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Isothermal Titration Calorimetry Studies Of Protein-Mediated Interactions And Preliminary Structural Studies Of Tandem Pdz1-2 Domain Of Psd-95 Protein, Ana Jankovic

Wayne State University Dissertations

Protein-mediated interactions that involve multiple ligands in their binding mechanisms are critical for many cellular functions. The primary focus of this dissertation research was to investigate such interactions for two proteins, the PDZ domain and frataxin, involving peptide and metal binding ligands, respectively. The three component projects of this work comprised (1) thermodynamic analysis of PDZ domain binding using calorimetry; (2) X-ray crystallographic structural studies of a PDZ dual domain; and (3) thermodynamic analysis of frataxin binding to iron. The specific goal of the research conducted with the PDZ domains was to understand the mechanism of action of multiple/tandem protein …

Interleukin-6 And Cyclooxygenase-2 Downregulation By Fatty-Acid Fractions Of Ranunculus Constantinopolitanus, Sabreen F. Fostok, Rima A. Ezzeddine, Fadia R. Homaidan, Jamal A. Al-Saghir, Ralph G. Salloum, Najat A. Saliba, Rabih S. Talhouk

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Medicinal plants represent alternative means for the treatment of several chronic diseases, including inflammation. The genus Ranunculus, a representative of the Ranunculaceae family, has been reported to possess anti-inflammatory, analgesic, antiviral, antibacterial, antiparasitic and antifungal activities, possibly due to the presence of anemonin and other. Different studies have shown the occurrence of unusual fatty acids (FAs) in Ranunculaceae; however, their therapeutic role has not been investigated. The purpose of this study is to characterize potential anti-inflammatory bioactivities in Ranunculus constantinopolitanus D'Urv., traditionally used in Eastern Mediterranean folk medicine.

Methods

The aerial part of R. constantinopolitanus was subjected to …

Differential Effects Of Th1, Monocyte/Macrophage And Th2 Cytokine Mixtures On Early Gene Expression For Molecules Associated With Metabolism, Signaling And Regulation In Central Nervous System Mixed Glial Cell Cultures, Robert P. Lisak, Joyce A. Benjamins, Beverly Bealmear, Liljana Nedelkoska, Diane Studzinski, Ernest Retland, Bin Yao, Susan Land

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Cytokines secreted by immune cells and activated glia play central roles in both the pathogenesis of and protection from damage to the central nervous system (CNS) in multiple sclerosis (MS).

Methods

We have used gene array analysis to identify the initial direct effects of cytokines on CNS glia by comparing changes in early gene expression in CNS glial cultures treated for 6 hours with cytokines typical of those secreted by Th1 and Th2 lymphocytes and monocyte/macrophages (M/M).

Results

In two previous papers, we summarized effects of these cytokines on immune-related molecules, and on neural and glial related proteins, …

Infant Social And Emotional Development: The Emergence Of Self In A Relational Context, Katherine L. Rosenblum, Carolyn Joy Dayton, Maria Muzik

Social Work Faculty Publications

No abstract provided.

Developing Leadership In A National Cohort Of Secondary Biology Teachers: Uses Of An On-Line Course Structure To Develop Geographically Distant Professional Learning Community, P. Balcerzak, V. May, B. Schaal

Journal of Mathematics and Science: Collaborative Explorations

This report is a descriptive study of the role that on-line courses might have on the development of Professional Learning Communities (PLC’s) that support national leadership initiatives of participating high school biology teachers. The one hundred teachers involved in the Life Sciences for a Global Community (LSGC) Institute are expected not only to deepen their content knowledge, but also impact their district and state biology curricula. Additionally, the dispersion of Institute participants across the country presents a unique opportunity to develop, communicate. and implement a national coherent reform agenda. However, the geographic distance presents a barrier to collaborative design of …

Best Practice Guideline For The Subcutaneous Administration Of Insulin In Adults With Type 2 Diabetes, Registered Nurses' Association Of Ontario

General Submissions: Community and Population-based Materials

The focus of this guideline is to support nurses, Registered Nurses (RNs) and Registered Practical Nurses (RPNs) in all practice settings, as they care for clients (18 years and older) with type 2 diabetes requiring subcutaneous insulin therapy. Specifically, this guideline would assist nurses who are not specialists in diabetes care to safely initiate and administer insulin, a "high-alert" medication. This guideline will provide answers to the question: What are the essential client self-care components to be addressed by nurses when caring for an adult with type 2 diabetes who requires subcutaneous insulin?

The Unviersity Of Texas Of The Permian Basin Spring 2009 Course Schedule, The University Of Texas Of The Permian Basin

Course Schedules

No abstract provided.

Rafinesque, Transylvania’S Famous Naturalist, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

No abstract provided.

2008-09 University Of Northern Iowa Swimming & Diving Media Guide, University Of Northern Iowa

Athletics Media Guides

Contents:

--2008-09 Roster --front cover
--Contents/General Information --1
--This is UNI --2-3
--Coaching Staff --4
--Facilities --5
--2008-09 Preview --6
--Roster --7
--Meet the Panthers --8-13
--2007-08 Best Times --14
--All-Time Bests --15
--Conference Records --16
--All-Time Results --17-19
--The Missouri Valley Conference --20

Bs 505 Introduction To Biblical Studies: New Testament, Keith Brewer

Syllabi

The primary text in this course is the Holy Bible. There are three basic theories behind the work of Bible translation: (1) Literal or formally equivalent; (2) Idiomatic or dynamically equivalent; and (3) Free or paraphrase. Some of the more literal versions of the Bible include the New American Standard Bible (NASB) and the Revised Standard Version (RSV) or the New Revised Standard Version (NRSV). Although both the King James Version (KJV) and the New King James Version (NKJV) fall into the category of literal translations, they are textually inferior to modern translations of the Bible. The New International Version …

Zero: What Is It, And How Do We Get There?, Victoria J. Fraser

Open Access Publications

No abstract provided.

Human T Cell Leukemia Virus Reactivation With Progression Of Adult T-Cell Leukemia-Lymphoma, Lee Ratner, William Harrington, Xuan Feng, Christian Grant, Steve Jacobson, Ariela Noy, Joseph Sparano, Jeannette Lee, Richard Ambinder, Nancy Campbell, Michael Lairmore

Open Access Publications

No abstract provided.

Ksr1 Modulates The Sensitivity Of Mitogen-Activated Protein Kinase Pathway Activation In T Cells Without Altering Fundamental System Outputs, Joseph Lin, Angus Harding, Emanuele Giurisato, Andrey S. Shaw

Open Access Publications

No abstract provided.

The Membrane Proteome Of The Mouse Lens Fiber Cell, Steven Bassnett, Phillip A. Wilmarth, Larry L. David

Open Access Publications

No abstract provided.

Unusual Composition Of A Yeast Chromosome Arm Is Associated With Its Delayed Replication, Célia Payen, Gilles Fischer, Christian Marck, Caroline Proux, David James Sherman, Jean-Yves Coppée, Mark Johnston, Bernard Dujon, Cécile Neuvéglise

Open Access Publications

No abstract provided.

Identification Of Deleterious Mutations Within Three Human Genomes, Sung Chun, Justin C. Fay

Open Access Publications

No abstract provided.

2009-10 Bryn Mawr College Undergraduate Catalog, Bryn Mawr College

Bryn Mawr College Calendar

No abstract provided.

Topics In Biomedical Optics: Introduction To The Feature Issue, Joseph P. Culver, Wolfgang Drexler, Rebekah A. Drezek, Irene Georgakoudi, Elizabeth M C Hillman, Rebecca Richards-Kortum

Open Access Publications

No abstract provided.

Capturing A Flavivirus Pre-Fusion Intermediate, Barbel Kaufmann, Paul R. Chipman, Heather A. Holdaway, Syd Johnson, Daved H. Fremont, Richard J. Kuhn, Michael S. Diamond, Michael G. Rossmann

Open Access Publications

No abstract provided.

Interleukin-10 Overexpression Promotes Fas-Ligand-Dependent Chronic Macrophage-Mediated Demyelinating Polyneuropathy, Dru S. Dace, Aslam A. Khan, Jennifer L. Stark, Jennifer Kelly, Anne H. Cross, Rajendra S. Apte

Open Access Publications

No abstract provided.

Late Life Depression With Cognitive Impairment: Evaluation And Treatment, Consuelo H. Wilkins, Jose Mathews, Yvette I. Sheline

Open Access Publications

No abstract provided.

The Theory Of Discovering Rare Variants Via Dna Sequencing, Michael C. Wendl, Richard K. Wilson

Open Access Publications

No abstract provided.

Selection Of Hyperfunctional Sirnas With Improved Potency And Specificity, Xiaowei Wang, Xiaohui Wang, Rajeev K. Varma, Lesslie Beauchamp, Susan Magdaleno, Timothy J. Sendera

Open Access Publications

No abstract provided.

Attention-Deficit/Hyperactivity Disorder In Preschool Children: An Investigation Of Validation Based On Visual Attention Performance, Mini Tandon, Xuemei Si, Andy Belden, Joan Luby

Open Access Publications

No abstract provided.

Lack Of X-Linked Inhibitor Of Apoptosis Protein Leads To Increased Apoptosis And Tissue Loss Following Neonatal Brain Injury, Tim West, Madeliene Stump, Gregory Lodygensky, Jeff J. Neil, Mohanish Deshmukh, David M. Holtzman

Open Access Publications

No abstract provided.

Blast-Related Brain Injury: Imaging For Clinical And Research Applications: Report Of The 2008 St. Louis Workshop, Tammie L.S Benzinger, David Brody, Mark A. Mintun, R. Gilbert Jost, Karen Kharasch, Philip V. Bayly, Maurizio Corbetta, Joseph P. Culver, Evan D. Kharasch, Christine Mac Donald, Daniel Marcus, Steve Petersen, Kathy J. Pierce, Jose Pineda, Joshua S. Shimony, Victor Sheng-Kwei Song, Gregory Zipfel, Et Al

Open Access Publications

No abstract provided.

A Host Type I Interferon Response Is Induced By Cytosolic Sensing Of The Bacterial Second Messenger Cyclic-Di-Gmp, Sarah M. Mcwhirter, Roman Barbalat, Kathryn M. Monroe, Mary F. Fontana, Mamoru Hyodo, Nathalie T. Joncker, Ken J. Ishii, Shizuo Akira, Marco Colonna, Zhijian J. Chen, Katherine A. Fitzgerald, Yoshihiro Hayakawa, Russell E. Vance

Open Access Publications

No abstract provided.

Artemisone And Artemiside Control Acute And Reactivated Toxoplasmosis In A Murine Model, Ildiko R. Dunay, Wing Chi Chan, Richard K. Haynes, L. David Sibley

Open Access Publications

No abstract provided.

Mutations In Ampg And Lytic Transglycosylase Genes Affect The Net Release Of Peptidoglycan Monomers From Vibrio Fischeri, Dawn M. Adin, Jacquelyn T. Engle, William E. Goldman, Margaret J. Mcfall-Ngai, Eric V. Stabb

Open Access Publications

No abstract provided.

The Many Faces Of Ret Dysfunction In Kidney, Sanjay Jain

Open Access Publications

No abstract provided.