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Efficacy And Safety Of Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine For Malaria In African Infants: A Pooled Analysis Of Six Randomised, Placebo-Controlled Trials, J.J. Aponte, D. Schellenberg, A. Egan, A. Breckenridge, I. Carneiro, J. Critchley, I. Danquah, A. Dodoo, R. Kobbe, B. Lell, J. May, Zul Premji, S. Sanz, E. Sevene, R. Soulaymani-Becheikh, P. Winstanley, S. Adjei, S. Anemana, D. Chandramohan, S. Issifou, F. Mockenhaupt F., S. Owusu-Agyei, B. Greenwood, M.P. Grobusch, P.G. Kremsner, E. Macete, H. Mshinda, R.D. Newman, L. Slutsker, M. Tanner, P. Alonso, C. Menendez

Pathology, East Africa

Background: Intermittent preventive treatment (IPT) is a promising strategy for malaria control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa. Methods: We pooled data from six double-blind, randomised, placebo-controlled trials (undertaken one each in Tanzania, Mozambique, and Gabon, and three in Ghana) that assessed the efficacy of IPTi with sulfadoxine-pyrimethamine. In all trials, IPTi or placebo was given to infants at the time of routine vaccinations delivered by WHO's Expanded Program on Immunization. Data from the trials for incidence of clinical malaria, risk of anaemia (packed-cell volume <25% or haemoglobin <80 g/L), and incidence of hospital admissions and adverse events in infants up to 12 months of age were reanalysed by use of standard outcome definitions and time periods. Analysis was by modified intention to treat, including all infants who received at least one dose of IPTi or placebo. Findings: The six trials provided data for 7930 infants (IPTi, n=3958; placebo, n=3972). IPTi had a protective efficacy of 30·3% (95% CI 19·8-39·4, p<0·0001) against clinical malaria, 21·3% (8·2-32·5, p=0·002) against the risk of anaemia, 38·1% (12·5-56·2, p=0·007) against hospital admissions associated with malaria parasitaemia, and 22·9% (10·0-34·0, p=0·001) against all-cause hospital admissions. There were 56 deaths in the IPTi group compared with 53 in the placebo group (rate ratio 1·05, 95% CI 0·72-1·54, p=0·79). One death, judged as possibly related to IPTi because it occurred 19 days after a treatment dose, was subsequently attributed to probable sepsis. Four of 676 non-fatal hospital admissions in the IPTi group were deemed related to study treatment compared with five of 860 in the placebo group. None of three serious dermatological adverse events in the IPTi group were judged related to study treatment compared with one of 13 in the placebo group. Interpretation: IPTi with sulfadoxine-pyrimethamine was safe and efficacious across a range of malaria transmission settings, suggesting that this intervention is a useful contribution to malaria control. Funding: Bill & Melinda Gates Foundation. © 2009 Elsevier Ltd. All rights reserved.

Joshua And The Education Of A Nation: Jamaica Educational Reform In The Manley-Era, 1972-1980, Dionne Dean

Master's Theses

Former Jamaican Prime Minister, Michael Manley and the Peoples National Party were concerned with the future manpower needs of the developing nation. They were also concerned with what education meant for the political process in Jamaica. World financial organizations such as the IMF and World Bank loaned the country millions of dollars to aid in the development of educational programs. However, they also expected a return on investment in the form of an educated labor force to be utilized by foreign investors. Foreign aid organizations such as CIDA and UNESCO also contributed greatly to educational advancement on the island. They …

Accurate Cylindrical-Coordinate Numerical Models For The Analysis Of Hydrologic Tests, John Edward Keller

Dissertations

Analytical solutions to well hydraulic problems have restrictive assumptions that often do not match real world conditions. Although numerical models more closely match reality, they either ran too slowly to be practical or lacked accuracy because of coarse grid spacing and large time steps. Advances in computer power over the last few decades now allow for accurate, fast numerical models that handle complex flow systems. The purpose of this dissertation was to develop flexible and accurate numerical modeling codes for the simulation of hydrologic tests. One of these numerical modeling codes, the Slug Test Simulator (STS), was designed for the …

Optimal Design Of Discrete-Time Delta Sigma Modulators, Matthew Edward Jackson

UNLV Theses, Dissertations, Professional Papers, and Capstones

In this thesis, optimal signal transfer functions (STFs) and noise transfer functions (NTFs) for discrete time delta sigma (ΔΣ) modulators are determined. For a given oversampling rate (OSR), these STFs and NTFs are optimized with respect to a weighted combination of the ΔΣ modulator's signal-to-noise ratio (SNR) and dynamic range (DR). This optimization problem is solved using a novel hybrid orthogonal genetic (HOG) algorithm that uses customized genetic operators to improve algorithm performance and accuracy when applied to multimodal, non-differentiable performance surfaces. To generate optimal system functions, the HOG algorithm is implemented as a constrained global optimizer to minimize cost …

Mineralogy And Micromorphology Of An Atacama Desert Soil, Chile: A Model For Hyperarid Pedogenesis, Michael S. Howell

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Atacama Desert is the oldest and driest desert on Earth. Hyperarid soils in this desert are dominated by rare (or exclusive) salt minerals and assemblages. Previous research details salt origins and abundance, however pedogenic processes involved in salt distribution are not adequately explained. Therefore, the main goal of this investigation was to identify and document evidence for hyperarid pedogenesis (via salt mineralogy and soil micromorphology) at a field site, Oficina Ercilla, located ~80 km northeast of Antofagasta, Chile within the Central Depression and hyperarid core of the Atacama Desert. This study presents an interpretational model for hyperarid pedogenesis, which …

Efficient Clustering Techniques For Managing Large Datasets, Vasanth Nemala

UNLV Theses, Dissertations, Professional Papers, and Capstones

The result set produced by a search engine in response to the user query is very large. It is typically the responsibility of the user to browse the result set to identify relevant documents. Many tools have been developed to assist the user to identify the most relevant documents. One such a tool is clustering technique. In this method, the closely related documents are grouped based on their contents. Hence if a document turns out to be relevant, so are the rest of the documents in the cluster. So it would be easy for a user to sift through the …

Experimental And Numerical Study Of A Proton Exchange Membrane Electrolyzer For Hydrogen Production, Sachin S. Deshmukh

UNLV Theses, Dissertations, Professional Papers, and Capstones

Hydrogen as a fuel source has received attention from researchers globally due to its potential to replace fossil based fuels for energy production. Research is being performed on hydrogen production, storage and utilization methods to make its use economically feasible relative to current energy sources. The PEM electrolyzer is used to produce hydrogen and oxygen using water and electricity. Focus of our study is to provide a benchmark experiment and numerical model of a single cell electrolyzer that can assist in improving the current state of understanding of this system. Parametric analysis of an experimental cell was performed to understand …

Islanded Operation Of A Distribution Feeder With Distributed Generation, Chandu Venu

UNLV Theses, Dissertations, Professional Papers, and Capstones

A distribution system that is equipped with distributed generators, such as roof-mounted photovoltaic systems, can operate as a microgrid (i.e., separated from the grid) under some specific conditions. A key feature of a microgrid is its ability to separate and isolate itself from the utility seamlessly with little or no disruption to the loads within the microgrid. Then, when the utility grid returns to normal, the microgrid automatically resynchronizes and reconnects itself to the grid, in an equally seamless manner. This thesis addresses the conditions necessary for proper microgrid operation: these include local generation-load mismatch, local energy storage, load switching, …

Analytical Method Development For Determination Of Volatile Organic Compounds In Calcareous Desert Soil, Mary F. Turner

UNLV Theses, Dissertations, Professional Papers, and Capstones

Soil sample preservation for volatile organic compound analysis generally requires short sample holding times or preservation of the sample's chemical constituents with sodium bisulfate (NaHSO 4 ). Calcareous soils cannot be preserved using NaHSO4 because effervescence will promote the loss of analytes, and short holding times before analysis are not practical for remote sampling locations. An experimental approach was developed for determination of volatile organic compounds (VOCs) in soil that utilizes solid sorbents for sample preservation and solid-phase microextraction (SPME) sample preparation technique coupled with gas chromatography/mass spectrometry (GC/MS) for analysis. Solid sorbents are used to sequester readily extractable (vapor …

Factors Related To The Unemployment Rate: A Statistical Analysis, Reanna Collins

Honors Program Theses

Current United States economic conditions have everyone searching for ways to solve the downward spiral that has instigated a crisis in the minds of many people. Rapidly increasing unemployment rates are key reasons leading to this feeling of emergency. A better understanding of unemployment trends over the past few decades and factors correlated to the rate could serve as future indicators of fluctuations in the unemployment rate. A statistical analysis was conducted to determine if any relationship between the unemployment rate and nine selected variables existed in order to identify trends in the unemployment rate and to produce a model …

Gender Segregation And The Physical Education Classroom, Amanda Kopplin-Rodgers

Graduate Research Papers

The purpose of this paper is to address the issue of single sex classrooms and student learning through an examination of the research on how females and males learn and the effects of gender segregation in the general education classroom. The discussion will also include the impact of Title IX on physical education classrooms and the effects of segregation in physical education classrooms. Limited research has been conducted to investigate the relationship among several variables affecting learning including: hearing, brain development, student gender, age, body image, self-esteem, teacher gender, and which type of classroom is most conducive to student learning. …

School Readiness : What It Means To Be "Ready" For Kindergarten, Brian D. Kingrey

Graduate Research Papers

This review of the literature examined the recent literature on the subject of school readiness. The purpose of this review of the literature was to identify how schools and parents view school readiness, as well as how emergent literacy plays a role in preparing students for public school education. Assessments, skills, early learning standards, literacy practices, and entry age were discussed.

In researching recent literature for the review multiple searches were conducted including the search terms of school readiness and transition. Pianta, Cox, and Snow (2007) discussed the domains of developmental functioning in the early childhood years, which served as …

Learning From Our History: Evaluating The Modern Housing Finance Market In Light Of Ancient Principles Of Justice, Brian Mccall

Faculty Articles

Since I first accepted an invitation to join this symposium, the subprime mortgage crisis has exploded into a systemic financial crisis. Analysis and pundits alike seem on a quest to outdo each other in using dramatic phrases to describe its historic proportions. The causes of a crisis so large must have a multiplicity of causes lying in the realms of bank regulation and supervision, the operation and regulation of the securitization market and the derivatives and insurance markets. Yet, the root and spark of the various financial reverberations initiated in the home mortgage finance market. My presentation will focus on …

Ay 2008/2009 Sec Meeting Minutes, 2008-10-29, Faculty Senate

Faculty Senate Archives

No abstract provided.

Catalog Denison University 2009-2010

Denison University Catalogs

Denison University Course Catalog 2009-2010

Dc Electrokinetic Transport Of Cylindrical Cells In Straight Microchannels, Ye Ai, Ali Beskok, David T. Gauthier, Sang W. Joo, Shizhi Qian

Biological Sciences Faculty Publications

Electrokinetic transport of cylindrical cells under dc electric fields in a straight microfluidic channel is experimentally and numerically investigated with emphasis on the dielectrophoretic (DEP) effect on their orientation variations. A two-dimensional multiphysics model, composed of the Navier-Stokes equations for the fluid flow and the Laplace equation for the electric potential defined in an arbitrary Lagrangian-Eulerian framework, is employed to capture the transient electrokinetic motion of cylindrical cells. The numerical predictions of the particle transport are in quantitative agreement with the obtained experimental results, suggesting that the DEP effect should be taken into account to study the electrokinetic transport of …

Musical Chairs Mortality Functions: Density-Dependent Deaths Caused By Competition For Unguarded Refuges, Jameal F. Samhouri, Richard R. Vance, Graham E. Forrester, Mark A. Steele

Natural Resources Science Faculty Publications

Structural refuges within which prey can escape from predators can be an important limiting resource for the prey. In a manner that resembles the childhood game of musical chairs, many prey species rapidly retreat to shared, unguarded refuges whenever a predator threatens, and only when refuges are relatively abundant do all prey individuals actually escape. The key feature of this process is that the per capita prey mortality rate depends on the ratio of prey individuals to refuges. We introduce a new class of mortality functions with this feature and then demonstrate statistically that they describe field mortality data from …

Facial Skin Motion Properties From Video: Modeling And Applications, Vasant Manohar

USF Tampa Graduate Theses and Dissertations

Deformable modeling of facial soft tissues have found use in application domains such as human-machine interaction for facial expression recognition. More recently, such modeling techniques have been used for tasks like age estimation and person identification. This dissertation is focused on development of novel image analysis algorithms to follow facial strain patterns observed through video recording of faces in expressions. Specifically, we use the strain pattern extracted from non-rigid facial motion as a simplified and adequate way to characterize the underlying material properties of facial soft tissues. Such an approach has several unique features. Strain pattern instead of the image …

Describing Patents As Real Options, Christopher A. Cotropia

Law Faculty Publications

This Article continues the use of real options in patent law by taking a step back. The Article proceeds in three parts. Part II describes the concept of real options and catalogs the existing economics and law literature discussing patents as real options. The Article then lays a foundation for previous and future discussions by describing in detail how patents are like real options. Specifically, Part III. identifies the particular patent doctrines that make up the common components of a real option-the option price, the exercise price, the expiration date, and the value of the underlying asset. This descriptive analysis …

Superposition Formulas For Darboux Integrable Exterior Differential Sys-Tems, Ian M. Anderson, Mark E. Fels, Peter J. Vassiliou

Mathematics and Statistics Faculty Publications

In this article we solve an inverse problem in the theory of quotients for differential equations. We characterize a family of exterior differential systems that can be written as a quotient of a direct sum of two associated systems that are constructed from the original. The fact that a system can be written as a quotient can be used to find the general solution to these equations. Some examples are given to demonstrate the theory.

Catalog 2009-2010, University Of North Florida

UNF Course Catalogs

No abstract provided.

Choosing The Right Path: Enhancement Of Biologically Relevant Sets Of Genes Or Proteins Using Pathway Structure, Reuben Thomas, Julia M. Gohlke, Geffrey F. Stopper, Frederick M. Parham, Christopher J. Portier

Biology Faculty Publications

A method is proposed that finds enriched pathways relevant to a studied condition using the measured molecular data and also the structural information of the pathway viewed as a network of nodes and edges. Tests are performed using simulated data and genomic data sets and the method is compared to two existing approaches. The analysis provided demonstrates the method proposed is very competitive with the current approaches and also provides biologically relevant results.

The Orchard Crossing Number Of An Abstract Graph, Elie Feder, David Garber

Publications and Research

.We introduce the Orchard crossing number, which is defined in a similar way to the well-known rectilinear crossing number. We compute the Orchard crossing number for some simple families of graphs. We also prove some properties of this crossing number.

Moreover, we define a variant of this crossing number which is tightly connected to the rectilinear crossing number, and compute it for some simple families of graphs.

Los Maridos En El 'Norte'; Las Mujeres ¿Bien Gracias?, B. Schmook, Claudia Radel

Environment and Society Faculty Publications

La migración de mexicanos hacia Estados Unidos ha sido una constante en las relaciones entre ambas naciones desde hace más de siglo y medio, pero se ha intesificado considerablemente en las últimas tres décadas. Factores diversos como la vecindad geográfica, tendencias demográficas y laborales, la creciente integrción económica, la crisis del campo y las intensas relaciones e intercambios entre los dos países, hacen inevitable estos movimientos poblacionales.

Hydrologic Interdependencies And Human Cooperation: The Process Of Adapting To Droughts, Joanna Endter-Wada, Theresa Selfa, Lisa Welsh

Environment and Society Faculty Publications

The Bear River Basin, which includes portions of Idaho, Utah, and Wyoming in the United States, has a dynamic history of human hydrologic adaptations in relation to a highly variable water supply. These adaptations are embedded in a geographical setting highly influenced by the legal, policy, and institutional contexts that govern allocation of water in this generally arid region. In response to several years of drought and a historically low water year in 2004, water users in the Bear River Basin tested the efficacy of the “law of the river” and innovative agreements that they had negotiated in recent years …

Conflicts And Financial Collapse: The Problem Of Secondary-Management Agency Costs, Steven L. Schwarcz

Faculty Scholarship

Corporate governance scholarship has long focused on conflicts of interest between firms and their top executive officers. This Essay contends that increasing leverage and financial complexity make it important for scholars to also focus on conflicts of interest between firms and their secondary managers.

Distribution Of Funds In Class Actions - Claims Administration, Francis Mcgovern

Faculty Scholarship

Most class action securities cases result in a settlement where the parties agree on a defined amount of money to be placed in a fund for distribution to eligible beneficiaries. Although the size of the fund and the losses suffered by eligible beneficiaries are defined, the number of potential beneficiaries who decide not to participate in the settlement by opting out and the number and value of losses eventually claimed by those eligible beneficiaries are not known until long after the settlement amount has been established. In any closed-end fund, like the securities class action settlements, there is the potential …

Middle Years Students' Use Of Self-Regulating Strategies In An Online Journaling Environment, Chris Campbell

Education Papers and Journal Articles

This study investigated boys’ capacity for self regulation in a Year 8 classroom at a regional secondary college in the state of Victoria, Australia. This was an exploratory descriptive study that sought to examine how the use of an online journal influenced students’ capacity to adaptively react (Zimmerman, 2002) to self-determined knowledge about the effectiveness of their method of learning and set learning goals (Ames & Ames, 1989; Midgley, Kaplan, & Middleton, 2001). An online recording and online journaling space were developed by the researcher. The journal has been designed to be engaging for young adolescent male students as well …

Expenditures And Information Disclosure In Two-Stage Political Contests, Roman M. Sheremeta

ESI Working Papers

This laboratory experiment studies two-stage contests between political parties. In the first stage, parties run their primaries and in the second stage the winners of the primaries compete in the general election. The resource expenditures in the first stage by the winning candidates are partially or fully carried over to the second stage. Experimental results support all major theoretical predictions: the first stage expenditures and the total expenditures increase, while the second stage expenditures decrease in the carryover rate. Consistent with the theory, the total expenditures increase in the number of candidates and the number of parties. Contrary to the …

Pleistocene Reorganization Of The Southern San Andreas Fault System, A. N. Steely, Susanne U. Janecke, G. J. Axen, R. J. Dorsey

Geosciences Faculty Publications

Structural and stratigraphic analyses along the western margin of the Salton Trough show that the San Andreas fault system was reorganized in early Pleistocene time from a system dominated by two fault zones (the San Andreas fault and the West Salton detachment fault) to a network of dextral faults that include the San Andreas and at least four dextral faults to the southwest. The San Felipe fault zone, one of these dextral faults, has ~5.8 ± 2.8 km of right separation and consists of three principal faults in the Peninsular Ranges. These are the San Felipe fault in the WNW, …