Digital Commons Network^™

The Rapid Identification Of Novel Anti-Mycobacterial Drugs And The Transporters Involved In Their Resistance, James Carroll

Theses

Despite the success of anti-mycobacterial drugs over the past 70 years, mycobacterial disease, particularly tuberculosis is still responsible for millions of deaths worldwide. Additionally, the emergence of Multidrug Resistant (MDR-TB) and Extensively Drug Resistant (XDR-TB) Tuberculosis throughout the world has motivated calls by the World Health Organization for novel mycobacterial drugs, vaccines and diagnostic tests. Consequently, this study sought to identify and evaluate the efficacy of a range of anti-mycobacterial compounds against a representative cohort of pathogenic mycobacterial species. The development and employment of the rapid, robust and inexpensive microtitre alamarBlue assay (MABA) facilitated the assessment of a vast array …

Phage Lysins - Structure, Genetics And Applications, Jennifer Garry

Theses

Antibiotics are of the utmost importance in the fight against pathogenic bacteria, however, in recent years there has been a continual increase in the development of antibiotic resistance among bacteria. As a result it has become essential to develop new technologies to combat these pathogens. One such technology is the application of phage lysins as antimicrobial agents against pathogenic infections. A promising phage lysin is LysK, a 495 amino-acid protein derived from Staphylococcal Phage K. LysK can lyse a wide range of staphylococcal species including MRSA. It is also capable of killing both live and dead cells increasing its potential …

Biosynthesis Of Exopolysaccharides From Lactic Acid Bacteria And Evaluation Of Their Prebiotic Potential, Colette Ann Forde

Theses

In this study, two strains of lactic acid bacteria (LAB) namely Weissella kimchii F28 and W. confusa MGl were used for the production of exopolysaccharides (EPS) from sucrose. Both strains produced glucan polysaccharides. In the case of W. kimchii F28, the EPS isolation procedure was performed six times, making modifications in order to optimize the yield of EPS. The maximum yield of EPS for this strain was 16 g per litre of culture. In the case of W. confusa MGl, the EPS isolation procedure was followed five times, resulting in a maximum yield of EPS for this strain of 34.4 …

Isolation And Molecular Characterization Of Mycobacterium Avium Subsp. Paratuberculosis In Ireland, Pierre Emmanuel Douarre

Theses

MAP is a proven animal pathogen causing Johne's disease, one of the most widespread and economically important diseases of ruminants. Since 1992 and the opening of the European market, the prevalence of MAP in Ireland has increased considerably. Improvements in diagnostic strategies for Ireland and elsewhere are urgently required. MAP infects a wide host range and has emerged as a potential threat to human health and has been associated with Crohn's disease. The control of paratuberculosis infection requires a better understanding of the genetic diversity of the pathogen. The objective of this study was to isolate and characterize this enteric …

Detection And Molecular Characterization Of Canine Enteric Viruses In Southern Ireland., Susan Mcelligott

Theses

Enteric viruses, such as canine parvovirus (CPV) and canine coronavirus (CCoV), are a major cause of gastroenteritis in dogs. More serious clinical symptoms occur in young pups, or when both of these viruses infect an animal simultaneously. Caliciviruses and rotaviruses can also cause gastroenteritis in dogs, but these viruses, while causing significant problems in other animal species and humans, are considered to be less significant pathogens of canines. However, on occasion, these viruses have been reported to produce severe clinical symptoms such as vomiting, haemorrhagic enteritis and severe dehydration.

Many viral vaccines for canines are formulated using old vaccine viral …

Toxicodynamics And Biotransformation Of Azaspiracids Incorporating Liquid Chromatography-Tandem-Mass Spectrometry (Lc-Ms/Ms) Techniques., Daniel O'Driscoll

Theses

Azaspiracids (AZAs) are a family of lipophilic polyether marine biotoxins, that have caused a number of human intoxication incidents in Europe since 1995, which was the first incident reported following the consumption by consumers of intoxicated shellfish {Mytilus edulis). This class of phycotoxins has been responsible for extended closures of shellfisheries in various locations around Europe, where levels of AZAl-3 are regulated in shellfish. Since their discovery in 1995, AZAs have become the focus of extensive research, resulting in the discovery of numerous analogues. Only AZAl and AZA2 have been found in phytoplankton and all the other analogues are believed …

Courtship And Copulation In Glaucous-Winged Gulls, Larus Glaucescens, Kelly M. Mcwilliams

Master's Theses

Using video recordings and scan counts, I examined the occurrence, sequences, and durations of behavior and environmental factors associated with courtship and copulation in glaucous-winged gulls, Larus glaucescens. Males and females in a pair had equivalent pre- and post-Mount behavior occurrences and durations. The main courtship sequence was Head Toss -- Courtship Beg/Respond -- Mounted/Mount, and felames appeared to initiate transitions between these pre-Mount behaviors. More Mounts occurred during the egg-laying stage of the breeding season, but copulation duration, wing-flag duration, and cloacal contacts per copulation showed no significant differences across sampling periods. Poisson analysis showed no significant grouping …

An Environment For Stroke Therapy Game Authoring, Simon Tam

All Theses and Dissertations (ETDs)

Stroke is the leading cause of disability in the industrialized world. The disabilities caused by stroke can significantly impact the quality of daily life for stroke survivors. Studies show that a high number of daily body movement repetitions can help recover lost motor functionality. However, many stroke patients do not perform the home exercises needed to reach this high number of repetitions. Games for rehabilitation have been shown to provide motivation to perform home exercises. However, because stroke can leave survivors with different levels of disability, custom games are required. Creating custom games, though, is time consuming and requires advanced …

Morphing Of Triangular Meshes In Shape Space, Stefanie Wuhrer, Prosenjit Bose, Chang Shu, Joseph O'Rourke, Alan Brunton

Computer Science: Faculty Publications

We present a novel approach to morph between two isometric poses of the same non-rigid object given as triangular meshes. We model the morphs as linear interpolations in a suitable shape space S. For triangulated 3D polygons, we prove that interpolating linearly in this shape space corresponds to the most isometric morph in R³ . We then extend this shape space to arbitrary triangulations in 3D using a heuristic approach and show the practical use of the approach using experiments. Furthermore, we discuss a modified shape space that is useful for isometric skeleton morphing. All of the newly presented …

A Curriculum Unit On Programming And Robotics, Marina U. Bers, Louise Flannery, Elizabeth Kazakoff, R. Jordan Crouser

Computer Science: Faculty Publications

The Tangible Kindergarten project studies how, when given age-appropriate tools, young children can actively engage in computer programming and robotics in a way that is consistent with developmentally appropriate practice. This research project explores the creation of novel human computer interaction techniques to support learning with technology in early elementary school, with a focus on kindergarten. Since many modern graphical user interfaces are not designed with the developmental needs of such young learners in mind, they are generally ill-suited for use in early elementary school classrooms, especially for computer programming activities. To overcome this problem, this research project has created …

Teaching Resources In Speleology And Karst: A Valuable Educational Tool, Jo De Waele

International Journal of Speleology

There is a growing need in the speleological community of tools that make teaching of speleology and karst much easier. Despite the existence of a wide range of major academic textbooks, often the caver community has a difficult access to such material. Therefore, to fill this gap, the Italian Speleological Society, under the umbrella of the Union International de Spéléologie, has prepared a set of lectures, in a presentation format, on several topics including geology, physics, chemistry, hydrogeology, mineralogy, palaeontology, biology, microbiology, history, archaeology, artificial caves, documentation, etc. These lectures constitute the “Teaching Resources in Speleology and Karst”, available online. …

Effect Of Photobiomodulation On Vinblastine-Poisoned Murine Hers Cells, Brian D. Hodgson, B. Pyszka, Michele M. Henry, E. Buchmann, Harry T. Whelan

School of Dentistry Faculty Research and Publications

Objective: The aim of this study was to investigate the effect of near-infrared (NIR) photobiomodulation on the proliferation and glutathione levels in murine Hertwig's epithelial root sheath (HERS) cells after poisoning with vinblastine. Background: Photobiomodulation has been shown to improve wound healing in a number of animal models. There have been no studies on the effect of photobiomodulation on cancer-related chemotherapy injury to the cells that initiate tooth root growth. Materials and Methods: Control groups consisted of murine HERS cells without vinblastine (VB−) and cells with vinblastine at 10, 20, and 30 ng/mL (VB10, VB20, and VB30). Experimental groups consisted …

Sailing The Seas Of Cheese, Erik Anderson

Contemporary Aesthetics (Journal Archive)

Memphis Elvis is cool; Vegas Elvis is cheesy. How come? To call something cheesy is, ostensibly, to disparage it, and yet cheesy acts are some of the most popular in popular culture today. How is this possible? The concepts of cheese, cheesy, and cheesiness play an important and increasingly ubiquitous role in popular culture today. I offer an analysis of these concepts, distinguishing them from nearby concepts like kitchy and campy. Along the way I draw attention to the important roles of cultural/historical context, background knowledge, and especially artist’s intentions as they are relevant to aesthetic assessments involving cheese and …

The Aesthetics Of Magnetic Resonance Imaging (Mri): From The Scientific Laboratory To An Artwork, Silvia Casini

Contemporary Aesthetics (Journal Archive)

This article investigates the aesthetic potential of Magnetic Resonance Imaging (MRI), a medical imaging technique, both inside the laboratory and in the arts. By combining Rancière’s understanding of aesthetics with Merleau-Ponty’s notion of embodied perception, it argues that an image-generating technique conceived in the scientific field can successfully migrate into the realm of fine art, opening up new aesthetic and perceptual possibilities. Although aesthetic qualities are already present in the laboratory, they remain hidden by the necessity of reading the image-data obtained according to the interpretative framework of the medical discourse. Two paths are covered: the first goes from the …

A Functional Model Of The Aesthetic Response, Daniel Conrad

Contemporary Aesthetics (Journal Archive)

In a process of somatic evolution, the brain semi-randomly generates initially-unstable neural circuits that are selectively stabilized if they succeed in making sense out of raw sensory input. The human aesthetic response serves the function of stabilizing the circuits that successfully mediate perception and interpretation, making those faculties more agile, conferring selective advantage. It is triggered by structures in art and nature that provoke the making of sense. Art is deliberate human action aimed at triggering the aesthetic response in others; thus, if successful, it serves the same function of making perception and interpretation more agile. These few principles initiate …

Recovery Of An Endangered Provision: Untangling And Reviving Critical Habitat Under The Engangered Species Act, Kalyani Robbins

Akron Law Faculty Publications

There has been long-term confusion among courts, agencies, developers, and environmental organizations regarding the legal, environmental, and economic impacts of designating critical habitat for species listed as threatened or endangered under the ESA. At the heart of this difficulty has been a need to understand the degree to which the protections for critical habitat can be distinguished from those for listed species generally. Critical habitat is primarily protected via section 7’s requirement that federal agencies consult with the Fish & Wildlife Service and the National Marine Fisheries Service to determine whether a proposed federal action either jeopardizes a listed species …

Reach Your Campus, Reach The World: Prioritizing Our Mission To And Through Those In Schools, Steve Case

All Books

DESCRIPTION

An estimated 70% of Seventh-day Adventist college and university students attend non-church sponsored schools. Many of these students are not finding a spiritual community they can connect with, creating a tremendous need for public campus ministry.

How can the Seventh-day Adventist Church intentionally foster biblical community on public college and university campuses? How can we reach both Adventist and non-Adventist students? How should we conduct evangelism to fit a changing world? These and many other questions were addressed at the 2009 180º Symposium held on the campus of Andrews University.

Papers presented at the 180º Symposium covered three major …

Encountering God In Life And Mission: A Festschrift Honoring Jon Dybdahl, Rudolf Maier

All Books

No abstract provided.

The Third Tear In Everyday Aesthetics, Katya Mandoki

Contemporary Aesthetics (Journal Archive)

Although totally overlooked by mainstream aesthetic theory, various paths were nevertheless left open for addressing everyday aesthetics, a natural yet surprisingly controversial topic. Why they were never taken until recently, when the theme of everyday aesthetics is now becoming fashionable, can be explained not only by the obvious fact of philosophical aesthetics’ restrictive focal point on art but, among other reasons, by a kind of fetishism that demands an object of recognized value for legitimating an aesthetic inquiry. This new popularity entails, however, certain theoretical risks such as clinging to traditional art-centric and beauty-centric categories to explain the everyday and …

Interpretation, Sincerity & "Theory", John Gibson

Contemporary Aesthetics (Journal Archive)

No abstract provided.

Rethinking Guardianship (Again): Substituted Decision Making As A Violation Of The Integration Mandated Of Title Ii Of The Americans With Disabilities Act, Leslie Salzman

Articles

In every state, when an adult has a diminished capacity to make decisions about personal affairs or property management, a court may transfer the individual’s right to make decisions to a guardian. This Article argues that, in most cases, it would be preferable to support decision making rather than supplant it through guardianship, and then seeks to locate a right to receive such support as a less restrictive alternative to the substituted decision making that characterizes guardianship.

Building on the reasoning in Olmstead v. L.C. and subsequent decisions interpreting the Americans with Disabilities Act’s integration mandate, this Article argues that …

Renshaw Cell Loss In A Transgenic Mouse Model Of Amyotrophic Lateral Sclerosis, Stephane Robert Leo Blanchard

Undergraduate Theses and Senior Projects

No abstract provided.

Spatial Memory And Antioxidant Defense In Long-Living Ames Dwarf Mice, Stephanie Branshaw

Undergraduate Theses and Senior Projects

No abstract provided.

Norepinephrine, Through Activation Of [Alpha]₁A Adrenergic Receptors, Stimulates The Production Of New Neurons, Leading To Alleviation Of Depression And Anxiety, Katie Collette

Undergraduate Theses and Senior Projects

No abstract provided.

Stories From Luis De LióN'S La Puerta Cielo In Translation, Jessica Skroch

Undergraduate Theses and Senior Projects

No abstract provided.

On The Nexus Of Socialism And Evolution, Allison Grace Krause

Undergraduate Theses and Senior Projects

No abstract provided.

The Wolseley Elm, Liza Jones

Undergraduate Theses and Senior Projects

No abstract provided.

Alpha-1a Adrenergic Receptor Stimulation Reduces Anxiety In Mice, Elizabeth Joan Luger

Undergraduate Theses and Senior Projects

No abstract provided.

Welfare As Happiness, John Bronsteen, Christopher Buccafusco, Jonathan Masur

Articles

Perhaps the most important goal of law and policy is improving people’s lives. But what constitutes improvement? What is quality of life, and how can it be measured? In previous articles, we have used insights from the new field of hedonic psychology to analyze central questions in civil and criminal justice, and we now apply those insights to a broader inquiry: how can the law make life better? The leading accounts of human welfare in law, economics, and philosophy are preference-satisfaction - getting what one wants - and objective list approaches - possessing an enumerated set of capabilities. This Article …

Disciplines And Jurisdictions: An Historical Note, Peter Goodrich

Articles

No abstract provided.