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Lipid-Based Paclitaxel And Doxorubicin Nanoparticles To Overcome P-Gp-Mediated Drug Resistance In Solid Tumors, Xiaowei Dong

University of Kentucky Doctoral Dissertations

Multidrug resistance (MDR) is a major obstacle limiting chemotherapeutic efficacy. The purpose of these studies was to investigate the potential application of injectable paclitaxel (PX) and doxorubicin (Dox)-loaded nanoparticles (NPs) engineered from oil-in-water microemulsion precursors for overcoming P-glycoprotein (P-gp)- mediated drug resistance in solid tumors.

An in-vitro study was performed to test whether the oil (stearyl alcohol and cetyl alcohol) used to make lipid nanoparticles could be metabolized. The results showed that the concentrations of the fatty alcohols within nanoparticles, which were quantitatively determined over time by gas chromatography, decreased to only 10-20% of the initial concentration after 15-24 h …

Bootstrap Enhanced N-Dimensional Deformation Of Space With Acoustic Resonance Spectroscopy, David John Link

University of Kentucky Doctoral Dissertations

Acoustic methods can often be used with limited or no sample preparations making them ideal for rapid process analytical technologies (PATs). This dissertation focuses on the possible use of acoustic resonance spectroscopy as a PAT in the pharmaceutical industry. Current good manufacturing processes (cGMP) need new technologies that have the ability to perform quality assurance testing on all products. ARS is a rapid and non destructive method that has been used to perform qualitative studies but has a major drawback when it comes to quantitative studies. Acoustic methods create highly non linear correlations which usually results in high level computations …

The Pharmacogenomics Of Egfr-Dependent Nsclc: Predicting And Enhancing Response To Targeted Egfr Therapy, Justin M. Balko

University of Kentucky Doctoral Dissertations

The introduction of tyrosine kinase inhibitors (TKI) targeting the epidermal growth factor receptor (EGFR) inhibitors to the clinic has resulted in an improvement in the treatment of non small cell lung cancer (NSCLC). However, many patients treated with EGFR TKIs do not respond to therapy. The burden of failed treatment is largely placed on the healthcare field, limiting the effectiveness of EGFR TKIs. Furthermore, responses are hindered by the emergence of resistance. Thus, two questions must be addressed to achieve maximum benefit of EGFR inhibitors: How can patients who will benefit from EGFR TKIs be selected a priori? How …

Imide-Functionalized Conjugated Polymers: Synthesis, Structure-Property And Device Studies, Xugang Guo

University of Kentucky Doctoral Dissertations

Organic semiconductors are widely studied as potential active components for consumer electronics due largely to their easily tuned properties and the promise of lower-cost solution-based processing technology. Imide-functionalized organic small molecule compounds have been one of the more important and studied organic semiconductors. However, very few imide-functionalized conjugated polymers have been reported in the literature. The body of this dissertation focuses on the synthesis, structure-property and device studies of imide-functionalized conjugated polymers. Reasons for choosing arylene imides as polymer building blocks include: a) they impart low-lying LUMOs to polymers, allowing band-gap engineering through choice of comonomers with variable electron-donating ability; …

Direct Electron-Beam Patterning Of Teflon-Af And Its Application To Optical Waveguiding, Vijayasree Karre

University of Kentucky Master's Theses

Thin films of Teflon AF have been directly patterned by electron-beam lithography without the need for post exposure chemical development. The relationship between pattern depth and exposure dose was found to be linear over a wide range of doses. Pattern depth was also observed to be dependent on initial film thickness. Teflon AF can be directly patterned at doses similar to typical e-beam resists. High resolution features as small as ~200 nm have been resolved. FTIR measurements revealed that CF3 and fluorinated dioxole groups play a significant role in the patterning mechanism. Teflon AF films also exhibited an increase in …

Collective Communication And Barrier Synchronization On Nvidia Cuda Gpu, Diego Alejandro Rivera-Polanco

University of Kentucky Master's Theses

GPUs (Graphics Processing Units) employ a multi-threaded execution model using multiple SIMD cores. Compared to use of a single SIMD engine, this architecture can scale to more processing elements. However, GPUs sacrifice the timing properties which made barrier synchronization implicit and collective communication operations fast.

This thesis demonstrates efficient methods by which these aggregate functions can be implemented using unmodified NVIDIA CUDA GPUs. Although NVIDIA's highest “compute capability" GPUs provide atomic memory functions, they have order N execution time. In contrast, the methods proposed here take advantage of basic properties of the GPU architecture to make implementations that are both …

Jupiter As Everyman: Michael Reisman And The Scholar As Teacher, James E. Baker

Georgetown Law Faculty Publications and Other Works

These are Chief Judge Baker’s remarks reflecting on the scholarship of Professor Michael Reisman in the field of national security law. Chief Judge Baker comments that Professor Reisman is a prolific writer and Scholar-Teacher dedicated to the study of force, minimization of suffering, and the advancement of human dignity and the law. He discusses how Professor Reisman’s work is distinctive in that it identifies and incorporates the critical influence of process, both formal and informal, in decisionmaking, which sometimes overshadows substance.

Antibiotic Prophylaxis For Leptospirosis, David Brett-Major, Robert J. Lipnick

Journal Articles: Epidemiology

BACKGROUND: Leptospira infection is a global zoonosis with significant health impact for agricultural workers and those persons whose work or recreation takes them into endemic areas.

OBJECTIVES: This systematic review assessed the current literature for evidence for or against use of antibiotic prophylaxis against Leptospira infection (leptospirosis).

SEARCH STRATEGY: The authors searched The Cochrane Hepato-Biliary Group Controlled Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, and SCI-Expanded as well as relevant professional society meeting abstracts until January 2009.

SELECTION CRITERIA: Prospective, randomised clinical trials studying antibiotic prophylaxis against leptospirosis were selected.

DATA …

General Formulation Of The Scattered Matter Waves By A Quantum Shutter, Yusuf Zi̇ya Umul

Turkish Journal of Physics

The scattering process of matter waves by a quantum shutter is investigated by using the spectrum integral representation. The scattered fields are expressed in terms of the Fresnel function. It is shown that the obtained equation gives the Moshinsky function for a one dimensional problem of the plane wave. Also a general integral representation is derived for two dimensional problems. The scattering of matter waves for some special wave-packets are examined analytically and numerically.

Superconducting State Parameters Of Al-Li Binary Alloys, Aditya M. Vora

Turkish Journal of Physics

Theoretical computation of superconducting state parameters (SSP) viz. electron-phonon coupling strength \lambda , Coulomb pseudopotential \mu^* , transition temperature T_C , isotope effect exponent \alpha and effective interaction strength N_o V of face centered cubic Al_{1-C} Li_C binary alloys have been made extensively in the present work using a model potential formalism for the first time. A considerable influence of various exchange and correlation functions on \lambda and \mu^* is found from the present study. The present results of the SSP are found in qualitative agreement with the available experimental data wherever exist.

Cover And Contents

Turkish Journal of Physics

No abstract provided.

Combined Analysis Of Solar Neutrino Data Within The Rsfp Framework Together With New Kamland Data, Deni̇z Yilmaz

Turkish Journal of Physics

A combined analysis of solar neutrino data together with the new KamLAND data is presented in the RSFP framework. It is investigated how the allowed regions are effected from the new KamLAND data at different \mu B values. Limits on \mu B value is found at the different confidence level intervals.

Generation Of Ultrafast Bright And Dark Pulse On Silicon Chip With Integrated Mach-Zehnder Interferometer Configuration, Jianwei Wu, Fengguang Luo

Turkish Journal of Physics

In this paper we propose and simulate ultrafast femtosecond bright and dark pulses, obtained simultaneously at the same center wavelength, based on silicon-on-insulator (SOI) waveguides in Mach-Zehnder interferometer (MZI) configuration; the ultrafast pulsed pump is injected into one MZI's arm and a continuous wave component (CW) is divided equally into the two MZI arms. Numerical results show that properties of the generated bright and dark pulses are strongly dependent on the launching optical powers of both the pump pulse and CW carriers, and on the waveguide length.

Unsteady Free Convection Flow With Thermal Radiation Past A Vertical Porous Plate With Newtonian Heating, Promise Mebine, Emmanuel Munakurogha Adigio

Turkish Journal of Physics

This paper considers exact solutions of unsteady free convection flow with thermal radiation past a vertical porous plate with Newtonian heating. The technique of Laplace transform was employed in deriving the solutions to the governing flow and energy equations. A parametric study of all parameters involved was conducted, and a representative set of results showing the effect of the radiation parameter N, the ratio of uniform suction to characteristic velocity parameter R, and the free convection parameter Gr on the velocity and temperature are illustrated graphically. The skin friction or shear and heat flux are discussed quantitatively. It is evident …

Cover And Contents

Turkish Journal of Physics

No abstract provided.

Cover And Contents

Turkish Journal of Physics

No abstract provided.

An Evaluation Of The Traveling Wave Ultrasonic Motor For Force Feedback Applications, Nishant Venkatesan

University of Kentucky Master's Theses

The traveling wave ultrasonic motor is considered for use in haptic devices where a certain input-output relation is desired between the applied force and the resulting motion. Historically, DC motors have been the standard choice for this purpose. Owing to its unique characteristics, the ultrasonic motors have been considered an attractive alternative. However, there are some limitations when using the ultrasonic motor for force-feedback applications. In particular, direct torque control is difficult, and the motor can only supply torque in the direction of motion. To accommodate these limitations we developed an indirect control approach. The experimental results demonstrate that the …

Nanomechanical Characterizations Of High Temperature Polymer Matrix Composite Resin: Pmr-15 Polyimide, David C. Jones

University of Kentucky Master's Theses

High Temperature Polymer Matrix Composites (HTPMCs) are widely used by the aerospace industry today because of their high specific strengths, light weight, and the ability to custom tailor their mechanical properties to individual applications. Because of the harsh environmental conditions these materials experience during service use, these composite structures are susceptible to a high rate of thermo-oxidative degradation that ultimately causes premature failure in service. The current knowledge base is lacking in the fundamental spatial variability of the constituent materials upon aging, which precludes composite developers from predicting lifetime mechanical properties of the composites in use. The current study summarizes …

Towards Reducing Fungicide Use In The Control Of Dollar Spot (Sclerotinia Homoeocarpa F.T. Bennett) Disease On Creeping Bentgrass (Agrostis Stolonifera L.), Kenneth Lee Cropper

University of Kentucky Master's Theses

Creeping bentgrass (Agrostis stolonifera L.) is commonly used on golf course greens and fairways in cool-humid regions but is plagued by numerous fungal diseases, one of which is dollar spot disease (Sclerotinia homoeocarpa F. T. Bennett). Dollar spot occurs frequently throughout the growing season requiring biweekly fungicide applications for complete control. The objective of this study was to investigate methods of reducing the number of fungicide applications needed to maintain dollar spot at acceptable levels through dew removal and potential mechanisms of resistance in bentgrass. In the first study, a combination of mowing three times a week and …

Reduced Frequency Motor Starting For Third World Power Systems, Taylor A. Begley

University of Kentucky Master's Theses

People in modern industrialized societies live a blessed life relative to those who do not when it comes to some modern conveniences. While many think nothing of flipping on a light switch or running electric appliances, there are people in third world countries could not imagine such things. As service projects are being undertaken to bring such conveniences to those less fortunate, there often is the harsh reality of a strict budget. An item that commands a large portion of said budget is often the diesel generator used to provide the facility with electricity. Generators serving motor loads are typically …

Detailed Surface Analysis Of Lip Seal Elastomers Ran Against Shafts Manufactured With Triangular Cavities, Vetrivel Kanakasabai

University of Kentucky Master's Theses

Previous experimental and theoretical results indicate that the keys to successful radial lip seals are the surface characteristics of the shaft and the microasperity pattern that develops due to wear on the elastomer. In this study, the lip seal was tested against five different patterns of shaft surface: plain stainless steel, triangular cavities oriented towards air, triangular cavities oriented towards oil, triangular cavities leading and triangular cavities lagging. Using Zygo optical profilometer and scanning electron microscope, a thorough surface characterization of the micro-asperities and microcavities is done on the lip seal elastomer. Correlation coefficients were calculated between the surface parameters …

Use Of Surface Geophysical Techniques To Locate A Karst Conduit In The Cane Run - Royal Spring Basin, Kentucky, Ganesh N. Tripathi

University of Kentucky Master's Theses

Groundwater flow in karst terrains is difficult to map because it can be concentrated through conduits that do not necessarily coincide with the surface features. We applied electrical resistivity (ER) and self-potential (SP) techniques at three sites to locate an inferred trunk conduit feeding a major spring in the Inner Bluegrass region of Kentucky. Royal Spring is the primary water supply for the city of Georgetown; the upper part of its basin coincides with the Cane Run watershed. ER and SP profiles were perpendicular to the inferred trunk conduit orientation. ER profiles (972 m total length) were measured using a …

Institute Of Clinical And Translational Sciences News, Vol. 2, Issue 7

ICTS Newsletters

No abstract provided.

The Neurofibromatosis 2 Protein, Merlin, Regulates Glial Cell Growth In An Erbb2- And Src-Dependent Manner, S. Sean Houshmandi, Ryan J. Emnett, Marco Giovannini, David H. Gutmann

Open Access Publications

No abstract provided.

Skin-Derived Tslp Triggers Progression From Epidermal- Barrier Defects To Asthma, Shadmehr Demehri, Mitsuru Morimoto, Michael J. Holtzman, Raphael Kopan

Open Access Publications

No abstract provided.

Nematode.Net Update 2008: Improvements Enabling More Efficient Data Mining And Comparative Nematode Genomics, John Martin, Sahar Abubucker, Todd Wylie, Yong Yin, Zhengyuan Wang, Makedonka Mitreva

Open Access Publications

No abstract provided.

Supplementing High-Density Snp Microarrays For Additional Coverage Of Disease-Related Genes: Addiction As A Paradigm, Scott F. Saccone, Laura J. Bierut, Elissa J. Chesler, Peter W. Kalivas, Caryn Lerman, Nancy L. Saccone, George R. Uhl, Chuan-Yun Li, Vivek M. Philip, Howard J. Edenberg, Stephen T. Sherry, Michael Feolo, Robert K. Moyzis, Joni L. Rutter

Open Access Publications

No abstract provided.

High-Resolution Sonography Of The Normal Extrapelvic Vas Deferens, William D. Middleton, Nirvikar Dahiya, Cathy K. Naughton, Sharlene A. Teefey, Cary A. Siegel

Open Access Publications

No abstract provided.

Bioinformatics Methods For Learning Radiation-Induced Lung Inflammation From Heterogeneous Retrospective And Prospective Data, Sarah J. Spencer, Damian Almiron Bonnin, Joseph O. Deasy, Jeffrey D. Bradley, Issam El Naqa

Open Access Publications

No abstract provided.

Detailed Analysis Of A Contiguous 22-Mb Region Of The Maize Genome, Robert S. Fulton, Laura Courtney, Scott Kruchowski, Tina A. Graves, Susan M. Rock, Stephanie Adams, Lucinda A. Fulton, Catrina Fronick, William Courtney, Sandra W. Clifton, Richard K. Wilson, Et Al.

Open Access Publications

No abstract provided.