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Inference For Time To Event And Sojourn Time Data Under Right Censoring Using Reweighting Approaches., Jie Fan

Electronic Theses and Dissertations

In this dissertation research, we aim to solve problems of two types of survival data, clustered survival data with potentially informative cluster size and sojourn time data. The methods for these two types of data are different. However, both data have right censored observations, and we use reweighting approaches to deal with the censoring issue. In the first part of the dissertation research, we consider marginal AFT models for correlated survival data with potentially informative cluster size. Informative cluster size means that the size of the correlated groups may be predictive of their survival characteristics. Two competing proposals, cluster-weighted AFT …

Morphological Characterization And Molecular Mediated Genetic Variation Of Thief Ant (Solenopsis Molesta Say, Hymenoptera: Formicidae), Ralph B. Narain

Department of Entomology: Dissertations, Theses, and Student Research

The thief ant, Solenopsis molesta (Say), a common nuisance ant species found throughout the United States is genetically related to other stinging ants. This research was undertaken to estimate genetic variation utilizing mitochondrial DNA sequences of cytochrome oxidase I in thief ant populations from various geographic locations. Thief ants were collected from nine states, identified to species using morphologic characteristics from available keys. DNA extractions were completed with Qiagen’s Gentra PUREGENE® DNA Isolation Kit using their solid tissue protocol. PCR reactions were run on the extracted DNA using primers Lep-F1 (forward) and Lep-R1 (reverse). The resulting DNA products were concentrated …

Nitrogen Mustard Reloaded: Synthesis And Structural Studies Of Dna Interstrand Crosslinks, Angelo Guainazzi

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Many of the drugs used in cancer chemotherapy target DNA to kill malignant cells. Some of them form DNA interstrand crosslinks (ICLs), which are extremely cytotoxic lesions that block essential metabolic process such as replication, transcription and recombination by forming covalent bonds between opposite strands of DNA. Despite the importance of chemotherapeutic agents that rely on ICLs for their efficacy, the mechanisms by which these lesions are repaired remains poorly understood. A major impediment in studying ICLs repair has been the limited availability of well-defined substrates. This dissertation describes the development of a new strategy for the synthesis of defined …

In Vitro Enabling Technologies For Use In The Aquatic Environment, Colm J. O'Dowd

Doctoral

O’Dowd, C., Mothersill, C.E., Cairns, M.T., Austin, B., Lyng, F.M., McClean, B. and Murphy, J.E.J. Assessing the mitochondrion as a biomarker of fish tissue damage using g radiation as a stress model in vitro.

There is an ever-increasing need for biomarkers to identify toxic stress in the aquatic environment. Such techniques need to be accurate, expeditious, ethical and economical. Typically, in vitro based platforms fit these criteria however many of these systems often undergo ‘assay drift’ and consequently do not fully represent the real-life situation.

In recent years, there has been growing interest in the mitochondrion and its (dys)function …

Carbon Nanotube Collimators: Fabrications And Applications, Lee Chow, Guang Chai, Thomas Schenkel

UCF Patents

Apparatus, methods, systems and devices for fabricating individual CNT collimators. Micron size fiber coated CNT samples are synthesized with chemical vapor deposition method and then the individual CNT collimators are fabricated with focused ion beam technique. Unfocused electron beams are successfully propagated through the CNT collimators. The CNT nano-collimators are used for applications including single ion implantation and in high-energy physics, and allow rapid, reliable testing of the transmission of CNT arrays for transport of molecules.

Integrated Fisheries Management Report. West Coast Demersal Scalefish Resource., Department Of Fisheries Western Australia.

Fisheries Management Papers

This report on the West Coast Demersal Scalefish fishery is the third in a series of Integrated Fisheries Management (IFM) resource reports required under the Government policy on IFM. Under this policy, the Chief Executive Officer of the Department of Fisheries is required to approve a sustainability report for each fishery, which includes a clear statement on the recommended harvest level.

Modeling And Its Numerical Method For Micro-Scaled Diffusion -Reaction Systems In The Neuromuscular Junction, Abdul Khaliq

Doctoral Dissertations

The main subject of this research is the neuromuscular junction (NMJ). The NMJ is a biological structure composed of the interface between a neuron and a muscle cell. Currently, there is not a fully three dimensional model of diffusion-reaction processes occurring in the NMJ. Developing a useful predictive model of this structure will assist in the therapeutic efforts to restore and rehabilitate NMJ function to humans and in developing strategies to prevent damage to the NMJ. This research work developed 1D mass transport and full 3D reaction diffusion models. A new finite difference scheme is presented for solving 1D mass …

The Role Of Bcl-2 Modifying Factor (Bmf) In Airway Epithelial Cell Death, Amelia H. T. Unione

Biomedical Sciences ETDs

One of the components that obstruct the airway in asthma is the sudden and increased secretion of mucus from metaplastic mucous cells in small airways. Because previous studies have shown that the resolution of mucous cell metaplasia (MCM) during prolonged exposure of mice to allergen is mediated by IFN gamma and the Bcl-2 family of proteins, we investigated the regulation and the role of a pro-apoptotic BH3 domain-only protein, Bmf, in airway epithelial cells (AECs) treated with IFN gamma. We hypothesize that Bmf is crucial for IFN gamma-induced cell death. Our findings show that IFN gamma suppressed Bmf expression in …

Biology, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Gold Nanoparticles And Their Polymer Composites: Synthesis Characterization And Applications, Nidhi Joshi

USF Tampa Graduate Theses and Dissertations

Gold nanoparticles are excellent candidates for all the biomedical applications due to their size and shape dependent optical and physiological properties. In this study, gold nanoparticles were synthesized chemically for bio-application. It was observed that the size and shape of gold nanoparticles depend strongly on the concentration of chemical solution, type of reducing agent used in the reaction, temperature of the solution and stabilizing agent for reaction. Transmission electron microscopy (TEM) has been used extensively to determine the size and shape of the gold nanoparticles. Optical properties of the size and shape selected nanoparticles were studied using UV-vis spectrophotometer in …

Growth, Reproductive Life-History Traits And Energy Allocation In Epinephelus Guttatus (Red Hind),E. Striatus (Nassau Grouper), And Mycteroperca Venenosa (Yellowfin Grouper) (Family Serranidae, Subfamily Epinephelinae), Nicolle Marie Cushion

Open Access Dissertations

Fish populations are regulated by both external environmental factors, e.g., water quality parameters and habitat, and internal reproductive biology and physiology processes. For many species and populations there is often ample external information, while critical internal, i.e., life-history trait (LHT), information is not available. For this study, I determined LHTs and energy allocation patterns for Epinephelus guttatus (red hind), E. striatus (Nassau grouper), and Mycteroperca venenosa (yellowfin grouper) harvested from The Bahamas. I determined age ranges, and how growth patterns and rates differed among the study species. The maximum ages were: 17, E. guttatus; 22, E. striatus; and 13, M. …

Foothill Corridor Plan, Jordan Smith, Alex Padilla

City and Regional Planning

No abstract provided.

Botanical Report Of Tierra Redonda Mountain Blm Area Of Critical Environmental Concern, San Luis Obispo County, California (W120˚59’41”; N35˚45’59”)., Anthony Baniaga, Andrew Theo Fitanides

Biological Sciences

The purpose of this document is to report the results of a botanical survey of a portion of the Tierra Redonda Mountain Area of Critical Environmental Concern. The survey was conducted for the Bureau of Land Management, and executed between October 2009 and June 2010. Tierra Redonda Mountain is the type locality for the Tierra Redonda formation, and has weathered to form steep slopes of exposed chaparral and protected woodlands. Four general community types were found; foothill woodland, chaparral, southern coastal scrub and dune scrub. Alliances determined by The Manual of California Vegetation (2nd ed.) were: Quercus douglasii Woodland, Quercus …

Development And Study Of Inhibitors Of Heat Shock Protein 70 Induction, Rongsheng Wang

All Theses and Dissertations (ETDs)

Tumor and cancer cells that over express heat shock protein 70: HSP70) are found to be multidrug resistant and thermo tolerant, creating a hurdle to existing therapy. Although HSP70 is recognized as an increasingly important drug target, the protein structure of this highly conserved chaperone remains challenging for direct targeting. An alternative strategy is to inhibit the transcription of HSP70. Among known small molecule inhibitors of HSP70 induction, quercetin has very low toxicity and has the advantage of being easily modified for structure-activity studies. One part of the dissertation focuses on the identification of quercetin derivatives with improved specificity and …

Common Ravens In Alaska's North Slope Oil Fields: An Integrated Study Using Local Knowledge And Science, Stacia Ann Backensto

Biological Sciences

Common ravens (Corvus corax) that nest on human structures in the Kuparuk and Prudhoe Bay oil fields on Alaska's North Slope are believed to present a predation risk to tundra-nesting birds in this area. In order to gain more information about the history of the resident raven population and their use of anthropogenic resources in the oil fields, I documented oil field worker knowledge of ravens in this area. In order to understand how anthropogenic subsidies in the oil fields affect the breeding population, I examined the influence of types of structures and food subsidies on raven nest site use …

Cell Wall/Surface Proteome Of Candida Albicans: Its Application In Rapid Identification Of Yeast Species By Mass Signature And Characterization By In Vitro And In Vivo Chemical Labelings, Jiang Qian

LSU New Orleans Theses and Dissertations

Candida albicans is an opportunistic fungal pathogen that may cause mucutaneous infection and/or disseminated candidasis if the host defense system is impaired (such as those in HIV patients). Cell surface of C. albicans is the frontier where initial interplay between host-pathogen takes place and therefore is of great importance in understanding the mechanism of hostpathogen interaction. MALDI-TOF-MS analysis of intact fungal cells yielded mass signatures for rapid species differentiation, strain grouping and yeast morphogenesis monitoring. Cell surface biotinylations at low temperature (4°C), enzymatic digestion of the intact fungal cell surface proteins ("whole cell shaving"), biotin-avidin affinity enrichment of biotinylated peptides, …

Synthesis And Sar Study Of Meperidine Analogues As Selective Serotonin Reuptake Inhibitors (Ssris), Xiaobo Gu

LSU New Orleans Theses and Dissertations

Meperidine has been shown to have potent binding affinity for serotonin transporters (SERT) (Ki = 41 nM) and be an inhibitor of serotonin reuptake. Based upon these pharmacological results meperidine has been identified as a lead compound for the development of a novel class of serotonin-selective reuptake inhibitors (SSRIs). A variety of potent analogues of meperidine have been synthesized and evaluated in vitro as potential ligands for the serotonin transporter. Substitutions have been made on the aryl ring, the ester moiety and the piperidine nitrogen of meperidine. Potent analogues of the aryl substituted series that included 4-iodophenyl, 2-naphthyl, 3,4-dichlorophenyl and …

Error Correcting Codes And The Human Genome., Suzanne Mclean Lyle

Electronic Theses and Dissertations

In this work, we study error correcting codes and generalize the concepts with a view toward a novel application in the study of DNA sequences. The author investigates the possibility that an error correcting linear code could be included in the human genome through application and research. The author finds that while it is an accepted hypothesis that it is reasonable that some kind of error correcting code is used in DNA, no one has actually been able to identify one. The author uses the application to illustrate how the subject of coding theory can provide a teaching enrichment activity …

Faculty Newsnotes 2010 No. 416, Office Of The Provost

Faculty Newsnotes (1972-2010)

No abstract provided.

Chemical Characterization Of Botanical Products: Comprehensive Speciation By Liquid Chromatography Particle Beam Mass Spectrometry, Joaudimir Castro Georgi

All Dissertations

The dietary supplement industry has expanded and many of these supplements have become an important aspect of people's everyday lives. In 1994, the U.S. Dietary Supplement Health and Education Act (DSHEA) classified numerous nutraceutical/botanical products as dietary supplements because of their beneficial medicinal properties and provided the necessary regulation to the supplement producers. Since then, the interest of the scientific community towards dietary supplements has grown intensively and numerous studies have been carried out in order to understand the chemical behavior of the active molecules in the human body. The development towards analytical methods for the quantification of the active …

Structural Equation Modeling With Time Series Data, Tianyi Zhang

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Structural Equation Modeling (SEM), also commonly referred to as path analysis in the absence of latent variables, is a powerful multivariate analysis approach to explore and to confirm causal relationships. It imposes a structure on the covariance matrix and the imposed structure is subsequently validated by the data. In recent years, SEM has been extended to analyze autoregressive moving average (ARMA) time series data assuming time-constant path coefficients. The mechanism of ARMA-based SEM makes it the ideal procedure for the analysis of directional brain functional pathways based on the multi-subject, multivariate time series data generated through the functional magnetic resonance …

Peripheral Taste System In Inbred Mouse Strains, William Wes Shelton

Theses and Dissertations (ETD)

Taster and non-taster mice strains have been used extensively in animal taste research. Inbred mouse strains C57 and FVB have been proposed to be tasters, where as strains 129 and Balb/C are classified as non-tasters. Therefore, evaluating the peripheral taste system in these mice is of great importance to determine if there are morphological differences that might explain the physiological classification. The purpose of the present study was to determine if inbred mice that have been shown to be tasters have a larger number of fungiform papillae, have larger fungiform papillae and have larger taste buds. My work in this …

Energy Restriction During Development In Breeding Gilts: An Economic Analysis, Justin Cech

Department of Agricultural Economics: Dissertations, Theses, and Student Research

Swine production has become a low-margin business. As costs of production have increased, producers are continuing to increase efficiency in market pig production and gilt development. Restricting energy intake during gilt development could have a positive impact on a producer’s bottom line, but few studies have economically analyzed production differences caused by energy restriction. This study utilized gilt development and market pig production data from biological studies that included a 2x2 factorial arrangement of half-sibling maternal lines (LWxLR and L45X) entering two gilt development programs. In one program, gilts were fed on an ad libitum basis. In the other, gilts …

F.F.A: Forensic + Funerary Architecture, Michael P. Cafro

Architecture Theses and Projects

This thesis document proposes the notion of an architecture that incorporates a three part program which involves violent and natural death cases. With scientific and larger public gathering spaces proposed in the building’s program, the users are grouped in a common environment that deals the subject of death. The general public are a witness to the building’s architecture and have the ability to react and become aware of their surroundings and possibly allow for an appreciation toward life.

Ampa Receptor Allosterism: Measurement Of The Conformational Changes In The Ligand Binding Domain Of A Functional Receptor, Jennifer Gonzalez-Mcgehee

Dissertations and Theses (Open Access)

Ionotropic glutamate receptors are important excitatory neurotransmitter receptors in the mammalian central nervous system that have been implicated in a number of neuropathologies such as epilepsy, ischemia, and amyotrophic lateral sclerosis. Glutamate binding to an extracellular ligand binding domain initiates a series of structural changes that leads to the formation of a cation selective transmembrane channel, which consequently closes due to desensitization of the receptor. The crystal structures of the AMPA subtype of the glutamate receptor have been particularly useful in providing initial insight into the conformational changes in the ligand binding domain; however, these structures are limited by crystallographic …

Tdiscovery And Development Of Novel Therapeutic Agents For Advanced Melanoma, Zhao Wang

Theses and Dissertations (ETD)

Malignant melanoma is the most dangerous form of skin cancer and accounts for about 75% of skin cancer deaths. Once diagnosed at the metastatic stage, it has a very poor prognosis with a median survival rate of 6 months and a 5-year survival rate of less than 5%. In addition, melanoma has become an important public health hazard owing to its rising incidence, which has been well documented over the past 50 years. Currently there is no effective way to treat melanoma. It is highly resistant to existing chemotherapy, radiotherapy, and immunotherapy. Over the past 30 years, only two drugs …

The Use Of The Palladium-Catalyzed Glycosylation For The Synthesis Of C- And O-Linked Glycosylated Natural Products, Xiaomei Yu

Graduate Theses, Dissertations, and Problem Reports (ETD)

The carbohydrate portions of natural products play a crucial role in their pharmacological properties. These properties can vary from improved water solubility, improved membrane transport properties, improved tissue targeting, as well as improved target binding. Herein we describe our efforts to use de novo synthesis to help elucidate the various roles carbohydrates play in biologically active glycosylated natural products.;The O'Doherty group has developed a method that uses asymmetric synthesis for the de novo synthesis of carbohydrates. In contrast to traditional carbohydrate methods, this de novo approach builds the desired functionality and stereochemistry within each sugar. This methodology relies on a …

The Role Of The Tumor Suppressor Kinase Lkb1 In Xenobiotic Metabolism, Rebecca Ann Kohnz

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The liver kinase-B1 (LKB1) is a serine/threonine kinase that has numerous roles in human disease. LKB1 was originally identified as a tumor suppressor kinase that, when inactivated, is responsible for the human inherited disorder Peutz-Jeghers syndrome which is characterized by benign gastric polyposis and increased cancer predisposition. More recently, inactivating LKB1 somatic mutations in humans have been found in 15-35% of non-small cell lung carcinomas and in 20% of cervical carcinomas. LKB1 functions as a master kinase upstream of 14 different substrates kinases and these substrates have critical roles in cell growth, polarity, and metabolism. Previous studies show that in …

Extracellular Matrix Proteins: Implications For Angiogenesis, Kent Edward Williams

All-Inclusive List of Electronic Theses and Dissertations

The extracellular matrix (ECM) is an essential requirement for maintaining permanent shape and rigidity in multicellular organisms. The ECM serves two main functions: scaffolding and signaling. Insoluble collagen and soluble proteoglycans, glycosaminoglycans (GAGs), and glycoproteins allow for water retention and flexibility. The signaling role of the ECM is essential for a multitude of events including vascular development and angiogenesis. Via interactions with vascular endothelial cells, proteins of the ECM can induce or repress angiogenesis.

Characterization Of Plutonium Particles Originating From The Bomarc Accident -1960, Richard Charles Gostic

UNLV Theses, Dissertations, Professional Papers, and Capstones

Within the U.S. arsenal, 32 accidents with nuclear weapons were reported between 1950 and 1980. One of these accidents occurred at McGuire AFB in 1960. A BOMARC missile armed with a nuclear warhead caught on fire and as a result the warhead was destroyed. Sub-millimeter particles consisting of weapons grade plutonium (WGPu) produced by this accident were distributed around the site and remained in the environment for 47 years. Soil cores known to contain WGPu particles produced by this accident were obtained. The particles were localized and removed from the soil with the aid of high resolution computed tomography. The …