Digital Commons Network^™

Inactivation Of The Fliy Gene Encoding A Flagellar Motor Switch Protein Attenuates Mobility And Virulence Of Leptospira Interrogans Strain Lai, Sumei Liao, Ai-Hua Sun, David M. Ojcius, Senlin Wu, Jinfang Zhao, Jie Yan

All Dugoni School of Dentistry Faculty Articles

Background: Pathogenic Leptospira species cause leptospirosis, a zoonotic disease of global importance. The spirochete displays active rotative mobility which may contribute to invasion and diffusion of the pathogen in hosts. FliY is a flagellar motor switch protein that controls flagellar motor direction in other microbes, but its role in Leptospira, and paricularly in pathogenicity remains unknown.

Results: A suicide plasmid for the fliY gene of Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai strain Lai that was disrupted by inserting the ampicillin resistance gene (bla) was constructed, and the inactivation of fliY gene in a mutant (fliY-) was confirmed by PCR and …

Bs News

Building Services Engineering

No abstract provided.

Making The Case: Did The Government's Response To Hurricane Katrina Violate The Equal Protection Clause., Michael Kogut

The Scholar: St. Mary's Law Review on Race and Social Justice

Abstract Forthcoming.

The Watchdog Role Of Newspapers: Newspaper Coverage Of Sinclair Broadcasting's Announcement To Air A One-Sided Documentary Right Before The 2004 Presidential Election., Greta Kaye Weiderman

Theses

AN ABSTRACT OF THE THESIS OF Greta K. Weiderman, for the Master of Arts degree in Mass Communication and Media Arts, presented on Aug. 21, 2009, at Southern Illinois University Carbondale. TITLE: THE WATCHDOG ROLE OF NEWSPAPERS: NEWSPAPER COVERAGE OF SINCLAIR BROADCASTING'S ANNOUNCEMENT TO AIR A ONE-SIDED DOCUMENTARY RIGHT BEFORE THE 2004 PRESIDENTIAL ELECTION MAJOR PROFESSOR: Dr. William Babcock This thesis is a content analysis examining newspaper coverage of Sinclair Broadcasting's announcement that it planned to air a program titled "Stolen Honor: Wounds that Never Heal" 13 days before the November 2004 presidential election. Sinclair Broadcast Group ordered its 61 …

Theodore Wilson Thompson: Southern Illinois Pioneer, Elisha L. Szyjka

Theses

Giant City State Park in Makanda, Illinois contains graffiti created by passersby and local residents. Many deem modern graffiti in parks as a depreciative behavior. However, the inscription created by Theodore Wilson Thompson in 1862 along the Giant City Nature Trail has implications for interpretive use by park staff. This is due to the inscription being etched prior to the park's establishment and Theodore's pioneering contributions to Makanda and Carbondale, Illinois. Therefore, Theodore Thompson was the focus of this study due to his inscription and the lack of park research conducted on his life history. In 1852, as a young …

Merit Selection And Performance Evaluation Of Alaska’S Judges, Teresa W. Carns

Alaska Law Review

No abstract provided.

Transgendered In Alaska: Navigating The Changing Legal Landscape For Change In Gender Petitions, Leslie Dubois-Need, Amber Kingery

Alaska Law Review

No abstract provided.

Vol 54 #3, Judy Zelenski

MPLA Newsletter

No abstract provided.

Editor’S Introduction, Samuel Totten

Genocide Studies and Prevention: An International Journal

Upon its inception in 2006, Genocide Studies and Prevention: An International Jour- nal 1:1 published a special issue entitled ‘‘Genocide in Darfur.’’ At that time, the crisis in Darfur had already been the focus of international attention for some three years. That special issue provided an overview of the crisis, the crimes perpetrated against black African women and girls of Darfur by government of Sudan (GoS) troops and the Janjaweed, the legal implications of the US determination that the atrocities in Darfur constituted genocide, a comparative analysis of the atrocities perpetrated in Rwanda in 1994 and Darfur in the early …

The Functioning Of Global Fit Statistics In Latent Growth Curve Modeling, Kathryn K. Deroche

Dissertations

No abstract provided.

The Existence Of Implicit Racial Bias In Nursing Faculty, Kathleen A. Fitzsimmons

Dissertations

No abstract provided.

A Comparison Study Of Sponsorship Effectiveness Between On-Site And Web-Based Sponsorship Activities, Issadee Kutintara

Dissertations

Virtually no evidence exists that current sponsorship activities on sporting event Web sites enable corporations to achieve sponsorship objectives including, but not limited to, increasing sales, improving image, or increasing awareness. The purpose of this study was to determine if significant differences of sponsorship effectiveness measures (brand awareness, attitude toward sponsorship, and purchase intentions) existed among a sample of Generation Y participants exposed to various sponsorship activities (on-site, online, and both on-site and online). The study surveyed 228 participants (112 on-site fans, 56 online fans, and 60 both on-site and online fans) exposed to the ESPN Winter X Games 13. …

An Information Prescription For Prescription Drug Regulation, Anita Bernstein, Joseph Bernstein

Faculty Scholarship

No abstract provided.

Full Issue 4.3

Genocide Studies and Prevention: An International Journal

No abstract provided.

No Association Of Obesity And Type 2 Diabetes Mellitus Related Genetic Variants With Colon Cancer, Cheryl L. Thompson, Sarah J. Plummer, Thomas C. Tucker, Graham Casey, Li Li

Markey Cancer Center Faculty Publications

Background: Obesity and type 2 diabetes mellitus (T2D) are known risk factors for colon cancer. Recent reports from a number of genome wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with obesity and T2D. Here we tested the hypothesis that these SNPs may also be associated with risk of colon cancer.

Methods: We genotyped nine SNPs reported in GWAS of obesity and/or T2D, including SNPs in HHEX, KCNJ11, SLC30A8, FTO, CDKN2, CDKAL1, TCF2, and the rs9300039 SNP in an intergenic region, in 561 colon cancer cases and 721 population controls.

Results: None of these SNPs were …

Discovery And Validation Of New Regulatory Rna Elements In Chlamydia Trachomatis, Yasser Mohammed Elsayed Metwally Abdelrahman

Theses and Dissertations (ETD)

Chlamydia trachomatis is an obligate intracellular bacterium that exhibits a unique biphasic developmental cycle that can be disrupted by growth in the presence of IFN-g and b-lactams, giving rise to an abnormal growth state termed persistence. Relatively little is known about the regulatory mechanisms that control temporal gene expression during the developmental cycle or the control of persistence and reactivation. Here we have examined the expression of a newly defined family of non-coding RNAs (ncRNAs) that are differentially expressed during the developmental cycle and the induction of persistence and reactivation (Using IFNγ and Carbenicillin). Non-coding RNAs were initially identified using …

Chitosan/Ellagic Acid Composite Materials For Local Cancer Therapy, Sung Woo Kim

Theses and Dissertations (ETD)

Current advances in the drug delivery have improved the therapeutic efficacy of the drug and minimized risks of side effects associated with toxicity of the drug. Implantable polymeric delivery system has gained increasing attentions for controlled drug release and localized treatments. In comparison to conventional chemotherapy, polymeric delivery systems are implantable at a local targeted site and biodegradable after a sufficient therapeutic span. The objectives of this project were to fabricate and characterize an implantable polymeric vehicle for a local chemotherapy and investigate its biological properties against cancer cells including human WM115 melanoma, human U87 glioblastoma, and rat C6 glioma …

Identification Of The Downstream Effector Genes Involved In Hoxb4-Induced Expansion Of Hematopoietic Progenitor Cells, Jie Jiang

Theses and Dissertations (ETD)

Overexpression of HOXB4, a member of Homeobox transcription factor family, promotes expansion of hematopoietic stem and progenitor cells bothin vivo and in vitro. However, the molecular mechanisms underlying this effect are not well understood. In order to identify direct target genes of HOXB4 in primary murine hematopoietice progenitor cells, we induced HOXB4 function in lineage-negative, murine bone marrow cells, using a tamoxifen-inducibleHOXB4-ER^T2fusion protein. Seventy seven genes with differentially changed expression in early response to HOXB4 have been identified as candidate target genes. Among them, we show that Hemogen (Hemgn), encoding a nuclear protein specifically …

Contribution Of The Membrane-Proximal Region Of The Vesicular Stomatitis Virus Glycoprotein To Host Cell Entry And Membrane Fusion, Elizabeth Lane Matheny

Theses and Dissertations (ETD)

Vesicular stomatitis virus (VSV) is an enveloped, nonsegmented, negative-sense, RNA virus belonging to the Rhabdoviridae family. VSV is considered the prototypic Rhabdovirus due to its simple genetic organization, broad host cell tropism, and ability to be easily grown in cell culture. Therefore, VSV has been used as the prototype to study viral entry, transcription, replication, and assembly. Viral entry, a critical step in the lifecycle of the virus, is mediated by the outer surface protein, G and will be the focus of this dissertation.

We hypothesize that the highly conserved residues in the membrane-proximal region of VSV G protein are …

Physical And Functional Coupling Of Cftr And Pde3a, Himabindu Penmatsa

Theses and Dissertations (ETD)

Formation of multiple-protein macromolecular complexes at specialized subcellular microdomains increases the specificity and efficiency of signaling in cells. In this study, we demonstrated that phosphodiesterase type 3A (PDE3A) is physically and functionally coupled to cystic fibrosis transmembrane conductance regulator (CFTR). PDE3A inhibition increases cyclic adenosine 3′, 5′-monophosphate (cAMP) levels in a compartmentalized manner at the plasma membrane, which potentiates CFTR channel function and further clusters PDE3A and CFTR into microdomains. Actin skeleton disruption reduces PDE3A-CFTR interaction; segregates PDE3A from its interacting partners thus compromise the integrity of the macromolecular complex. Consequently, PDE3A inhibition no longer activates CFTR channel function in …

The Use Of Classroom Walk-Through Observations As A Strategy For Improving Teaching And Learning: Teacher Perspective, Leslie Mcentire, Mark Weller, Thomas R. Sorensen

Dissertations

The purpose of this study was to investigate the use of classroom walk-through observations and their effect on Communication Arts and Mathematics Missouri Assessment Program (MAP) scores, summer school placement, discipline referrals, and retention. This study was conducted in three Midwestern Middle Schools. This study focused on classroom walk-through observations. If the principal increased the number of classroom walk-through observations, would it have an impact on Communication Arts and Mathematics MAP scores, summer school placement, discipline referrals and retention? This study will attempt to determine if classroom walk-through observations had an impact on Communication Arts MAP scores, Mathematics MAP scores, …

Zhong Guo Gao Zhong Sheng Yin Jiu Zhuang Kuang Yan Jiu De Hui Gu [Review Of Studies Of Chinese High School Students’ Drinking Behavior], Ian Newman, Ling Qian, Jianguo Zhang, Jie Zhao, Ying Zhang

Department of Educational Psychology: Faculty Publications

No abstract provided.

Molecular Strain Typing Of Mycobacterium Tuberculosis Isolates To Detect Cross-Contamination Events. Proposed Modifications To Prevent Its Recurrence., Sahal A. Al-Hajoj

Saudi Medical Journal

OBJECTIVES: To investigate possible cross-contamination events of Mycobacterium tuberculosis cultures, and also to shed light on cross-contamination problems in our laboratories. METHODS: At the TB Research Unit in the Department of Comparative Medicine Research Centre of King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia, we received 22 TB isolates sub-cultured on Lowenstein-Jensen media from a local laboratory in Riyadh on 1st July 2005. We finger printed all 22 isolates in question using a polymerase chain reaction-based spoligotype molecular technique. The epidemiological and clinical data were reviewed. RESULTS: All 22 cases had been proven to be cross-contaminated …

Effectiveness Of Ankaferd Blood Stopper In The Topical Control Of Active Bleeding Due To Cutaneous-Subcutaneous Incisions., Behcet Al, Cuma Yildirim, Murat Cavdar, Suat Zengin, Hasan Buyukaslan, Mehmet E. Kalender

Saudi Medical Journal

OBJECTIVES: To assess the effectiveness of Ankaferd blood stopper (ABS) in the topical control of bleeding due to cutaneous/subcutaneous incisions. METHODS: We included in this study, 69 patients with cancer that were admitted for port insertion to the Emergency Department of Gaziantep University Hospital, Gaziantep, Turkey, between May and July 2008. We used the wet compress form of ABS in 37 patients (group I), and regular dry sterile sponges in 32 patients (group II), to stop the bleeding that occurs during the clinically indicated vascular port insertion in patients with cancer. The success rate in terms of bleeding control, time …

The Use Of Sweat Chloride Test For Screening Cystic Fibrosis Among Malnourished Children Suffering From Frequent Respiratory Infections., Nazih K. Abu-Alshiekh, Sameer M. Kofahi, Zuhair M. Nusair

Saudi Medical Journal

OBJECTIVES: To establish a reliable cost-effective screening criterion for cystic fibrosis (CF) among underweight children suffering from frequent chest infections using the sweat chloride test (SCT). METHODS: In a cross-sectional study, 145 children with frequent chest infections were seen in the Pediatric Department at Prince Rashed Bin Al-Hassan Hospital, Irbid, Jordan, between January and December 2008. Their age ranged from 2-12 years (87 males and 58 females). We obtained 11 children with positive polymerase chain reaction (PCR) for CF from hospital laboratory records, and 134 had no confirmed CF. Nutritional anthropometric assessment of weight-for-age and height-for-age based on the Centers …

A Balanced Anesthesia With Dexmedetomidine Decreases Postoperative Nausea And Vomiting After Laparoscopic Surgery., Islam M. Massad, Wafa A. Mohsen, Asma S. Basha, Khaled R. Al-Zaben, Mahmoud M. Al-Mustafa, Subhi M. Alghanem

Saudi Medical Journal

OBJECTIVES: To evaluate the effect of adding dexmedetomidine to a balanced anesthetic technique on postoperative nausea and vomiting after laparoscopic gynecological surgeries. METHODS: A prospective double-blind randomized study was designed at Jordan University Hospital, Amman, Jordan between December 2008 and February 2009. Eighty-one female patients in their child-bearing age (17-48 years); American Society of Anesthesiologists (ASA) clinical status I, who were scheduled for elective diagnostic laparoscopic surgeries under general anesthesia were divided into 2 groups. Group D (n=42) received dexmedetomidine infusion, while group P (n=39) received 0.9% sodium chloride infusion along with the balanced anesthesia. The incidence of early (up …

Is There A Relationship Between Body Mass Index And Serum Vitamin D Levels?, Abdulmohsen H. Al-Elq, Mir Sadat-Ali, Haifa A. Al-Turki, Fathma A. Al-Mulhim, Amein K. Al-Ali

Saudi Medical Journal

OBJECTIVES: To evaluate the relationship between vitamin D level and body mass index (BMI) among Saudi Arabian citizens. METHODS: Four hundred healthy individuals aged > or =25 years (200 males and 200 females) were included in this cross-sectional study. Subjects were recruited in the period between 1st February 2008 and 31st May 2008 from the medical staff and employees of King Fahd Hospital of the University, Al-Khobar, Kingdom of Saudi Arabia, and from patients attending the endocrinology, orthopedic, and infertility clinics at the same hospital. Clinical evaluation was carried out, and BMI was calculated. Serum 25 hydroxy vitamin D (25OHD), in …

The Frequency Of 21-Alpha Hydroxylase Enzyme Deficiency And Related Sex Hormones In Iraqi Healthy Male Subjects Versus Patients With Acne Vulgaris., Khalifa E. Sharquie, Adil A. Noaimi, Basil O. Saleh, Zainab N. Anbar

Saudi Medical Journal

OBJECTIVES: To find out the frequency of nonclassical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency among Iraqi healthy male individuals versus male patients with acne vulgaris. METHODS: This case-control study and single-center examination of hormone levels in a cohort of volunteers was conducted in the Department of Dermatology, Baghdad Teaching Hospital, and in the Physiological Chemistry Department of the College of Medicine, Baghdad University, Baghdad, Iraq, from September 2007 to February 2008. RESULTS: The frequency of 21-hydroxylase enzyme deficiency in healthy male subjects was 1:43 (2.3%), while in male patients with acne vulgaris, this was 6:43 (13.95%). Serum 17-hydroxyprogesterone …

Current Practice In The Management Of Patients With Type 2 Diabetes Mellitus In Saudi Arabia., Abdulmohsen H. Al-Elq

Saudi Medical Journal

OBJECTIVES: To gather data on current practices in the management of patients with type 2 diabetes mellitus (T2DM) in Saudi Arabia and to evaluate the degree of compliance with international guidelines. METHODS: This paper represents the results of the Saudi Arabia T2DM data collected at the cross-sectional part of Wave 2006 of the International Diabetes Management Practices Study (IDMPS). Data were collected on a case report form from 28 health centers all over the Kingdom of Saudi Arabia, in the period between 01/12/2006 and 30/12/2006. It included demographic and socioeconomic profile in addition to diabetes management and metabolic control. RESULTS: …

Road Map Of An Ear, Nose, And Throat Clinic During The 2008 Hajj In Makkah, Saudi Arabia., Ameen Z. Alherabi

Saudi Medical Journal

OBJECTIVES: To present our experience in the development of our own local electronic Makkah Ear, Nose, and Throat (ENT) - Hajj Database, and provide a road map for the ENT Clinic during Hajj. METHODS: This prospective cohort study was conducted between November 28 and December 10, 2008 (1429 Hijri Hajj season). All patients presenting to the ENT Clinic at Al-Noor Specialist Hospital, Makkah, Kingdom of Saudi Arabia were recorded. RESULTS: A total of 1047 patients were included. The mean age was 26 ± 6.4 years. There were 663 males (63.3%), and 384 females (36.7%). Among them, 361 patients (34.5%) were …