Digital Commons Network^™

Garden Grove, Iowa: From Mormon Way Station To Permanent Settlement, 1846-1852, Jill N. Crandell

Theses and Dissertations

When the Mormon people began evacuating Nauvoo, Illinois, in February 1846, they intended to leave the United States and build a home for themselves in the West, where they could practice their religion without persecution. However, as Brigham Young led thousands through severe rain and mud that spring, he soon decided that too many of the Saints were unprepared for the long journey to the mountains. Mormons built way stations across Iowa, places where they planted crops, raised log cabins, and obtained the necessary food and supplies. After the Saints moved on to Utah in following years, many of these …

Intrinsic Features Of The Multisensory Cortical Area Lrss In The Ferret, Alexandru Ioan Cojanu

Theses and Dissertations

Environmental events simultaneously transduced by more than one sensory modality underlie multisensory processing in the CNS. While most studies of multisensory processing examine functional effects, none have evaluated the influence of local or columnar circuitry. The goal of the present study is to examine of local features of the ferret lateral rostral suprasylvian sulcus (LRSS), a multisensory cortex. Immunostaining revealed the cytoarchitectonic features of the LRSS: thick supragranular layers, a narrow layer IV, and moderately stained but differentiated infragranular layers. Golgi-Cox techniques were used with light microscopy and digital reconstruction to document neuronal morphology. Among the 90 reconstructed neurons, 4 …

Printed Matter, Inc., The First Decade: 1976-1986, Claire Dixon

Theses and Dissertations

This thesis provides an account of the events of the first ten years of Printed Matter, Inc., a distribution center for artists’ books established in New York City in 1976. Included are descriptions of the individuals who formed Printed Matter’s first board, their objectives, books published by Printed Matter, and the windows installation program. This thesis also describes challenges the board members faced, including lack of organization, difficulty cultivating a broad public audience, and inadequate income. In addition, it recounts the gradual streamlining of business practices, and the realignment of goals and expectations for the genre as board members accepted …

Humphry Davy: Science, Authorship, And The Changing Romantic, Marianne Lind Baker

Theses and Dissertations

In the mid to late 1700s, men of letters became more and more interested in the natural world. From studies in astronomy to biology, chemistry, and medicine, these "philosophers" pioneered what would become our current scientific categories. While the significance of their contributions to these fields has been widely appreciated historically, the interconnection between these men and their literary counterparts has not. A study of the "Romantic man of science" reveals how much that figure has in common with the traditional "Romantic" literary figure embodied by poets like William Wordsworth and Samuel Taylor Coleridge. This thesis interrogates connections between Romantic …

Pierced Through The Ear: Poetic Villainy In Othello, Kathleen Emerald Somers

Theses and Dissertations

The paper examines Othello as metapoetry. Throughout the play, key points of comparison between Iago and Shakespeare's methodologies for employing allegory, symbolism, and mimetic plot and character construction shed light upon Shakespeare's self-reflexive use of poetry as an art of imitation. More specifically, the contrast between Shakespeare and Iago's poetry delineates between dynamic and reductive uses of allegory, emphasizes an Aristotelian model of mimesis that makes reason integral to plot and character formation, and underscores an ethical function to poetry generally. In consequence of the division between Iago and Shakespeare as unethical and ethical poets respectively, critical contention concerning the …

Adar2-Dependent Rna Editing Of Glur2 Is Involved In Thiamine Deficiency-Induced Alteration Of Calcium Dynamics, Shuchen Lee, Guang Yang, Yue Yong, Ying Liu, Liyun Zhao, Jing Xu, Xiaomin Zhang, Yanjie Wan, Chun Feng, Zhiqin Fan, Yong Liu, Jia Luo, Zun-Ji Ke

Internal Medicine Faculty Publications

BACKGROUND: Thiamine (vitamin B1) deficiency (TD) causes mild impairment of oxidative metabolism and region-selective neuronal loss in the central nervous system (CNS). TD in animals has been used to model aging-associated neurodegeneration in the brain. The mechanisms of TD-induced neuron death are complex, and it is likely multiple mechanisms interplay and contribute to the action of TD. In this study, we demonstrated that TD significantly increased intracellular calcium concentrations [Ca2+]i in cultured cortical neurons.

RESULTS: TD drastically potentiated AMPA-triggered calcium influx and inhibited pre-mRNA editing of GluR2, a Ca2+-permeable subtype of AMPA receptors. The Ca2+ permeability of GluR2 is regulated …

Substrates Of The Arabidopsis Thaliana Protein Isoaspartyl Methyltransferase 1 Identified Using Phage Display And Biopanning, Tingsu Chen, Nihar Nayak, Susmita Maitra Majee, Jonathan Lowenson, Kim R. Schäfermeyer, Alyssa C. Eliopoulos, Taylor D. Lloyd, Randy Dinkins, Sharyn E. Perry, Nancy R. Forsthoefel, Steven G. Clarke, Daniel M. Vernon, Zhaohui Sunny Zhou, Tomas Rejtar, A. Bruce Downie

Horticulture Faculty Publications

The role of protein isoaspartyl methyltransferase (PIMT) in repairing a wide assortment of damaged proteins in a host of organisms has been inferred from the affinity of the enzyme for isoaspartyl residues in a plethora of amino acid contexts. The identification of PIMT target proteins in plant seeds, where the enzyme is highly active and proteome long-lived, has been hindered by large amounts of isoaspartate-containing storage proteins. Mature seed phage display libraries circumvented this problem. Inclusion of the PIMT co-substrate, S-adenosylmethionine (AdoMet), during panning permitted PIMT to retain aged phage in greater numbers than controls lacking co-substrate or when …

Biological Rationale For The Use Of Dna Methyltransferase Inhibitors As New Strategy For Modulation Of Tumor Response To Chemotherapy And Radiation., Giovanni L Gravina, Claudio Festuccia, Francesco Marampon, Vladimir M Popov, Richard G Pestell, Bianca M Zani, Vincenzo Tombolini

Kimmel Cancer Center Faculty Papers

Epigenetic modifications play a key role in the patho-physiology of many tumors and the current use of agents targeting epigenetic changes has become a topic of intense interest in cancer research. DNA methyltransferase (DNMT) inhibitors represent a promising class of epigenetic modulators. Research performed yielded promising anti-tumorigenic activity for these agents in vitro and in vivo against a variety of hematologic and solid tumors. These epigenetic modulators cause cell cycle and growth arrest, differentiation and apoptosis. Rationale for combining these agents with cytotoxic therapy or radiation is straightforward since the use of DNMT inhibitor offers greatly improved access for cytotoxic …

Toksisitas Akut Daun Justicia Gendarussa Burm, Berna Elya, Juheini Amin, Emiyanah Emiyanah

Makara Journal of Science

Acute Toxicity of Justicia gendarussa Burm. Leaves. Preminelary experiment showed that ethanolic extract of gandarusa leaves (Justicia gendarussa Burm.) could decreased uric acid blood level on rats. The aim of this experiment was to determine of the value LD50 and liver function based on activities of aminotransferase. Animals test which were used in this experiment were 50 males and 50 females white mice. They were divided into 5 groups. Group 1 as control group was given aquadest. Group 2-5 were treated by ethanolic extract of gandarusa leaves with dosage 4, 8, 16, and 32 g/kg bw. The LD50 value was …

Vol. 61, No. 4, November 24, 2010, University Of Michigan Law School

Res Gestae

•Turning Up the Heat in Hutchins •Law & Lit •Torts and Football •The Beer Gal •Save Yourself •Zach Letter Law •Beauty and the Bite •Jenny Runkles •Kicking it Old School •Alt-Prom Pics •Crossword

The Anchor, Volume 124.10: November 24, 2010, Hope College

The Anchor: 2010

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.

Calcium Regulates Vesicle Replenishment At The Cone Ribbon Synapse., Norbert Babai, Theodore M. Bartoletti, Wallace B. Thoreson

Journal Articles: Ophthalmology

Cones release glutamate-filled vesicles continuously in darkness, and changing illumination modulates this release. Because sustained release in darkness is governed by vesicle replenishment rates, we analyzed how cone membrane potential regulates replenishment. Synaptic release from cones was measured by recording postsynaptic currents in Ambystoma tigrinum horizontal or OFF bipolar cells evoked by depolarization of simultaneously voltage-clamped cones. We measured replenishment after attaining a steady state between vesicle release and replenishment using trains of test pulses. Increasing Ca(2+) currents (I(Ca)) by changing the test step from -30 to -10 mV increased replenishment. Lengthening -30 mV test pulses to match the Ca(2+) …

Mccomas, Eric Donald, B. 1983 (Fa 484), Manuscripts & Folklife Archives

Folklife Archives Finding Aids

Finding aid and full-text (click on "Additional File" below) for Folklife Archives Project 484. Folkore material classified by genre. Information collected by Eric Donald McComas related to folklore genres for a folk studies class at Western Kentucky University.

Why Are We Getting Fatter? Uab Researchers Seek A Mysterious Culprit, Alicia Rohan

Browse All News

No abstract provided.

Identification Of A Single-Nucleotide Insertion In The Promoter Region Affecting The Sodc Promoter Activity In Brucella Neotomae, Dina A. Moustafa, Neeta Jain, Nammalwar Sriranganathan, Ramesh Vemulapalli

Department of Comparative Pathobiology Faculty Publications

Brucella neotomae is not known to be associated with clinical disease in any host species. Previous research suggested that B. neotomae might not express detectable levels of Cu/Zn superoxide dismutase (SOD), a periplasmic enzyme known to be involved in protecting Brucella from oxidative bactericidal effects of host phagocytes. This study was undertaken to investigate the genetic basis for the disparity in SOD expression in B. neotomae. Our Western blot and SOD enzyme assay analyses indicated that B. neotomae does express SOD, but at a substantially reduced level. Nucleotide sequence analysis of region upstream to the sodC gene identified a single-nucleotide …

Spartan Daily November 23, 2010, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 135, Issue 46

Ua51/1 Collections & Connections, Jennifer Wilson

Collections & Connections

This is the Fall-Winter issue of WKU Libraries' biannual newsletter distributed among Library and Museum Friends and the entire WKU community. This issue features the project for The Horse in Kentucky Exhibit," "Harry Potter Night event in the Kentucky Building, the coming Christmas activities in the Kentucky Museum, the upcoming Southern Kentucky Book Fest, and the "Fall into Books" program that has just concluded. In this issue, there are also reports on the Libraries' food drive, its Java City concerts, the popular "Far Away Places" and "Kentucky Live!" talk series and the ongoing construction of the Confucius Institute Experience Center …

Independent - Nov. 23, 2010, Ivan Favelevic

The Independent (1988-present)

No abstract provided.

Stable Isotopes Of Fossil Teeth Corroborate Key General Circulation Model Predictions For The Last Glacial Maximum In North America, Matthew J. Kohn, Moriah Mckay

Geosciences Faculty Publications and Presentations

Oxygen isotope data provide a key test of general circulation models (GCMs) for the Last Glacial Maximum (LGM) in North America, which have otherwise proved difficult to validate. High δ18O pedogenic carbonates in central Wyoming have been interpreted to indicate increased summer precipitation sourced from the Gulf of Mexico. Here we show that tooth enamel δ18O of large mammals, which is strongly correlated with local water and precipitation δ18O, is lower during the LGM in Wyoming, not higher. Similar data from Texas, California, Florida and Arizona indicate higher δ18O values than in the Holocene, which is also predicted by GCMs. …

Chronology Of The Grotte Du Renne (France) And Implications For The Context Of Ornaments And Human Remains Within The Châtelperronian, Thomas Higham, Roger Jacobi, Michèle Julien

KIP Articles

There is extensive debate concerning the cognitive and behavioral adaptation of Neanderthals, especially in the period when the earliest anatomically modern humans dispersed into Western Europe, around 35,000–40,000 B.P. The site of the Grotte du Renne (at Arcy-sur-Cure) is of great importance because it provides the most persuasive evidence for behavioral complexity among Neanderthals. A range of ornaments and tools usually associated with modern human industries, such as the Aurignacian, were excavated from three of the Châtelperronian levels at the site, along with Neanderthal fossil remains (mainly teeth). This extremely rare occurrence has been taken to suggest that Neanderthals were …

Atmospheric Compensation Over Case Ii Waters: Simultaneous Aerosol And Water Constituent Retrieval, Donald Taylor

Theses

In many algorithms designed to retrieve water constituent concentrations, an assumption of negligible water-leaving radiance is made in the near infrared (NIR) wavelengths (750-950 [nm]). This allows fairly accurate atmospheric correction to be applied to the oceanic imagery. Given this assumption, it is possible to derive model estimates of aerosol type and density and compensate for its effects in other regions of the spectrum. Unfortunately this assumption is only valid in areas of very low total suspended sediment (TSS) concentrations, such as open ocean waters. Increased TSS load causes significant back-scattering within the water, increasing the water leaving signal in …

The Monster In The Closet: Misperception Of Mental Illness, Sarah Alexandra Bernstein

Honors Thesis and Capstone Projects

Mental illness affects all major aspects of an individual‟s life. From basic needs such as shelter and employment, to interactions with family, partners, and friends, the diagnosis represents likely difficulties due to stigma and negative attitudes. Efforts to bring forth the recognition and acceptance of mental illness in the United States, as well as around the world, start by confronting misconceptions through examination of causes. Increased access to needed resources and funding for treatment are also needed and may be accomplished through the use of media, education, and rising voices lobbying for the rights of people with mental illness.

Fusarium Head Blight: Winter Wheat Cultivar Responses And Characterization Of Pathogen Isolates, John Fredy Hernandez Nopsa

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Fusarium Head Blight (FHB) is a destructive disease of wheat (Triticum aestivum L). FHB reduces yield and grain quality and causes accumulation of the mycotoxin deoxynivalenol (DON) in grain. Cultivar resistance is one of the most effective management strategies for FHB. Experiments were conducted to 1) identify winter wheat cultivars with resistance to FHB and DON accumulation, 2) determine the effect of winter wheat cultivar on the relationship between FHB and DON concentration, and 3) identify the major species of Fusarium causing FHB in Nebraska and characterize its isolates. Differences (P ≤ 0.05) were detected among cultivars in …

Volume 108, Number 13 - Tuesday, Nov 23, 2010, Saint Mary's College Of California

The Collegian

No abstract provided.

Inferential Methods For High-Throughput Methylation Data, Maria Capparuccini

Theses and Dissertations

The role of abnormal DNA methylation in the progression of disease is a growing area of research that relies upon the establishment of sound statistical methods. The common method for declaring there is differential methylation between two groups at a given CpG site, as summarized by the difference between proportions methylated db=b1-b2, has been through use of a Filtered Two Sample t-test, using the recommended filter of 0.17 (Bibikova et al., 2006b). In this dissertation, we performed a re-analysis of the data used in recommending the threshold by fitting a mixed-effects ANOVA model. It was determined that the 0.17 filter …

The Prospector, November 23, 2010, Utep Student Publications

The Prospector

Headline: Turkey-less Thanksgiving

The Problem Of The Commons: Still Unsettled After 100 Years, Robert Stavins

Fondazione Eni Enrico Mattei Working Papers

The problem of the commons is more important to our lives and thus more central to economics than a century ago when Katharine Coman led off the first issue of the American Economic Review. As the U.S. and other economies have grown, the carrying-capacity of the planet - in regard to natural resources and environmental quality — has become a greater concern, particularly for common-property and open-access resources. The focus of this article is on some important, unsettled problems of the commons. Within the realm of natural resources, there are special challenges associated with renewable resources, which are frequently characterized …

The Impact Of Protest Responses In Choice Experiments, Melina Barrio, Maria Loureiro

Fondazione Eni Enrico Mattei Working Papers

Not much attention has been given to protest responses in choice experiments (CE). Using follow-up statements, we are able to identify protest responses and compute welfare estimates with and without the inclusion of such protest responses. We conclude that protest responses are fairly common in CE, and their analysis affects the statistical performance of the empirical models. In particular, when the sample is corrected by protests, our results come from utility consistent models. Thus, future choice experiments should consider the role of protest responses as contingent valuation studies have done.

Valuation Of Linkages Between Climate Change, Biodiversity And Productivity Of European Agro-Ecosystems, Ruslana Rachel Palatnik, Paulo A.L.D. Nunes

Fondazione Eni Enrico Mattei Working Papers

It is clear that climate change involves changes in temperature and precipitation and therefore directly affects land productivity. However, this is not the only channel for climatic change to affect agro-systems. Biodiversity is subject to climatic fluctuations and in turn may alter land productivity too. Firstly, biodiversity is an input into agro-ecosystems. Secondly, biodiversity supports the functioning of these systems (e.g. the balancing of the nutrient cycle). Thirdly, agro-systems also host important wildlife species which, though not always, play a functional role in land productivity, nonetheless constitute important sources of landscape amenities. The present paper illustrates a unique attempt to …

Does The Cause Of Death Matter? The Effect Of Dread, Controllability, Exposure And Latency On The Vsl, Anna Alberini, Milan Ščasný

Fondazione Eni Enrico Mattei Working Papers

The Value of a Statistical Life is a key input into the calculation of the benefits of environmental policies that save lives. To date, the VSL used in environmental policy analyses has not been adjusted for age or the cause of death. Air pollution regulations, however, are linked to reductions in the risk of dying for cancer, heart disease, and respiratory illnesses, raising the question whether a single VSL should be applied for all of these causes of death. We conducted a conjoint choice experiment survey in Milan, Italy, to investigate this question. We find that the VSL increases with …