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2009

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Cis-Regulatory Sequence And Co-Regulatory Transcription Factor Functions In Erα-Mediated Transcriptional Repression, Richard Leroy Smith Jul 2009

Cis-Regulatory Sequence And Co-Regulatory Transcription Factor Functions In Erα-Mediated Transcriptional Repression, Richard Leroy Smith

Theses and Dissertations

Estrogens exert numerous actions throughout the human body, targeting healthy tissue while also enhancing the proliferative capacity of breast cancers. Estrogen signaling is mediated by the estrogen receptor (ER), which binds DNA and ultimately affects the expression of adjacent genes. Current understanding of ER-mediated transcriptional regulation is mostly limited to genes whose transcript levels increase following estrogen exposure, though recent studies demonstrate that direct down-regulation of estrogen-responsive genes is also a significant feature of ER action. We hypothesized that differences in cis-regulatory DNA was a factor in determining target gene expression and performed computational and experimental studies to test this …

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The Alestle - Vol. 61 No. 73 - 07/29/2009, Southern Illinois University Edwardsville Jul 2009

The Alestle - Vol. 61 No. 73 - 07/29/2009, Southern Illinois University Edwardsville

The Alestle

Vol. 61 No. 73

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Mexico Cements Relations With Chile; Dispute Emerges On Rice Imports From Uruguay, Ladb Staff Jul 2009

Mexico Cements Relations With Chile; Dispute Emerges On Rice Imports From Uruguay, Ladb Staff

SourceMex

No abstract provided.

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Role Of Endothelin-1 In The Regulation Of The Swelling-Activated Cl- Current In Atrial Myocytes, Wu Deng Jul 2009

Role Of Endothelin-1 In The Regulation Of The Swelling-Activated Cl- Current In Atrial Myocytes, Wu Deng

Theses and Dissertations

Swelling-activated Cl- current (ICl,swell) is an outwardly rectifying Cl- current that influences cardiac electric activities and acts as a potential effector of mechanoelectrical feedback that antagonizes the effects of stretch-activated cation channels. Persistent activation of ICl,swell has been observed in multiple models of cardiovascular diseases. Previously we showed that angiotensin II (AngII) signaling and reactive oxygen species (ROS) produced by NADPH oxidase (NOX) are involved in the activation of ICl, swell by both beta1-integrin stretch and osmotic swelling. Because endothelin-1 (ET-1) is a potential downstream mediator of AngII and ETA receptor blockade abrogates AngII-induced ROS generation, we studied how ET-1 …

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A Cellular Mechanism For Dendritic Spine Loss Following Traumautic Brain Injury In Rat, Brian Low Jul 2009

A Cellular Mechanism For Dendritic Spine Loss Following Traumautic Brain Injury In Rat, Brian Low

Theses and Dissertations

Traumatic brain injury is a leading cause of death and disability in the United States. The injury is often composed of two processes: the primary injury, which can involve irreversible loss of tissue, and the secondary injury, which involves a cascade of reactive processes such as excitotoxicity that occur in the hours and days after the initial insult. Excitotoxic stimulation of neuronal circuits can lead to cellular dysfunction and modulation of neuronal sensitivity. One mechanism of dysfunction involves the calcium-regulated phosphatase, calcineurin. Calcineurin has been shown to be involved in the modulation of the neuronal post-synaptic structures known as dendritic …

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Genetic Differentiation Of The Parasitoid, Cotesia Congregata (Say), Based On Host-Plant Complex, Georgia Karns Jul 2009

Genetic Differentiation Of The Parasitoid, Cotesia Congregata (Say), Based On Host-Plant Complex, Georgia Karns

Theses and Dissertations

Endoparasitoids of herbivorous lepidopterans have intimate relationships with their host species as well as the plant on which their host develops. Characteristics of both hosts and plants can affect parasitoid success in tri-trophic systems and thus, drive diversification. Genetic differentiation was estimated for Cotesia congregata (Say) collected from two distinct host-plant complexes, Manduca sexta L. on tobacco (Nicotiana tabacum L.) and Ceratomia catalpae, (Haworth) on catalpa (Catalpa bignonioides Walker), in the mid-Atlantic region of North America using seven microsatellite loci and the mitochondrial COI locus. Microsatellite allele frequencies were differentiated based on host-plant complex, and COI haplotypes from individuals on …

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Innexons, Membrane Channels For Atp, Control Microglia Migration To Nerve Lesions, Stuart E. Samuels Jul 2009

Innexons, Membrane Channels For Atp, Control Microglia Migration To Nerve Lesions, Stuart E. Samuels

Open Access Dissertations

ATP released upon nerve injury is an important chemotactic activator of microglia; however, the source of the extracellular ATP is uncertain. In large glial cells such as astrocytes, chemical or mechanical stimulation or injury causes an intracellular calcium wave that moves from cell to cell propagated by extracellular ATP through a regenerative ATP-induced ATP-release mechanism. In mammals a prime candidate for the ATP release channel is the pannexon, a hexamer of the invertebrate gap junction homologue pannexin1, although the pharmacologically similar protein connexin is also a candidate. I hypothesized that upon nerve injury, ATP released through pannexon channels activates microglia …

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Wyatt, Albert F., 1861-1943 (Sc 1959), Manuscripts & Folklife Archives Jul 2009

Wyatt, Albert F., 1861-1943 (Sc 1959), Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid only for Manuscripts Small Collection 1959. Letter, 14 April 1908, from A. F. Wyatt, Mt. Sterling, Kentucky to H. R. Cowles, Statesville, North Carolina regarding the availability of horses for sale.

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Crafting Authenticity, Allison N. Schumacher Jul 2009

Crafting Authenticity, Allison N. Schumacher

Theses and Dissertations

Authenticity is what we want from the world around us, from others, and crucially from ourselves and what we make. As it relates to graphic design, I define authenticity as a perceived match between form and purpose. For the designer, its quality is found in the process of simultaneously developing a concept and crafting the design/object.

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Salmonella In Broiler Litter And Properties Of Soil At Farm Location., Victoriya V. Volkova, R. Hartford Bailey, Robert W. Wills Jul 2009

Salmonella In Broiler Litter And Properties Of Soil At Farm Location., Victoriya V. Volkova, R. Hartford Bailey, Robert W. Wills

CVM Publications

Contamination of litter in a broiler grow-out house with Salmonella prior to placement of a new flock has been shown to be a precursor of the flock's Salmonella contamination further down the production continuum. In the southern USA, broiler grow-out houses are primarily built on dirt pad foundations that are placed directly on top of the native soil surface. Broiler litter is placed directly on the dirt pad. Multiple grow-out flocks are reared on a single litter batch, and the litter is kept in the houses during downtime between flocks. The effects of environmental determinants on conditions in broiler litter, …

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Active Student Engagement By Using Cooperative Learning Strategies, Austin Martinez Jul 2009

Active Student Engagement By Using Cooperative Learning Strategies, Austin Martinez

Theses and Dissertations

The purpose of this study was to explore possible solutions to student interaction and product quality in a ninth grade English class by using strategies in cooperative learning. Reciprocal learning, jigsaw, and skills practice were used to promote student interaction and cooperation during a lesson on William Shakespeare's "Romeo and Juliet." The data reveals that the three student participants have the skills necessary to succeed and excel in cooperative learning strategies, and previous student achievements may not necessarily indicate an ability or inability to master a cooperative learning activity. Implications for using cooperative learning strategies in the classroom are discussed.

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Species Composition, Seasonal Activity, And Aggregations Of Dung Beetles On Cattle Pastures In Arkansas, Justin George Fiene Jul 2009

Species Composition, Seasonal Activity, And Aggregations Of Dung Beetles On Cattle Pastures In Arkansas, Justin George Fiene

Student Theses and Dissertations

The species composition, seasonal activities, and aggregations of dung beetles (Scarabaeidae and Geotrupidae) were monitored from April 2007 to September 2008 using ten dung-baited pitfall traps operated weekly at a site in northeastern Arkansas. Collections comprised 236,880 beetles, representing 22 species including Colobopterus erraticus L. and Onthophagus taurus Schreber, which are new state records. Labarrus pseudolividus Balthasar comprised 97.7 % of the total trap catch, with the majority being collected in June, July and August 2007 which involved two separate mass occurrences during that time. Colonizing dung beetles expressed strong intraspecific aggregation, while interspecific aggregation, though present, were typically of …

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Platinum Complexes And Methods Of Use, Heidi Kay, Jay W. Palmer, Joseph A. Stanko Jul 2009

Platinum Complexes And Methods Of Use, Heidi Kay, Jay W. Palmer, Joseph A. Stanko

USF Patents

The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to treat or prevent infection by a virus or a bacterial or parasitic organism in vivo or in vitro.

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A Sequential Algorithm To Identify The Mixing Endpoints In Liquids In Pharmaceutical Applications, Akriti Saxena Jul 2009

A Sequential Algorithm To Identify The Mixing Endpoints In Liquids In Pharmaceutical Applications, Akriti Saxena

Theses and Dissertations

The objective of this thesis is to develop a sequential algorithm to determine accurately and quickly, at which point in time a product is well mixed or reaches a steady state plateau, in terms of the Refractive Index (RI). An algorithm using sequential non-linear model fitting and prediction is proposed. A simulation study representing typical scenarios in a liquid manufacturing process in pharmaceutical industries was performed to evaluate the proposed algorithm. The data simulated included autocorrelated normal errors and used the Gompertz model. A set of 27 different combinations of the parameters of the Gompertz function were considered. The results …

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The Potential Role For Capb In Pathogenesis Of Francisella Tularensis, Eric Fleming Jul 2009

The Potential Role For Capb In Pathogenesis Of Francisella Tularensis, Eric Fleming

Theses and Dissertations

Francisella tularensis was a facultative intracellular pathogen and a gram-negative coccobacillus which has been categorized by the CDC as a potential class A select agent due to its highly infectious properties and high mortality rates. Francisella tularensis was also responsible for the zoonotic disease tularemia, which was usually transmitted by arthropod vectors or via contact with infected animals. Francisella tularensis subspecies novicida has been used by many researchers in genetic pathogenesis experiments to try to elucidate genes responsible for virulence factors. One of these virulence factors was a capsular material which has been thought to be involved in either increasing …

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Consequences Of Weight Cycling: An Increase In Disease Risk?, Kelley Strohacker†, Katie C. Carpenter†, Brian K. Mcfarlin‡ Jul 2009

Consequences Of Weight Cycling: An Increase In Disease Risk?, Kelley Strohacker†, Katie C. Carpenter†, Brian K. Mcfarlin‡

International Journal of Exercise Science

Research indicates that weight cycling, or “yo-yo dieting” is a common occurrence in obese populations. The long term negative health consequences of weight cycling are debated and it is unclear whether or not this weight change pattern poses a greater disease risk compared to obesity maintenance. This review discusses the prevalence of weight cycling and physiological alterations occurring during weight loss that promotes weight regain. We also discuss the effect weight regain has upon adipose tissue in terms of rate and type of accumulation. Also within this review are discussions surrounding the previously published literature based upon human and rodent …

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Physical Activity Is Associated With Percent Body Fat And Body Composition But Not Bmi In White And Black College Students, Michael Zanovec†, Anantha P. Lakkakula†, Lisa G. Johnson‡, Georgianna Tuuri‡ Jul 2009

Physical Activity Is Associated With Percent Body Fat And Body Composition But Not Bmi In White And Black College Students, Michael Zanovec†, Anantha P. Lakkakula†, Lisa G. Johnson‡, Georgianna Tuuri‡

International Journal of Exercise Science

The objective of this study was to examine the association of self-reported physical activity (PA) with body composition in 290 college students (49% male, 60% White) 18-25 years of age. Outcome measures included: self-reported PA levels calculated in MET-hrs·wk-1 from the International Physical Activity Questionnaire (IPAQ); body mass index (BMI; in kg·m-2); and body composition variables estimated by dual-energy X-ray absorptiometry (DXA). Mean activity levels of the sample were 39.8 ± 23.8 MET-hrs·wk-1. Participants were divided into quartiles of PA levels: ≥0 to <24.0, ≥24.0 to <34.0, ≥34.0 to <51.25, and ≥51.25 MET-hrs·wk-1 and body composition variables were compared by group. Chi-square analyses revealed a significant difference for gender by PA quartile [χ2 (3, N=290) = 32.42, p < 0.0001], and for gender by race by PA quartile [χ2 (9, N=290) = 37.82, p < 0.0001]. MET-hrs·wk-1 was inversely correlated with %BF (r = -0.40, p < 0.0001) but not BMI (r = 0.05, p = 0.43). When comparing body composition variables across PA quartiles, no significant differences were observed for BMI; however, subjects in the highest quartile of PA had a lower percent body fat (%BF) and fat mass (FM), and a higher lean-tissue mass (LTM) compared to subjects in the other three groups. In this cohort of young adults, participants in the highest activity group had a more fit body composition profile (e.g., lower %BF, lower FM, and higher LTM) which was not reflected in BMI and was independent of gender and race.

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Academic And Research Programs In Exercise Science, South Korea, Kyung-Shin Park, Wook Song Jul 2009

Academic And Research Programs In Exercise Science, South Korea, Kyung-Shin Park, Wook Song

International Journal of Exercise Science

We appreciate the opportunity to review academic curriculum and current research focus of Exercise Science programs in South Korea. The information of this paper was collected by several different methods, including e-mail and phone interviews, and a discussion with Korean professors who attended the 2009 ACSM annual conference. It was agreed that exercise science programming in South Korea has improved over the last 60 years since being implemented. One of distinguishable achievement is that exercise science programs after the 1980’s has been expanded to several different directions. It does not only produce physical education teachers but also attributes more to …

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Brought To You By The People’S Republic Of The Onion, Haiyan Lee Jul 2009

Brought To You By The People’S Republic Of The Onion, Haiyan Lee

China Beat Blog: Archive 2008-2012

America’s finest news source The Onion has a new owner! Since last week, readers have been bombarded with the good tiding, from the modified masthead, logo, and tagline, to news headlines, editorials, audio and video clips, and ads, lots of ads. The new owner goes by the appetizing name of Yu Wan Mei 鱼完美 Amalgamated Salvage Fisheries and Polymer Injection Group, supposedly a Chinese conglomerate from the inland province of Sichuan. The corporation specializes in fish by-products salvaged from the “ocean’s bounty.” Some of its finer samples are “Broiled Shark Gums,” “Multi-Flavor Variety Pack Of Pickled Fish Cloaca,” “Lightning Power …

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July 27, 2009: Food Inc., Bruce Ledewitz Jul 2009

July 27, 2009: Food Inc., Bruce Ledewitz

Hallowed Secularism

Blog post, “Food Inc.“ discusses politics, theology and the law in relation to religion and public life in the democratic United States of America.

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The Influence Of Antiretroviral Therapy On Qtc Interval Amongst Hiv Patients At Aga Khan University Hospital, Nairobi, Jay Shavadia Jul 2009

The Influence Of Antiretroviral Therapy On Qtc Interval Amongst Hiv Patients At Aga Khan University Hospital, Nairobi, Jay Shavadia

Master of Medicine in Clinical Pathology

Aim: To determine the influence of antiretroviral (ARV) therapy on the QTC interval amongst HIV-infected patients. Design: Prospective Comparative survey of two population samples Patients and Setting: One hundred and thirty ARV naïve and one hundred and thirty treated HIV-positive patients selected from in and out patient departments of Aga Khan University Hospital underwent clinical evaluation and 12 lead resting ECG between August 2008 and March 2009. Methodology: Eligible HIV-positive patients were conveniently sampled and had a 12-lead electrocardiogram (ECG) performed to determine the QTinterval, corrected for the heart rate by the Bazzet formula. Analysis was then performed to determine …

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Rock Wales And Max Wales Oral History Interview, Rock Wales, Max Wales Jul 2009

Rock Wales And Max Wales Oral History Interview, Rock Wales, Max Wales

LGBTQ+ Oral History Project

An oral history transcript with Rock Wales and Max Wales (both pseudonyms), a gay couple who live in a LGBTQ+ retirement community. Most of the interview focuses on people in their community.

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July 27, 2009 Reporter, University Of Alabama At Birmingham Jul 2009

July 27, 2009 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

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Specific Levels Of Therapeutic Ultrasound Stimulate The Release Of Inflammatory And Angiogenic Mediators From Macrophages In Culture, Thomas Turner Jul 2009

Specific Levels Of Therapeutic Ultrasound Stimulate The Release Of Inflammatory And Angiogenic Mediators From Macrophages In Culture, Thomas Turner

Theses and Dissertations

Therapeutic ultrasound (TUS) is a treatment modality that is used to accelerate tissue healing. TUS is thought to affect cellular processes of tissue healing, especially those that occur in the inflammatory and early proliferative phases. TUS can be applied using various parameter selections including intensity, wavelength, duty cycle and treatment duration and no clear consensus exists on optimal parameters for healing enhancement. Macrophages are important mediators of inflammation and their actions are critical to normal progression into the proliferative phase of healing. They complete many functions during these periods of tissue healing, among those being release of cytokines and growth …

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The Regulation Of Platelet Activating Factor Acetylhydrolase By Oxidized Phospholipids, Rachael Griffiths Jul 2009

The Regulation Of Platelet Activating Factor Acetylhydrolase By Oxidized Phospholipids, Rachael Griffiths

Theses and Dissertations

Platelet-activating factor acetylhydrolase (PAFAH) is elevated in atherosclerosis and may play a role in pathogenesis of this disease. Molecular mechanisms regulating the expression of this lipoprotein-associated PLA2 are indistinct. Mildy oxidized low density lipoprotein (oxLDL) and monocytes (the primary source of PAFAH) are co-localized in early atheromas. Monocytes are activated by oxidized phospholipids (oxPL) in the oxLDL particle. We hypothesized that oxPL-activated monocytes are the source of increased levels of PAFAH in atherosclerosis. We found that PAFAH expression is significantly induced by OxPAPC and in particular long-chain fractions of oxPAPC in monocytes and cytokine-differentiated DC, but not cytokine-differentiated MO. Furthermore, …

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College Students' Use Of Science Content During Socioscientific Issues Negotiation: Impact Of Evolution Understanding And Acceptance, Samantha R. Fowler Jul 2009

College Students' Use Of Science Content During Socioscientific Issues Negotiation: Impact Of Evolution Understanding And Acceptance, Samantha R. Fowler

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to explore the evolution science content used during college students' negotiation of biology-based socioscientific issues (SSI) and examine how it related to students' conceptual understanding and acceptance of biological evolution. Specific research questions were, (1a) what specific evolutionary science content do college students evoke during SSI negotiation, (1b) what is the depth of the evolutionary science content reflected in college students' SSI negotiation, and (2) what is the nature of the interaction between evolution understanding and evolution acceptance as they relate to depth of use of evolution content during SSI negotiation? The Socioscientific Issues …

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Ma 2010 Gubernatorial Election Poll 7/26/2009, Unh Survey Center Jul 2009

Ma 2010 Gubernatorial Election Poll 7/26/2009, Unh Survey Center

All UNH Survey Center Polls

TITLE: Support for Obama Remains High in NH 7/9/2009

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Preservation Tools For Blogs, Victoria Ann Reich Jul 2009

Preservation Tools For Blogs, Victoria Ann Reich

Future of Today's Legal Scholarship Symposium

No abstract provided.

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Using Works Of Visual Art To Teach Matrix Transformations, James Luke Akridge, Rachel Bowman, Peter Hamburger, Bruce Kessler Jul 2009

Using Works Of Visual Art To Teach Matrix Transformations, James Luke Akridge, Rachel Bowman, Peter Hamburger, Bruce Kessler

Mathematics Faculty Publications

The authors present a modern technique for teaching matrix transformations on $\R^2$ that incorporates works of visual art and computer programming. Two of the authors were undergraduate students in Dr. Hamburger's linear algebra class, where this technique was implemented as a special project for the students. The two students generated the images seen in this paper, and the movies that can be found on the accompanying webpage www.wku.edu/\~{\space}bruce.kessler/.

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July 25, 2009 (Pages 4323-4408), Pennsylvania Legislative Reference Bureau Jul 2009

July 25, 2009 (Pages 4323-4408), Pennsylvania Legislative Reference Bureau

Volume 39 (2009)

No abstract provided.

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