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Articles 17971 - 18000 of 21167
Full-Text Articles in Entire DC Network
Met Receptor Tyrosine Kinase Degradation Is Altered In Response To The Leucine-Rich Repeat Of The Listeria Invasion Protein Internalin B, Xiu Gao, Marta Lorinczi, Kristen S. Hill, Natasha C. Brooks, Hatem Dokainish, Keith Ireton, Lisa A. Elferink
Met Receptor Tyrosine Kinase Degradation Is Altered In Response To The Leucine-Rich Repeat Of The Listeria Invasion Protein Internalin B, Xiu Gao, Marta Lorinczi, Kristen S. Hill, Natasha C. Brooks, Hatem Dokainish, Keith Ireton, Lisa A. Elferink
Faculty Bibliography 2000s
Entry of the bacterial pathogen Listeria monocytogenes into host epithelial cells is critical for infection and virulence. One major pathway for Listeria entry involves binding of the bacterial protein Internalin B to the host receptor tyrosine kinase Met ( hepatocyte growth factor receptor). Activation of Met and downstream signaling cascades is critical for Listeria entry. Internalin B is composed of several structural domains including an N-terminal leucine-rich repeat that is sufficient for binding Met and stimulating downstream signal transduction. Internalin B is monomeric, whereas the leucine-rich repeat is dimeric when expressed as an isolated fragment. The different quaternary states of …
Decorin Is A Novel Antagonistic Ligand Of The Met Receptor, Silvia Goldoni, Ashley Humphries, Alexander Nyström, Sampurna Sattar, Rick T. Owens, David J. Mcquillan, Keith Ireton, Renato V. Iozzo
Decorin Is A Novel Antagonistic Ligand Of The Met Receptor, Silvia Goldoni, Ashley Humphries, Alexander Nyström, Sampurna Sattar, Rick T. Owens, David J. Mcquillan, Keith Ireton, Renato V. Iozzo
Faculty Bibliography 2000s
Decorin, a member of the small leucine-rich proteoglycan gene family, impedes tumor cell growth by down-regulating the epidermal growth factor receptor. Decorin has a complex binding repertoire, thus, we predicted that decorin would modulate the bioactivity of other tyrosine kinase receptors. We discovered that decorin binds directly and with high affinity (K(d) = similar to 1.5 nM) to Met, the receptor for hepatocyte growth factor (HGF). Binding of decorin to Met is efficiently displaced by HGF and less efficiently by internalin B, a bacterial Met ligand. Interaction of decorin with Met induces transient receptor activation, recruitment of the E3 ubiquitin …
Bacterial Selenoproteins: A Role In Pathogenesis And Targets For Antimicrobial Development, Sarah Rosario
Bacterial Selenoproteins: A Role In Pathogenesis And Targets For Antimicrobial Development, Sarah Rosario
Electronic Theses and Dissertations
Selenoproteins are unique proteins in which selenocysteine is inserted into the polypeptide chain by highly specialized translational machinery. They exist within all three kingdoms of life. The functions of these proteins in biology are still being defined. In particular, the importance of selenoproteins in pathogenic microorganisms has received little attention. We first established that a nosocomial pathogen, Clostridium difficile, utilizes a selenoenzyme dependent pathway for energy metabolism. Following this initial characterization, we demonstrate that this pathway is linked to production of toxins by this organism. Finally, we show that interruption of selenium metabolism is a viable pathway for development of …
Mcp-1 And App Involvement Of Glial Differentiation And Migration Of Neuroprogenitor Cells, Emmanuel Vrotsos
Mcp-1 And App Involvement Of Glial Differentiation And Migration Of Neuroprogenitor Cells, Emmanuel Vrotsos
Electronic Theses and Dissertations
Neuroprogenitor cells are an important resource because of their potential to replace damaged cells in the brain caused by trauma and disease. It is of great importance to better understand which factors influence the differentiation and migration of these cells. Previously it has been reported that neuroprogenitor cells undergoing apoptotic stress have increased levels of Amyloid precursor protein (APP) and increased APP expression results in glial differentiation. APP activity was also shown to be required for staurosporine induced glial differentiation of neuroprogenitor cells. Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that is expressed during inflammatory. The binding of MCP-1 to …
The Effects Of Computer-Assisted Repeated Readings On The Reading Performance Of Middle School Students With Mild Intellectual Disabilities, Mark Cerasale
Electronic Theses and Dissertations
The No Child Left Behind Act of 2001 has mandated that all public school students will be reading at grade level by the 2013-2014 school year. Florida has embarked on an agenda to ensure that the kindergarten through high school student population is reading at or above grade level by 2014. Many of Florida's low-performing student population, including middle school students with high incidence disabilities, are reading below grade level. Using a multiple baseline across subjects design, this study examined the impact of computer-assisted repeated readings on the reading performance of three middle school students with mild intellectual disabilities over …
Beliefs Of Graduate Students About Unstructured Computer Use In Face-To-Face Classes With Internet Access And Its Influence On Student Recall, Gregory Johnson
Beliefs Of Graduate Students About Unstructured Computer Use In Face-To-Face Classes With Internet Access And Its Influence On Student Recall, Gregory Johnson
Electronic Theses and Dissertations
The use of computers equipped with Internet access by students during face-to-face (F2F) class sessions is perceived as academically beneficial by a growing number of students and faculty members in universities across the United States. Nevertheless, some researchers suggest unstructured computer use detached from the immediate class content may negatively influence student participation, increase distraction levels, minimize recall of recently presented information, and decrease student engagement. This study investigates graduate students' beliefs about computer use with Internet access during graduate face-to-face lecture classes in which computer use is neither mandated nor integrated in the class and the effect of such …
Educational Video Game Effects Upon Mathematics Achievement And Motivation Scores: An Experimental Study Examining Differences B, Wendi Kappers
Educational Video Game Effects Upon Mathematics Achievement And Motivation Scores: An Experimental Study Examining Differences B, Wendi Kappers
Electronic Theses and Dissertations
An experimental research study using a mixed-method analysis to was conducted to examine educational video game effects on mathematics achievement and motivation between sexes. This study examined sex difference in a 7th grade mathematics (Mathematics 2/Mathematics 2 Advanced) classroom (n=60) learning algebra. Attributes and barriers relating to educational video game play, preference, and setting characteristics were explored. To examine achievement and motivation outcomes, a repeated-measure (SPSS v14) test was used. The analysis included ethnographic results from both student and teacher interview and observation sessions for data triangulation. Results revealed a statistically significant academic mathematics achievement score increase (F =21.8, df …
The Adolescent Experience In-Depth: Using Data To Identify And Reach The Most Vulnerable Young People—Guinea 2005, Population Council
The Adolescent Experience In-Depth: Using Data To Identify And Reach The Most Vulnerable Young People—Guinea 2005, Population Council
Poverty, Gender, and Youth
“The Adolescent Experience In-Depth: Using Data to Identify and Reach the Most Vulnerable Young People: Guinea 2005” is part of a series of Population Council guides that draw principally on data from the Demographic and Health Surveys to provide decisionmakers at all levels—from governments, nongovernmental organizations, and advocacy groups—with evidence on the situation of adolescent girls and boys and young women aged 10–24 years. The data are presented in graphs, tables, and maps (wherever possible), providing multiple formats to make the information accessible to a range of audiences. Section I is the Foreword. Section II offers brief technical notes specific …
Significant Measurement Of Mean Carotid Intima-Media Thickness In Sustained Essential Hypertension, Ismail I. Hussein, Marwan S. Al-Nimer
Significant Measurement Of Mean Carotid Intima-Media Thickness In Sustained Essential Hypertension, Ismail I. Hussein, Marwan S. Al-Nimer
Neurosciences
OBJECTIVE: To assess the significant association of atherosclerosis quantified by screening intima media thickness of bilateral common and internal carotid arteries in patients with asymptomatic and persistent hypertension with and without ischemic stroke. METHODS: Subjects in this investigation were recruited from the vascular Doppler unit at Baghdad Teaching Hospital in Baghdad, Iraq during 2005. A total number of 119 (61 females and 58 males), with ages ranging from 40-70 years, were able to comply with the observational comparative study protocol. They are grouped into healthy normotensive (I), asymptomatic (preclinical) hypertension (II), sustained hypertension without (III) and with ischemic stroke (IV). …
Risk Data In Insurance Interpretation, Michelle Boardman
Risk Data In Insurance Interpretation, Michelle Boardman
Connecticut Insurance Law Journal
No abstract provided.
The Road From “Twin Peaks” – And The Way Back, Michael W. Taylor
The Road From “Twin Peaks” – And The Way Back, Michael W. Taylor
Connecticut Insurance Law Journal
No abstract provided.
The 2008 Mental Health Parity And Addiction Equity Act: An Overview Of The New Legislation And Why An Amendment Should Be Passed To Specifically Define Mental Illness And Substance Use Disorders, Sara Nadim
Connecticut Insurance Law Journal
No abstract provided.
Predatory Lending And Its Insurance Consequences, Erin O'Leary
Predatory Lending And Its Insurance Consequences, Erin O'Leary
Connecticut Insurance Law Journal
No abstract provided.
Examining Current Proposals For Increasing The Federal Role In Dealing With Coastal Hurricane Risk, Louis Cruz
Examining Current Proposals For Increasing The Federal Role In Dealing With Coastal Hurricane Risk, Louis Cruz
Connecticut Insurance Law Journal
No abstract provided.
In Step With Hiv Vaccines? A Content Analysis Of Local Recruitment Campaigns For An International Hiv Vaccine Study, Paula M. Frew, Wendy Macias, Kayshin Chan, Ashley Harding
In Step With Hiv Vaccines? A Content Analysis Of Local Recruitment Campaigns For An International Hiv Vaccine Study, Paula M. Frew, Wendy Macias, Kayshin Chan, Ashley Harding
Environmental & Global Health Faculty Research
During the past two decades of the HIV/AIDS pandemic, several recruitment campaigns were designed to generate community involvement in preventive HIV vaccine clinical trials. These efforts utilized a blend of advertising and marketing strategies mixed with public relations and community education approaches to attract potential study participants to clinical trials (integrated marketing communications). Although more than 30,000 persons worldwide have participated in preventive HIV vaccine studies, no systematic analysis of recruitment campaigns exists. This content analysis study was conducted to examine several United States and Canadian recruitment campaigns for one of the largest-scale HIV vaccine trials to date (the “Step …
Do Executions Lower Homicide Rates: The Views Of Leading Criminologists', Michael L. Radelet, Traci L. Lacock
Do Executions Lower Homicide Rates: The Views Of Leading Criminologists', Michael L. Radelet, Traci L. Lacock
Journal of Criminal Law and Criminology
No abstract provided.
When Is A Police Officer An Officer Of The Law: The Status Of Police Officers In Schools, Peter Price
When Is A Police Officer An Officer Of The Law: The Status Of Police Officers In Schools, Peter Price
Journal of Criminal Law and Criminology
No abstract provided.
Off-Court Misbehavior: Sports Leagues And Private Punishment, Janine Young Kim, Matthew J. Parlow
Off-Court Misbehavior: Sports Leagues And Private Punishment, Janine Young Kim, Matthew J. Parlow
Journal of Criminal Law and Criminology
No abstract provided.
The Criminalization Of Poverty, Kaaryn Gustafson
The Criminalization Of Poverty, Kaaryn Gustafson
Journal of Criminal Law and Criminology
No abstract provided.
Legal Disparities In The Capital Of Capital Punishment, Scott Phillips
Legal Disparities In The Capital Of Capital Punishment, Scott Phillips
Journal of Criminal Law and Criminology
No abstract provided.
Aces And Eights: Why The Unlawful Internet Gambling Enforcement Act Resides In Dead Man's Land In Attempting To Further Curb Online Gambling And Why Expanded Criminalization If Preferable To Legalization, Jonathan Conon
Journal of Criminal Law and Criminology
No abstract provided.
Consciousness Is Computational: The Lida Model Of Global Workspace Theory, B. Baars, S. Franklin
Consciousness Is Computational: The Lida Model Of Global Workspace Theory, B. Baars, S. Franklin
CCRG Papers
No abstract provided.
Parental Rights And Public School Curricula: Revisiting Mozert After 20 Years, Eric A. Degroff
Parental Rights And Public School Curricula: Revisiting Mozert After 20 Years, Eric A. Degroff
The Journal of Law and Education
No abstract provided.
Primary &(And) Secondary Education Recent Decisions
Primary &(And) Secondary Education Recent Decisions
The Journal of Law and Education
No abstract provided.
Book Review, Richard Fossey
Parents' Right To Direct Their Children's Education And Student Sex Surveys - Counterpoint, Kathleen Conn
Parents' Right To Direct Their Children's Education And Student Sex Surveys - Counterpoint, Kathleen Conn
The Journal of Law and Education
No abstract provided.
In Defense Of Voluntary Desegregation: All Things Are Not Equal, Derek W. Black
In Defense Of Voluntary Desegregation: All Things Are Not Equal, Derek W. Black
Faculty Publications
This Article analyzes the concept of racial stigma in Justice Kennedy’s controlling opinion in Parents Involved in Community Schools v. Seattle School District No. 1. The Article reveals that Kennedy’s fundamental concern is that using racial classifications to achieve voluntary desegregation racially stigmatizes students. In particular, he assumes that the classifications undermine individualism and reduce children to “racial chits.” He fails, however, to recognize the purpose of voluntary desegregation and the unique characteristics that distinguish it from other race-conscious programs. Kennedy is not alone. Commentators and schools may have “over-defended” voluntary desegregation, articulating multiple justifications rather than focusing on the …
Leadership Orientation Style And Use Of Power: A Study Of New Jersey Male Superintendents, Sandra Deluca
Leadership Orientation Style And Use Of Power: A Study Of New Jersey Male Superintendents, Sandra Deluca
Seton Hall University Dissertations and Theses (ETDs)
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A Study In Police Preparedness To Respond To Active Shooter Situations To Provide A Safer Learning Environment In The Schools Of Bergen County, New Jersey, Jeffrey T. Dino
Seton Hall University Dissertations and Theses (ETDs)
The research in this study was conducted to explore the influence that the Bergen County Prosecutor's Office Directive 05-01 had on the training and future preparations of all sworn police officers in Bergen County, New Jersey in response to active-shooter situations in the schools of their jurisdictions. Because attendance in schools is mandatory for children to the age of 16 in New Jersey it becomes imperative that the police departments of the state, and more specifically for the purpose of this study the police officers in Bergen County, are able to provide a safe learning environment while children are in …
An Examination Of The Impact Of Attending An Electronic Technology Rich Program On The Teaching Styles Of Senior Student Teachers, Joseph J. Martinelli
An Examination Of The Impact Of Attending An Electronic Technology Rich Program On The Teaching Styles Of Senior Student Teachers, Joseph J. Martinelli
Seton Hall University Dissertations and Theses (ETDs)
The purpose of this study was to determine whether attending an electronic technology rich program had an impact on the teaching styles of senior student teachers. It is clear from this research that senior student teachers have benefits from attending such a program. Three research questions were used to guide this study: what ways teachers are currently using technology; how are teachers in this study using technology in their planning of the learning experience; how teachers' technology attitudes, understandings and skills change over time. A web based survey tool, which was delivered electronically to senior student teachers both in elementary …