Digital Commons Network^™

The Potential For Nutrigenomics In Prevention Of Metabolic Syndrome, J. David Gangemi, Dana King

Journal of the South Carolina Academy of Science

No abstract provided.

The Integrated Biomedical Science Graduate Program At The University Of South Carolina, Richard Hunt

Journal of the South Carolina Academy of Science

No abstract provided.

Synthesis Of Fatty Acid Binding Protein Inhibitors: A New Approach For Diabetes Treatment, Shekelia Baccus, M. Perry Davis Jr, David R. Magnin

Journal of the South Carolina Academy of Science

No abstract provided.

Generation Of A Retroviral Vector That Expresses An Anti-Hiv-1 Tat Hammerhead Ribozyme, Lindsey E. Padgett, William H. Jackson

Journal of the South Carolina Academy of Science

No abstract provided.

The Effect Of Incubation Time On The Generation Of Benzene In Sierra Mist Free, Sarah Law

Journal of the South Carolina Academy of Science

No abstract provided.

Downregulation Of Hiv-1 Vif By A Hammerhead Ribozyme Expressed From A Retroviral Vector, Audrey M. Hendley, William Jackson

Journal of the South Carolina Academy of Science

No abstract provided.

Effect Of Thaw Temperature On Murine Blastocyst Development, Heather M. Barton, H. Lee Higdon Iii, Ph.D., Jennifer E. Graves-Herring M.S., William R. Boone, Ph.D.

Journal of the South Carolina Academy of Science

No abstract provided.

The Effects Of Growing Method And The Food Processing System On Bacterial Concentration In Spinach, Thad S. Moore, Lisa W. Norman

Journal of the South Carolina Academy of Science

No abstract provided.

Temperature Changes Resulting From A Gaalas Laser In The Decontamination Of A Failing Dental Implant, Adam B. Oppenheimer

Journal of the South Carolina Academy of Science

No abstract provided.

Where Do Mouse Embryos Thrive Best? Comparison Of Mammalian Embryo Development Under Varying Laboratory Environments, Yvonne K. Kao, H. Lee Higdon Iii, Ph.D, Jennifer E. Graves-Herring , M.S., William R. Boone Ph.D

Journal of the South Carolina Academy of Science

No abstract provided.

Besafe - Asian Pacific Islander Model Book, Nmaetc Staff

National Minority AIDS Education and Training Center Publications

Softback cultural competency book detailing the BESAFE model for Asian Pacific Islander Americans, 6.75 inches by 9.5 inches.

Preparation And Characterization Of Blackberry Extracts And Their Anticancer And Anti-Inflammatory Properties, Jin Dai

University of Kentucky Doctoral Dissertations

Blackberries are rich in polyphenols including anthocyanins. Polyphenols are hypothesized to have biological activities that impact positively on human health. The purpose of these studies was to develop phenolic extracts from selected cultivars of blackberries currently grown in Kentucky as potential Botanical Drug Products for the treatment and prevention of cancer and inflammatory diseases.

An ultrasound-assisted ethanol extraction method was employed to obtain anthocyanin-containing extracts (ACEs) from puree or powder (lyophilized puree) of blackberries. ACEs were analyzed for total anthocyanin and phenolics content, polymeric color, and total antioxidant capacity (TAC). The influence of water content in the extraction system was …

The Impact Of Mental Challenge On Indicators Of Endothelial Function In Obese Individuals, Chun-Jung Huang

Theses and Dissertations

A number of investigators have examined psychological stress-induced endothelial dysfunction, however, the underlying mechanisms for these responses have not been clearly elucidated. The purpose of this study was to compare the effects of mental challenge on forearm blood flow, total antioxidant capacity (a measure of oxidative stress), the release of norepinephrine (NE; stress induced neurotransmitter), and pro-inflammatory cytokine responses [both lipopolysaccharide (LPS)-stimulated TNF-α and IL-6 cytokine and mRNA] in lean and obese individuals. Twelve subjects who had a BMI above 30 kg/m2 and were above 30% body fat were categorized as obese and twelve subjects with a BMI below 25 …

Kingdom Compossible, Ryan Lauterio

Theses and Dissertations

Does God exist? Can we know for sure? What might it mean to know this? Furthermore what might it look like to make works of art while also seeking to find answers to these questions? This thesis details my personal experiences growing up in a world steeped in postmodernism and my move to answer such questions while looking to develop a meaningful, clear worldview and body of work. I have turned my focus on specific episodes in my life, which significantly illuminate a progression of thinking and experience. Together these thoughts and experiences have become the impetus for both questions …

Contributions Of Gut Bacteria To Bacillus Thuringiensis-Induced Mortality Vary Across A Range Of Lepidoptera, Nichole Broderick, Courtney Robinson, Matthew Mcmahon, Kenneth Raffa

Department of Biology Faculty Publications

Gut microbiota contribute to the health of their hosts, and alterations in the composition of this microbiota can lead to disease. Previously, we demonstrated that indigenous gut bacteria were required for the insecticidal toxin of Bacillus thuringiensis to kill the gypsy moth, Lymantria dispar. B. thuringiensis and its associated insecticidal toxins are commonly used for the control of lepidopteran pests. A variety of factors associated with the insect host, B. thuringiensis strain, and environment affect the wide range of susceptibilities among Lepidoptera, but the interaction of gut bacteria with these factors is not understood. To assess the contribution of gut …

Inheritance Of Shoulder Spotting In The Tetra, Hyphessobrycon Bentosi Characidae, Jack Frankel

Department of Biology Faculty Publications

The tetra (Hyphessobrycon bentosi) exhibits two phenotypes associated with shoulder spotting. Fish possess ei-ther a prominent black vertical spot located directly behind the operculum (H. b. bentosi,  bentosi  white  tip  tetra) or  lack  this spot (H. b. rosaceus, rosy tetra). Segregation patterns observed from the progenies of ten different crosses suggest that the  inheritance  of  these  phenotypes  is  controlled  by  two  autosomal  loci  acting  in  a complementary  fashion,  with  domi-nance at both loci required for the expression of the spotted phenotype. 

Metabolomic Investigation Of A New Rat Model Of Autosomal Recessive Polycystic Kidney Disease, Hayley White

Theses : Honours

Metabolomics is complementary to genomics, transcriptomics and proteomics; however, it has the capacity to reflect the activities of the organism at a functional level. Metabolomics can therefore be used as a diagnostic tool by identifying the up- or down-regulation of metabolites in the cell, tissue, plasma, serum or urine. Specifically, these are, but are not limited to, identifying biomarkers of disease, monitoring drug treatments, and monitoring surgical procedures such as organ transplant. Autosomal recessive polycystic kidney disease (ARPKD) makes up 5-8% of patients requiring kidney dialysis and/or transplantation and of these, an estimated 50% of patients progress to end-stage renal …

Reasons For Migration And Cultural Distance In South African Women's Migratory Adjustment Experiences: A Phenomenological Account, Ida Steyn

Theses : Honours

Researchers have identified migration to a new country as a stressful life event that is associated with loss of family, friends and community, and adjustment difficulties in the new country (Markovizky & Samid, 2008). In addition, involuntary migration and adaption to a new cultural environment is known to be a factor of psychological distress. Much is unknown about the adjustment of involuntary migrants during the critical period of reestablishment in the new environment. Moreover, less is known about transition processes between similar cultural contexts. It might be that transition is not as well supported when there is cultural similarity between …

Balancing Multiple Roles: A Pilot Study Exploring The Complexity Of Role Balance In Working Mothers With Primary School Aged Children, Katherine Prince

Theses : Honours

For working mothers, maintaining a balance between work and parenting roles is a challenge. Each role presents its own set of physical, mental and temporal demands which frequently compete for the limited personal and environmental resources available to the mother. These competing demands can create conflict and stress, which prompts a coping response. The coping response initiated is a physiological reaction to the mother's appraisal of her situational conflict, and follows a process of appraisal. Firstly the working mother appraises the conflict itself. This is followed by the appraisal of the personal and environmental resources, constraints and demands. Finally, a …

Trauma Practitioners' Lived Experience Of The Impact Of Therapy On Trauma Recovery Outcomes, Francess M. Day

Theses : Honours

Much has been written about evidence-based treatments for Posttraumatic Stress Disorder (PTSD). A number of treatment guides have been written (e.g. AMCPH, 2007; Briere 2006; Foa Keane, & Friedman, 2000;). Medicare criteria based on empirical research and outcome measures stipulate which treatments and practitioner qualifications will be funded. However, little is known about the relationship between these guidelines and what clinicians actually utilize in trauma treatment and use as indicators of good outcomes. The research studies compromise external validity by excluding the majority of typical PTSD clientele, necessitating exploration of treatment effectiveness in diverse real-life populations (Spinazzola, Blaustein, & van …

Constellations, Pathways Through The Body : An Exploration Creating New Movement Pathways Using Dual Patterning, Gemma Laing

Theses : Honours

This research paper is an exploration of the creation of movement using dual patterning, which is the tracing of two patterns simultaneously as a dual task. This piece of writing discusses practitioners Twyla Tharp, Trisha Brown and Lisa Kraus in their experiments with altering bodily habit. It also discusses patterns, imagery, bodily knowledge, and coordination to help facilitate the experiment. Thoughts and findings from the studio are discussed from the process to gain understanding of the experiment. Utilizing bodily intelligence or bodily knowledge, the body initially experiences a separation of hemispheres or halves of the body to enable the process …

Youth Aspirations And Sense Of Place In A Changing Rural Economy: The Coos Youth Study, Nena F. Stracuzzi

Carsey Publications

Youth in rural Coos County have surprisingly strong ties to their communities, finds a new report from the Carsey Institute. The brief is the first to report on a ten-year panel study of students who began seventh and eleventh grades in 2007 in Coos, New Hampshire's northernmost and most rural county.

Universal Health Insurance Coverage: Progress And Issues., Jonathan Gruber

Center for Policy Research

Jonathan Gruber was a key architect of Massachusetts’ ambitious health reform effort, and in 2006 became an inaugural member of the Health Connector Board, the main implementing body for that effort. He delivered this lecture on October 2, 2009, and his references are to Congressional bills that were under consideration on that date. He laid out the universal coverage debate that’s gone on for a long time in the United States; described a new solution that he think they found for Massachusetts; described how the Massachusetts reform works; and how it can be extended nationally. Finally he spent time on …

Role Of Mel-18 In Regulating Protein Sumoylation And Identification Of A New Polymorphism In Bmi-1, Jie Zhang

University of Kentucky Doctoral Dissertations

Small ubiquitin-like modifier (SUMO) regulates numerous biological functions. In a previous study we found that sumoylation of HSF2 is involved in regulating HSF2 bookmarking function, but the mechanism that mediates this regulation was unknown. The results in my work support the intriguing hypothesis that polycomb protein, Mel-18, actually functions as an anti-SUMO E3 protein, interacting both with HSF2 and the SUMO E2 Ubc9, but acting to inhibit Ubc9 activity and thereby decrease sumoylation of the HSF2.

This study also suggested that Mel-18 negatively regulates the sumoylation of other cellular proteins, and we extend its targets to RanGAP1 protein. The results …

Evaluating The Effects Of Organic And Conventional Inputs On Soil Chemical And Biological Properties In A Four-Year Vegetable Rotation And The Investigation Of Soil Microbial Properties On Plant Gene Expression, Audrey Law

University of Kentucky Doctoral Dissertations

The objective of this research was to determine the effects of conventional inputs on soil chemical and biological properties compared to organic systems in a four year vegetable rotation. Tillage and cover crops were the same in all treatments to avoid confounding factors often present in similar research. Additional experiments investigated plant gene expression in organic and conventional management systems and in soils with decreased microbial diversity. Experimental plots were prepared in the spring of 2004; four replications of three management treatments, organic, low-input and conventional, were arranged in a randomized complete block design. The rotation consisted of edamame soybean, …

Alterations Of Zinc Transporters In Alzheimer's Disease, Ganna Lyubartseva

University of Kentucky Doctoral Dissertations

Alzheimer’s disease (AD), one of the major causes of disability and mortality in Western societies, is a progressive age-related neurodegenerative disorder. Increasing evidence suggests the etiology of AD may involve disruptions of zinc (Zn) homeostasis. We hypothesize that disruption of Zn homeostasis leads to alterations of Zn transporter (ZnT) proteins, resulting in increased production of neurotoxic amyloid beta (Aβ) peptide in AD brain. To address this hypothesis we carried out the following studies.

1. We characterized alterations of ZnT-1, ZnT-4 and ZnT-6 in the brain of preclinical AD (PCAD) subjects, who show no overt clinical manifestations of AD but demonstrate …

Neuroscience And Health Law: An Integrative Approach?, Stacey A. Tovino

Faculty Articles

Clinicians and scientists use functional magnetic resonance imaging (fMRI) to map sensory, motor, and cognitive function and to study the neural correlates of a range of physical and mental conditions, behaviors, characteristics, and preferences. Due to its move outside the clinical and research contexts, fMRI raises a number of ethical, legal, and social issues that are being examined within the overlapping fields of neuroethics and neurolaw. The early neuroethics and neurolaw scholarship focused heavily on the implications of fMRI for evidence law, criminal law, criminal procedure, and constitutional law. Little attention has been paid, however, to the implications of advances …

Index Of Titles And Authors, Volumes 1-20

Basic Communication Course Annual

No abstract provided.

[Introduction To] Racism And Sexual Oppression In Anglo-America: A Genealogy, Ladelle Mcwhorter

Bookshelf

Does the black struggle for civil rights make common cause with the movement to foster queer community, protest anti-queer violence or discrimination, and demand respect for the rights and sensibilities of queer people? Confronting this emotionally charged question, Ladelle McWhorter reveals how a carefully structured campaign against abnormality in the late 19th and early 20th centuries encouraged white Americans to purge society of so-called biological contaminants, people who were poor, disabled, black, or queer. Building on a legacy of savage hate crimes—such as the killings of Matthew Shepard and James Byrd—McWhorter shows that racism, sexual oppression, and discrimination against the …

Subcellular Localization Of Marine Bacterial Alkaline Phosphatases, H. Luo, Ronald Benner, R. A. Long, Jianjun Hu

Faculty Publications

Bacterial alkaline phosphatases (APases) are important enzymes in organophosphate utilization in the ocean. The subcellular localization of APases has significant ecological implications for marine biota but is largely unknown. The extensive metagenomic sequence databases from the Global Ocean Sampling Expedition provide an opportunity to address this question. A bioinformatics pipeline was developed to identify marine bacterial APases from the metagenomic databases, and a consensus classification algorithm was designed to predict their subcellular localizations. We identified 3,733 bacterial APase sequences (including PhoA, PhoD, and PhoX) and found that cytoplasmic (41%) and extracellular (30%) APases exceed their periplasmic (17%), outer membrane (12%), …