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2009

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Dna Topoisomerases I From Pseudomonas Aeruginosa And Vaccinia Virus And Their Use As Drug Targets, Teesta Jain Jan 2009

Dna Topoisomerases I From Pseudomonas Aeruginosa And Vaccinia Virus And Their Use As Drug Targets, Teesta Jain

LSU Doctoral Dissertations

Pseudomonas aeruginosa encodes a putative topoisomerase with sequence similarity to the type IB topoisomerase enzyme from vaccinia virus. Residues in the active site are conserved, notably Tyr292 which would be predicted to form the transient covalent bond to DNA. The gene encoding the P. aeruginosa topoisomerase I (PAT) was cloned and expressed in E. coli. The enzyme relaxes supercoiled DNA, while a mutant of P. aeruginosa containing a Tyr292 to Phe substitution at the active site was found to be catalytically inert. This is consistent with the role of Tyr in forming the covalent intermediate. Like vaccinia topoisomerase (VT), PAT …

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Remediating Impacts Of Global Climate Change-Induced Submergence On Salt Marsh Ecosystem Functions, Camille Lafosse Stagg Jan 2009

Remediating Impacts Of Global Climate Change-Induced Submergence On Salt Marsh Ecosystem Functions, Camille Lafosse Stagg

LSU Doctoral Dissertations

Impacts of global climate change, such as sea level rise and severe drought, have altered the hydrology of coastal salt marshes resulting in submergence and subsequent degradation of ecosystem function. A potential method of rehabilitating these systems is the addition of sediment-slurries to increase the elevation of the marsh surface, thus ameliorating the effects of excessive inundation. Although this technique is growing in popularity, the successful restoration of ecological function after sediment addition has received little attention. The purpose of this research was to determine if sediment subsidized salt marshes are functionally equivalent to natural marshes and whether salt marshes …

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Experimental Design, Synthesis And Application Of Molecular Micelle Modified Polymeric Nanoparticles For Drug Delivery Systems And Free Radical Detection, Gabriela M. Ganea Visser Jan 2009

Experimental Design, Synthesis And Application Of Molecular Micelle Modified Polymeric Nanoparticles For Drug Delivery Systems And Free Radical Detection, Gabriela M. Ganea Visser

LSU Doctoral Dissertations

Biodegradable and biocompatible polymeric nanoparticles such as poly (lactide-co-glycolide) (PLGA) nanoparticles have been extensively studied as drug delivery systems for a variety of pharmaceutical agents. Nanoparticle surface properties are primarily determined by the emulsifiers used in the synthesis process, which have a significant impact on nanoparticle physico-chemical and biological properties. Anionic amino acid – based molecular micelles were used in the emulsification process to prepare monodisperse, small (below 100 nm) PLGA nanoparticles with a well defined spherical shape. Such molecular micelle – modified nanoparticles were used as drug carriers for delivery of antioxidants. Thymoquinone is a natural antioxidant, and an …

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Iron Mediated Pecipitation Of Phenol: Protein Aggregates From Sugar Cane Juice, Lee R. Madsen Ii Jan 2009

Iron Mediated Pecipitation Of Phenol: Protein Aggregates From Sugar Cane Juice, Lee R. Madsen Ii

LSU Doctoral Dissertations

The Louisiana cane sugar industry is moving toward a vertically integrated arrangement where raw sugar producers will have an interest in refining. In the sugar refining process, raw sugar is affined to remove ~50 % of the color. The new refinery that will be built in Louisiana, however, will not include affining stations. To reduce costs of refining, either affining stations will need to be installed at each mill or new technologies that provide equivalent color reduction (~50% or ~750 IU) need to be implemented. As part of this dissertation a new technology for color reduction at raw sugar mills …

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An Examination Of Louisiana Educational School Improvement Legislation, Policy Decisions, Initiatives, And Fiscal Expenditure From 1997 To 2005, Belinda Marie Cambre Jan 2009

An Examination Of Louisiana Educational School Improvement Legislation, Policy Decisions, Initiatives, And Fiscal Expenditure From 1997 To 2005, Belinda Marie Cambre

LSU Doctoral Dissertations

This study sought to identify major school improvement reform programs and initiatives in Louisiana during the period of 1997 to 2005. The criteria used to identify each program included: state funding that averaged at least $2 million per year in state funds; programs that affected teachers and students for school improvement purposes; and, programs that remained in place for at least two school years. The study ultimately yielded nine initiatives that met each of the above listed criteria. Some, but not all, were the result of the School and District Accountability Commission, which was established by Act 478, the 1997 …

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Institutional Challenges For Mining And Sustainability In Peru, Anthony J. Bebbington, Jeffrey T. Bury Jan 2009

Institutional Challenges For Mining And Sustainability In Peru, Anthony J. Bebbington, Jeffrey T. Bury

Geography

Global consumption continues to generate growth in mining. In lesser developed economies, this growth offers the potential to generate new resources for development, but also creates challenges to sustainability in the regions in which extraction occurs. This context leads to debate on the institutional arrangements most likely to build synergies between mining, livelihoods, and development, and on the socio-political conditions under which such institutions can emerge. Building from a multiyear, three-country program of research projects, Peru, a global center of mining expansion, serves as an exemplar for analyzing the effects of extractive industry on livelihoods and the conditions under which …

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