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2009

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Articles 56101 - 56105 of 56105

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Endotoxin Emissions From Commercial Composting Activities, Lewis Deacon, Louise Pankhurst, Jian Liu, Gillian H. Drew, Enda T. Hayes, Simon Jackson, J Longhurst, P Longhurst, Simon Pollard, Sean Tyrrel Jan 2009

Endotoxin Emissions From Commercial Composting Activities, Lewis Deacon, Louise Pankhurst, Jian Liu, Gillian H. Drew, Enda T. Hayes, Simon Jackson, J Longhurst, P Longhurst, Simon Pollard, Sean Tyrrel

School of Biomedical Sciences

No abstract provided.

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Crosstalk Of Vegf And Notch Pathways In Tumour Angiogenesis: Therapeutic Implications, J-L Li, Al Harris Jan 2009

Crosstalk Of Vegf And Notch Pathways In Tumour Angiogenesis: Therapeutic Implications, J-L Li, Al Harris

School of Biomedical Sciences

Angiogenesis is regulated by a number of angiogenic factors through many signalling pathways. The VEGF pathway and Notch signalling are perhaps two of the most important mechanisms in regulation of embryonic vascular development and tumour angiogenesis. Blockade of the VEGF pathway effectively inhibits tumour angiogenesis and growth in preclinical models. The successes in phase III trials have added anti-VEGF agents to standard cancer therapy in several major cancers. A recent flurry of findings indicate that DLL4/Notch signalling decreases angiogenesis by suppressing endothelial tip cell formation; importantly, blockade of DLL4/Notch signalling strikingly increases non-productive angiogenesis but significantly reduces the growth of …

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Dna Replication In The Human Malaria Parasite And Potential For Novel Drug Development, J Li Jan 2009

Dna Replication In The Human Malaria Parasite And Potential For Novel Drug Development, J Li

School of Biomedical Sciences

Rather than simply "itemising" the replication steps and the proteins involved, replication is tackled from a novel perspective. The book provides logical groupings of processes based upon biochemical similarities.

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Objectively Measured Physical Activity And Its Association With Adiponectin And Other Novel Metabolic Markers: A Longitudinal Study In Children (Earlybird 38)., Bs Metcalf, An Jeffery, J Hosking, Ld Voss, N Sattar, Tj Wilkin Jan 2009

Objectively Measured Physical Activity And Its Association With Adiponectin And Other Novel Metabolic Markers: A Longitudinal Study In Children (Earlybird 38)., Bs Metcalf, An Jeffery, J Hosking, Ld Voss, N Sattar, Tj Wilkin

Peninsula Medical School

OBJECTIVE: Recent evidence suggests that, in children, traditional markers of metabolic disturbance are related only weakly to physical activity. We therefore sought to establish the corresponding relationships with newer metabolic markers. RESEARCH DESIGN AND METHODS: This was a nonintervention longitudinal study of 213 healthy children recruited from 54 schools in Plymouth, U.K. MTI accelerometers were used to make objective 7-day recordings of physical activity at ages 5 +/- 0.3 (mean +/- SD), 6, 7, and 8 years. Overall physical activity was taken as the average of the four annual time points. The metabolic markers at 8 years were adiponectin, leptin, …

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The Size Of The Treatment Effect: Do Patients And Proxies Agree?, Der Linden Fah Van, Jolijn J. Kragt, Jeremy C. Hobart, Martin Klein, Alan J. Thompson, Der Ploeg Hm Van, Chris H. Polman, Bernard M.J. Uitdehaag Jan 2009

The Size Of The Treatment Effect: Do Patients And Proxies Agree?, Der Linden Fah Van, Jolijn J. Kragt, Jeremy C. Hobart, Martin Klein, Alan J. Thompson, Der Ploeg Hm Van, Chris H. Polman, Bernard M.J. Uitdehaag

Peninsula Medical School

No abstract provided.

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