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Science-Technology Division, Christine Whitaker

Sci-Tech News

No abstract provided.

Full Issue: Vol. 62, No. 4

Sci-Tech News

No abstract provided.

Upregulation Of Heme Oxygenase-1 Combined With Increased Adiponectin Lowers Blood Pressure In Diabetic Spontaneously Hypertensive Rats Through A Reduction In Endothelial Cell Dysfunction, Apoptosis And Oxidative Stress, Jian Cao, George Drummond, Kazuyoshi Inoue, Komal Sodhi, Xiao Ying Li, Shinji Omura

Pharmaceutical Science and Research

This study was designed to investigate the effect of increased levels of HO-1 on hypertension exacerbated by diabetes. Diabetic spontaneously hypertensive rat (SHR) and WKY (control) animals were treated with streptozotocin (STZ) to induce diabetes and stannous chloride (SnCl2) to upregulate HO-1. Treatment with SnCl2 not only attenuated the increase of blood pressure (p<0.01), but also increased HO-1 protein content, HO activity and plasma adiponectin levels, decreased the levels of superoxide and 3-nitrotyrosine (NT), respectively. Reduction in oxidative stress resulted in the increased expression of Bcl-2 and AKT with a concomitant reduction in circulating endothelial cells (CEC) in the peripheral blood (p<0.005) and an improvement of femoral reactivity (response to acetylcholine). Thus induction of HO-1 accompanied with increased plasma adiponectin levels in diabetic hypertensive rats alters the phenotype through a reduction in oxidative stress, thereby permitting endothelial cells to maintain an anti-apoptotic environment and the restoration of endothelial responses thus preventing hypertension.

Intramedullary Spinal Cord Metastases And Radiation Therapy: A Case Report, Daniel Ikeda, James S. Harrop Md

JHN Journal

Intramedullary spinal cord metastases (ISCM) are a clinically rare, although devastating, complication of disseminated cancer. These lesions have been reported to originate from many types of solid tumors, although primary lung carcinoma, particularly small cell, is the most common etiology. These metastases, which can occur anywhere along the spinal cord, often represent the end-stage of the disease process with limited survival outcomes.

Patients with ISCM may develop a variety of neurological deficits with treatment goals aimed at palliation. Different modalities of treatment have been found to preserve or restore ambulation and neurological function. The options for therapeutic intervention include surgical, …

Cervical Intramedullary Ganglioma, Harminder Singh Md, Ashwini Sharan Md, John K. Ratliff Md

JHN Journal

A 48 year male presented to the ER with severe headaches which were episodic in nature and which had been present for several weeks. Patient had a history of traumatic head injury (TBI) several years prior. Otherwise, he was in good health with no significant past medical or surgical history.

On physical exam, patient was oriented x 3 with an intact cranial nerve exam. He had significant upper and lower extremity spasticity with mild hand intrinsic weakness. His motor exam was otherwise unremarkable. His gait was very spastic. He had sustained lower extremity clonus, upgoing toes, and increased tone in …

Surgeon Opinions On Use Of Epidural Steroids In Treatment Of Lumbar Disk Disease: Results Of An Online Survey, John K. Ratliff Md, Mitchell Maltenfort Phd, Bryan Lebude

JHN Journal

“Standard of care” can vary along regional and specialty lines; it is common to discover that a local “standard” can be different somewhere else. Opinions may differ between pain management specialists, primary care physicians, and spine surgeons with regard to use of conservative treatment modalities.

Opinion within a given group of practitioners, however, should converge. Local differences between hospitals may exist, but conferences, professional journals, and national boards for certification are mechanisms that should act to maintain homogeneity within a professional group. It could be expected that commonly utilized treatment approaches within a well defined group of sub-specialists should converge. …

Case Report: Intramedullary Cervical Spinal Cord Hemangioblastoma With An Evaluation Of Von Hippel-Lindau Disease, Steven Falowski Md, Ashwini Sharan Md, James S. Harrop Md, John K. Ratliff Md

JHN Journal

History of Present Illness

MO is a 49 year old male with a history of multiple sclerosis who presents with a one year history of progressive numbness in his shoulders bilateral and upper back. The patient describes occasional sharp pains that radiate to his first three fingers on his right hand. He denies weakness, clumsiness, difficulty walking, or bladder/bowel dysfunction. He describes no problems with handwriting, or fine motor skills.

Jhn Journal (Download The Full Pdf Of This Issue), Robert H. Rosenwasser Md

JHN Journal

Complete December 2008 issue of JHN Journal

Spinal Cord Stimulators: An Introduction, Steven Falowski Md

JHN Journal

Pain can be divided into two broad categories, nociceptive pain and neuropathic pain. Nociceptive pain is a dull, throbbing pain which results from irritated nerves after physical tissue injury. This is seen commonly in cancer or after a fracture. Nociceptive pain is amenable to treatment with pain medications such as opioids and/or anti-inflammatories. Neuropathic pain is described as burning, shooting, or shocking pain. This type of pain results from nerve damage or abnormal nerve conduction such as pain exhibited with failed back syndrome, post surgical pain, neuromas, shingles, and complex regional pain syndrome (previously called RSD or causalgia). Neuropathic pain …

Minimally Invasive Surgery For Skull Base Tumors, James J. Evans Md, Marc R. Rosen Md

JHN Journal

The Jefferson Center for Minimally Invasive Cranial Base Surgery and Endoscopic Neurosurgery reflects three of the current evolutions in neurological surgery. The first of these is reflected in the name of the Center itself. Surgical Procedures, Minimally Invasive, a Medline Subject Heading since 1998, is defined as:

Procedures that avoid use of open invasive surgery in favor of closed or local surgery. These generally involve use of laparoscopic devices and remote-control manipulation of instruments with indirect observation of the surgical field through an endoscope or similar device. With the reduced trauma associated with minimally invasive surgery, long hospital stays may …

Clinical Guidelines Written By Residents, David W. Andrews Md

JHN Journal

“Variation” is an innocent word that that can represent many levels of frustration to the clinician. Variation among patients is the least of these; the physician expects patients and their individual problems to be as diverse as the human race itself. Variation within a practice should be due to matching the specific needs of the specific patient. Other variations can mean trouble if they represent differences in understanding of the problem among clinicians and other allied health practitioners. These differences could be between institutions or even between shifts within one institution.

Design, Analysis, And Development Of Cost Effective Canine Wheelchairs., Edward Bros Fowler

Electronic Theses and Dissertations

Hind limb paralysis may occur in dogs for a variety of neurological or musculoskeletal reasons. For dogs with limited mobility their lack of ability to ambulate can have a great impact on their physical and mental health. Canine wheelchairs can provide these dogs with a mobility option. The purpose of this project was to design a cost effective, adjustable, and lightweight canine wheelchair for dogs with hind limb paralysis. To account for the diverse range of canine breed sizes, wheelchairs were categorized into three separate designs (small, medium, and large size wheelchairs). A quality function deployment (QFD) matrix was created …

Rear Impact Crashworthiness Of A Manual Wc19 Wheelchair Occupied By A 50th Percentile Atd., Zdravko Salipur

Electronic Theses and Dissertations

For persons with disabilities, access to transportation is necessary for integration into society. The Americans with Disabilities Act (ADA) has been instrumental in assuring transportation access to individuals with disabilities for purposes of employment, education, and recreation. A substantial number of wheelchair users may not be able to transfer from their wheelchair to a motor vehicle seat during transportation. It is necessary to afford these wheelchair users the same level of safety as occupants seated in motor vehicle seats. The purpose of this study was to investigate the response of a manual wheelchair used as a motor vehicle seat, while …

Comparative Evaluation Of Ethanol Yield From Htf Corn Varieties In The Whisky Production Process., Kara Marie Zoeller

Electronic Theses and Dissertations

In the whisky industry there is a balance between the desire to adhere to the traditional production process and the desire to increase profit margins. One solution that follows both stipulations is to increase the alcohol yield of a given batch of whisky. This can be achieved by utilizing high total fermentable corn which has a higher concentration of fermentable starches than other corn. HTF corn has the potential for a greater final ethanol yield. By simply using a higher quality of raw materials, the integrity of the process is maintained while allowing for an increase in output. Ten strains …

Alternative Land Use Patterns To Minimize Congestion (Volume 1: Comparative Analysis Of Mixed Land Use And Separated Land Use Neighborhoods), Amica Bose, Jon D. Fricker

JTRP Technical Reports

Urban sprawl creates serious traffic congestion. Alternative land use patterns may be the best solution. New Urbanists claim that, by placing frequently-visited sites within walking distance of homes and creating a pleasant walking environment, people are more willing to choose non-motorized transportation mode to do such activities.

Part I of this study investigated the ability of travel demand models to estimate the impacts of alternative land use patterns. Part II conducted an economic viability analysis for a mixed land use neighborhood and collected land use preferences at meetings of neighborhood associations. The objective in Part III was to evaluate the …

The Posthuman Ethos In Cyberpunk Science Fiction, María Goicoechea

CLCWeb: Comparative Literature and Culture

In her article "The Posthuman Ethos in Cyberpunk Science Fiction" María Goicoechea explores the posthuman tendencies of Anglo-American popular culture as they are manifested in the representations of the cyborgs, clones, and artificial intelligences that populate cyberpunk science fiction. Choosing the figure of the cyborg as the central myth of cyberculture, Goicoechea exposes the underlying tensions and contradictions present in cyberpunk prescient visions of humanity's evolution. Goicoechea reviews the variety of contradictory meanings that have been sedimented over this hybrid creature, using as ideological framework the digital narratives of "Technoromanticism" and "Cybergothic," respectively the dominant and the countercultural trend inside …

People Profile: Laura Cerruti, Editor

Against the Grain

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Publisher-Library Relations: What Assets Does A University Press Bring To The Partnership?, Patrick H. Alexander

Against the Grain

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Local, Sustainable, And Organic Publishing: A Library-Press Collaboration At The University Of California, Catherine A. Mitchell, Laura Cerruti

Against the Grain

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Atg Special Report -- Researcher: The Open Source Solution For Managing Electronic Resources, Rachel A. Erb

Against the Grain

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I Hear The Train A Comin' -- All I Really Need To Know..., Greg Tananbaum

Against the Grain

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Purposeful Collaboration For Research Libraries And University Presses, Michael J. Furlough

Against the Grain

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Book Reviews -- Monographic Musings, Debbie Vaughn

Against the Grain

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The Coefficient Partnership: Project Euclid, Cornell University Library And Duke University Press, Terry Ehling, Erich Staib

Against the Grain

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Random Ramblings -- Introductions, Bob Holley

Against the Grain

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Technology Left Behind -- Ravelry Revelry, Cris Ferguson

Against the Grain

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Back Talk -- Cd In Digital Era Calis, Anthony (Tony) W. Ferguson

Against the Grain

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Atg Special Report -- Some Considerations In Selecting Scientific Journal Backfiles, Ann Bolek

Against the Grain

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Something To Think About -- Mixing It Up Charleston Style!, Mary E. (Tinker) Massey

Against the Grain

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From Your (First It's Not, Then It's Cold) Editor, Katina Strauch

Against the Grain

No abstract provided.