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The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3a Receptor-Mediated Currents In Xenopus Laevis Oocytes, Keun-Hang Susan Yang, Sehamuddin Galadari, Dmytro Isaev, Georg Petroianu, Toni S. Shippenberg, Murat Oz

Mathematics, Physics, and Computer Science Faculty Articles and Research

The effect of the plant-derived nonpsychotropic cannabinoid, cannabidiol (CBD), on the function of hydroxytryptamine (5-HT)3A receptors expressed in Xenopus laevis oocytes was investigated using two-electrode voltage-clamp techniques. CBD reversibly inhibited 5-HT (1 μM)-evoked currents in a concentration-dependent manner (IC50 = 0.6 μM). CBD (1 μM) did not alter specific binding of the 5-HT3A antagonist [3H]3-(5-methyl-1H-imidazol-4-yl)-1-(1-methylindol-3-yl)propan-1-one (GR65630), in oocytes expressing 5-HT3A receptors. In the presence of 1 μM CBD, the maximal 5-HT-induced currents were also inhibited. The EC50 values were 1.2 and 1.4 μM, in the absence and presence of CBD, indicating that CBD acts as a noncompetitive antagonist of 5-HT3 …

Molecular Effects Of Metolachlor Exposure On Human Cells, Sean Hartnett

Dissertations and Theses @ UNI

Metolachlor is one of the most commonly used herbicides in the United States of America. Numerous studies have shown that exposure to this herbicide results in decreased cell proliferation, growth and reproductive ability in different organisms. However, pervious studies used high concentrations of metolachlor to see molecular effects. In the study presented here, we investigated the effects of metolachlor on human cells. Previous cell proliferation analysis from our laboratory has shown that metolachlor is capable of significantly inhibiting the growth of normal human fibroblasts and HepG2 cells at 1.6 parts per billion (ppb) and 50 ppb. We assessed cellular effects …

Locating Henry In The “Un-”: Proto-Postmodern Negation Of Character, Allusion, Narrative And Structure In John Berryman’S The Dream Songs, Joseph Russell Hendryx

Dissertations and Theses @ UNI

John Berryman's The Dream Songs encompasses an extensive and complex negation of characterization and structure, offering a method of interpretation that focuses on the negations and the absences expressed in and presented by the song cycle. Through his nonlinear account of his life and through the historical and literary allusions he uses to express himself, Henry obscures any effort for readers to discover a stable, absolute identity. Like Henry himself, his unnamed companion unsuccessfully fulfills a variety of roles that critics have attempted to prescribe for him; he fails to perform any notable thematic or structural purpose for the poem, …

Leisure: Definitions, Patterns, And Constraints: A Study Of University Students In China, Shisi Zhou

Dissertations and Theses @ UNI

China has witnessed tremendous social transformation in the last three decades due to the introduction of the "open door" policy and economic reforms in the late 1970s, which has resulted in great changes in Chinese culture and identity considerations. University students, as one of the most energetic and creative groups of individuals in the society, are playing and will play an important role in leading leisure lifestyles in China in the future. The purpose of this study was to examine the understanding of leisure (xiuxian in Chinese), leisure patterns, and constraints among university students in China.

Undergraduate students (N = …

The Relationship Between Aggression And Measures Of Neuroticism And Agreeableness In College Students, Ashley Alexandra Buol

Dissertations and Theses @ UNI

Past studies on aggression have typically focused on physical aggression (Crick & Grotpeter, 1995). Recently, however, researchers have started to look at a subtle form of aggression known as relational aggression (Crick & Grotpeter, 1995). There have also been few studies that have focused on perceptions of aggression, as well as the personality traits that may be associated with these perceptions. Thus, the current study was designed to explore the relationship between personality characteristics, specifically agreeableness and neuroticism, and perceptions of aggression. The relationship between the levels of aggression and perceptions of aggression was also examined. Four questionnaires were utilized …

Improving The Instruction And Learning Of Topographic Maps Through The Use Of Geospatial Technologies, Troy Dean Schwemm

Dissertations and Theses @ UNI

Geographic information technologies (GIT) are spatially based technologies that include geographic information systems (GIS), remote sensing, and global positioning systems (GPS). Though GIT has been used in society for decades, and has grown tremendously in the last 10 years as advancements in technology have become available, its inclusion into the K-12 curriculum has not kept pace. As the educational reform movement places an ever increasing amount of pressure on schools to produce technologically literate, workforce ready graduates, school districts are scrambling to find creative, innovative ways to accomplish this task. Rather than learning passively, GIT allows students to construct their …

Mitochondrial Inheritance And Natural Phenotypic Variation Among Caenorhabditis Briggsae Populations, Anna Luella Coleman-Hulbert

Dissertations and Theses

Mutations affecting the mitochondrial electron transport chain cause numerous neurodegenerative disorders in humans and affect longevity in other organisms. A natural model system to study the relationship between mitochondrial function and aging within an evolutionary or population genetic context has been lacking. Natural populations of Caenorhabditis briggsae nematodes were recently found to harbor mitochondrial genetic variation with likely functional consequences for aging. Specifically, C. briggsae isolates containing high frequencies of a deletion mutation affecting the mitochondrial NADH dehydrogenase 5 (ND5) gene were found to have reduced reproductive fitness and lifespan and elevated levels of mutagenic superoxide. Here, rates …

Between Non-Intervention And Protection: A Study On The Case Of Darfur And The Responsibility To Protect, David Ryan Lucas

Dissertations and Theses

This thesis explores the obstacles in establishing a consistent and effective response framework for humanitarian catastrophe and the importance of maintaining a sustained dialogue to this end. It does so by recognizing the underlying conflict between two positions: the norm of non-intervention of states into the affairs of others, and the protection of individuals caught in the middle of violent conflict. The importance of working towards a resolution of this conflict is illustrated through the case study of Darfur, where a divided international community led an insufficient response to the crisis that can ultimately be judged as a failure. Lastly, …

Production, Characterization And Possible Applications Of Monoclonal Antibodies Generated Against Toluene Diisocyanate-Conjugated Proteins, Tinashe Blessing Ruwona

Dissertations and Theses

Diisocyanates are very reactive low molecular weight chemicals that are widely used in the manufacture of polyurethane products. Diisocyanate exposure is one of the most commonly reported causes of occupational asthma. Although diisocyanates have been identified as causative agents of respiratory diseases, the specific mechanisms by which these diseases occur remain largely unknown.

Tandem mass spectrometry was used to unambiguously identify the binding site of isocyanates within four model peptides (Leu-enkephalin (Leu-enk, YGGFL), Angiotensin I (DRVYIHPFHL), Substance P-amide (RPKPQQFFGLM-NH₂), and Fibronectin-adhesion promoting peptide (FAPP, WQPPRARI)). In each case, isocyanates were observed to react to the N-terminus of the …

Development Of A Portable Cavity Ring-Down Spectroscopic Technique For Measuring Stable Isotopes In Atmospheric Methane, Gregory A. Bostrom

Dissertations and Theses

Trace gases can have a significant impact on the Earth's climate, and the analysis of changes in these gases and an understanding of how much of these changes are a result of human activity is important for understanding global climate change. Methane (CH₄) is the second only to CO₂ in radiative forcing over the last 200 years, and its concentration in the atmosphere has more than doubled since 1750. Sources and sinks of CH₄ have characteristic isotopic effects, which shift the relative concentration of the methane isotopologues. Spectroscopic techniques for of analysis the isotopic composition of …

Bioelectric Applications For Treatment Of Melanoma, Stephen J. Beebe, Karl H. Schoenbach, Richard Heller

Bioelectrics Publications

Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in …

Recueil D’Outils Sur Les Aspects Sociaux Et Organisationnels Des Interventions Externes En Sst. Partie 1 : Présentation Des Outils, Geneviève Baril-Gingras, Marie Bellemare, Pierre Poulin, Julie Ross

Rapports de recherche scientifique

No abstract provided.

Recueil D’Outils Sur Les Aspects Sociaux Et Organisationnels Des Interventions Externes En Sst. Partie 4 : Guide De La Feuille De Route, Geneviève Baril-Gingras, Marie Bellemare, Pierre Poulin, Julie Ross

Rapports de recherche scientifique

No abstract provided.

Évaluation De La Toxicité Du Béryllium En Fonction De La Forme Chimique Et De La Taille Des Particules, Caroline Muller, Bruce Mazer, Fariba Salehi, Séverine Audusseau, Ginette Truchon, Jean Lambert, Gilles L Espérance, Gaston Chevalier, Suzanne Philippe, Yves Cloutier, Pierre Larivière, Joseph Zayed

Rapports de recherche scientifique

Click here for the English version of this report

Au cours des dernières années, plusieurs auteurs ont remis en cause le niveau de protection accordé aux travailleurs par la valeur seuil reconnue pour le béryllium (Be) et ses sels (VEMP Québec, TLV (TWA) ACGIH). La prévalence des effets associés au Be suggère que les risques sont en fonction de sa spéciation. Par ailleurs, il semble que les particules fines constituent la fraction d’intérêt pour l’occurrence de tels effets. L’objectif de cette recherche est d’évaluer la toxicité du Be en fonction de la forme chimique et de la taille particulaire.

Pour …

The Effective Use Of Confrontation In Family Therapy: A Process Study, Timothy Michael Digiacomo

Psychology Theses & Dissertations

Although contemporary practitioners have rejected the confrontational style and perceived aggressiveness of earlier family therapists in favor of a more "collaborative" stance, confrontation, as a technique, is still widely used in almost all forms of psychotherapy, including family therapy. The present process study explored what makes confrontation more or less effective in motivating clients to recognize and reevaluate counterproductive ways of interacting. Using videotaped family therapy sessions, confrontation clarity, emotional reactivity, and the use of suggestion were examined in relation to client levels of acceptance of confrontation immediately following the confrontation, as well as in relation to overall …

Tragic Pleasure In Shakespeare's King Lear And Othello, Luella Fu

CMC Senior Theses

This thesis is an examination of reader or audience response to Shakespeare’s tragedies. Primarily, it identifies key pleasures that Shakespeare’s King Lear and Othello offer. The complementary nature of these two plays is such that the analysis of their various pleasures allows for an in-depth treatment of the topic and also reflects the diversity of emotional response elicited by Shakespeare’s tragedies. The kinds of pleasure addressed in this study are catharsis as explained by Aristotle, the delight of violent passion as advocated by DuBos, pleasure from details in the work, satisfaction from the coherence of the tragedy, and pleasure in …

Erbb/Her Receptor Activation And Preclinical Efficacy Of Lapatinib In Vestibular Schwannoma, Sylwia Ammoun, Clare H. Cunliffe, Jeffrey C. Allen, Luis Chiriboga, Filippo G. Giancotti, David Zagzag, C. Oliver Hanemann, Matthias A. Karajannis

Peninsula Medical School

Vestibular schwannomas (VS) arising sporadically or in patients with neurofibromatosis type 2 (NF2) consistently lack expression of Merlin, a tumor suppressor. Conventional treatment options include surgery and radiotherapy but there is no validated medical option. Recent evidence suggests that Merlin deficiency may result in abnormal activation of receptor tyrosine kinases (RTKs) and downstream signaling, promoting tumor growth. Although small-molecule RTK inhibitors are widely available for clinical use, no such therapy has been validated in patients with VS. To screen for RTK activation, surgical VS specimens from patients with and without NF2 were analyzed by phospho-RTK profiling arrays. Downstream signaling pathway …

Immunohistochemical Demonstration Of S100 In The Lung Of Philippines Swamp Buffalo (Bubalus Bubalis Carabensis), Abigail Joyce G. Tuzon

Undergraduate Theses

No abstract provided.

When Resistance Is Not Enough: The Role Of Ecotage In Radical Environmentalism, Kris R. Brown

CMC Senior Theses

As a starting point, I've created a simple, five step argument for my view on humanity's environmental responsibility. The first four steps are premises upon which I will elaborate to some degree over the course of this paper, and the fifth step is a conclusion that should necessarily follow from the premises if they are true.

1) Humans are currently threatening the earth's viability as a habitat for living thing.

2) Humans have a duty not to threaten the earth's viability as a habitat for living things.

3) Our duty not to threaten the viability of the earth as a …

Hindutva And Anti-Muslim Communal Violence In India Under The Bharatiya Janata Party (1990-2010), Elaisha Nandrajog

CMC Senior Theses

On May 16, 1998, under the directives of the Hindu nationalist Bharatiya Janata Party (BJP)-led coalition, the Indian government detonated three nuclear bombs in the Rajasthan desert, near a site called Pokhran.1 If the name of India’s inter-ballistic missile, Agni, the god of fire in the Vedic tradition, is inscribed in antiquity, its symbolism in 1998 was entirely new, reflecting the rise of a political party that emblematizes a chauvinistic, majoritarian stance.2 To celebrate India’s accomplishment, the Vishva Hindu Parishad (VHP), a sister organization of the BJP, ordered the construction of a temple dedicated to Shakti, the goddess of strength, …

Laying Bare The Sins Of The Father: Exploring White Fathers In Post-Apartheid Literature, Casey M. Reck

CMC Senior Theses

This Thesis is an exploration of white fathers in three post-apartheid novels: Mark Behr's The Smell of Apples, Nadine Gordimer's The House Gun, and J. M. Coetzee's Disgrace. By examining the link between private white hegemonic masculinity and the apartheid government, the Thesis analyzes the transitional process as these men try to adopt less authoritative identities.

The Consequences Of Increasing Ocean Acidification On Local And Global Fishing Industries, Alyson N. Stark

CMC Senior Theses

As human activities continue to generate accelerating levels of carbon dioxide emissions, the world’s oceanic resources are threatened by variability in seawater chemistry, known as ocean acidification. Recent increases in atmospheric carbon dioxide have resulted in decreased carbonate ion concentrations and ocean pH levels, leading to increasingly acidic waters. The exact consequences of these chemical changes on ecosystems and individual species are difficult to predict; however, research has shown that economically valuable calcifying species will experience reduced reproductive fitness and population declines. Ocean acidification, therefore, poses an immediate risk to both fish stocks and fishery industries. From a local perspective, …

How Users Actually Use Financial Statements: A New Tool For Research In Experimental Accounting, Kevin Burke

CMC Senior Theses

This thesis presents a new methodology based on directly measuring user behavior and making decisions based on experimental results. I have built and tested a tool which will enable researchers to use the methodology to determine whether particular financial statement presentations are more beneficial than others. The tool records user movement on a computer screen with mouse tracking, which allows researchers to track user behavior in greater detail than ever before. The methodology was tested on a subject pool of non-professional financial analysts and junior professionals, who were presented with a company’s financial data in the current GAAP and a …

Solar Development In The Mojave Desert, Joseph B. Swartley

CMC Senior Theses

For more than two centuries, humans have been spewing “greenhouse gases” into the atmosphere through the burning of fossil fuels, deforestation, and the development of land, causing the planet’s surface temperature to increase at an accelerated rate. Climate change is one of the most pressing issues that the world is facing today, and in order to combat the effects of climate change, it is necessary to adopt the use of more renewable technology, namely solar energy. The United States' best region for solar development is the Mojave Desert, and many large-scale projects are being built or proposed to be built …

The Effects Of Communication Disorders On Social Development, Heather M. Back

CMC Senior Theses

This paper explores literature on the effects of communication disorders on the social development of children. The paper discusses such topics as the effects of communication disorders on personality development, the ability to make friends and resolve conflict with peers, and academic success. It also discusses the influences of multiculturalism and bilingualism on the diagnosis of communication disorders and reflects on the importance of awareness of cultural differences in communication style to avoid a misdiagnosis. Research shows that without intervention and treatment communication disorders can have irreversible detrimental effects on a child’s ability to develop effect social-communication, to make friends, …

From Disco To Electronic Music: Following The Evolution Of Dance Culture Through Music Genres, Venues, Laws, And Drugs., Ambrose Colombo

CMC Senior Theses

Electronic dance music is a genre that has been long in the making. Starting with disco in the 1970s, dance culture genres evolved into house, acid house, techno, garage, 2-step, hardcore, gabba, san frandisco, electro, and many others. This paper studies the transformation of electronic sound, and the contributing/impeding factors involved. Drug use is heavily related to the creation and enjoyment of music, and features prominently in the history of dance culture. Starting with the use of acid in the 1960s and progressing to the use of acid, Quaaludes, poppers, speed in the 1970s, with MDA featured in clubs toward …

Equal Bmd After Daily Or Triweekly Exercise In Growing Rats, B. D. Kayser, J. K. Godfrey, R. M. Cunningham, R. A. Pierce, S. V. Jaque, Ken D. Sumida

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The purpose of this study was to examine the efficacy of continuous resistance training (3 days/wk) compared to interrupted resistance training where 20-24 h separated an exercise bout (i.e. 6 days/wk) for enhancing bone mineral density (BMD) in growing male rats. The total volume of work performed per week between the two resistance training programs was equivalent by design. Young male rats were randomly divided into Control (Con, n = 9), 3 days/wk resistance trained group (RT3, n = 9), and 6 days/wk resistance trained group (RT6, n = 9). The RT3 and RT6 groups were conditioned to climb a …

Trust And The Green Consumer: The Fight For Accountability In Renewable Energy Credits, Kelly Crandall

University of Colorado Law Review

Renewable energy credits ("RECs")--commodities representing a megawatt-hour of renewable electricity but tradable separately from the electricity itself-developed to encourage renewable energy investment and to allow individuals and corporations without direct access to renewable energy to subsidize its construction. RECs can be sold voluntarily or applied to state-imposed renewable energy purchase obligations. These state mandates, known as renewable portfolio standards, have contributed dramatically to the demand for RECs. Yet, despite their popularity, RECs are regulated inconsistently: neither federal nor state consumer protection law fully mitigates the opportunities they create for deceptive advertising. This Comment critiques the existing regulatory scheme (or lack …

Definitions Of The Phenotypic Manifestations Of Sickle Cell Disease., Samir K Ballas, Susan Lieff, Lennette J Benjamin, Carlton D Dampier, Matthew M Heeney, Carolyn Hoppe, Cage S Johnson, Zora R Rogers, Kim Smith-Whitley, Winfred C Wang, Marilyn J Telen

Department of Medicine Faculty Papers

Sickle cell disease (SCD) is a pleiotropic genetic disorder of hemoglobin that has profound multiorgan effects. The low prevalence of SCD ( approximately 100,000/US) has limited progress in clinical, basic, and translational research. Lack of a large, readily accessible population for clinical studies has contributed to the absence of standard definitions and diagnostic criteria for the numerous complications of SCD and inadequate understanding of SCD pathophysiology. In 2005, the Comprehensive Sickle Cell Centers initiated a project to establish consensus definitions of the most frequently occurring complications. A group of clinicians and scientists with extensive expertise in research and treatment of …

Resource Selection By Elk In An Agro-Forested Landscape Of Northwestern Nebraska, David M. Baasch, Justin W. Fischer, Scott E. Hygnstrom, Kurt C. Vercauteren, Andrew J. Tyre, Joshua J. Millspaugh, James W. Merchant, Jerry D. Volesky

School of Natural Resources: Faculty Publications

In recent years, elk have begun recolonizing areas east of the Rocky Mountains that are largely agroforested ecosystems composed of privately owned land where management of elk is an increasing concern due to crop and forage depredation and interspecific disease transmission. We used a Geographic Information System, elk use locations (n = 5013), random locations (n = 25,065), discrete-choice models, and information-theoretic methods to test hypotheses about elk resource selection in an agro-forested landscape located in the Pine Ridge region of northwestern Nebraska, USA. Our objectives were to determine landscape characteristics selected by female elk and identify publicly owned land …