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2008

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Characterization Of Yeast 18s Rrna Dimethyl Transferase, Dim1p, Nagesh Pulicherla Jan 2008

Characterization Of Yeast 18s Rrna Dimethyl Transferase, Dim1p, Nagesh Pulicherla

Theses and Dissertations

Eukaryotic ribosome biogenesis, a dynamic and coordinated multistep process which requires more than 150 trans-acting factors, has been intensely studied in the yeast Saccharomyces cerevisiae. This evolutionarily conserved process involves numerous cleavages of pre-rRNA, modification of nucleotides, and concomitant assembly of the ribosomal proteins onto the rRNA. Considerable information is available about the importance of conserved pre-rRNA cleavage events in ribosome biogenesis; however, very little is known about the exact role of modified nucleotides, which cluster within the functionally important regions of the ribosome. One conserved group of modifications is the dimethylation of two adjacent adenosines at the 3´ end …

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Probe Level Analysis Of Affymetrix Microarray Data, Richard Ellis Kennedy Jan 2008

Probe Level Analysis Of Affymetrix Microarray Data, Richard Ellis Kennedy

Theses and Dissertations

The analysis of Affymetrix GeneChip® data is a complex, multistep process. Most often, methodscondense the multiple probe level intensities into single probeset level measures (such as RobustMulti-chip Average (RMA), dChip and Microarray Suite version 5.0 (MAS5)), which are thenfollowed by application of statistical tests to determine which genes are differentially expressed. An alternative approach is a probe-level analysis, which tests for differential expression directly using the probe-level data. Probe-level models offer the potential advantage of more accurately capturing sources of variation in microarray experiments. However, this has not been thoroughly investigated, since current research efforts have largely focused on the …

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Schema, Ann Walsh Jan 2008

Schema, Ann Walsh

Theses and Dissertations

A schema is described as a diagram showing the basic outline of something, or as an organizational or conceptual pattern in the mind. It is also, in Kantian philosophy, a method that allows the understanding to apply concepts to the evidence of the senses. My Schema is a model of emergence.

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Voice By Design: Experiments In Redistributing Media, Bizhan Khodabandeh Jan 2008

Voice By Design: Experiments In Redistributing Media, Bizhan Khodabandeh

Theses and Dissertations

In this project I conduct two experiments in redistributing media power and reflect upon how successful they were. The experiments include a poster campaign specific to Richmond and a project dealing with educating people about guerrilla media techniques.

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The Director's Presence, Paul Stephen Wurth Jan 2008

The Director's Presence, Paul Stephen Wurth

Theses and Dissertations

This text is partial record and narrative of the process and productions of Orphans by Lyle Kessler that opened on March 29th 2007 for a four day run ending on April 1st, The Pillowman by Martin McDonagh that opened October 28th 2007 for a three day run ending on October 30th, and Terra Nova by Ted Tally that opened on February 21st 2008 for a four day run ending on February 24th. The majority of the text follows the three shows from Spring 2007, Fall 2007, to Spring 2008, focusing on the process of direction of each production. Incorporated in …

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Evaluation Of An Early Discharge Policy For Infants With Apnea Of Prematurity, Cheryl N. Bodamer Jan 2008

Evaluation Of An Early Discharge Policy For Infants With Apnea Of Prematurity, Cheryl N. Bodamer

Theses and Dissertations

This research examines the safety and cost effectiveness of an institutional policy on discharge of preterm infants with Apnea of Prematurity (AOP) from the Virginia Commonwealth University Medical Center Newborn Intensive Care Unit (VCUNC NICU) with caffeine therapy and a cardiorespiratory monitor. This practice policy was developed over a decade ago as a cost containment measure in neonatal care and continues to be implemented today despite the lack of a formal evaluation. The secondary objective was to examine through a review of the literature the psychosocial impact of premature birth on the family and the potential effect on the infant's …

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The Use Of Implants Vs. Endodontics: Practitioner Attitudes In 2007, Gardiner Mckay Packer Jan 2008

The Use Of Implants Vs. Endodontics: Practitioner Attitudes In 2007, Gardiner Mckay Packer

Theses and Dissertations

The purpose of this study was to determine what factors influence dentists when deciding whether to place an implant or perform endodontic retreatment. Null hypothesis: Dentists today are no more likely to place an implant than to perform endodontic retreatment. A twelve-item questionnaire was mailed to 525 general dentists and specialists who are members of the Richmond Dental Society. Response rate was 61.9%. The questionnaire included items on demographics, practice profile and cases of failing endodontic therapy which participants were asked to consider and chose between endodontic retreatment or implant placement. The relationship between the treatment choices and the characteristics …

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Examining The Behavioral And Molecular Aspects Of Adolescent Nicotine Dependence: Implications For Vulnerability To Drugs Of Abuse, Dena Heath Kota Jan 2008

Examining The Behavioral And Molecular Aspects Of Adolescent Nicotine Dependence: Implications For Vulnerability To Drugs Of Abuse, Dena Heath Kota

Theses and Dissertations

Approximately 200 million men and 100 million women smoke worldwide. In the United States, an estimated 25.9 million men (23.9 percent) and 20.7 million women (18.1 percent) are smokers. The commencement of smoking at a young age is thought to increase addiction liability, decrease the probability of successful cessation, and correlate with a higher number of cigarettes smoked per day. Studies from the World Health Organization indicate that between 80,000 and 100,000 children start smoking every day worldwide. These statistics suggest that adolescence is a critical phase for developing nicotine dependence. The work in this dissertation contributes to the further …

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5-Ht3 Receptor Ligands And Their Effect On Psychomotor Stimulants, Jessica Nicole Worsham Jan 2008

5-Ht3 Receptor Ligands And Their Effect On Psychomotor Stimulants, Jessica Nicole Worsham

Theses and Dissertations

Drug abuse and addiction are considered to be a result, at least in part, of the rewarding effects produced by increasing dopamine levels. 5-HT3 serotonin receptors have been shown to indirectly affect dopamine levels. Therefore, the effect of the 5-HT3 receptor partial agonist, MD-354, on the actions of psychomotor stimulants was analyzed in mouse locomotor activity assays to determine whether MD-354 is working through a 5-HT3 receptor agonist or antagonist mode of action. Studies with (+)amphetamine and (+)methamphetamine in combination with MD-354 indicated MD-354 is either devoid of action or is behaving similar to the 5-HT3 receptor antagonist, ondansetron. This …

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The Psychosocial Influence Of Dental Esthetics In Adolescents As Judged By Peers, Scott Thomas Henson Jan 2008

The Psychosocial Influence Of Dental Esthetics In Adolescents As Judged By Peers, Scott Thomas Henson

Theses and Dissertations

The purpose of this study was to determine if dental esthetics affects the perception of adolescents regarding their peer's social aptitude in specific areas such as athletics, popularity, leadership, and academics. Ten patient photographs (4 males, 6 females) from a private orthodontic practice in Richmond, VA were selected for inclusion in this study. The frontal smiling photographs were digitally modified with insertion of either an ideal smile (straight) or a non-ideal smile (crooked) to create an image identical to the original except for an altered dental complex. Laypersons rated the straight and crooked patient photographs for athletic performance, socialization skills …

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Magic, Mystery, Illusion And Magic, Alexis Semtner Jan 2008

Magic, Mystery, Illusion And Magic, Alexis Semtner

Theses and Dissertations

This document vaguely describes what happened to me and my paintings during my time spent at VCU.

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In Pursuit Of Paternal Significance: Fathers' Influence On Their Daughters' And Sons' Sexual Behaviors And Beliefs, Rachel S. Everley Jan 2008

In Pursuit Of Paternal Significance: Fathers' Influence On Their Daughters' And Sons' Sexual Behaviors And Beliefs, Rachel S. Everley

Theses and Dissertations

The United States has the highest teen pregnancy and adolescent STD rates of any industrialized nation. Numerous factors are involved in adolescent sexual decision-making and the social-ecological framework suggests that there are multiple levels of influence on adolescent development, including familial. Utilizing survey data from the Virginia Abstinence Education Initiative (VAEI), this project specifically explores paternal influences on adolescent sexual behavior and beliefs by examining paternal residence in the home, perceived paternal figure sexual beliefs, and father-child relationship factors. Results indicate that paternal figures influence their daughters' and sons' sexual behaviors as well as beliefs. Differences in paternal figure influence …

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Blending Doctrine, Practice, And Purpose In Legal Education: The Case For An Integrated Pedagogy, Debra M. Schneider Jan 2008

Blending Doctrine, Practice, And Purpose In Legal Education: The Case For An Integrated Pedagogy, Debra M. Schneider

Theses and Dissertations

Traditional legal education is sorely imbalanced. A law student receives rigorous training in legal doctrine and analytical skills—he learns to "think like a lawyer"—but is left with little training in practical skills or his ethical role in society. Moreover, law schools rely almost exclusively on the ineffectual pedagogy of the case-dialogue, or "Socratic," method. Several factors explain this entrenched imbalance, most notably the academy's top-down power structure and its budget constraints. Increasingly, however, the marketplace is demanding practice-ready lawyers who have strong training not only in doctrine but in practical skills and ethics. Law schools, responding to this market pressure, …

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Organizing Around A Center: A Design Incubator And Business Center, Mindy Carter Jan 2008

Organizing Around A Center: A Design Incubator And Business Center, Mindy Carter

Theses and Dissertations

This thesis explores the development of an interdisciplinary design incubator and community business center in Richmond, Virginia through the adaptive reuse of a retired, historic school building. In contrast to the deteriorating conditions of Patrick Henry School, renewed growth abounds in its extraordinary site surroundings—the 105 acres of Forest Hill Park, which serves as the virtual backyard of the school building. This dualism provided a prime opportunity for discovering the design possibilities in connecting a built space to its physical surroundings and for giving meaningful new life to an abandoned space.

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Characterization Of Microorganisms Of Interest To Homeland Security And Public Health Utilizing Liquid Chromatography/Mass Spectrometry, Robert A. Everley Jan 2008

Characterization Of Microorganisms Of Interest To Homeland Security And Public Health Utilizing Liquid Chromatography/Mass Spectrometry, Robert A. Everley

Theses and Dissertations

Liquid chromatography/quadrupole time of flight mass spectrometry (LC/QTOF MS) utilizing electrospray ionization was employed to monitor protein expression in Escherichia coli and Shigella organisms. Automated charge state deconvolution, spectral subtraction and spectral mirroring were used to reveal subtle differences in the LC/MS data. Reproducible intact protein biomarkers were discovered based on their unique mass, retention time and relative intensity. These markers were implemented to differentiate closely related strain types, (e.g. two distinct isolates of E. coli O157:H7) and to correctly identify unknown pathogens. Notable, was the distinction of multiple serotypes of enterohaemorrhagic E. coli which cannot be distinguished by clinical …

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Inflammation-Associated Gene Regulation In Primary Astrocytes, Glial Tumors And Cellular Differentiation, Katarzyna Marta Wilczynska Jan 2008

Inflammation-Associated Gene Regulation In Primary Astrocytes, Glial Tumors And Cellular Differentiation, Katarzyna Marta Wilczynska

Theses and Dissertations

This dissertation elucidates several independent molecular mechanisms that function in astrocytes and glial tumor cells, and suggest that developmental and inflammatory signals may contribute to the development of brain tumors. First, we analyzed the mechanism of TIMP-1 activation in astrocytes and glioblastoma cells. TIMP-1 expression is activated by IL-1, which is the major neuroinflammatory cytokine, via simultaneous activation of IKK/NF-kB and MEK3/6/p38/ATF-2 pathways in primary human astrocytes. In contrast to astrocytes, TIMP-1 is expressed at lower levels in glioblastomas, and is not regulated by IL-1 due to either dysfunctional IKK/NF-kB or MEK3/6/p38/ATF-2 activation. Thus, we propose a novel mechanism of …

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Greenlife: A Sustainable Retail Space, Veronica J. Ledford Jan 2008

Greenlife: A Sustainable Retail Space, Veronica J. Ledford

Theses and Dissertations

GreenLife is the name of the retail interior design project that embodies this thesis. Using interior design as a medium to influence customers,I sought to create an environment that promotes a connection to nature and an awareness of creative possiblities within the context of a store. It addresses the problem of personal social responsiblity by using shopping, a dominant activity in the western world, as a tool for change. As a project, GreenLife attempts to answer three questions: How does design inform cultural experience? How can a connection with nature inform consumerism? Can a store transcend its purpose from filling …

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Moments Of Absorption, Sarah K. Kaufman Jan 2008

Moments Of Absorption, Sarah K. Kaufman

Theses and Dissertations

Moments of Absorption explores the conceptual and visual themes that are presented in my MFA thesis exhibition. The research looks into the absorption of the nude subject, the gestures that communicate this absorption, and the domestic space as a stage for the presentation of these gestures. This work investigates a tension between the theatrical and the natural as represented by images.

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Grace Street Senior Center, Virginia Brockett Jan 2008

Grace Street Senior Center, Virginia Brockett

Theses and Dissertations

Societal structure has changed through the decades to reflect a contemporary interest in youth culture. The nuclear family, where generations lived under one roof no longer exists, leaving the elderly on the periphery of the family structure. Where once grandparents, parents and children all cohabitated, now the oldest family members are relegated to solitary retirement and aging alone. Studies have shown that "depression in the elderly is more likely to lead to suicide. Elderlywhite men are at greatest risk, with suicide rates in people ages 80 to 84 more than twice that of the general population. The National Institute of …

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Principals Give Voice To The Isllc Standards--An Investigation Of Leadership Job Priorities, Marcia Muse Jan 2008

Principals Give Voice To The Isllc Standards--An Investigation Of Leadership Job Priorities, Marcia Muse

Theses and Dissertations

Due to the increasing demands on educational administrators it has become essential that leadership priorities be established. This study investigated elementary school principals' job responsibilities and how the school administrator prioritized the many facets of the job. The literature supported the continued escalation of job demands on the school principal. Thus with growing accountability, it is essential that school leaders learn to balance the responsibilities of being the instructional leader and the school manager. A purposeful sample of 25 elementary school principals in central Virginia was used in a qualitative study. Principals from small (0-350), medium (351-750), and large (751-1200) …

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Electromyographic Characterization In An Animal Model Of Dystonia, Kunal Dilip Chaniary Jan 2008

Electromyographic Characterization In An Animal Model Of Dystonia, Kunal Dilip Chaniary

Theses and Dissertations

Kernicterus causes damage to the auditory system and the basal ganglia in humans. Although the Gunn rat model of kernicterus has been extensively used to characterize the auditory features, this model has not been utilized to systematically investigate the movement disorder. In the present study, spontaneously jaundiced (jj) 16 day old Gunn rat pups were treated with sulfadimethoxine to exacerbate bilirubin neurotoxicity and compared to saline treated jjs and non-jaundiced (Nj) littermates. Electromyographic (EMG) activity was recorded from antagonistic hip muscles in dystonic and in normal appearing rats. Raw EMG signals were decomposed using the Discrete Wavelet Transform based multi-resolution …

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One Hundred And Fifty Percent Elasticity, Eli Mikael Kessler Jan 2008

One Hundred And Fifty Percent Elasticity, Eli Mikael Kessler

Theses and Dissertations

The sculptural environments I create immerse the viewer in a decrepit vaudevillian past. The sculptures allude to narratives within Community Theater as well as the Drag Show. Making becomes an act; manipulating materials such as synthetic hair and paint are associated with the guise of the makeup artist. Frantic rehearsal logic prevails as a dress is repurposed into a male giant's costume and window blinds are used to construct a boat's deck. This collusion asks the viewer to transgress the boundary of the stage, becoming a voyeur privileged to the world of exiled props and role reversal.

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Regulation Of Platelet-Activating Factor Acetylhydrolase By Oxidized Phospholipids And Proinflammatory Cytokines, Muralikrishna Mukkamala Jan 2008

Regulation Of Platelet-Activating Factor Acetylhydrolase By Oxidized Phospholipids And Proinflammatory Cytokines, Muralikrishna Mukkamala

Theses and Dissertations

Platelet-Activating Factor Acetylhydrolase (PAFAH) is a monocyte-derived phospholipase A2 that catalyzes the hydrolysis of platelet-activating factor (PAF) and has been implicated in atherosclerosis. Although PAF and other proinflammatory stimuli are postulated to induce the enzyme, mechanisms controlling PAFAH expression are largely unknown at present. We have shown that PAFAH induction in monocytes is increased in response to oxidized phospholipids. The PAFAH 5' flanking region has at least 10 putative Stat elements, and IL-6 has been shown to be downstream from the prostaglandin receptor, EP2, which has been shown to bind oxidized phospholipids, prompting the hypothesis that Stat proteins might regulate …

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Beyond The Early Adopters: Examining The Potential For Car-Sharing In Richmond, Virginia, Steven P. Spears Jan 2008

Beyond The Early Adopters: Examining The Potential For Car-Sharing In Richmond, Virginia, Steven P. Spears

Theses and Dissertations

Car-sharing is a membership-based mobility service that offers short-term vehicle rentals. Studies have shown that car-sharing can increase transportation sustainability by encouraging the use of public transit and reducing vehicle miles traveled. This thesis examines the potential for car-sharing in Richmond, Virginia through an attitude-based qualitative pilot study. Using the theory of planned behavior as a framework, urban and suburban residents were asked questions that measured car-sharing intention strength, mode choice habit, and life change effects. The study found that even among those with positive attitudes toward car-sharing, existing habits, lack of adequate commuting alternatives and the needs of non-driving …

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A Capillary-Based Microfluidic System For Immunoaffinity Separations In Biological Matrices, Michael Peoples Jan 2008

A Capillary-Based Microfluidic System For Immunoaffinity Separations In Biological Matrices, Michael Peoples

Theses and Dissertations

The analysis of biological samples in clinical or research settings often requires measurement of analytes from complex and limited matrices. Immunoaffinity separations in miniaturized formats offer selective isolation of target analytes with minimal reagent consumption and reduced analysis times. A prototype capillary-based microfluidic system has been developed for immunoaffinity separations in biological matrices with laser-induced fluorescence detection of labeled antigens or antibodies. The laboratory-constructed device was assembled from two micro syringe pumps, a microchip mixer, a micro-injector, a diode laser with fused-silica capillary flow cell, and a separation capillary column. The columns were prepared from polymer tubing and packed under …

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Entertainment News: Agitprop To Colbertisms, Chanelle Renee Vigue Jan 2008

Entertainment News: Agitprop To Colbertisms, Chanelle Renee Vigue

Theses and Dissertations

At the beginning of the twentieth century, newspaper theatre was born from the need to inform those who could not read the news for themselves. There have been many contributors and influential factors to the multi-faceted evolution of newspaper theatre. Contributors include Meyerhold, Piscator, Brecht, Hallie Flanagan and Arthur Arent, and Augusto Boal. Influential factors include technology, politics, and the influence of theatrical movements. The most popular and most frequent contributors to contemporary newspaper theatre are the legitimate news media and comedy news shows.

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If Your Love Were A Grain Of Sand Mine Would Be A Universe Of Beaches, Valerie Anne Molnar Jan 2008

If Your Love Were A Grain Of Sand Mine Would Be A Universe Of Beaches, Valerie Anne Molnar

Theses and Dissertations

Each stitch is a piece of me that I give, a moment of my life and a unit of my love, meticulously culminated into a universal visual language. The optimist in me knits for the cause, while my formalist counterpart works to make the images that sell my thoughts. I knit for the lovers.I make these objects as a practice and a confirmation of my optimism. I make these images to communicate and persuade as a serious contender while at the same time retaining my own optimism and sanity by promising to never take myself too seriously.

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Spark Gap, Lillian Cox-Richard Jan 2008

Spark Gap, Lillian Cox-Richard

Theses and Dissertations

"Spark Gap" is an invisible electrical force made visible in spaces between things. This usually describes the space of air between two conductors; a non-conductive gap in an otherwise complete electric circuit, across which a quick luminous disruptive electrical discharge occurs. This interstitial space is the distance between two ideas, arced with a running leap. The arc can also be the difference between two things, a gap that becomes apparent only when the two are held in close proximity. In my thesis exhibition, "Spark Gap," a sea urchin shaped orb sits atop a tower of ladders. The orb is broken …

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Lighting The Box,Daylighting As The Primary Organizer In Multifamily Housing, Sara Lovette Jan 2008

Lighting The Box,Daylighting As The Primary Organizer In Multifamily Housing, Sara Lovette

Theses and Dissertations

This project started out as program for multi-family housing with a need for natural light, then, it changed. Through countless studies, it became evident that what started as an animal made up of bones and tissues was really just the vessel for the animal's soul. Light is the soul of design. The program represents the tissue and bones of the animal that is design.In this project two paths were taken. The first being pragmatic, the design bound by the program. Where in the second, the concept, light, beats up the program and ultimately makes for an inspiring place to live.

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An Scir Model Of Meningococcal Meningitis, Kalimah Vereen Jan 2008

An Scir Model Of Meningococcal Meningitis, Kalimah Vereen

Theses and Dissertations

A model for meningitis is developed by adding a class of carriers to the basic SIR model. This model is used to analyze the impact a vaccination program can have on the health of the population of epidemic prone countries. Analysis of the model shows the local stability of the disease free equilibrium, the existence of an endemic equilibrium and computation of the reproduction number, ℜ0 . Using a MATLAB program we simulate a time course of the model using parameters gathered from the World Health Organization. The numerical solution demonstrates that our reproduction number was correct. We thenconcluded that …

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