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2009

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In Vitro And In Vivo Evaluation Of Transdermal Absorption Of Naproxen Sodium, Dalia Attia Jan 2009

In Vitro And In Vivo Evaluation Of Transdermal Absorption Of Naproxen Sodium, Dalia Attia

Pharmacy

Naproxen sodium is a non steroidal antiinflammatory drug, used in the treatment of inflammatory and degenerative disorders of the musculoskeletal system. It is widely prescribed for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, gout, extra-articular disorders, bursitis, tendonitis, and non articular rheumatic condition. Naproxen sodium has some side effects when taken orally, epigastric pain, heartburn, nausea, diarrhoea, vomiting, peptic ulcer, and hepatic impairment. The aim of this study was to formulate topical gel containing 1% of naproxen sodium using various ratios of different type of gel forming agents as pectin, hydroxypropylmethyl cellulose low and high viscosity (HPlv&hv), carboxymethyl cellulose …

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The Ghost In Our Genes: Legal And Ethical Implications Of Epigenetics, Mark A. Rothstein, Yu Cai, Gary E. Marchant Jan 2009

The Ghost In Our Genes: Legal And Ethical Implications Of Epigenetics, Mark A. Rothstein, Yu Cai, Gary E. Marchant

Health Matrix: The Journal of Law-Medicine

No abstract provided.

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Expanding Access To Investigational Drugs For Treatment Use: A Policy Analysis And Legislative Proposal, Austin Winniford Jan 2009

Expanding Access To Investigational Drugs For Treatment Use: A Policy Analysis And Legislative Proposal, Austin Winniford

Health Matrix: The Journal of Law-Medicine

No abstract provided.

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University Of Baltimore Law Review Volume 38 Number 2 (Winter 2009) Front Matter Jan 2009

University Of Baltimore Law Review Volume 38 Number 2 (Winter 2009) Front Matter

University of Baltimore Law Review

No abstract provided.

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Comments: Treasuring The Chesapeake: An Analysis Of Climate Change And Its Impact On The Chesapeake Bay And Maryland's Surrounding Coastal Regions, Lauren F. Jones Jan 2009

Comments: Treasuring The Chesapeake: An Analysis Of Climate Change And Its Impact On The Chesapeake Bay And Maryland's Surrounding Coastal Regions, Lauren F. Jones

University of Baltimore Law Review

No abstract provided.

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Evolution Of Tolerance To Pcbs And Susceptibility To A Bacterial Pathogen (Vibrio Harveyi) In Atlantic Killifish (Fundulus Heteroclitus) From New Bedford (Ma, Usa) Harbor, Diane Nacci, Marina Huber, Denise Champlin, Saro Jayaraman, Sarah Cohen, Eric Gauger, Allison Fong, Marta Gomez-Chiarri Jan 2009

Evolution Of Tolerance To Pcbs And Susceptibility To A Bacterial Pathogen (Vibrio Harveyi) In Atlantic Killifish (Fundulus Heteroclitus) From New Bedford (Ma, Usa) Harbor, Diane Nacci, Marina Huber, Denise Champlin, Saro Jayaraman, Sarah Cohen, Eric Gauger, Allison Fong, Marta Gomez-Chiarri

Fisheries, Animal and Veterinary Sciences Faculty Publications

A population of the non-migratory estuarine fish Fundulus heteroclitus (Atlantic killifish) resident to New Bedford (NB), Massachusetts, USA, an urban harbor highly contaminated with polychlorinated biphenyls (PCBs), demonstrates recently evolved tolerance to some aspects of PCB toxicity. PCB toxicology, ecological theory, and some precedence supported expectations of increased susceptibility to pathogens in NB killifish. However, laboratory bacterial challenges of the marine pathogen Vibrio harveyi to wild fish throughout the reproductive season and to their mature laboratory-raised progeny demonstrated comparable survival by NB and reference killifish, and improved survival by NB males. These results are inconsistent with hypothesized trade-offs of adaptation, …

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From Swarms To Summer Camps : A Theoretical Deconstruction Of Cohesion Among Groups Of Latency Aged Boys, Prairie Youn-Yuen Chiu Jan 2009

From Swarms To Summer Camps : A Theoretical Deconstruction Of Cohesion Among Groups Of Latency Aged Boys, Prairie Youn-Yuen Chiu

Theses, Dissertations, and Projects

This thesis is an interdisciplinary theoretical deconstruction of cohesion among groups of latency aged boys. Process research on the development of cohesion among informally organized groups of latency aged boys is lacking. Also, much of cohesion research is adult-oriented, rather than child-oriented. This project seeks to elucidate some of the hows of cohesion among this population by applying a biological theory examining cohesion among aggregates of animals to a social psychological theory considering cohesion among latency aged boys. It is the author's hope that such an approach will yield valuable insights into the mechanisms of cohesion and its facilitation, while …

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Recycling The Past: Resettling Displaced Persons Communities In Northern Iraq With The Aid Of Heirless Property, Samantha Klein Jan 2009

Recycling The Past: Resettling Displaced Persons Communities In Northern Iraq With The Aid Of Heirless Property, Samantha Klein

Cardozo Journal of International and Comparative Law

No abstract provided.

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Examination Of The Capacity Of The Cathelicidins To Control Bacillus Anthracis Pathogenesis, Mark W. Lisanby Jan 2009

Examination Of The Capacity Of The Cathelicidins To Control Bacillus Anthracis Pathogenesis, Mark W. Lisanby

All ETDs from UAB

cillus anthracis is a gram-positive, spore forming bacterium that causes infection through three routes: cutaneous, gastrointestinal and pulmonary. Historically, anthrax pathogenesis was thought to be initiated via the uptake of spores by resident macrophages, which then transited to the regional lymph nodes. While en-route, the spores germinated and developed into bacilli within the phagolysosome, escaped into the cytoplasm, killed the cell and eventually the host. Following the recent use of B. anthracis as a biological weapon, researchers began to reevaluate anthrax pathogenesis in order to develop novel treatments. One aspect of anthrax pathogenesis that saw renewed interest was the intracellular …

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Klf4 And Retinoid Receptor Signaling In Cancer, Wen Jiang Jan 2009

Klf4 And Retinoid Receptor Signaling In Cancer, Wen Jiang

All ETDs from UAB

The fight against cancer has generated wide interest in understanding the genetic mechanisms behind the disease. One group of oncogenes – transcription factors – offers many opportunities for treatment or prevention. Among these transcription factors is KLF4, which functions in post-mitotic epithelial cells to promote differentiation. KLF4 has tumorigenic activity in both in vitro and in vivo models. In analyzing transcripts that were induced by KLF4, we noted the induction of multiple nuclear receptors, including retinoid receptors. Retinoids are well-established as chemopreventive agents, but the mechanisms by which they act to prevent cancer remain unclear. Previous studies have shown that …

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Pathological Modification Of Tau Induce Toxicity And Facilitate Cell Death, Tori A. Matthews Jan 2009

Pathological Modification Of Tau Induce Toxicity And Facilitate Cell Death, Tori A. Matthews

All ETDs from UAB

eimer’s disease (AD) is a progressive neurodegenerative disorder characterized by two major pathophysiological hallmarks, beta-amyloid (A��) plaques and tau tangles. In AD and other tau associated neurodegenerative disorders, termed tauopathies, a critical role in promoting neuronal degeneration has been demonstrated for hyperphosphorylated forms of tau. Recent findings suggest that cleavage of tau in the carboxyl-terminal region (Asp421) may also promote deleterious effects of tau on neuronal health. In the first half of my study, the relationship between Asp421 cleaved tau and a common AD associated stressor (endoplasmic reticulum [ER] stress) was investigated using an inducible cortical neuronal model. Cells expressing …

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Concepts Of Freedom: Ethical, Epistemological, Ontological, Marijo Cook Jan 2009

Concepts Of Freedom: Ethical, Epistemological, Ontological, Marijo Cook

LSU Master's Theses

Traditionally, the defense of freedom appeals to moral responsibility: if we are not free, then we have no moral responsibility, but we believe in responsibility, so we must acknowledge that we are free. In this thesis, I show some of the ways that this argument has been attacked, both by showing that we might not be morally responsible and by showing that we might be morally responsible without being free. Then I argue that the defense of freedom needs a broader scope in order to succeed. Arguments from Kant’s Critique of Pure Reason are used to show that we must …

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The Stereotypic Portrayal Of Women In Slasher Films: Then Versus Now, Chad Brewer Jan 2009

The Stereotypic Portrayal Of Women In Slasher Films: Then Versus Now, Chad Brewer

LSU Master's Theses

ABSTRACT In entertainment, the media often portray various social groups, including women, in certain negative ways and as having more negative qualities than other traditional social groups, such as white males. These portrayals provide viewers with ways of thinking about and acting towards members of a particular group, thus affecting communication and perception. This research seeks to analyze data on horror film stereotyping in a new way not by merely observing stereotypes of women in horror film, but by examining the content across time-periods and societal change. A textual analysis will compare 16 total films, 8 original films versus the …

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Typewriters Typing Typist: A Performance History, Sarah Kathryn Jackson Jan 2009

Typewriters Typing Typist: A Performance History, Sarah Kathryn Jackson

LSU Master's Theses

This study contributes to the ongoing exploration of the multiple ways visual and material artifacts perform. I take a look at how typewriters or rather how two representations of typewriters perform. I focus on two different images of working women, each rendered in terms of a popular female stereotype of the period. I selected the images because they bookend a period of time in which typewriters emerged to the fore as an efficient tool of reproduction in the business world. In turn, two different perspectives on the relationship between the typist and her typewriter, woman and machine, are provided. The …

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The Expedition, Shawn Quincy Foreman Jan 2009

The Expedition, Shawn Quincy Foreman

LSU Master's Theses

I want my audience to experience awe. I use this to express my view on the argument of reality. Can reality truly be known? I further explain the use of nontraditional and traditional painting techniques to produce my paintings and drawings. My thesis entitled “The Expedition” is an abbreviated journey through my life.

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Xavier Gonzalez, Erika Katayama Jan 2009

Xavier Gonzalez, Erika Katayama

LSU Master's Theses

This essay analyzes a sampling of Xavier Gonzalez’s paintings and murals, and examines the connections between Gonzalez and Pablo Picasso through journals and notes by Gonzalez himself. Gonzalez’s career as an artist spanned decades, during which he explored many different types of media. His watercolors draw upon a Cubist legacy and integrate geometric elements within his realist subject matter. Gonzalez’s murals for the New Orleans Lakefront Airport feature sweeping scenes of flight that capture the modern experience. The murals represent the apex of Gonzalez’s career as an artist working in public spaces, though they later faded into oblivion as the …

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Survivorship, Tunneling And Feeding Behaviors Of Formosan Subterranean Termite (Isoptera: Rhinotermitidae) In Response To Trans-Caryophyllene, Qiaoling Qi Jan 2009

Survivorship, Tunneling And Feeding Behaviors Of Formosan Subterranean Termite (Isoptera: Rhinotermitidae) In Response To Trans-Caryophyllene, Qiaoling Qi

LSU Master's Theses

The Formosan subterranean termite, Coptotermes formosanus Shiraki, an invasive species from southern China, is one of the most destructive wood pests in the United States. Presently, termites are managed through chemical control. However, some synthetic chemicals cause serious environmental problems due to their persistence and toxicity. There is growing interest in using natural compounds with low toxicity to mammals to control termites. Trans-caryophyllene is a component of essential oil found in many flowering plants. It is especially abundant in clove oil. It has also been found to be released from the roots of maize damaged by insects. I investigated caryophyllene …

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Determining Gene Copy Number In Transfected Caprine Fibroblast Cells, Jessica A. Wilson Jan 2009

Determining Gene Copy Number In Transfected Caprine Fibroblast Cells, Jessica A. Wilson

LSU Master's Theses

Transgene expression in stably transgenic organisms is affected by many factors, including the copy number of the transgene in the genome, and by interactions between the transgene and flanking DNA sequences. Transgene copy number has also been shown to effect genetic stability in transgenic plants. Two commonly used methods for transfecting cells are liposome mediated transfection and electroporation. Little is known about the mean transgene copy number or variability of the copy number with these techniques. Quantitative PCR (Q-PCR) has been shown to be an effective method for determining transgene copy number. The objective of this study was to determine …

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Neurotoxin In A Louisiana Estuary: Quantitative Analysis Of Domoic Acid In Gulf Menhaden (Brevoortia Patronus) And Qualitative Modeling Of Links In A Shark Nursery, Ross Del Rio Jan 2009

Neurotoxin In A Louisiana Estuary: Quantitative Analysis Of Domoic Acid In Gulf Menhaden (Brevoortia Patronus) And Qualitative Modeling Of Links In A Shark Nursery, Ross Del Rio

LSU Master's Theses

Harmful algal blooms are an increasing problem for coastal waters world-wide. The diatom genus, Pseudo-nitzschia, is of particular concern in Louisiana, due to the potential for several species to produce the neurotoxin domoic acid (DA). While trophic transfer of DA to consumers has repeatedly occurred along the California coast, little is known about trophic transfer of recently detected DA in the Gulf of Mexico. In this study, the presence of DA in gulf menhaden (Brevoortia patronus) and the potential for trophic transfer to higher order consumers was investigated. In addition, the effects of this transfer and other algal toxins that …

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A Geochemical Paleoecological Analysis Of Miocene Mammalian Mega Fauna Of Fort Polk, Louisiana, Travis Lamar Atwood Jan 2009

A Geochemical Paleoecological Analysis Of Miocene Mammalian Mega Fauna Of Fort Polk, Louisiana, Travis Lamar Atwood

LSU Master's Theses

Through a combination of vertebrate paleontology and geochemistry much can be discovered about the environments about the past. Fort Polk’s vertebrate fossil sites are important because they reflect a time when the Antarctic ice cap was just beginning to form during the middle Miocene cooling period just after the middle Miocene Climatic Optimum (~15Ma). This study tested the hypothesis that Miocene seasonality will be preserved in the isotopic geochemistry of terrestrial vertebrate remains at central North American Gulf Coastal sites. Geochemistry was used to understand fossil diagenesis, faunal communities and paleoenvironments. Fort Polk, LA sites range in age from 13.5 …

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Effects Of Clenbuterol On Skeletal And Cardiac Muscle In Horses, Jessica Thompson Jan 2009

Effects Of Clenbuterol On Skeletal And Cardiac Muscle In Horses, Jessica Thompson

LSU Master's Theses

Clenbuterol is a commonly prescribed β2-adrenergic agonist approved for veterinary use as a bronchodilator in horses with reactive and obstructive airway disease. Potential for abuse of this drug in the horse industry is substantial, due to the perceptions that clenbuterol increases performance and lean muscle mass. Although anabolic effects have been confirmed in multiple species, recent studies into the effects of clenbuterol in exercising horses suggest that clenbuterol doses within therapeutic ranges negatively impact aerobic capacity and cardiac function. Results of studies in murine models demonstrate that clenbuterol directly induces skeletal and cardiac muscle cell death at high doses. Three …

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Chondrocyte Death In Canine Osteochondral Explants Exposed To 0.5 Percent Bupivacaine, Geoffrey Stuart Hennig Jan 2009

Chondrocyte Death In Canine Osteochondral Explants Exposed To 0.5 Percent Bupivacaine, Geoffrey Stuart Hennig

LSU Master's Theses

Objective: Our in vitro study evaluated chondrocyte death in canine articular cartilage exposed to 0.5% bupivacaine without (B) and with methylparaben (BP) and compared the viability with intact (SI) and mechanically debrided surfaces (SR). We hypothesized that B or BP would cause chondrocyte death in vitro in a time dependent manner and that chondrocyte death would be increased in SI osteochondral cores compared to SR. Materials and Methods: Intact cartilage cores with underlying subchondral bone were collected aseptically from both humeral heads of 16 fresh canine cadavers. Joints from each dog were randomly assigned to SI or SR. Ten osteochondral …

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Mightier Than The Sword: Writing 19th-Century Crime, Megan Lawrence Jan 2009

Mightier Than The Sword: Writing 19th-Century Crime, Megan Lawrence

LSU Master's Theses

Nineteenth-century France, obsessed with personal property, strained under multiple changes in government and the new 1804 Code Napoléon, becomes fascinated with criminal literature. Victor Hugo, Eugène Sue, and Emile Zola span the century with their criminal literature and fascinate their audience. Taking advantage of this nineteenth-century French interest in crime, these popular authors also spread political commentary through their novels. Theft, rape and murder are each treated differently in the nineteenth-century French Penal Code, and I suggest that Hugo, Sue and Zola mirror this inconsistency on the part of the law and its resulting effect on society so well that …

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Regulation Of Adipose Tissue Metabolism By Nfkb P65 In Transgenic Mice, Tianyi Tang Jan 2009

Regulation Of Adipose Tissue Metabolism By Nfkb P65 In Transgenic Mice, Tianyi Tang

LSU Master's Theses

Inflammation has been widely reported to regulate adipocyte functions in adipose tissue. Our early study suggests that NFkB signaling pathway is activated by inflammation and involved in inhibition of insulin sensitivity in adipocytes. NFkB was found to inhibit PPARg function through several possible mechanisms in 3T3-L1 adipocytes. To test this possibility in vivo, we increased the NFkB activity in adipocytes in transgenic mice by expression of NFkB p65 subunit under the aP2 gene promoter. The phenotype study shows that the food intake, physical activity and development are similar in the two groups. The reproductivity was not different in the two …

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Mechanisms And Countermeasures Of Microgravity Induced Bone Loss: In Vitro And In Vivo Model Systems, Ritu Saxena Jan 2009

Mechanisms And Countermeasures Of Microgravity Induced Bone Loss: In Vitro And In Vivo Model Systems, Ritu Saxena

All ETDs from UAB

Rapid bone loss occurs during prolonged periods of weightlessness experienced by astronauts during spaceflights which leads to osteopenia and increased fracture risk upon return to earth. Spaceflight studies have shown that the bone loss occurs as a result of both a decrease in bone formation and an increase in bone resorption, however, the molecular mechanisms still need to be elucidated. Previous studies from our laboratory and other groups have indicated that modeled microgravity leads to inhibition of osteoblastogenesis and a stimulation of adipogenesis of human mesenchymal stem cells in osteogenic medium which is most likely mediated by a decrease in …

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Immunotherapy Of Cancer Employing Γδ-T Cells: A Study Examining Their Utility And Feasibility, Benjamin Hester Beck Jan 2009

Immunotherapy Of Cancer Employing Γδ-T Cells: A Study Examining Their Utility And Feasibility, Benjamin Hester Beck

All ETDs from UAB

Unlike antigen-specific alpha beta-T cells, gamma delta-T cells can recognize and lyse cancerous cells rapidly upon encounter in a manner that does not require the recognition of tumor-specific antigens. Given the well-documented capacity of gamma delta-T cells to innately kill malignant cells, efforts are now underway to exploit the antitumor properties of gamma delta-T cells for clinical purposes. Here, we present for the first time preclinical in vivo mouse models of gamma delta-T cell-based immunotherapy directed against breast cancer. These studies were explicitly designed to approximate clinical situations in which adoptively-transferred gamma delta-T cells would be employed therapeutically against breast …

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Identification Of New Strategies For The Treatment Of Glioblastoma Multiforme Utilizing A Pharmacogenomic Approach: Genetic Profiles Associated With Patient Prognosis And Outcome To Capecitabine Treatment, Jessica Marie Grunda Jan 2009

Identification Of New Strategies For The Treatment Of Glioblastoma Multiforme Utilizing A Pharmacogenomic Approach: Genetic Profiles Associated With Patient Prognosis And Outcome To Capecitabine Treatment, Jessica Marie Grunda

All ETDs from UAB

Glioblastoma multiforme (GBM) is the most lethal form of primary brain neoplasm with average patient survival between 9 and 15 months even with the most aggressive treatment modalities. Unfortunately, this poor outcome has not appreciably changed in the past 50 years emphasizing the lack of traditional `trial and error' methods in identifying an efficacious treatment for GBM. Pharmacogenomics is greatly impacting cancer research through the development of personalized medicine and rationally designed treatment paradigms for the development of more efficacious and less toxic treatment modalities. The main objective of this research was to utilize a pharmacogenomic approach to identify new …

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Simone Martini's St. Louis Of Toulouse And Its Cultural Context, Suzette Denise Scotti Jan 2009

Simone Martini's St. Louis Of Toulouse And Its Cultural Context, Suzette Denise Scotti

LSU Master's Theses

This thesis provides a cultural and historical context for Simone Martini’s painting, St. Louis of Toulouse Crowning Robert of Naples, a landmark of Early Renaissance Sienese art. It offers a detailed analysis of the painting’s style, themes, and unusual iconography based on an examination of the political and religious climate of early fourteenth-century Angevin Naples. In particular, it investigates the motives of Robert of Naples, the probable patron, in commissioning the work. While ostensibly intended to commemorate his brother Louis of Toulouse on the occasion of his sanctification in 1317, the painting nevertheless served Robert’s own political agenda: the validation …

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A Humanistic View Of Satan: The Role Of Satan In Stephen Adly Guirgis' The Last Days Of Judas Iscariot, Yohance Myles Jan 2009

A Humanistic View Of Satan: The Role Of Satan In Stephen Adly Guirgis' The Last Days Of Judas Iscariot, Yohance Myles

LSU Master's Theses

The role of Satan, in The Last Days of Judas Iscariot, was selected as the topic of this thesis in acting to be submitted to the Graduate School of Louisiana State University in partial fulfillment of the requirements for graduation with the Master of Fine Arts degree in Theater. The thesis includes an introduction; discussions of acting methods: the Art of Being, logical thinking, rhythmic sounds, the rehearsal process, journal notes, photos, research, and a conclusion. It details my role/character from a theatrical and humanistic point of view. I will highlight points that will reveal my daily discoveries of this …

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Influence Of Tick Transmission On The Host Response To Rickettsial Infection, Soma Chowdhury Jan 2009

Influence Of Tick Transmission On The Host Response To Rickettsial Infection, Soma Chowdhury

LSU Master's Theses

Several members of the spotted fever group (SFG) of Rickettsia are transmitted to the host through infected ixodid (hard) ticks, which can serve as both vectors and reservoirs. Multiple studies have demonstrated that ticks secrete proteins into the bite site of the host that suppress innate and adaptive immune responses. While this suppression of immune responses is beneficial to the tick, it may also be beneficial to the transmitted Rickettsia. We hypothesize that Rickettsia utilize the tick’s ability to alter the host immune response at the tick feeding site to successfully establish infection. In the current study, we analyzed how …

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