Digital Commons Network^™

Cd151 Reinforces Vascular Stability By Balancing Endothelial Cell Adhesion And Cytoskeletal Tension, Feng Zhang

Theses and Dissertations (ETD)

Tetraspanin CD151 is highly expressed in endothelial cells and regulates pathological angiogenesis. However, the mechanism by which CD151 promotes vascular morphogenesis and whether CD151 engages other vascular functions are unclear. We observed that CD151 is required for the maintenance of endothelial capillary-like structures formed in vitro and the integrity of lung endothelial cell-cell contacts in vivo. As a master regulator of endothelial cell-matrix and cell-cell adhesions, CD151 is needed for the optimal functions of various cell adhesion proteins such as integrin, cadherin, and CD44. The loss of CD151 elevates the cellular intrinsic contraction by upregulating RhoA signaling and downregulating of …

Design Of Lipid And Polymeric Carriers For Nucleic Acid Delivery, Lin Zhu

Theses and Dissertations (ETD)

The objectives of the study were to investigate and develop lipid and polymeric carriers for nucleic acid delivery. These included: i) to develop novel cationic lipids for plasmid, oligonucleotide, and siRNA delivery; ii) to develop a novel polymeric delivery system, polyethylene glycol (PEG) based bio–conjugate, for oligonucleotide delivery; iii) to develop a novel bio–conjugate delivery system for siRNA delivery.

In Chapter 2, we discussed the barriers and strategies of nucleic acid delivery, as well as summarized the commonly used lipids, polymers, and the corresponding carriers in terms of their characteristics, applications, advantages and limitations.

Cationic lipids are most commonly used …

Interactions Of Francisella Tularensis With Components Of The Host Fibrinolytic System, Shawn Russell Clinton

Theses and Dissertations (ETD)

Francisella tularensis (FT) is a Gram-negative coccobacillus and causative agent of a life-threatening disease commonly referred to as tularemia. Due to the highly infectious nature of the organism, its previous development as a biowarfare agent and its potential use in acts of bioterrorism, this bacterium is listed as a Category A select agent by the Centers for Disease Control and Prevention (CDC). Efforts to understand the pathogenic mechanisms of FT within the host environment are vital for the development of safe and effective vaccines, as well as treatments, against tularemia. Though considered an intracellular pathogen, FT research of late has …

Emissions Characterization And Particle Size Distribution From A Dpf-Equipped Diesel Truck Fueled With Biodiesel Blends, Idowu O. Olatunji

Graduate Theses, Dissertations, and Problem Reports (ETD)

Biodiesel may be derived from either plant or animal sources, and is usually employed as a compression ignition fuel in a blend with petroleum diesel (PD). Emissions differences between vehicles operated on biodiesel blends and PD have been published previously, but data do not cover the latest engine technologies. Prior studies have shown that biodiesel offers advantages in reducing particulate matter, with either no advantage or a slight disadvantage for oxides of nitrogen emissions. Literature also suggests that diesel engine exhaust particle number emissions are dominated by nucleation mode particles (NMPs) if present, while the mass emissions are dominated by …

The Effects Of Resveratrol On Oxidative Stress And Muscle Atrophy, Janna Renee Jackson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Resveratrol (3,5,4,trihydroxystilbene) is a naturally occurring polyphenol found in over seventy plant species that has been shown to have anti-oxidant, anti-apoptotic and anti-aging properties. Resveratrols' capacity to enhance the endogenous anti-oxidant system, upregulate anti-apoptotic proteins and improve mitochondrial function, presumably through the activation of the N AD+ dependent deacetylase Sirtuin1, suggests that supplementation with resveratrol may potentially protect skeletal muscle from the detrimental effects of increases in oxidative stress and the subsequent increase in apoptotic signaling that are present in many atrophic conditions. Therefore, the major goals of this dissertation are to further understand the interplay between oxidative stress and …

Spectral Approaches To Natural Mesh Processing, Takamitsu Kawai

Graduate Theses, Dissertations, and Problem Reports (ETD)

Mesh design is a major bottleneck in the creation of computer games and animation. Therefore simplifying the process of mesh editing is an important problem. Natural mesh processing is generally difficult to perform since natural meshes often have nontrivial surface shapes and high degrees of freedom. In this study I present novel approaches to natural mesh processing utilizing spectral methods based on the manifold harmonic basis.;Geometric scaling transformations do not respect the biological processes which govern the size and shape of living creatures. I describe an approach to scaling which can be related to biological function. Known biological laws of …

4-H Try Coordinator's Manual, Donna Carter, Katrina Pearce

All Current Publications

This manual is for the TRY volunteer program's coordinator.

Marketing And Feeding Cull Cows, Dillon M. Feuz

All Current Publications

This publication provides ways to enhance the value of cull cows by innovating marketing and feeding practices.

An Evaluation Of The Risk And Return Associated With Four Cattle Feeding Alternatives In Utah, Dillon M. Feuz, Caleb Bott

All Current Publications

This publication serves as an evaluation of the risk and return associated with four cattle feeding alternatives.

Calibrating And Operating Manure Spreaders, Process Improvement For Animal Feeding Operations, John Harrison, Rich Koenig, Kerry Goodrich

All Current Publications

This guide outlines simplified methods to calibrate manure spreaders based on determining the load and area covered by the load.

Backyard Composting In Utah, Kitt Farrell-Poe, Rich Koenig

All Current Publications

This publication explains the benefits of composting and how to successfully start a compost in your own backyard.

Drinking Water Fact Sheet: Drinking Water Treatment Systems, Nancy Mesner, Barbara Daniels

All Current Publications

This fact sheet provides information about drinking water treatment systems. This fact sheet discusses different types of water treatment systems available to homeowners. It includes a table with water contaminants or problems, possible causes of the problem, and solutions.

Drinking Water Fact Sheet: Nitrate, Nancy Mesner, Barbara Daniels

All Current Publications

This fact sheet provides information about nitrates, including sections about what nitrates are, where they come from, health concerns from exposure, drinking water standard for nitrates, how to know if there is nitrate in a water supply, and what can be done to reduce nitrate in drinking water.

Drinking Water Fact Sheet: Coliform Bacteria, Nancy Mesner, Barbara Daniels

All Current Publications

This fact sheet provides information about coliform bacteria. Including sections about what coliform bacteria is, how it enters drinking water, health concerns from exposure, drinking water standards, and how to treat drinking water that contains coliforms.

Strategies For Preparing Computer Science Students For The Multicore World, Richard Brown, Elizabeth Shoop, Joel C. Adams, Curtis Clifton

University Faculty Publications and Creative Works

Multicore computers have become standard, and the number of cores per computer is rising rapidly. How does the new demand for understanding of parallel computing impact computer science education? In this paper, we examine several aspects of this question: (i) What parallelism body of knowledge do today's students need to learn? (ii) How might these concepts and practices be incorporated into the computer science curriculum? (iii) What resources will support computer science educators, including non-specialists, to teach parallel computing? (iv) What systemic obstacles impede this change, and how might they be overcome? We address these concerns as an initial framework …

Understanding Your Watershed Fact Sheet: Dissolved Oxygen, Nancy Mesner, John Geiger

All Current Publications

Dissolved oxygen describes oxygen molecules which have actually dissolved in water. Sometimes people confuse bubbles in water with dissolved oxygen, but in reality the dissolved form of oxygen cannot be seen.

Understanding Your Watershed Fact Sheet: Nitrogen, Nancy Mesner, John Geiger

All Current Publications

Nitrogen is an essential nutrient for plants and animals that is used in the structure of proteins and other molecules. Nitrogen is found in a variety of forms throughout the global environment.

Understanding Your Watershed Fact Sheet: Ph, Nancy Mesner, John Geiger

All Current Publications

pH is a measurement of the acidity or alkalinity (base) of a solution. When substances dissolve in water they produce charged molecules called ions. Acidic water contains extra hydrogen ions (H+) and basic water contains extra hydroxyl (OH-) ions.

Equine Vision And Its Effect On Behavior, Patricia Evans

All Current Publications

This publication describes horses vision and how to work horses to the best advantage.

December 2010 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Montana Kaimin, December 1, 2010, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

String Theory And Our Relationship With Nature: The Convergence Of Science, Curriculum Theory, And The Environment, Virginia Therese Bennett

College of Graduate Studies: Theses & Dissertations

Curriculum Theory affords us the opportunity to examine education from a multitude of directions. This work takes advantage of that opportunity to explore the relationships between science, nature, and curriculum using string theory and our ideas about the environment as a backdrop. Both the energy and multiple possibilities created by strings and the rich history leading up to the theory help to illustrate the many opportunities we have to advance discussions in alternative ways of looking at science. By considering the multiple dimensions inherent in string theory as multiple pathways and interweaving metaphors from Deleuze and Guattari, Michel Serres, and …

Faunal Analysis And Comparative Study Of Mont Repose Plantation, Misty Y. Dunn

College of Graduate Studies: Theses & Dissertations

Over the past several years excavations have been underway within a structure at the Mont Repose plantation site located near Coosawhatchie, South Carolina. This structure has yielded an array of artifacts including numerous faunal remains. Species recovered thus far include domestic species such as cow, pig, and chicken. The wild species represented within the collection include deer, opossum, raccoon, fish, bird, turtle, and alligator. By comparing the findings from the Mont Repose structure with other coastal plantation sites, it is suggested that conclusions can be drawn about who was occupying the structure. Also, it may be possible to determine the …

From Peasants To Farmers: Peasant Differentiation, Labor Regimes, And Land-Rights Institutions In China's Agrarian Transition, Q. Forrest Zhang, John A. Donaldson

Research Collection School of Social Sciences

The development of factor markets has opened Chinese agriculture for the penetration of capitalism. This new round of rural transformation—China’s agrarian transition— raises the agrarian question in the Chinese context. This study investigates how capitalist forms and relations of production transform agricultural production and the peasantry class in rural China. The authors identify six forms of nonpeasant agricultural production, compare the labor regimes and direct producers’ socioeconomic statuses across these forms, and evaluate the role of China’s land-rights institution in shaping these forms. The empirical investigation presents three main findings: (1) Peasant differentiation : capitalist forms of agricultural production differentiate …

European Union Food Law Update, Emilie H. Leibovitch

Journal of Food Law & Policy

This EU Food Law Update will focus on the recent developments in the areas of genetically modified organisms, novel foods, feed safety, transmissible spongiform encephalopathy, salmonella and food borne diseases, food additives, organic farming, food contact materials, and labeling.

The Bifidogenicity Of The Prebiotic Galactooligosaccharides, Lauren M. G. Davis

Department of Food Science and Technology: Dissertations, Theses, and Student Research

The goal of this research was to determine the effect of different doses of galactooligosaccharide (GOS) on the fecal microbiota of healthy adults, with a focus on bifidobacteria. The study was designed as a single-blinded study, with eighteen subjects consuming GOS-containing chocolate chews at four increasing dosage levels; 0, 2.5, 5.0, and 10.0 g. Subjects consumed each dose for 3 weeks, with a two-week baseline period preceding the study and a two-week washout period at the end. Cultural methods were used for bifidobacteria, Bacteroides, enterobacteria, enterococci, lactobacilli, and total anaerobes; culture-independent methods included denaturing gradient gel electrophoresis (DGGE) and …

Acetate Causes Alcohol Hangover Headache In Rats., Christina R Maxwell, Rebecca Jay Spangenberg, Jan B Hoek, Stephen D Silberstein, Michael L Oshinsky

Department of Neurology Faculty Papers

BACKGROUND: The mechanism of veisalgia cephalgia or hangover headache is unknown. Despite a lack of mechanistic studies, there are a number of theories positing congeners, dehydration, or the ethanol metabolite acetaldehyde as causes of hangover headache.

METHODS: We used a chronic headache model to examine how pure ethanol produces increased sensitivity for nociceptive behaviors in normally hydrated rats.

RESULTS: Ethanol initially decreased sensitivity to mechanical stimuli on the face (analgesia), followed 4 to 6 hours later by inflammatory pain. Inhibiting alcohol dehydrogenase extended the analgesia whereas inhibiting aldehyde dehydrogenase decreased analgesia. Neither treatment had nociceptive effects. Direct administration of acetate …

Theresource, Georgia Southern University

Human Resources (2010-2023)

• Casual Labor
• Medical Assistance Leave Program
• Town Hall Meeting
• eLearning
• DOAS Loss Control Tip
• Benefits Information

The Noble Savage And Ecological Indian: Cultural Dissonance And Representations Of Native Americans In Literature, Brooke D. Mcnaughton

Undergraduate Honors Capstone Projects

This thesis provides a unique approach to understanding the historical origins and contemporary social ramifications of the use of the concepts of the Noble Savage and the Ecological Indian within literature. I first examine the history of the Noble Savage concept in literature by examining relevant social movements, and then its eventual transition into its modern counterpart, the Ecological Indian. Authors who employ the use of these concepts typically portray Natives in a way which provides an idealized alternative for white cultural woes. Consequently, this idealization creates problems with modern Native identity. In the second half of this project I …

Conservation From The Bottom-Up: Human, Financial, And Natural Capital As Determinants Of Resilient Livelihoods In Kigoma Rural, Tanzania, Yared J. Fubusa

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Rhetoric of "community-based conservation" has gained prominence among development specialists and environmentalists, yet such projects are often implemented from the top-down in Africa. This dissertation contends that only a bottom-up approach can foster resilient livelihoods and environmental stewardship.

This study focused on determinants of household resilience within a poverty-stricken agricultural community near Gombe Stream National Park (GSNP) in western Tanzania. The research purpose was to explore: 1) relationships between villagers and GSNP management; 2) how groups and individuals view priority livelihood problems and solutions; 3) various attributes of households; and 4) perceived trends for household resilience and how these are …