects on the behavior of foraging ant colonies, we built agent-based models of the foraging and recruitment behavior of harvester ants of the genus Pogonomyrmex. We optimized the behavior of these models using genetic algorithms over a variety of food distributions and colony sizes, and validated their behavior by comparison with data collected on harvester ants foraging for seeds in the field. …

The Preservation Of Archaeological Records And Photographs, Kelli Bacon

Department of Anthropology: Theses and Student Research

Substantive and organized research about archaeological records and photograph preservation, especially those written by and for archaeologists, are few. Although the Society for American Archaeology has a code of ethics regarding archaeological records preservation, and the federal government has regulations regarding the care and preservation of federally owned archaeological collections, there is a lack of resources. This is detrimental to archaeology because not all archaeologists, given the maturity of the discipline, understand how important it is to preserve archaeological records and photographs. Without documents and photographs from projects, irreplaceable information is lost. This thesis adds to the existing body of …

Statistics For National Development, Sani I. Doguwa

CBN Journal of Applied Statistics (JAS)

Good statistics that has been collected according to agreed good practices are crucial as a tool for development. Gross domestic product (GDP) and other measures of economic activity such as Gross National Income (GNI) together with their individual components, show how the economy is responding to government policy and other influences. The balance of payments can demonstrate the requirement for policy adjustments and is also one of the indicators scrutinised by potential foreign investors in the country. Agricultural statistics clearly have implications for longer-term planning, particularly if they show a move away from the land into urban areas or a …

Rejecting Refugees: Homeland Security's Administration Of The One-Year Bar To Asylum, Philip G. Schrag, Andrew I. Schoenholtz, Jaya Ramji-Nogales, James P. Dombach

William & Mary Law Review

Since 1980, the Refugee Act has offered asylum to people who flee to the United States to escape persecution in their homeland. In 1996, however, Congress amended the law to bar asylum—regardless of the merits of the underlying claim—for any applicant who fails to apply within one year of entering the United States, unless the applicant qualifies for one of two exceptions to the rule.

In the years since the bar was established, anecdotal reports have suggested that genuine refugees, with strong claims to asylum, have been rejected solely because of the deadline. Many scholars and practitioners suspected that this …

性別差異在醫學生與醫師人數以及專科別選擇之10年趨勢探討, 韋君 陳, 大成 璩, 潤秋 陳, 聖原 張

Journal of Medical Education

Physician manpower is considered to be an important index when evaluating medical service quality. Furthermore, gender has become an important topic recently. Variations in the gender profile of physicians may influence outcomes in terms of medical services. As a result, concern has focused lately on differences in the distributions of male and female physicians across specialties. We collected data from the Department of Education, Taiwan, and the National Health Insurance Database, Taiwan, in order to examine the male/female distribution of first year medical students, graduated medical students and new physicians over the years 1998 to 2007. Furthermore, we evaluated the …

A Question On My Mind: Robert Mccorkle's 1844 Letter To Joseph Smith, Hal R. Boyd, Susan E. Black

BYU Studies

Robert McCorkle (1807–1873) was one of many Americans curious about Mormonism. In 1844 he visited Nauvoo, Illinois, then headquarters of the Latter-day Saints. He hoped to obtain an audience with Joseph Smith but was able only to hear Smith speak at public meetings. When he returned to his home in Tennessee, he wrote to Smith, asking questions and describing his willingness to relocate to Nauvoo if Smith could prove that he was a true prophet. Interestingly, McCorkle wrote much of his letter in rhymed verse and hoped that Joseph Smith would reply in verse. It does not appear that Smith …

St. Louis Luminary: The Latter-Day Saint Experience At The Mississippi River, 1854–1855, Susan E. Black

BYU Studies

The St. Louis Luminary, a Latter-day Saint newspaper printed in St. Louis, was printed for only one year but chronicles the status of the LDS Church on the American frontier in 1854 and 1855. The 2010 book The Best of the St. Louis Luminary gives an in-depth history of the newspaper and its contents and includes a DVD of scans of the entire volume of the newspaper in a searchable format. This article is excerpted from that book. The newspaper played a significant role in the national discussion of polygamy, which had not been publicly announced until 1852. The …

The Prairie Naturalist, Vol. 42, Issue 3/4, December 2010, The Great Plains Natural Science Society

The Prairie Naturalist

EDITOR'S NOTE: REPORTING RESULTS OF DATA ANALYSIS, PREPARING SCIENTIFIC MANUSCRIPTS, AND WEBSITE DEVELOPMENT EFFORTS • Christopher N. Jacques

Current Distribution of Rare Fishes in Eastern Wyoming Prairie Streams • Christina E. Barrineau, Elizabeth A. Bear, and Anna C. Senecal

Diets of Nesting Swainson's Hawks in Relation to Land Cover in Northwestern North Dakota • Robert K. Murphy

Resource Selection of Greater Prairie-Chicken and and Sharp-Tailed Grouse Broods in Central South Dakota • Mark A. Norton, Kent C. Jensen, Anthony P. Leif, Thomas R. Kirschenmann, and Gregory A. Wolbrink

Population Characteristics of Central Stonerollers in Iowa Streams • Scott M Bisping, …

Seasonal Yellow Perch Harvest In Two Dissimilar South Dakota Fisheries, Casey W. Schoenebeck, Michael L. Brown, David O. Lucchesi

The Prairie Naturalist

Angler effort and fish harvest in South Dakota have historically been quantified through summer and winter creel surveys. However, the late-summer, pulsed recruitment of yellow perch (Perea flavescens) into a fishery combined with an increase in fall movement and feeding activity suggested September and October could be significant periods of perch harvest in South Dakota lakes. Seasonal trends in angler effort and yellow perch harvest during 2005-2007 were compared for high- and low-quality yellow perch fishery types commonly found in eastern South Dakota glacial lakes. High-quality yellow perch fisheries are characterized by fast growth (mean total length at age-3 greater …

Resource Selection Of Greater Prairie-Chicken And Sharp-Tailed Grouse Broods In Central South Dakota, Mark A. Norton, Kent C. Jensen, Anthony P. Leif, Thomas R. Kirschenmann, Gregaory A. Wolbrink

The Prairie Naturalist

Habitat use of sympatric greater prairie-chicken (Tympanuchus cupido) and sharp-tailed grouse (T. phasianellus) broods during the brood-rearing season has not been quantified for stable prairie grouse populations in large contiguous grassland landscapes in the Northern Great Plains. Characteristics of habitats used by prairie grouse broods were described based on data collected from 35 broods (18 greater prairie-chicken and 17 sharp-tailed grottse) during the breeding seasons of 2004 and 2005. Greater prairie-chicken and sharp-tailed grouse broods used vegetation with visual obstruction heights 2:26 cm and 37 cm, respectively. Greater prairie-chicken broods selected western wheatgrass (Pascopyrum smithii …

The Effect Of Explicitly Differentiated Reading Instruction Groups On Eighth-Grade Students' Achievement, Behavior, And Engagement In A School Seeking To Reestablish Adequate Yearly Progress Benchmarks, Sean P. Dunphy

Student Work

The purpose of this study was to determine the effect of explicitly differentiated reading instruction groups on eighth-grade students’ achievement, behavior, and engagement in a school seeking to reestablish adequate yearly progress benchmarks. The results of this study supported student participation in explicitly differentiated reading instruction groups. Because students in High Reading Ability (n = 25), Middle Reading Ability (n = 25), and Low Reading Ability (n = 25) groups maintained average to above average achievement test scores on several measures with commensurate classroom grade performance, and appropriate behavior and engagement to support school success during eighth grade, the results …

Factors Affecting Literacy Achievement Of Eighth Grade Middle School Instrumental Music Students, Johnny T. Brauch Kurt

Student Work

The purpose of this pretest-posttest comparative efficacy study was to analyze factors affecting literacy achievement of eighth grade middle school instrumental music students (n = 38) including (a) socioeconomic status (SES), (b) gender, (c) grade point average (GPA), (d) music motivation, (e) music involvement, and (f) instrument section. The findings of this study indicate that, utilizing the Iowa Tests of Basic Skills (ITBS) reading comprehension, reading vocabulary, and science subtests and the Northwest Evaluation Association (NWEA) Reading Measure of Academic Progress (MAP) as the dependent variables for each of the six independent variables, significant growth over time was made in …

Near Miss Reporting: An Educational Program, William Strub

Nursing Masters

In October 2007, the Medicare system contemplated future introduction of a new policy, which would no longer pay for eight preventable medical errors. With this potential new change in policy it becomes increasingly more important for health care institutions to monitor (track) medical errors and determine what measures can be taken proactively to prevent the occurrence of errors. The errors that might not be financially reimbursed under Medicare in the future include: - Sponges and/or surgical tools left in patients after surgery - Treatment of problems arising from air embolisms or incompatible blood transfusions - Treatment of bedsores developed while …

December 2010 Commencement Program, Bowling Green State University

Commencement Programs

No abstract provided.