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2008

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Child–Adult Differences In Second-Language Phonological Learning: The Role Of Cross-Language Similarity, Wendy Baker-Smemoe, Pavel Trofimovich, James E. Flege, Molly Mack, Randall Halter Jan 2008

Child–Adult Differences In Second-Language Phonological Learning: The Role Of Cross-Language Similarity, Wendy Baker-Smemoe, Pavel Trofimovich, James E. Flege, Molly Mack, Randall Halter

Faculty Publications

This study evaluated whether age effects on second language (L2) speech learning derive from changes in how the native language (L1) and L2 sound systems interact. According to the “interaction hypothesis” (IH), the older the L2 learner, the less likely the learner is able to establish new vowel categories needed for accurate L2 vowel production and perception because, with age, L1 vowel categories become more likely to perceptually encompass neighboring L2 vowels. These IH predictions were evaluated in two experiments involving 64 native Korean- and English-speaking children and adults. Experiment 1 determined, as predicted, that the Korean children were less …

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Expression Patterns Of Arabidopsis Drg Genes: Promoter-Gus Fusions, Quantitative Rt-Pcr And Patterns Of Protein Accumulation In Response To Environmental Stresses, Joel P. Stafstrom Jan 2008

Expression Patterns Of Arabidopsis Drg Genes: Promoter-Gus Fusions, Quantitative Rt-Pcr And Patterns Of Protein Accumulation In Response To Environmental Stresses, Joel P. Stafstrom

Faculty Articles, Papers, and Other Scholarship

DRGs are very highly conserved GTP-binding proteins. All eukaryotes contain DRG1 and DRG2 orthologs. Arabidopsis has three DRGs: AtDRG1 (At4g39520), AtDRG2 (At1g17470), and AtDRG3 (At1g72660). DRG2 and DRG3 encode proteins that are 95% identical; identity between DRG1 and DRG2/3 is 55%. The focus of this article is expression of Arabidopsis DRGs. DRG1 and DRG2 promoter-GUS constructs showed similar spatial expression in seedlings and mature organs, but gene-specific differences were noted. Quantitative real-time PCR experiments indicated similar levels of DRG1 and DRG2 mRNA accumulation in most tissues. DRG3 transcripts were very low in all tissues. Heat stress at 37 C led …

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Concurrent Cloud-To-Ground Lightning And Precipitation Enhancement In The Atlanta, Georgia (Usa) Urban Region, M.L. Bentley, L.S. Rose, J.A. Stallins Jan 2008

Concurrent Cloud-To-Ground Lightning And Precipitation Enhancement In The Atlanta, Georgia (Usa) Urban Region, M.L. Bentley, L.S. Rose, J.A. Stallins

Faculty Articles, Papers, and Other Scholarship

This study explores how the Atlanta, Georgia (United States), urban region influences warm-season (May through September) cloud-toground lightning flashes and precipitation. Eight years (1995–2003) of flashes from the National Lightning Detection Network and mean accumulated precipitation from the North American Regional Reanalysis model were mapped under seven different wind speed and direction combinations derived from cluster analysis. Overlays of these data affirmed a consistent coupling of lightning and precipitation enhancement around Atlanta. Maxima in precipitation and lightning shifted in response to changes in wind direction. Differences in the patterns of flash metrics (flash counts versus thunderstorm counts), the absence of …

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Fatalities Associated With Nonconvective High-Wind Events In The United States, Walker S. Ashley, A.W. Black Jan 2008

Fatalities Associated With Nonconvective High-Wind Events In The United States, Walker S. Ashley, A.W. Black

Faculty Articles, Papers, and Other Scholarship

A database was compiled for the period 1980–2005 to assess the threat to life in the conterminous United States from nonconvective high-wind events. This study reveals the number of fatalities from these wind storms, their cause, and their unique spatial distributions. While tornadoes continue to cause the most wind-related fatalities per year, nonconvective high winds (defined as phenomena such as downslope and gap winds, gradient winds, dust storms, and winds associated with midlatitude cyclones) have the potential to fatally injure more people than thunderstorm or hurricane winds. Nonconvective wind fatalities occur more frequently in vehicles or while boating. Fatalities are …

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The Impact Of Feedback On Self-Rated Driving Ability Among Older Adults, Michelle Lynn Ackerman Jan 2008

The Impact Of Feedback On Self-Rated Driving Ability Among Older Adults, Michelle Lynn Ackerman

All ETDs from UAB

No abstract provided.

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Systemically Screwing Dads: Out Of Control Paternity Schemes, Jeffrey A. Parness Jan 2008

Systemically Screwing Dads: Out Of Control Paternity Schemes, Jeffrey A. Parness

Faculty Articles, Papers, and Other Scholarship

In 1983 in Lehr v. Robertson, the U.S. Supreme Court recognized that paternity opportunity interests for biological fathers in children born to unwed mothers usually implicate federal constitutional life, liberty or property interests and thus warrant guarantees of fair procedures in adoptions. In 1989 in Michael H. v. Gerald D., the court reiterated that for any such father, there is the unique opportunity to develop a relationship with his offspring, though a similar paternity opportunity may be unavailable where the child is born to a mother married to another. Under Lehr and Michael H., when paternity schemes systematically and unfairly …

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Age Model And Core‐Seismic Integration For The Cenozoic Arctic Coring Expedition Sediments From The Lomonosov Ridge, Jan Backman, Martin Jakobsson, Martin Frank, Francesca Sangiorgi, Henk Brinkhuis, Catherine Stickley, Matthew O'Regan, Reidar Løvlie, Heiko Pälike, David Spofforth, Jérôme Gattacecca, Kate Moran, John W. King, Chip Heil Jan 2008

Age Model And Core‐Seismic Integration For The Cenozoic Arctic Coring Expedition Sediments From The Lomonosov Ridge, Jan Backman, Martin Jakobsson, Martin Frank, Francesca Sangiorgi, Henk Brinkhuis, Catherine Stickley, Matthew O'Regan, Reidar Løvlie, Heiko Pälike, David Spofforth, Jérôme Gattacecca, Kate Moran, John W. King, Chip Heil

Graduate School of Oceanography Faculty Publications

Cenozoic biostratigraphic, cosmogenic isotope, magnetostratigraphic, and cyclostratigraphic data derived from Integrated Ocean Drilling Program Expedition 302, the Arctic Coring Expedition (ACEX), are merged into a coherent age model. This age model has low resolution because of poor core recovery, limited availability of biostratigraphic information, and the complex nature of the magnetostratigraphic record. One 2.2 Ma long hiatus occurs in the late Miocene; another spans 26 Ma (18.2–44.4 Ma). The average sedimentation rate in the recovered Cenozoic sediments is about 15 m/Ma. Core‐seismic correlation links the ACEX sediments to the reflection seismic stratigraphy of line AWI‐91090, on which the ACEX sites …

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Multiracial Tobacco, Alcohol, And Drug Use: An Investigation Of The Function Of Racial Identity In A Longitudinal Sample From Youth To Young Adulthood, Julia Katrina Crumly Jan 2008

Multiracial Tobacco, Alcohol, And Drug Use: An Investigation Of The Function Of Racial Identity In A Longitudinal Sample From Youth To Young Adulthood, Julia Katrina Crumly

All ETDs from UAB

The purpose of the research is threefold. The first purpose is to determine if multiracial individuals are at a higher risk for alcohol, tobacco, and drug use. The second purpose is to determine the relationship between racial identity and risk behaviors. The third purpose is to determine how the change/no change of racial identity longitudinally contributes to one’s risk to engage in risk behaviors. A national representative longitudinal data set was obtained and analyzed for the purpose of this study. Results of the study reveal that there are differences in multiracial groups for risk behaviors, minority identification is not necessarily …

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The Effects Of Maternal Prenatal Insults On The Bmi Growth Trajectory Of Children Between The Ages Of 5-12 Years, Anthony Goudie Jan 2008

The Effects Of Maternal Prenatal Insults On The Bmi Growth Trajectory Of Children Between The Ages Of 5-12 Years, Anthony Goudie

All ETDs from UAB

The level of childhood obesity in the United States is at epidemic proportions. Most population studies looking at the factors contributing to childhood obesity focus on obesity as a dichotomous outcome. The purpose of this study is to test for the effects of maternal prenatal insult behaviors on the growth trajectory of a sample of children 5-12 years of age in the United States. This is the first known study to use a latent growth curve model and a cohort-concurrent analytical design to test the association between maternal prenatal insult behaviors and the annual longitudinal increase in body mass index …

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Gender Difference In Cardiovascular Risk Indicator And Cardiovascular Disease Among Veterans With Ptsd, Elizabeth Frazier Jan 2008

Gender Difference In Cardiovascular Risk Indicator And Cardiovascular Disease Among Veterans With Ptsd, Elizabeth Frazier

All ETDs from UAB

Using the allostatic load model of disease processes, this study investigated gender differences on cardiovascular risk and cardiovascular disease among PTSD and MDD veterans. Cross-sectional analysis of 884 de-identified veteran's data from four VISN7 primary care clinics was completed via ANCOVAs and binary logistic regression analyses. Veterans with PTSD had significantly higher levels of SBP. Among female veterans without PTSD, MDD was associated with increased DBP. Among veterans with neither PTSD nor MDD, male veterans had higher levels of DBP. Veterans without PTSD and men had higher rates of cardiovascular disease. Study results support continued focus on gender differences in …

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Growth Hormone Signaling And Action In Osteoblasts, Douglas J. Digirolamo Jan 2008

Growth Hormone Signaling And Action In Osteoblasts, Douglas J. Digirolamo

All ETDs from UAB

Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) exert profound growth promoting actions during pre- and post-natal skeletal development. GH and IGF- 1 appear to cause these anabolic actions by influencing a variety of effects on osteoblast proliferation, differentiation, and survival. However, because GH stimulates the production of IGF-1 from the liver and other GH-responsive peripheral tissues, including bone, the individual contributions of these two molecules to anabolic responses in bone remains poorly defined. In this dissertation research, I sought to distinguish the direct and indirect (IGF-1 dependent) GH actions on osteoblasts. In the first section of this thesis, I …

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Effects Of Aerobic Exercise On The Asthmatic Lung, Matthew M. Hewitt Jan 2008

Effects Of Aerobic Exercise On The Asthmatic Lung, Matthew M. Hewitt

All ETDs from UAB

Asthma is identified by the clinical symptoms of wheezing, chest tightness, dyspnea and cough, and by the presence of airway hyperresponsiveness (AHR) to inhaled stimuli. We have reported previously that repeated bouts of moderate intensity aerobic exercise attenuate airway inflammatory responses in a mouse model of atopic asthma. Because the effects of exercise on physiological responses are dependent upon several variables, including total exercise duration, the hypothesis of the current work was that differing amounts of moderate intensity aerobic exercise exert dissimilar effects on AHR and airway inflammation. The aims to test this hypothesis included: 1) determine the effect of …

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Molecular Regulation Of Pax5-Mediated Biological Functions, Ti He Jan 2008

Molecular Regulation Of Pax5-Mediated Biological Functions, Ti He

All ETDs from UAB

B lineage cells are major players in the adaptive immune system. Pax5 is essential for B lineage cell development and function. Pax5 controls B lineage cell developmental progression by regulating expression of many B lineage specific genes and the B lineage specific VH to DJH recombination; and the meantime, Pax5 also represses the transcription of lineage- and developmental stage- inappropriate genes to restrict the B lineage developmental pathway. It is not clear how Pax5-mediated function can be regulated to fulfill its role in different biological reactions. In this dissertation, we focused on the study of the molecular regulation of Pax5-mediated …

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Biogenesis, Trafficing, And Function Of Wild-Type And Mutant Cystic Fibrosis Transmembrane Conductance Regulator (Cftr), Asta Jurkuvenaite Jan 2008

Biogenesis, Trafficing, And Function Of Wild-Type And Mutant Cystic Fibrosis Transmembrane Conductance Regulator (Cftr), Asta Jurkuvenaite

All ETDs from UAB

Cystic fibrosis (CF) is a genetic disease resulting from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-activated chloride channel that functions at the apical surface of epithelial cells and plays a critical role in mucociliary clearance. The most common mutation in the CFTR gene involves a deletion of phenylalanine at position 508 in the protein (ΔF508 CFTR). ΔF508 CFTR is recognized as misfolded in the endoplasmic reticulum (ER) and is degraded. In vitro manipulations such as culturing cells at 27°C can “rescue” ΔF508 CFTR to the plasma membrane (rΔF508 CFTR), but no pharmacological agent has produced comparable …

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Wavelet-Based Regression And Classification For Longitudinal Diffusion Tensor Imaging Data, William R. Prucka Jan 2008

Wavelet-Based Regression And Classification For Longitudinal Diffusion Tensor Imaging Data, William R. Prucka

All ETDs from UAB

Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique capable of in vivo characterization of the spatial and angular dependence of free water diffusion in tissue. By studying intra- and extra-cellular water mobility, inference can be made about the surrounding medium. The non-uniform angular dependence of diffusion, known as anisotropy, is evident in fibrous tissues, which exhibit greater diffusion parallel versus perpendicular to the fiber orientation. DTI’s sensitivity to anisotropy makes it an effective tool for measuring the integrity of fibrous myelinated white matter tracts in the brain. For demyelinating diseases such as multiple sclerosis (MS), DTI has …

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The Magnitude Of Repression By Cro Protein In The Presence Of Lambda Operator Variants, Shabnam Sarker Jan 2008

The Magnitude Of Repression By Cro Protein In The Presence Of Lambda Operator Variants, Shabnam Sarker

Honors Theses

Synthetic genetic circuits were constructed to observe the dynamics of repression by the Cro and scCro repressors. Each circuit contained at least one repressor and a reporter gene. Cro repressor is one of two opposite repressors. This artificial switch also had a single-chain cro (scCro) protein that would not have to dimerize like Cro to be fimctional. Such repressors bind operator sites to prevent fiirther transcription fi-om the promoters. The Lac Repressor (LacR) was used to prevent transcription firom Pr. The inducer EPTG was used to remove the Lac Repressor. A reporter gene LacZ is transcribed from Pr. The protein …

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Institutionalized Islam: A Study Of The Union Des Organisations Islamiques De France, Andrus Gareth Ashoo Jan 2008

Institutionalized Islam: A Study Of The Union Des Organisations Islamiques De France, Andrus Gareth Ashoo

Honors Theses

This paper examines the role of Islamic religious authority in France as it pertains to the possibilities and limitations of Muslims becoming French. Such religious authority has emerged in the form of an institutionalized Islam promoted by both the Muslim community and the French government. One of the major federations, the Union des organisations islamiques de France (UOIF), was used as a case study. Primary data was collected from the websites of the UOIF and of affiliated organizations, pamphlets, and newsletters for the Rencontre annuelle des musulmans de France (RAMF). The nature of the data collected centered on the UOIF's …

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The Role Of Ddx3 In Regulating Apoptosis, P53 And Snail, Mianen Sun Jan 2008

The Role Of Ddx3 In Regulating Apoptosis, P53 And Snail, Mianen Sun

All ETDs from UAB

Cancer is a common disease that causes high rates of lethality. Resistance to cancer therapy is one major obstacle for producing an effective cancer treatment. Clarifying mechanisms of cancer development, such as resistance to apoptosis and metastasis, can provide important information for developing effective cancer treatment strategies. In the present study, DDX3 was demonstrated to have effects on both responses to cancer treatment and cancer development. DDX3 together with glycogen synthase kinase-3 (GSK-3) was found to impede death receptor-induced apoptosis, which is important because death receptors are activated by some cancer treatments. Additionally, DDX3 was shown to regulate two proteins …

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An Examination Of Mental Health Factors Related To Risk -Taking Behaviors In Children And Adolescents., Sarah B. Stevens Jan 2008

An Examination Of Mental Health Factors Related To Risk -Taking Behaviors In Children And Adolescents., Sarah B. Stevens

Graduate Theses, Dissertations, and Problem Reports (ETD)

Children and adolescents within the child welfare system are at risk for developing significant mental health problems, due in large part to the chaotic environments in which they live. In many cases, these youth are removed from their family of origin and placed in out-of-home or “foster” care. Many times these children and adolescents endured repeated placements and transitions, which make them vulnerable to problems in the future, particularly by engaging in risky behaviors that may increase the likelihood that they return to the system as parents themselves. This study investigated the impact of anxiety and depression on sexual activity …

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An Evaluation Of The Non-Target Effects Of Mosquito Control Pesticides On Uca Pugnax Physiology, Limb Regeneration And Molting Processes., Todd A. Stueckle Jan 2008

An Evaluation Of The Non-Target Effects Of Mosquito Control Pesticides On Uca Pugnax Physiology, Limb Regeneration And Molting Processes., Todd A. Stueckle

Graduate Theses, Dissertations, and Problem Reports (ETD)

Coastal and estuarine organisms face increasing multiple challenges unique to their environment which include natural and anthropogenic stressors that threaten their physiology, fitness, and population persistence. Synthetic pyrethroid and insect growth regulator pesticide use for agriculture, urban and municipal pest control are of increasing concern in coastal areas as other pesticide groups come under strict regulations and that they possess the potential to significantly impact aquatic resources. My research focuses on how current insecticide release in or near coastal marsh environments alter the physiology, limb regeneration and molting ability of a crustacean indicator species, Uca pugnax, in the intertidal and …

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The Impact Of Traumatic Stress And Alcohol Exposure On Youth: Implications For Lawyers, Judges, And Courts, Frank E. Vandervort Jan 2008

The Impact Of Traumatic Stress And Alcohol Exposure On Youth: Implications For Lawyers, Judges, And Courts, Frank E. Vandervort

Articles

Since its inception in the late nineteenth century, the juvenile court has been concerned with the legal problems of children and their families. From the court’s earliest days, it has sought to address child abuse and neglect and juvenile delinquency as social problems that result from familial and community breakdown. Over the decades, researchers from various disciplines have provided varying explanations of how and why family systems break down, why some parents fail to nurture their children, why some physically or sexually abuse their children, and why some children become delinquent.

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Integrating Community, Education, And Global Sustainability: The Vash Recycling Model., Tracy A. Vash Jan 2008

Integrating Community, Education, And Global Sustainability: The Vash Recycling Model., Tracy A. Vash

Graduate Theses, Dissertations, and Problem Reports (ETD)

Action research engages researchers and communities in iterative, reflective inquiry to address issues and solve problems with the support of data analysis. The study was structured by and analyzed using the prototype Vash Recycling Model (VRM). For three years, January 2005 through December 2007, this study engaged textiles, apparel, and merchandising students at West Virginia University in collaboration with The Mission, a homeless shelter in Clarksburg, in a joint recycling project. The VRM, found to be an effective guide in textiles and apparel recycling, assisted environmental sustainability, and in 2007 eliminated 679,271 pounds of waste from the landfill while generating …

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Stepping Over Obstacles Of Different Heights And Varied Shoe Traction Alter The Kinetic Strategies Of The Leading Limb, Jeremy J. Houser, Leslie M. Decker, Nikolaos Stergiou Jan 2008

Stepping Over Obstacles Of Different Heights And Varied Shoe Traction Alter The Kinetic Strategies Of The Leading Limb, Jeremy J. Houser, Leslie M. Decker, Nikolaos Stergiou

Journal Articles

This study aims to investigate the effects of shoe traction and obstacle height on friction during walking to better understand the mechanisms required to avoid slippage following obstacle clearance. Ten male subjects walked at a self-selected pace during eight different conditions: four obstacle heights (0%, 10%, 20%, and 40% of limb length) while wearing two different pairs of shoes (low and high traction). Frictional forces were calculated from the ground reaction forces following obstacle clearance, which were sampled with a Kistler platform at 960 Hz. All frictional peaks increased with increases in obstacle height. Low traction shoes yielded smaller peaks …

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Multifactor Effects And Evidence Of Potential Interaction Between Complement Factor H Y402h And Loc387715 A69s In Age-Related Macular Degeneration, Sanna P. Seitsonen, Päivi Onkamo, Gang Peng, Momiao Xiong, Petri V. Tommila, Päivi H. Ranta, Juha M. Holopainen, Jukka A. Moilanen, Tapani Palosaari, Kai Kaarniranta, Seppo Meri, Ilkka R. Immonen, Irma E. Järvelä Jan 2008

Multifactor Effects And Evidence Of Potential Interaction Between Complement Factor H Y402h And Loc387715 A69s In Age-Related Macular Degeneration, Sanna P. Seitsonen, Päivi Onkamo, Gang Peng, Momiao Xiong, Petri V. Tommila, Päivi H. Ranta, Juha M. Holopainen, Jukka A. Moilanen, Tapani Palosaari, Kai Kaarniranta, Seppo Meri, Ilkka R. Immonen, Irma E. Järvelä

Faculty, Staff and Student Publications

BACKGROUND: Variants in the complement cascade genes and the LOC387715/HTRA1, have been widely reported to associate with age-related macular degeneration (AMD), the most common cause of visual impairment in industrialized countries. METHODS/PRINCIPAL FINDINGS: We investigated the association between the LOC387715 A69S and complement component C3 R102G risk alleles in the Finnish case-control material and found a significant association with both variants (OR 2.98, p = 3.75 x 10(-9); non-AMD controls and OR 2.79, p = 2.78 x 10(-19), blood donor controls and OR 1.83, p = 0.008; non-AMD controls and OR 1.39, p = 0.039; blood donor controls), respectively. Previously, …

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Faculty Publications 2007, Lsu Health Sciences Center New Orleans Jan 2008

Faculty Publications 2007, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 623 publications.

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What Comes Next, Mario Podeschi Jan 2008

What Comes Next, Mario Podeschi

Masters Theses

A narrator named Mario Podeschi watches a character named Mario Podeschi be sent back in time from graduate school to his freshman year of high school. A twenty-four year old in a fifteen year-old body, the Mario character retains aH of his old memories leading up to Spring of2008 and tries to use them to his own benefit at his small town Illinois high school. Fifteen year-old Mario readdicts himself to cigarettes, chases high school crushes, and distances himself from his old friends. Not that his second chance at high school is a complete failure~he finds his soulmate in Saturday …

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Cutting Back The Mask: Character And Coiffure In Fiction By F. Scott Fitzgerald, Ernest Hemingway, And Robert Penn Warren, Lisa Anne Powell Jan 2008

Cutting Back The Mask: Character And Coiffure In Fiction By F. Scott Fitzgerald, Ernest Hemingway, And Robert Penn Warren, Lisa Anne Powell

Masters Theses

Realistic fiction has recorded changing fashions of architecture and landscape, clothing and coiffure. For at least three centuries, writers of narrative have described the clothing and the hairstyles of their fictional women both to set them within a specific time ar place and to offer a key to their character. Hair as natural endowment and artificial adornment has served as an essential component to the character costume. Novelists have understood that women send messages, albeit sometimes unconscious ones, about themselves, their lives, and their feelings through the style, color and length of their hair. Writers have sometimes described women's hair …

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Educated Mothers At Home: Motivation, Expectations, And Experiences, Adrienne Lynn Riegle Jan 2008

Educated Mothers At Home: Motivation, Expectations, And Experiences, Adrienne Lynn Riegle

Masters Theses

This studuy explored the motivation for educated stay-at-home mothers (SAHНMs) to stay at home with their children and examined expectations and experiences regarding their decision. Twenty-two participants earned the minimum of a bachelor's degree or higher prior to staying at home with their own children for a period of at least 1 year and responded to an online survey of demographic information and open-ended questions. Qualitative data analysis led to a theoretical model of the SAHM experience. The model included 3 specific concepts: 1) individual interests as motivation; 2) commitment to and identity associated with the SAHM; and 3) the …

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Synthesis Of Bowl-Shaped Polycyclic Aromatic Compounds And Homo-Bi-Dentate 4,5-Diarylphenanthrene Ligands, Daehwan Kim Jan 2008

Synthesis Of Bowl-Shaped Polycyclic Aromatic Compounds And Homo-Bi-Dentate 4,5-Diarylphenanthrene Ligands, Daehwan Kim

Graduate Theses, Dissertations, and Problem Reports (ETD)

A new synthetic pathway leading to buckybowls was developed via cascade cyclization reactions of benzannulated enyne-allenes. The convergent assembly of the benzannulated enediynyl propargylic alcohols and the efficient cascade cyclizations of the resulting enyne-allenes leading to polycyclic aromatic dibromides for subsequent palladium-catalyzed intramolecular arylation reactions are the key features of this synthetic pathway. Three new buckybowls with their structures confirmed by X-ray structure analyses were thus synthesized.;Polycyclic aromatic hydrocarbon bearing ten fused ring system was successfully synthesized by using diindeno-fused 4H-cyclopenta[ def]phenanthrene prepared from the thionyl chloride-induced cascade cyclization reactions of the corresponding enediynyl propargylic alcohols. Direct tandem Knoevenagel condensation …

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Palladium-Catalyzed Syntheses Of Indoles, Pyrroloindoles, Quinolines; A Base-Mediated Formation Of N-Alkoxyindoles, And Progress Toward The First Total Synthesis Of Echinosulfone A., Serge R. Banini Jan 2008

Palladium-Catalyzed Syntheses Of Indoles, Pyrroloindoles, Quinolines; A Base-Mediated Formation Of N-Alkoxyindoles, And Progress Toward The First Total Synthesis Of Echinosulfone A., Serge R. Banini

Graduate Theses, Dissertations, and Problem Reports (ETD)

A variety of heterocyclic compounds including indoles, quinolines, and pyrroloindoles has been synthesized. The key step in these alkaloids' syntheses is a palladium-catalyzed reductive N-heteroannulation previously discovered in our laboratory. The ultimate reducing agent in these palladium-catalyzed cyclizations is carbon monoxide. Furthermore, a base-mediated formation of 2-unsubstituted N-alkoxyindoles is described from readily available nitrostyrenes. Finally, progress towards the first total synthesis of the highly bioactive Echinosulfone A is reported.

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