Digital Commons Network^™

Nicotinic Acetylcholine Receptor Kinetics Of The Neuromuscular Junction Simulated Using Spice: An Illustration Of Physiological Process Simulation With Conventional Circuit Simulation Software, Robert B. Szlavik

Biomedical Engineering

With the advent of modern day computational power, there is a great deal of interest in the simulation and modeling of complex biological systems. A significant effort is being made to develop generalized software packages for the simulation of cellular processes, metabolic pathways and complex biochemical reaction systems. The advantages to being able to implement and simulate complex biological systems in a virtual environment are several. Simulations of this type, if sufficiently detailed, provide experimental physiologists with the ability to visualize the dynamics of a given biological system of interest. The validity of hypotheses related to the system under study …

Science In The Law School Curriculum: A Snapshot Of The Legal Education Landscape, Mara Merlino, James T. Richardson, Jared Chamberlain, Victoria Springer

Journal of Legal Education

No abstract provided.

Parent Education Seminar: Children's Emotional Development, Barbara E. Kase

Regis University Student Publications (comprehensive collection)

The purpose of this project was to examine how attachment theory and emotional reactivity intersect in emotional regulation and to develop an educational seminar that increases parent/caregiver's awareness of behaviors that shape a child's emotional development. Attachment is an emotional connection between the parent/caregiver and child that alleviates the child's wariness and stress. Parent/caregiver and infant interactions form attachment patterns that: (a) describe the parent's response to the child's emotional reactivity, (b) result in relational styles, and (c) affect the quality of the emotional connection between them. The quality of the attachment affects the child's emotional development and influences the …

An Automatic Alogorithm For Detecting Stent Endothelialization From Volumetric Optical Coherence Tomography Datasets, Garret T. Bonnema, Kristen O'Halloran Cardinal, Stuart K. Williams, Jennifer K. Barton

Biomedical Engineering

Recent research has suggested that endothelialization of vascular stents is crucial to reducing the risk of late stent thrombosis. With a resolution of approximately 10 μm, optical coherence tomography (OCT) may be an appropriate imaging modality for visualizing the vascular response to a stent and measuring the percentage of struts covered with an anti-thrombogenic cellular lining. We developed an image analysis program to locate covered and uncovered stent struts in OCT images of tissue-engineered blood vessels. The struts were found by exploiting the highly reflective and shadowing characteristics of the metallic stent material. Coverage was evaluated by comparing the luminal …

Estimation And Testing For The Effect Of A Genetic Pathway On A Disease Outcome Using Logistic Kernel Machine Regression Via Logistic Mixed Models, Dawei Liu, Debashis Ghosh, Xihong Lin

Harvard University Biostatistics Working Paper Series

No abstract provided.

A Powerful And Flexible Multilocus Association Test For Quantitative Traits, Lydia Coulter Kwee, Dawei Liu, Xihong Lin, Debashis Ghosh, Michael P. Epstein

Harvard University Biostatistics Working Paper Series

No abstract provided.

Undergraduate Schedule Of Classes For 2008, Fall [Full Fall Semester Session] | Academic Calendar | Class Schedule, Office Of The Registrar, Stony Brook University

Calendars

No abstract provided.

Academic Calendar | Undergraduate Schedule Of Classes For 2008, Fall [Full Fall Semester Session] | Class Schedule, Office Of The Registrar, Stony Brook University

Calendars

No abstract provided.

Searching The Biological Literature, John L. Kelland

Public Services Faculty Publications

Table of Contents. Chapter 1. Organization of the Scientific Literature and the Flow of Information in the Sciences. Chapter 2. Primary Sources. Chapter 3. Reference Sources. Chapter 4. Databases. Chapter 5. Basic Principles of Searching and Search Logic Chapter 6. Citation Indexes and Citation Searching . Chapter 7. The Citation Concept and its Impact on Society Chapter 8. Resources on the World Wide Web Chapter 9. U. S. Government Publications Chapter 10. Lessons Learned Index

Holy Cross Magazine, Vol. 42, No. 3, Summer 2008, College Of The Holy Cross

Holy Cross Magazine

Remembrance and Celebration
For 28 years, Jerry Colbert ’64, the producer of the PBS holiday concerts, has honored our nation and glorified our freedom.
By Rebecca Smith ’99

Arbor Studies
It is a little-known fact that the Holy Cross campus is a registered arboretum—a collection of maintained specimen trees. Read about the history of the award-winning landscape that defines our unique campus.
By James Dempsey

Bugs and Bones
The inaugural Ardizzone awards enable pioneering faculty field work
By Rebecca Smith ’99

Syllabus: Understanding Jesus
Rev. William Reiser, S.J., professor of religious studies
By Pam Reponen

Flashback: When Houdini escaped from …

Investigating The Complexity Of Respiratory Patterns During The Laryngeal Chemoreflex, Andrei Dragomir, Yasemin Akay, Aidan K. Curran, Metin Akay

Dartmouth Scholarship

The laryngeal chemoreflex exists in infants as a primary sensory mechanism for defending the airway from the aspiration of liquids. Previous studies have hypothesized that prolonged apnea associated with this reflex may be life threatening and might be a cause of sudden infant death syndrome. In this study we quantified the output of the respiratory neural network, the diaphragm EMG signal, during the laryngeal chemoreflex and eupnea in early postnatal (3–10 days) piglets. We tested the hypothesis that diaphragm EMG activity corresponding to reflex-related events involved in clearance (restorative) mechanisms such as cough and swallow exhibit lower complexity, suggesting that …

Global N Removal By Freshwater Aquatic Systems Using A Spatially Distributed, Within‐Basin Approach, Wilfred M. Wollheim, Charles J. Vorosmarty, A. F. Bouwman, Pamela Green, John Harrison, Ernst Linder, Bruce J. Peterson, Sybil P. Seitzinger, James P. M. Syvitski

Faculty Publications

We explored the role of aquatic systems in the global N cycle using a spatially distributed, within‐basin, aquatic nitrogen (N) removal model, implemented within the Framework for Aquatic Modeling in the Earth System (FrAMES‐N). The model predicts mean annual total N (TN) removal by small rivers (with drainage areas from 2.6–1000 km2), large rivers, lakes, and reservoirs, using a 30′ latitude × longitude river network to route and process material from continental source areas to the coastal zone. Mean annual aquatic TN removal (for the mid‐1990s time period) is determined by the distributions of aquatic TN inputs, mean annual hydrological …

The Influence Of N-Acetyl-L-Cysteine On Oxidative Stress And Nitric Oxide Synthesis In Stimulated Macrophages Treated With A Mustard Gas Analogue, Victor Paromov, Min Qui, Hongsong Yang, Milton Smith, William L. Stone

ETSU Faculty Works

Background: Sulphur mustard gas, 2, 2′-dichlorodiethyl sulphide (HD), is a chemical warfare agent. Both mustard gas and its monofunctional analogue, 2-chloroethyl ethyl sulphide (CEES), are alkylating agents that react with and diminish cellular thiols and are highly toxic. Previously, we reported that lipopolysaccharide (LPS) significantly enhances the cytotoxicity of CEES in murine RAW 264.7 macrophages and that CEES transiently inhibits nitric oxide (NO) production via suppression of inducible NO synthase (iNOS) protein expression. NO generation is an important factor in wound healing. In this paper, we explored the hypotheses that LPS increases CEES toxicity by increasing oxidative stress and that …

Budget Fy 2008-2009, Swosu Administration

SWOSU Fiscal Year Budgets

The Southwestern Oklahoma State University Budget FY 2009. Submitted June 19, 2008.

Steroid Receptor Coactivator-1 From Brain Physically Interacts Differentially With Steroid Receptor Subtypes, Heather A. Molenda-Figueira, Suzanne D. Murphy, Katherine L. Shea, Nora K. Siegal, Yingxin Zhao, Joseph G. Chadwick Jr., Larry A. Denner, Marc J. Tetel

Faculty Research and Scholarship

In vitro studies reveal that nuclear receptor coactivators enhance the transcriptional activity of steroid receptors, including estrogen (ER) and progestin receptors (PR), through ligand-dependent interactions. Whereas work from our laboratory and others shows that steroid receptor coactivator-1 (SRC-1) is essential for efficient ER and PR action in brain, very little is known about receptor-coactivator interactions in brain. In the present studies, pull-down assays were used to test the hypotheses that SRC-1 from hypothalamic and hippocampal tissue physically associate with recombinant PR or ER in a ligand-dependent manner. SRC-1, from hypothalamus or hippocampus, interacted with PR-A and PR-B in the presence …

Vol.36 N.02 June 19th 2008, Brown Publishing Company

Black Voice News

No abstract provided.

Western News, June 19, 2008, Western Michigan University

Western News (1972-2018)

Story highlights: Kalamazoo Promise findings released; Theatre students to perform at worldwide Anglican conference; Retirements, tenure and faculty promotions; On Campus with Lori Groh.

Unh Hubbard Center: New Research On Mutation In Yeast Can Enhance Understanding Of Human Diseases, Beth Potier

Media Relations

No abstract provided.

Enterotoxin Preconditioning Restores Calcium-Sensing Receptor-Mediated Cytostasis In Colon Cancer Cells, Giovanni Mario Pitari, Jieru E. Lin, Fawad J. Shah, Wilhelm J. Lubbe, David Zuzga, Peng Li, Stephanie Schulz, Scott A Waldman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Guanylyl cyclase C (GCC), the receptor for diarrheagenic bacterial heat-stable enterotoxins (STs), inhibits colorectal cancer cell proliferation by co-opting Ca(2+) as the intracellular messenger. Similarly, extracellular Ca(2+) (Ca(2+)(o)) opposes proliferation and induces terminal differentiation in intestinal epithelial cells. In that context, human colon cancer cells develop a phenotype characterized by insensitivity to cytostasis imposed by Ca(2+)(o). Here, preconditioning with ST, mediated by GCC signaling through cyclic nucleotide-gated channels, restored Ca(2+)(o)-dependent cytostasis, reflecting posttranscriptional regulation of calcium-sensing receptors (CaRs). ST-induced GCC signaling deployed CaRs to the surface of human colon cancer cells, whereas elimination of GCC signaling in mice nearly abolished …

Central Florida Future, Vol. 40 No. 57, June 19, 2008

Central Florida Future

Missing pieces; Urine luck for a good musical; Women's issues push campaign; Simulator to train potential teachers.

Connecting With Diverse Students Through Dialogue Journals, Jacqueline G. Mikkelson

Theses and Dissertations

The purpose of this explorative study was to determine how a White, female, beginning teacher could attempt to build relationships with African American and Hispanic students in a third grade classroom. There were 5 participants: 3 female and 2 male, all of whom were from working class African American or Hispanic families. I implemented dialogue journals into my lessons so that my students and I could learn personal attributes of one another. I retained 8 dialogue journal conversations from all 5 students. Upon completion of dialogue journal implementation, students completed a written self-evaluation survey with open-ended questions pertaining to their …

The Weekly Challenger, June 19, 2008, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The June 19, 2008, issue of The Weekly Challenger.

Ke Alakai, Vol. 81, No. 04 (2008-06-19), Brigham Young University Hawaii

Ke Alaka'i

No abstract provided.

Communication Systems And Hiv/Aids Sexual Decision Making In Older Adolescent And Young Adult Females, Rasheeta D. Chandler Ms, Arnp, Fnp-Bc

USF Tampa Graduate Theses and Dissertations

Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (HIV/AIDS) is a national priority for several reasons including its endemic/pandemic status and economic demand. Adolescents 15 to 24 years old who are sexually active acquire nearly half of all new Sexually Transmitted Infections (STIs). Recent findings from the Centers of Disease Control (CDC) have documented increased teen birth rates, escalating births to unwed mothers, and STIs ascribed to one in four adolescent females, are reasons to enhance effective prevention efforts.

The specific aim of the study, based on Bandura's social cognitive theory, was to test associations among communication system methods and …

Corn (Zea Mays) And Soybean (Glycine Max) Tolerance To Broadcast Flaming, Teixeira Z. Heverton, Santiago Ulloa, Avishek Datta, Stevan Z. Knezevic

RURALS: Review of Undergraduate Research in Agricultural and Life Sciences

Propane flaming can be used as one of the alternatives to chemical weed control. A field experiment was conducted during summer 2007 at the Haskell Agricultural Laboratory near Concord, NE to determine the responses of corn (Zea mays) and soybean (Glycine max) to broadcast flaming utilizing different rates of propane. The 5-leaf corn (V5, plant height 25 cm) and V3 soybean (plant height 8 cm) were flamed using propane rates of 0, 12, 31, 48, 69 and 87 kg/ha. The responses of the corn and soybean plants were described by logistic models. In general, soybean was more susceptible to propane …

The Many Faces Of Fear: Comparing The Pathways And Impacts Of Nonconsumptive Predator Effects On Prey Populations, Evan L. Preisser, Daniel I. Bolnick

Biological Sciences Faculty Publications

Background:

Most ecological models assume that predator and prey populations interact solely through consumption: predators reduce prey densities by killing and consuming individual prey. However, predators can also reduce prey densities by forcing prey to adopt costly defensive strategies.

Methodology/Principal Findings:

We build on a simple Lotka-Volterra predator-prey model to provide a heuristic tool for distinguishing between the demographic effects of consumption (consumptive effects) and of anti-predator defenses (nonconsumptive effects), and for distinguishing among the multiple mechanisms by which anti-predator defenses might reduce prey population growth rates. We illustrate these alternative pathways for nonconsumptive effects with selected empirical examples, and …

John Jay College Performance Goals And Targets Year-End Results: 2007-2008 Academic Year, John Jay College Of Criminal Justice

Reports and Publications from John Jay College

No abstract provided.

Optimization And Characterization Of Biodiesel Production From Cottonseed And Canola Oil, Hem Joshi

All Theses

Transesterification of cottonseed oil and canola oil was carried out using low molecular weight alcohols and potassium hydroxide. For cottonseed oil, a central composite design with eight factorial, six center and six axial points was used to study the effect of catalyst concentration, molar ratio of ethanol to cottonseed oil and reaction temperature on percentage yield and percentage initial absorbance (%A385nm) of the biodiesel. Catalyst concentration and molar ratio of ethanol to cottonseed oil were the most influential variables affecting percentage conversion and percentage initial absorbance. Maximum percentage yield of 98 % is predicted at a catalyst concentration of 1.07 …

Quantitative Measure Of Cytotoxicity Of Anticancer Drugs And Other Agents., Zhimin Tao, Eyone Jones, Jerry Goodisman, Abdul-Kader Souid

Chemistry - All Scholarship

Many anticancer drugs act on cancer cells to promote apoptosis, which includes impairment of cellular respiration (mitochondrial O(2) consumption). Other agents also inhibit cellular respiration, sometimes irreversibly. To investigate the sensitivity of cancer cells to cytotoxins, including anticancer drugs, we compare the profiles of cellular O(2) consumption in the absence and presence of these agents. Oxygen measurements are made at 37 degrees C, using glucose as a substrate, with [O(2)] obtained from the phosphorescence decay rate of a palladium phosphor. The rate of respiration k is defined as -d[O(2)]/dt in a sealed container. Different toxins produce different profiles of impaired …

A Reverse Transcriptase-Pcr Assay For Detecting Filarial Infective Larvae In Mosquitoes, Sandra J. Laney, Caitlin J. Buttaro, Sabato Visconti, Nils Pilotte, Reda M.R. Ramzy, Gary J. Weil, Steven A. Williams

Biological Sciences: Faculty Publications

Background: Existing molecular assays for filarial parasite DNA in mosquitoes cannot distinguish between infected mosquitoes that contain any stage of the parasite and infective mosquitoes that harbor third stage larvae (L3) capable of establishing new infections in humans. We now report development of a molecular L3-detection assay for Brugia malayi in vectors based on RT-PCR detection of an L3-activated gene transcript.

Methodology/Principal Findings: Candidate genes identified by bioinformatics analysis of EST datasets across the B. malayilife cycle were initially screened by PCR using cDNA libraries as templates. Stage-specificity was confirmed using RNA isolated from infected mosquitoes. Mosquitoes were collected daily …