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The Influence Of Heel Height On Sagittal Plane Knee Kinematics During Landing Tasks In Recreationally Active Collegiate Females, Kelly Lindenberg

Electronic Theses and Dissertations

The purpose of this study was to determine if varying heel lift heights added to athletic shoe wear would alter sagittal plane knee kinematics when landing from jumping maneuvers. The hypothesis was that increased heel height would increase knee flexion at initial contact (KAIC), increase the peak knee flexion angle (KAPeak), and slow the rate of knee excursion (RKE). Fifty recreationally active, college-age females participated. Subjects performed two single-limb landing tasks: a forward hop and a jump-landing maneuver. Each participant performed five repetitions of each jump while wearing three different heel lifts placed on the under-side of a standardized athletic …

Use Of The Electronic Health Record In Private Medical Practices, Archish Maharaja

Electronic Theses and Dissertations

The purpose of this study is to examine the use of the electronic health record (EHR) by physicians in Allegheny and Westmoreland counties in Southwestern Pennsylvania. Five research questions were designed to inquire about the physician practice characteristics and its relationship to the EHR deployment, the importance of educational intervention in the EHR adoption, and the physician's belief if the EHR contributes to improvements in the quality of patient care and practice productivity and profitability. A survey of The Use of Electronic Health Records by Medical Practices was used to collect 169 physician responses from the two counties. This survey …

An "Island" Study Abroad Program And Its Impact On The Intercultural Sensitivity And Cross-Cultural Adaptability Of Its Participants: Perspectives From A Research Intensive University, Gita Maharaja

Electronic Theses and Dissertations

Globalization touches every sphere of our modern lives, and it has become more critical than ever that today's generation gains an understanding of other cultures and develops the ability to adapt to ever-changing environments. One important way that higher education has attempted to prepare students for these challenges is to offer study abroad programs, in which students are given the opportunity for educational experiences in other countries.

Traditionally, study abroad programs have involved immersion in the host culture, with particular emphasis on using and learning the native language. However, other types of program designed to make the experience of living …

On Whether Or Not Merleau-Ponty's Phenomenology Of Lived Body Experience Can Enrich St. Thomas Aquinas's Integral Anthropology, Joshua Miller

Electronic Theses and Dissertations

I argue that Merleau-Ponty's phenomenology of lived body experience can be used to enrich Aquinas's integral anthropology. In Chapter One I lay out the possibilities of such an enrichment by examining contemporary philosophers of mind who draw on Aquinas and Merleau-Ponty in strikingly similar ways. Analytical Thomists, as represented by Eric LaRock, and thinkers seeking to integrate neuropsychology and phenomenology, like Ralph Ellis, argue that that the concept of form (taken from Aquinas and Merleau-Ponty respectively) is necessary for properly understanding the human being as an integral unity of intellectual principle and body. I then pose potential objections to my …

Emotion Knowledge And Relational Aggression In Preschoolers, Karen Morine

Electronic Theses and Dissertations

The preschool years are an important time in a child's emotional development. Children learn how to navigate peer relationships and understand the source of others' emotions, one of the most important tasks of this developmental period. Deficits in emotion knowledge have been linked with increased aggressive behaviors and poor peer acceptance. This study's main objective was to clarify whether emotion knowledge is related to relational aggression in young children. In addition, the role of age, sex, siblings, depressed affect, and peer acceptance and rejection was examined in the context of relational aggression. Sixty-six preschool children from ages 3 to 4 …

Preparation And Characterization Of Oil-In-Water Nano-Emulsions Of Trifluoperazine For Parenteral Drug Delivery, Toluwalope Onadeko

Electronic Theses and Dissertations

Objectives: 1.) To develop and characterize an optimal formulation of oil-in-water nano-emulsions of trifluoperazine for parenteral delivery. 2.) To perform short term stability testing of the optimal formulation and monitor the potency using high performance chromatography (HPLC).

Materials and Methods: Emulsions containing soybean oil, water, trifluoperazine hcl as an amphiphilic drug, phospholipon 90 and Tween 80 as surfactant blend were prepared using the Thin-layer hydration method. Z-average, polydispersity index, zeta potential of emulsions were determined. A fully randomized 2X2X2X2X2 statistical design was developed using JMP software. Optimal formulation was selected based on desirable properties of low z-average and polydispersity index, …

The Lived Experience Of The African American Pregnancy That Ends In Preterm Birth, Clarise Hairston Ottley

Electronic Theses and Dissertations

The research study was undertaken to help fill the gap in understanding the disparity between the current preterm birth rates of African American women and White women. A phenomenological methodology was used with a sample of seven African American women who had experienced preterm birth. The findings provide insight into experience of a pregnancy that ends in preterm birth.

An in-depth understanding of the contextual factors associated with preterm birth in African American women was provided through a description of experiences as voiced by the participants themselves. Their stories provided rich, detailed data and insight into their lived experiences, revealing …

Low Density Lipoprotein Receptor And Alzheimers Disease, Rangaraj K. Gopalraj

University of Kentucky Doctoral Dissertations

Since apoE allele status is the predominant Alzheimers disease (AD) genetic risk factor, functional single nucleotide polymorphisms (SNPs) in brain apoE receptors represent excellent candidates for association with AD. Therefore, three low density lipoprotein receptor (LDLR) SNPs were evaluated by TaqMan allelic discrimination assays for association with AD and I found that certain haplotypes alter the odds of AD. A SNP within LDLR exon 12, rs688, was identified in silico as neutralizing a putative exon splicing enhancer (ESE). Since LDLR is a major apoE receptor in the brain, I hypothesized that rs688 modulates LDLR splicing in neural tissues and associates …

A Protocol Suite For Wireless Personal Area Networks, Karl E. Persson

University of Kentucky Doctoral Dissertations

A Wireless Personal Area Network (WPAN) is an ad hoc network that consists of devices that surround an individual or an object. Bluetooth^® technology is especially suitable for formation of WPANs due to the pervasiveness of devices with Bluetooth^® chipsets, its operation in the unlicensed Industrial, Scientific, Medical (ISM) frequency band, and its interference resilience. Bluetooth^® technology has great potential to become the de facto standard for communication between heterogeneous devices in WPANs.

The piconet, which is the basic Bluetooth^® networking unit, utilizes a Master/Slave (MS) configuration that permits only a single master and up to …

The Role Of The Hip Abductor Muscle Complex In The Function Of The Pathological Hip Joint, Maureen Kelly Dwyer

University of Kentucky Doctoral Dissertations

The number of patients electing to undergo total hip arthroplasty (THA) in the United States has been projected to double by the year 2030, with a growing number of these patients below the age of 65 years. This cohort of patients not only desires to return to pain free daily activity, but wishes to participate in recreation and sporting activities. However, many of these patients report pain, impairments, and functional limitations following THA. The number one deficit observed for patients who fail conventional post-operative rehabilitation is persistent weakness of the hip abductor muscles. In order to safely progress these patients …

Vortex Model Of Open Channel Flows With Gravel Beds, Brian James Belcher

University of Kentucky Doctoral Dissertations

Turbulent structures are known to be important physical processes in gravel-bed rivers. A number of limitations exist that prohibit the advancement and prediction of turbulence structures for optimization of civil infrastructure, biological habitats and sediment transport in gravel-bed rivers. This includes measurement limitations that prohibit characterization of size and strength of turbulent structures in the riverine environment for different case studies as well as traditional numerical modeling limitations that prohibit modeling and prediction of turbulent structure for heterogeneous beds under high Reynolds number flows using the Navier-Stokes equations. While these limitations exist, researchers have developed various theories for the structure …

Three-Dimensional Free Surface Non-Hydrostatic Modeling Of Plunging Water With Turbulence And Air Entrained Transport, Tien Mun Yee

University of Kentucky Doctoral Dissertations

The advance in computational fluid dynamics in recent years has provided the opportunity for many fluid dynamic problems to be analyzed numerically. One such problem concerns the modeling of plunging water into a still water body, often encountered in pump stations. Air bubbles introduced into the system by the plunging jet can be a significant problem, especially when consumed into operating pumps. The classical approach to investigate the hydrodynamics of plunging jet in pump stations is by physical model studies. This approach is time consuming, tedious and costly. The availability of computational power today, along with appropriate numerical techniques, allows …

Adolphe Nourrit, Gilbert-Louis Duprez, And Transformations Of Tenor Technique In The Early Nineteenth Century: Historical And Physiological Considerations, Jason Christopher Vest

University of Kentucky Doctoral Dissertations

The April 1837 debut of tenor Gilbert-Louis Duprez at the Paris Opéra sparked uproarious applause and inspired a new group of tenors with a different vocal technique from tenors of the previous generation. Whereas previous tenors of the nineteenth century sang in a graceful, light, and flexible style that complemented the operatic compositions of Gluck, Rossini, and Bellini, Duprez sang in a powerful, forceful voice that brought new dramatic fervor to the existing repertoire of French Grand Opera. Duprez’ stentorian vocal representations of Arnold in Rossini’s Guillaume Tell and Robert in Meyerbeer’s Robert le diable, among others, inspired composers …

Effects Of Mindfulness And Meditation Experience On Cognitive And Emotional Functioning And Ego Depletion, Emily Lauren Brown Lykins

University of Kentucky Doctoral Dissertations

Mindfulness is increasingly recognized as an important phenomenon both clinically and empirically, with mindfulness-based interventions demonstrated to be efficacious across a wide variety of patient populations and disorders (i.e., Baer, 2003). Though debate regarding the exact definition of mindfulness continues, generally accepted definitions involve the common elements of intentionally directing attention toward the present moment and adopting an accepting, nonjudgmental, and/or nonreactive orientation, intent, or attitude (i.e., Baer et al., 2006; Bishop et al., 2004). Several testable predictions in the cognitive and emotional domains were derived from the operational definition of mindfulness provided by Bishop et al. (2004). Recent empirical …

Investigations Of S-Glutathionylation Of Brain Proteins In The Progression Of Alzheimer's Disease And Of A Potential Glutatione Mimetic As A Treatment Of Alzheimer's Disease, Shelley Faye Newman

University of Kentucky Doctoral Dissertations

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by neurofibrillary tangles, senile plaques and loss of synapses. Many studies support the notion that oxidative stress plays an important role in AD pathogenesis. Previous studies from our laboratory employed redox proteomics to identify oxidatively modified proteins in the AD inferior parietal lobule (IPL). The proteins were consistent with AD pathology and have been central to further investigations of the disease. The present study was focused on the identification of specific targets of protein S-glutathionylation in AD, early AD (EAD), and mild cognative impairment (MCI) using a redox proteomics approach. In AD …

Persistent Currents And Quantum Critical Phenomena In Mesoscopic Physics, Oleksandr Zelyak

University of Kentucky Doctoral Dissertations

In this thesis, we study persistent currents and quantum critical phenomena in the systems of mesoscopic physics. As an introduction in Chapter 1 we familiarize the reader with the area of mesoscopic physics. We explain how mesoscopic systems are different from quantum systems of single atoms and molecules and bulk systems with an Avogadro number of elements. We also describe some important mesoscopic phenomena.

One of the mathematical tools that we extensively use in our studies is Random Matrix Theorty. This theory is not a part of standard physics courses and for educational purposes we provide the basics of Random …

Lipid-Based Paclitaxel And Doxorubicin Nanoparticles To Overcome P-Gp-Mediated Drug Resistance In Solid Tumors, Xiaowei Dong

University of Kentucky Doctoral Dissertations

Multidrug resistance (MDR) is a major obstacle limiting chemotherapeutic efficacy. The purpose of these studies was to investigate the potential application of injectable paclitaxel (PX) and doxorubicin (Dox)-loaded nanoparticles (NPs) engineered from oil-in-water microemulsion precursors for overcoming P-glycoprotein (P-gp)- mediated drug resistance in solid tumors.

An in-vitro study was performed to test whether the oil (stearyl alcohol and cetyl alcohol) used to make lipid nanoparticles could be metabolized. The results showed that the concentrations of the fatty alcohols within nanoparticles, which were quantitatively determined over time by gas chromatography, decreased to only 10-20% of the initial concentration after 15-24 h …

Image Of God: Effect On Coping, Psycho-Spiritual Well-Being And Fear Of Recurrence In Early Breast Cancer Survivors, Judith Anne Schreiber

University of Kentucky Doctoral Dissertations

The purpose of this dissertation was to examine whether a breast cancer survivor’s view of God influences her religious coping strategies, depression, anxiety, stress, fear of recurrence, and psychological well-being. These variables were selected based on literature that demonstrates relationships among them for breast cancer survivors. The specific aims of this dissertation were to: 1) identify religious coping strategies common to each of the four views of God; 2) examine the relationship of psychological well-being (Ryff) and religious coping strategies; and 3) examine differences in depression, anxiety, stress, fear of recurrence, and psychological well-being among women holding various views of …

Bootstrap Enhanced N-Dimensional Deformation Of Space With Acoustic Resonance Spectroscopy, David John Link

University of Kentucky Doctoral Dissertations

Acoustic methods can often be used with limited or no sample preparations making them ideal for rapid process analytical technologies (PATs). This dissertation focuses on the possible use of acoustic resonance spectroscopy as a PAT in the pharmaceutical industry. Current good manufacturing processes (cGMP) need new technologies that have the ability to perform quality assurance testing on all products. ARS is a rapid and non destructive method that has been used to perform qualitative studies but has a major drawback when it comes to quantitative studies. Acoustic methods create highly non linear correlations which usually results in high level computations …

Analysis Of Security Measures For Sequences, Ramakanth Kavuluru

University of Kentucky Doctoral Dissertations

Stream ciphers are private key cryptosystems used for security in communication and data transmission systems. Because they are used to encrypt streams of data, it is necessary for stream ciphers to use primitives that are easy to implement and fast to operate. LFSRs and the recently invented FCSRs are two such primitives, which give rise to certain security measures for the cryptographic strength of sequences, which we refer to as complexity measures henceforth following the convention. The linear (resp. N-adic) complexity of a sequence is the length of the shortest LFSR (resp. FCSR) that can generate the sequence. Due …

Using Thr Ffm To Understand And Integrate The Deficits Of Psychopathy, Karen J. Derefinko

University of Kentucky Doctoral Dissertations

Psychopathy is associated with several behavioral and psychophysiological deficits. Lynam (2002) has argued that the use of an overarching conceptualization of psychopathy can provide a parsimonious explanation of psychopathic pathology. The current study examined relations between tasks used to explore psychopathic pathology and dimensions from the Five Factor Model of personality. Undergraduate participants completed the NEO PI-R, the BART, a go/no-go task, an emotional morph task, and provided physiological responses to stimuli. While hypothesized relations to FFM psychopathy composites were generally unsupported, other interesting relations to traits were identified. Results indicated that hypoarousal to negative stimuli was negatively related to …

Preparation And Characterization Of Blackberry Extracts And Their Anticancer And Anti-Inflammatory Properties, Jin Dai

University of Kentucky Doctoral Dissertations

Blackberries are rich in polyphenols including anthocyanins. Polyphenols are hypothesized to have biological activities that impact positively on human health. The purpose of these studies was to develop phenolic extracts from selected cultivars of blackberries currently grown in Kentucky as potential Botanical Drug Products for the treatment and prevention of cancer and inflammatory diseases.

An ultrasound-assisted ethanol extraction method was employed to obtain anthocyanin-containing extracts (ACEs) from puree or powder (lyophilized puree) of blackberries. ACEs were analyzed for total anthocyanin and phenolics content, polymeric color, and total antioxidant capacity (TAC). The influence of water content in the extraction system was …

Studies On The Role Of Acid Sphingomyelinase And Ceramide In The Regulation Of Tace Activity And Tnfα Secretion By Macrophages, Krasimira Rozenova

University of Kentucky Doctoral Dissertations

Acid Sphingomyelinase (ASMase) activity has been proposed to mediate LPS signaling in various cell types. This study shows that in macrophages, ASMase is a negative regulator of LPS-induced TNFα secretion. ASMasedeficient (asm^-/-) mice and isolated peritoneal macrophages produce several fold more TNFα than their wild-type (asm^+/+) counterparts when stimulated with LPS. The mechanism for these differences however is not transcriptional but post-translational.

The TNFα converting enzyme (TACE) catalyzes the maturation of the 26kD precursor (proTNFα) to the active 17kD form (sTNFα). In mouse peritoneal macrophages, the activity of TACE rather than the rate of TNFα mRNA …

Viable Institutions, Judicial Power, And Post-Communist Constitutional Courts, Kirill Mikhaylovich Bumin

University of Kentucky Doctoral Dissertations

In pursuing their goals, newly-created constitutional courts of Eastern Europe and the former Soviet republics are affected by their institutional setting and capabilities. Yet, previous studies did not explore how constitutional courts develop over time and what noteworthy implications for politics and society result from their institutional growth. To address this gap in the literature, I measured a variety of organizational characteristics and constructed an index of institutional development for the twenty eight constitutional courts in the post-communist countries from the initial year of their transitions through 2005. I argued that high values on this measure (which I labeled the …

Investigation Of Surface Fine Grained Laminae, Streambed, And Streambank Processes Using A Watershed Scale Hydrologic And Sediment Transport Model, Joseph Paul Russo

University of Kentucky Doctoral Dissertations

Sediment transport at the watershed scale in the Bluegrass Region of Kentucky is dominated by surface fine grained laminae, streambed, and streambank erosion; high instream sediment storage; and surface erosion processes. All these processes can be impacted by agricultural, urban, and suburban land-uses as well as hydrologic forcing. Understanding sediment transport processes at the watershed scale is a need for budgeting and controlling sediment pollution, and watershed modeling enables investigation of the cumulative effect of sediment processes and the parameters controlling these processes upon the entire sediment budget for a watershed. Sediment transport is being modeled by coupling the hydrologic …

Pattern Recognition Integrated Sensing Methodologies (Prisms) In Pharmaceutical Process Validation, Remote Sensing And Astrobiology, Thaddaeus S. Hannel

University of Kentucky Doctoral Dissertations

Modern analytical instrumentation is capable of creating enormous and complex volumes of data. Analysis of large data volumes are complicated by lengthy analysis time and high computational demand. Incorporating real-time analysis methods that are computationally efficient are desirable for modern analytical methods to be fully utilized. The use of modern instrumentation in on-line pharmaceutical process validation, remote sensing, and astrobiology applications requires real-time analysis methods that are computationally efficient.

Integrated sensing and processing (ISP) is a method for minimizing the data burden and sensing time of a system. ISP is accomplished through implementation of chemometric calculations in the physics of …

Long-Period Ground Motions In The Upper Mississippi Embayment From Finite-Fault, Finite-Difference Simulations, Kenneth A. Macpherson

University of Kentucky Doctoral Dissertations

A 3D velocity model and 3D wave propagation code have been employed to simulate long-period ground motions in the upper Mississippi embayment. This region is exposed to seismic hazard in the form of large earthquakes in the New Madrid seismic zone and observational data are sparse, making simulation a valuable tool for predicting the effects of large events. These simulations were undertaken in order to estimate ground-motion characteristics and to investigate the influence of the 3D embayment structure and finite-fault mechanics. There are three primary fault zones in the New Madrid seismic zone, each of which was likely associated with …

Three Essays On Residential Real Estate Brokerage, Jason S. Beck

University of Kentucky Doctoral Dissertations

The first essay investigates how individual characteristics influence sales outcomes for houses they help transact. It develops hedonic housing models to assess the impacts of agent characteristics such as the level of recent and concurrent agent activity on sales outcomes (price and time on market). This is done in a Multiple Listing Service (MLS) setting using seven years of data obtained from a large Midwestern city. I find evidence that more active listing agents sell homes more quickly, though they do so to the detriment of final sales price. I also find that more listings concurrently held by agents have …

Study Of Qcd Critical Point Using Canonical Ensemble Method, Anyi Li

University of Kentucky Doctoral Dissertations

QCD at non-zero baryon density is expected to have a critical point where the finite temperature crossover at zero density turns into a first order phase transition. To identify this point, we use the canonical ensemble approach to scan the temperaturedensity plane through lattice QCD simulations with Wilson-type fermions. In order to scan a wide range of the phase diagram, we develop an algorithm, the ”winding number expansion method” (WNEM) to fix the numerical instability problem due to the discrete Fourier transform for calculating the projected determinant. For a given temperature, we measure the chemical potential as a function of …

Biology And Management Of The Bed Bug, Cimex Lectularius L. (Heteroptera: Cimicidae), Alvaro Romero

University of Kentucky Doctoral Dissertations

The near absence of bed bugs from human dwellings for fifty or more years has left us with limited knowledge of its biology and few answers to eliminate populations. I explored a diverse set of objectives to answer key questions concerning bed bug biology and control. Major objectives were studies of circadian rhythmicity, pyrethroid resistance, sublethal effects of insecticides, synergism of pyrethroids, and evaluation of a pyrrole insecticides, chlorfenapyr. Additional studies included persistence of Borrelia in bed bugs after ingestion, and aggregation factors from feces.

In the absence of host stimuli, insects were much more active in the dark than …