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2010

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Coevolution At The Population Level: Empirical Studies In An Insect-Plant Interaction, Rodrigo Cogni May 2010

Coevolution At The Population Level: Empirical Studies In An Insect-Plant Interaction, Rodrigo Cogni

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Coevolution, the reciprocal evolutionary change in interacting species driven by natural selection, has an enormous importance on ecological and evolutionary theory. However, there are very few empirical studies demonstrating coevolution. In particular for plant-herbivore interactions, even though there are many adaptations that seem to be the result of the interaction, just a few empirical evidences on the processes leading to these adaptations exist. I used a highly integrative approach to study coevolution in an ideal plant-herbivore system: the alkaloid bearing legume Crotalaria pallida and its seed predator, the arctiid moth Utetheisa ornatrix. To unravel coevolutionary dynamics and to demonstrate reciprocal …

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Authority And Force: Investigating Authority In The Works Of Thomas Hobbes And In J.M. Coetzee's Diary Of A Bad Year, Ciahnan Quinn Darrell May 2010

Authority And Force: Investigating Authority In The Works Of Thomas Hobbes And In J.M. Coetzee's Diary Of A Bad Year, Ciahnan Quinn Darrell

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

`Authority' is said to govern force; it is a word one is born into, a word that shapes what one knows, and even what he is able to see, but it is also a word that conceals its precise meaning and which refuses to divulge its origins. The relationship between force and authority is dynamic, intimate, and infinitely complex; authority and force are often conflated, or differentiated only by the thinnest and most porous of tissue. As force and authority commingle, articulating the difference between the two becomes increasingly problematic, and the most profound consequence of this inability to distinguish …

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Indicator, Joseph A. Esser May 2010

Indicator, Joseph A. Esser

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Making art is a journey. Like links of a chain, each work leads to the next and so on and so on. This progression can be subtly altered as the artist grows; new techniques, new experiences and changes in personal beliefs all affect the work. Occasionally the next step can be an evolutionary leap. This, I believe, is where one series ends and another begins. Although the new work may be drastically different, it is forever linked to what came before.Through the examination of my own work, I found it more and more necessary to start the story before the …

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A Role For The Transcriptional Repressor Rest In Patterning The Zebrafish Neural Tube, Keith Pendleton Gates May 2010

A Role For The Transcriptional Repressor Rest In Patterning The Zebrafish Neural Tube, Keith Pendleton Gates

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The spatial and temporal control of gene expression is key to generation of specific cellular fates during development. Studies of the transcriptional repressor REST/NRSF (RE1 Silencing Transcription factor/Neural Restrictive Silencing Factor) have provided important insight into the role that epigenetic modifications play in differential gene expression. Functional studies place REST within multiple developmental pathways and transcriptional networks. However, findings between different groups are often incongruent, and little progress has been made on understanding the embryonic lethality of the Rest knockout mice. What emerges from the controversies surrounding REST function is that the cellular context of REST is paramount. Here, zebrafish …

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Invasions, Insurgency And Interventions: Sweden's Wars In Poland, Prussia And Denmark 1654-1658, Christopher Gennari May 2010

Invasions, Insurgency And Interventions: Sweden's Wars In Poland, Prussia And Denmark 1654-1658, Christopher Gennari

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

In 1655 Sweden was the premier military power in northern Europe. When Sweden invaded Poland, in June 1655, it went to war with an army which reflected not only the state's military and cultural strengths but also its fiscal weaknesses. During 1655 the Swedes won great successes in Poland and captured most of the country. But a series of military decisions transformed the Swedish army from a concentrated, combined-arms force into a mobile but widely dispersed force. Fiscal necessities also drove acts of violence which quickly angered the Polish populace. This sparked a religiously fueled partisan insurgency against Swedish occupation. …

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A New Way Of Approaching The Absolute Through Art: The Sacred Mirrors Of Alex Grey, Julie Gilbert May 2010

A New Way Of Approaching The Absolute Through Art: The Sacred Mirrors Of Alex Grey, Julie Gilbert

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

A connection with the viewer is a crucial aspect of art which addresses the spiritual. In order for this type of art to be successful, it must transform its viewer, enabling them to see the ultimate truth, of the Absolute nature of all things. Contemporary artist Alex Grey sees himself as a visionary, believing that the purpose of his art is to reunite humanity with its own collective spirituality--to help people realize their true nondual nature and interconnectedness. The spiritual aspect of Grey's art places him in the tradition of twentieth-century abstract artists, such as Kandinsky and the American Abstract …

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The Role Of The Tumor Suppressor Kinase Lkb1 In Xenobiotic Metabolism, Rebecca Ann Kohnz May 2010

The Role Of The Tumor Suppressor Kinase Lkb1 In Xenobiotic Metabolism, Rebecca Ann Kohnz

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The liver kinase-B1 (LKB1) is a serine/threonine kinase that has numerous roles in human disease. LKB1 was originally identified as a tumor suppressor kinase that, when inactivated, is responsible for the human inherited disorder Peutz-Jeghers syndrome which is characterized by benign gastric polyposis and increased cancer predisposition. More recently, inactivating LKB1 somatic mutations in humans have been found in 15-35% of non-small cell lung carcinomas and in 20% of cervical carcinomas. LKB1 functions as a master kinase upstream of 14 different substrates kinases and these substrates have critical roles in cell growth, polarity, and metabolism. Previous studies show that in …

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Stand Up Next To A Mountain: The Art Of Barkley L. Hendricks, 1964-1977, Lori Louise Salmon May 2010

Stand Up Next To A Mountain: The Art Of Barkley L. Hendricks, 1964-1977, Lori Louise Salmon

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

This thesis explores the creative accomplishments of American artist Barkley L.Hendricks and argues that the 1960s and 1970s represented a pivotal moment forfigurative painting in American Art because of its relationship between nationality andrace. In 1967, Stokely Carmichael and Charles V. Hamilton's revolutionary work"BlackPower" exposed the depths of systemic racism in the United States and provided a radicalpolitical framework for reform. I examine Hendricks' artistic efforts and achievementsduring this sociopolitical Movement. In particular, this thesis will investigate thefollowing: the idiosyncrasies in Hendricks' art that demonstrate how the artist'srepresentations of American life, in fact, construct African-American identity within alarger debate about …

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Exposing The 'Quiet Trauma': The Illness Narratives Of Jo Spence, Ebonipearl Emele J. Jones May 2010

Exposing The 'Quiet Trauma': The Illness Narratives Of Jo Spence, Ebonipearl Emele J. Jones

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

According to trauma theorist E. Ann Kaplan,"quiet traumas" are events that are personal, and that do not effect the larger scheme of things. Jo Spence, a British photographer, processed her quiet traumas-breast cancer and leukemia-through art and brought them into the public sphere, in order for a collective witness and healing experience, with the concept of her works as being of therapeutic value for herself, as well as for viewers. This thesis examines a few of Spence's photographs in tandem with her critical writings, as well as putting her works into an art historical context, being compared and contrasted to …

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Novel Amyloid Beta-Protein Degrading Enzymes. Membrane Type 1 Matrix-Metalloproteinase And Myelin Basic Protein, Mei-Chen Liao May 2010

Novel Amyloid Beta-Protein Degrading Enzymes. Membrane Type 1 Matrix-Metalloproteinase And Myelin Basic Protein, Mei-Chen Liao

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The progressive accumulation of á-amyloid (Aá) in senile plaques and in the cerebral vasculature is the hallmark of Alzheimer's disease (AD) and related disorders. Several major pathways for Aá clearance include receptor-mediated cellular uptake, blood-brain barrier transport and direct proteolytic degradation. My thesis focused on two novel Aá degrading enzymes- Membrane type 1 matrix metalloproteinase (MT1-MMP) and myelin basic protein (MBP). Matrix metalloproteinase 2 (MMP2) was shown to be expressed in reactive astrocytes surrounding amyloid plaques and may contribute to Aá degradation. MT1-MMP is the physiological activator for the zymogen pro-MMP2. In addition to MMP2, its activator MT1-MMP was also …

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Involvement Of Surfactant Proteins In Ocular Innate Defense, Xiaolan Lin May 2010

Involvement Of Surfactant Proteins In Ocular Innate Defense, Xiaolan Lin

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The ocular surface is a delicate structure that susceptible to injury and infection. Ulcerative keratitis is a painful eye condition characterized by stromal infection, ulcerative epithelium, decreased vision and cornea scar. Due to the reason that formation of vascularization, fibrosis or scarring in corneal epithelium can cause disastrous effects on vision, inflammatory response in the eye must be tightly controlled in space and time. Ocular innate defense system consists of antimicrobial peptides and immune cells that secreted or accumulated at the surface; they work in concert to eliminate intruding pathogens. Under normal circumstances, innate immunity suffices in providing quick, non-specific …

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Investigation Of The Dynamics Of Qpx, A Pathogen Of The Hard Clam Mercenaria Mercenaria, In The Environment And Clams, Qianqian Liu May 2010

Investigation Of The Dynamics Of Qpx, A Pathogen Of The Hard Clam Mercenaria Mercenaria, In The Environment And Clams, Qianqian Liu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Quahog Parasite Unknown (QPX) is a potentially lethal pathogen of the hard clam Mercenaria mercenaria along the northeastern coast of the United States. To enumerate QPX in clams and in environmental samples, a SYBR Green real-time quantitative PCR (qPCR) assay targeting the ITS region of the QPX rRNA operon was developed. The qPCR assay was used to test samples collected in 2006 from the site of a recent QPX disease outbreak in Raritan Bay, NY, and from a site where QPX has not been detected in Peconic estuary, NY. No QPX was detected in any seawater sample analyzed while QPX …

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Mechanism And Inhibition Of Bacterial Enoyl-Acp Reductases: Towards Novel Antibacterial Drugs, Hao Lu May 2010

Mechanism And Inhibition Of Bacterial Enoyl-Acp Reductases: Towards Novel Antibacterial Drugs, Hao Lu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Resistance to existing antimicrobial agents is a global threat to human health care, and new drugs with novel mechanisms of action are required in order to keep pace with the emergence of drug resistant pathogens. The bacterial fatty acid biosynthesis (FAS-II) pathway represents a validated yet relatively unexploited target for new antibiotic development and consequently there is significant interest in developing potent inhibitors of FAS-II enzymes. In this work we have focused on the FAS-II enoyl-ACP reductase enzyme which is known to be essential for bacterial survival. We cloned, expressed and purified the enoyl-ACP reductase from Francisella tularensis (ftuFabI). The …

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Strange And Imponderable: The Wooster Group And Vieux Carre, Matthew Mcmahan May 2010

Strange And Imponderable: The Wooster Group And Vieux Carre, Matthew Mcmahan

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

During a six month internship (from May to November 2009) with the experimental theatre company the Wooster Group, I documented the rehearsal process of their latest piece based on Tennessee Williams's Vieux Carr . In this thesis I provide, after a brief survey of the performance history and theory surrounding the company's oeuvre, an inside look into the group's new performance centered around Vieux Carr , and show how they use sub-texts, such as Andy Warhol's cinematic trilogy, Flesh, Trash, and Heat, along with work from postmodern video artist Ryan Trecartin, to demonstrate how the Wooster Group brings three qualities …

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Ring Opening Metathesis Polymerization Of 1-Substituted Cyclobutene Derivatives And Its Application To Antimicrobials: From Homopolymers To Alternating Copolymers, Airong Song May 2010

Ring Opening Metathesis Polymerization Of 1-Substituted Cyclobutene Derivatives And Its Application To Antimicrobials: From Homopolymers To Alternating Copolymers, Airong Song

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Ring opening metathesis polymerization (ROMP) is a chain-growth polymerization based on the ring opening of strained cyclic olefins providing a range of polymeric materials. Living ROMP of highly strained norbornene derivatives generates linear polymers with accurate molecular weight control and low polydispersities (PDIs). However, internally heterogeneous mixtures are obtained because the polymerization reactions lack complete stereochemical and regiochemical control. 1-Substituted cyclobutene amides undergo ruthenium-catalyzed ROMP to provide polymers with translationally invariant backbones (E-configuration) and excellent PDIs. To better understand the structural factors that control the regio- and stereochemistry of the ROMP reactions of 1-substituted cyclobutenes, several 1-subsituted cyclobutenes with varied …

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Self-Conscious Portrait: Narcissism And Self-Loathing In My Life And Work, Danielle Rago May 2010

Self-Conscious Portrait: Narcissism And Self-Loathing In My Life And Work, Danielle Rago

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

In this thesis, I will highlight the undercurrent of narcissism and self-loathing, a.k.a. self-conscious framing, in nine of my works completed over the last three years. I will also discuss several other themes which unite my work, namely fat identity and abjection, gender identity and performance, and sexual power dynamics. I will describe the work in chronological order, grouping pieces thematically, and sequentially. This structure will allow me to explore specific elements relevant to my chosen theme in the order they were devised, thus charting my artistic development over time.

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Generating Video Frames With Depth Of Field And Motion Blur Effects For 3d Animation, Karthik Sathyanarayana May 2010

Generating Video Frames With Depth Of Field And Motion Blur Effects For 3d Animation, Karthik Sathyanarayana

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Researchers in the field of Image Processing and Computer Vision have been working hard to understand and resolve the problems arising due to depth of field (DOF) effects and relative motion between the scene and imaging system. The varying degradation seen in the image of an object due to its depth characteristics is called depth dependent defocus blur and the blurring effect observed in the images of moving objects is called motion blur. We have developed a set of algorithms to generate shift-variant defocus and motion blur effects and have presented the same through this thesis. Our algorithm precisely takes …

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Restoration Of The Hudson River Oyster: A Physiological And Spatial Assessment Of Crassostrea Virginica's Restoration Potential In The Hudson River, Ny, Adam Faulkner Starke May 2010

Restoration Of The Hudson River Oyster: A Physiological And Spatial Assessment Of Crassostrea Virginica's Restoration Potential In The Hudson River, Ny, Adam Faulkner Starke

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The Hudson River was once home to abundant eastern oyster (Crassostrea virginica, (Gremlin 1791) populations which catered to an enormous fishery and supplied a number of vital ecological services to the estuary. Since this time, oysters have become depleted and the estuary's vitality has been compromised. Recognizing the current state of the Hudson, a comprehensive restoration plan has been implemented and targets the recovery of oysters and oyster reefs. To begin moving forward with these plans, a two year study investigating the physiological responses of the oyster to New York's Hudson River was made. The results have provided useful insights …

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Hybrid Nanostructures For Bone Tissue Engineering, Ruipeng Xue May 2010

Hybrid Nanostructures For Bone Tissue Engineering, Ruipeng Xue

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Natural bone is composed of natural polymers, collagen fibers and nano-crystals of minerals, mainly nano-hydroxyapatite (HA). Bone cells, which maintain the activities and metabolism of bone, are supported by and interact with this organic-inorganic hybrid matrix. Artificial bone tissue scaffolds mimicking the natural bone's extracellular matrix based on synthetic hybrid cellulose acetate (CA)-hydroxyapatite nano-composites were fabricated in this work in 3D matrix architecture for bone cell regeneration, using a single step nano-manufacturing technique. Cultured human osteoblasts were seeded on CA and CA-HA scaffolds, after which cell proliferative capacity and viability were studied using complementary assays. The interactions between the cells …

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Extent Of Denitrification In Northport Groundwater, Caitlin Young May 2010

Extent Of Denitrification In Northport Groundwater, Caitlin Young

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Long Island drinking water is provided by a sole source aquifer with nitrate levels exceeding the federal limit of 10ppm in some communities. Previous studies undertaken in the community of Northport identified a 50% loss of nitrogen in the system (MUNSTER, 2004; MUNSTER, 2008). A study of 15N- NO3- and 18O-NO3 identified sewage and fertilizer applications as the primary nitrogen contaminators in Northport (BLEIFUSS et al. | 2000) but did not conclusively find evidence of denitrification or ammonia volatilization in the isotope signature. No study to date has been able to identify the mechanism for 50% nitrogen loss within the …

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P53 Action In Suppressing Acute Myeloid Leukemia, Zhen Zhao May 2010

P53 Action In Suppressing Acute Myeloid Leukemia, Zhen Zhao

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Acute myeloid leukemia (AML) is the major form of adult acute leukemia. It is characterized by colonial expansion of malignant myeloid progenitors in bone marrow, resulting in insufficient generation of normal blood components to cause sever infection, fatigue, and hemorrhage in patients. p53 is a tumor suppressor that commonly mutates in human cancers. p53 mutations have profound effects on AML biology and are associated with the clinical aggressiveness and drug resistance. However, how p53 loss influences AML development remains to be determined. Mouse models recapitulating molecular alterations of human cancer are useful tools to dissect the in vivo roles of …

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F.F.A: Forensic + Funerary Architecture, Michael P. Cafro May 2010

F.F.A: Forensic + Funerary Architecture, Michael P. Cafro

Architecture Theses and Projects

This thesis document proposes the notion of an architecture that incorporates a three part program which involves violent and natural death cases. With scientific and larger public gathering spaces proposed in the building’s program, the users are grouped in a common environment that deals the subject of death. The general public are a witness to the building’s architecture and have the ability to react and become aware of their surroundings and possibly allow for an appreciation toward life.

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Buffalo Outer Harbor Quays, Ryan Decker May 2010

Buffalo Outer Harbor Quays, Ryan Decker

Architecture Theses and Projects

Buffalo, a once prominent American city hit by hard times, has the opportunity to rebuild. It has industrial resources and transport options. It has a booming education system and medical business. Its technology sector is rapidly expanding. The city has a chance right now to create new glory days. This project is about transforming a forgotten piece of land, a large swath of man-made waterfront that since the fall of Bethlehem Steel has been nothing more than equipment storage, on arguably the best portion of the city’s waterfront. Combining heavy industry, shipping, living, working, and waterfront recreation into one new …

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Black And White On Black: Whiteness And Masculinity In The Works Of Three Australian Writers - Thomas Keneally, Colin Thiele, And Patrick White., Matthew Israel Byrge May 2010

Black And White On Black: Whiteness And Masculinity In The Works Of Three Australian Writers - Thomas Keneally, Colin Thiele, And Patrick White., Matthew Israel Byrge

Electronic Theses and Dissertations

White depictions of Aborigines in literature have generally been culturally biased. In this study I explore four depictions of Indigenous Australians by white Australian writers. Thomas Keneally's The Chant of Jimmie Blacksmith (1972) depicts a half-caste Aborigine's attempt to enter white society in a racially-antipathetic world that precipitates his ruin. Children's author Colin Thiele develops friendships between white and Aboriginal children in frightening and dangerous landscapes in both Storm Boy (1963) and Fire in the Stone (1973). Nobel laureate Patrick White sets A Fringe of Leaves (1976) in a world in which Ellen Roxburgh's quest for freedom comes only through …

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The Effects Of Betadine®, Polyvinylpyrrolidone (Pvp), And Iodine On Regeneration In The Planarian Dugesia Tigrina., Traci R. Shaffer May 2010

The Effects Of Betadine®, Polyvinylpyrrolidone (Pvp), And Iodine On Regeneration In The Planarian Dugesia Tigrina., Traci R. Shaffer

Electronic Theses and Dissertations

The freshwater planarian has a great capacity to regenerate and is an ideal animal model in the study of stem cell and regeneration biology. In this study planarian regenerating new tails were exposed to nonlethal doses of Betadine®, Polyvinylpyrrolidone (PVP), and Iodine. Betadine® is a topical antiseptic commonly used in the healthcare setting and may have a detrimental effect on wound healing. PVP is linked to iodine to create povidone-iodine, the active ingredient in Betadine®. Initially, a preliminary test was performed on the worms to determine the nonlethal concentrations of these chemicals . After this nonlethal concentration was determined, tails …

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Effects Of Corn Silage Hybrids And Dietary Nonforage Fiber Sources On Productive Performance In Early Lactating Dairy Cows Fed High Forage Diets, Michael Shane Holt May 2010

Effects Of Corn Silage Hybrids And Dietary Nonforage Fiber Sources On Productive Performance In Early Lactating Dairy Cows Fed High Forage Diets, Michael Shane Holt

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This experiment was conducted to determine the effects of corn silage hybrids and nonforage fiber sources (NFFS) in high forage diets formulated with high dietary proportion of alfalfa hay (AH) and corn silage (CS) on ruminal fermentation and productive performance by early lactating dairy cows. Eight multiparous Holstein cows (4 ruminally fistulated) averaging 36 ± 6.2 d in milk were used in a duplicated 4 × 4 Latin square design experiment with a 2 × 2 factorial arrangement of treatments. Cows were fed 1 of 4 dietary treatments during each of the four 21-d periods. Treatments were: 1) conventional corn …

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Our Mountain Home: The Oscar And Emma Swett Ranch, Carolyn Toone May 2010

Our Mountain Home: The Oscar And Emma Swett Ranch, Carolyn Toone

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In this thesis, I examined the lives of my great-grandparents, Oscar and Emma Swett. Oscar began a homestead in the Uinta Mountains in 1909, which he successfully ran for nearly sixty years. My grandmother was born on the ranch, and my own father spent much of his time there. I look at how land policy changed from encouraging ranching and farming in the early 1900's to tourism and recreation in the 1960's, with the coming of the Flaming Gorge Dam. The lives of my great-grandparents and their children were shaped by these changes and they felt the consequences of the …

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Coyote Diet And Movements In Relation To Winter Recreation In Northwestern Wyoming: Implications For Lynx Conservation, Jennifer L. Burghardt Dowd May 2010

Coyote Diet And Movements In Relation To Winter Recreation In Northwestern Wyoming: Implications For Lynx Conservation, Jennifer L. Burghardt Dowd

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Increased snowmobile use in mountainous terrain has been highlighted as a conservation concern for some Canada lynx (Lynx canadensis) populations. Snow compaction resulting from winter recreation may potentially facilitate access by coyotes (Canis latrans) to habitats used by lynx during winter. Increased interactions could result in either exploitation or interference competition between the two species. Two recent, yet geographically distinct, studies showed contrasting findings regarding coyote movements and their use of snow-compacted trails during the winter. These findings suggest coyote association with snow-compacted trails may be regionally specific and dependent upon ecosystem dynamics and snow characteristics. …

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"To Drink From Places": Uncovering A Rich Way Of Life Near The Grand Canyon's North Rim, Melinda Snow Rich May 2010

"To Drink From Places": Uncovering A Rich Way Of Life Near The Grand Canyon's North Rim, Melinda Snow Rich

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The chapters of this thesis focus on the history and stories of the people who built and traveled down the highways--Highway 89A, Highway 89, and Highway 67--that branch out from the junction in front of Jacob Lake Inn, the Bowman/Rich family's 87-year-old lodge. The family's role in building roads, supporting and encouraging the growing tourist industry in Kanab and the North Rim of the Grand Canyon, and the converging effects of these choices have created the unique family culture and contributed to the history of the Grand Canyon region over time. Ultimately this thesis is about relationships, about the connections, …

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Extracellular Matrix Proteins: Implications For Angiogenesis, Kent Edward Williams May 2010

Extracellular Matrix Proteins: Implications For Angiogenesis, Kent Edward Williams

All-Inclusive List of Electronic Theses and Dissertations

The extracellular matrix (ECM) is an essential requirement for maintaining permanent shape and rigidity in multicellular organisms. The ECM serves two main functions: scaffolding and signaling. Insoluble collagen and soluble proteoglycans, glycosaminoglycans (GAGs), and glycoproteins allow for water retention and flexibility. The signaling role of the ECM is essential for a multitude of events including vascular development and angiogenesis. Via interactions with vascular endothelial cells, proteins of the ECM can induce or repress angiogenesis.

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