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2008

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Population Status, Hunting Regulations, And Harvests Of The Rocky Mountain Population Of Greater Sandhill Cranes, 1981–2005, Kammie L. Kruse, David E. Sharp, James A. Dubovsky Jan 2008

Population Status, Hunting Regulations, And Harvests Of The Rocky Mountain Population Of Greater Sandhill Cranes, 1981–2005, Kammie L. Kruse, David E. Sharp, James A. Dubovsky

Proceedings of the North American Crane Workshop

The Rocky Mountain Population (RMP) of greater sandhill cranes (Grus canadensis tabida) was not hunted in the U.S. from 1916 until 1981, when Arizona initiated the first modern-day season. Hunting programs in the U.S. were subsequently expanded to 6 states for the RMP and have been guided by a cooperative flyway management plan, including a harvest strategy, which has been periodically updated and endorsed by the Central and Pacific Flyway Councils. From a management perspective, 3 population parameters have been identified to monitor the status and health of this population: harvest, recruitment, and population size. The number of …

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Serological Survey For Infectious Bursal Disease Virus Exposure In Captive Cranes, Barry K. Hartup, Holly S. Sellers Jan 2008

Serological Survey For Infectious Bursal Disease Virus Exposure In Captive Cranes, Barry K. Hartup, Holly S. Sellers

Proceedings of the North American Crane Workshop

Between September 2001 and March 2002, unusually high morbidity and mortality was observed during releases of endangered, captive-reared whooping cranes (Grus americana) in central Florida. An ongoing epidemiological investigation has implicated infectious bursal disease virus (IBDV; Family Birnaviridae) as the likely etiological agent (Spalding et al. 2008). The source of this virus remains unknown. A previous serological survey showed positive antibody titers to IBDV serotype 2 were present in small numbers of juvenile and adult whooping cranes at the International Crane Foundation (ICF), Baraboo, Wisconsin and the Patuxent Wildlife Research Center, Laurel, Maryland between 1995 and 2003 (Hartup et al. …

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Do We Need Such Rare Birds?, Stephen A. Nesbitt Jan 2008

Do We Need Such Rare Birds?, Stephen A. Nesbitt

Proceedings of the North American Crane Workshop

Gruidae is one of the oldest bird families; the genus Grus dates back at least 9 million years. Though they may have been around a long time, it is unlikely that cranes were ever among the most abundant of birds. Several of the 15 crane species occur today in such low numbers that they are considered in danger of becoming extinct. It has been posited that at the time of European colonization of North America whooping cranes may have numbered 10,000 individuals, so whooping cranes have likely always been rare birds. Rare has often been used as a synonym for …

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Winter Habitat Selection By A Reintroduced Population Of Migratory Whooping Cranes: Emerging Patterns And Implications For The Future, Lara E. A. Fondow Jan 2008

Winter Habitat Selection By A Reintroduced Population Of Migratory Whooping Cranes: Emerging Patterns And Implications For The Future, Lara E. A. Fondow

Proceedings of the North American Crane Workshop

In an effort to model the reintroduced eastern migratory population of whooping cranes (Grus americana) after the remaining wild whooping crane population, biologists selected the salt marshes of Chassahowitzka National Wildlife Refuge (NWR), Florida as the winter release site for ultra-light led juvenile cranes due to its similarities to Aransas NWR, Texas. Releases began in the fall of 2001, and the 3 subsequent winter seasons have afforded the opportunity to observe whether habitat selection by these whooping cranes would be influenced by the pre-selection of salt marsh. Intensive monitoring efforts each winter have revealed a dominant early-winter pattern. …

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Surveillance For West Nile Virus At The International Crane Foundation 2000–2004, Barry K. Hartup Jan 2008

Surveillance For West Nile Virus At The International Crane Foundation 2000–2004, Barry K. Hartup

Proceedings of the North American Crane Workshop

Between 2000 and 2004, serum samples collected annually from captive cranes at the International Crane Foundation (ICF) were analyzed for the presence of West Nile virus (WNV) antibodies using a plaque reduction neutralization test. Eighteen individual cranes representing 8 species were identified with positive titers (geometric mean = 188, range 40 – 1280, n = 29). Whooping cranes (Grus americana) represented the largest proportion of seropositive individuals (33%). Flock seroprevalence increased rapidly in 2003 and 2004 to a peak of 10%, representing a four-fold increase following index cases in 2000. None of the seropositive cranes, however, showed clinical signs consistent …

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Current Status Of Nonmigratory Whooping Cranes In Florida, Martin J. Folk, Stephen A. Nesbitt, Jeannette M. Parker, Marilyn G. Spalding, Stephen B. Baynes, Kristen L. Candelora Jan 2008

Current Status Of Nonmigratory Whooping Cranes In Florida, Martin J. Folk, Stephen A. Nesbitt, Jeannette M. Parker, Marilyn G. Spalding, Stephen B. Baynes, Kristen L. Candelora

Proceedings of the North American Crane Workshop

Two hundred eighty-nine nonmigratory whooping cranes (Grus americana) were released in Central Florida from 1993-2005. As of January 2006, we had monitored 50 birds (16 pairs) but suspect 10 others had also survived, for a population estimate of 60 birds. The sex ratio for monitored birds was 1:1. From 47 nest attempts (1999-2005), only 4 chicks have fledged and survived to independence. Efforts are underway to determine why recruitment has been lower than expected. Other challenges for the project have included birds colliding with power lines, dispersing beyond their normal range (beyond Florida), forming pair bonds with Florida sandhill cranes …

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Is The Annual March Survey Of The Midcontinental Sandhill Crane Population Appropriately Timed To Reliably Estimate Population Size?, Gary L. Krapu, David A. Brandt Jan 2008

Is The Annual March Survey Of The Midcontinental Sandhill Crane Population Appropriately Timed To Reliably Estimate Population Size?, Gary L. Krapu, David A. Brandt

Proceedings of the North American Crane Workshop

The U.S. Fish and Wildlife Service relies on an annual aerial photo-corrected survey conducted on the fourth Tuesday of March each year in the Central Platte River Valley (CPRV) and North Platte River Valley (NPRV) of Nebraska to estimate size of the midcontinental population (MCP) of sandhill cranes (Grus canadensis) to help guide population management. Wide unaccounted for annual fluctuations in survey counts over the past 25 years have raised concerns that many cranes either have left the Platte before the survey, have not yet arrived, or over fly the Platte entirely in some years. As a result, …

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Survival And Sources Of Mortality In Florida Sandhill Crane Chicks: Hatching To Fledging, Stephen A. Nesbitt, Stephen T. Schwikert, Marilyn G. Spalding Jan 2008

Survival And Sources Of Mortality In Florida Sandhill Crane Chicks: Hatching To Fledging, Stephen A. Nesbitt, Stephen T. Schwikert, Marilyn G. Spalding

Proceedings of the North American Crane Workshop

Forty-five pairs of Florida sandhill cranes (Grus canadensis pratensis) were monitored during the nesting seasons from 1996 through 1999. Thirty-eight chicks were produced from 25 successful nests. Twenty-one of these survived to fledging age. Predation was the source of most (81%) of the mortality for which a cause was determined. Mammals were the primary predator. Average age at time of mortality was 27.2 days for the 17 chicks lost.

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Interaction Of Young Florida Sandhill Cranes With Their Parents, Stephen A. Nesbitt, Paul S. Kubilis, Stephen T. Schwikert Jan 2008

Interaction Of Young Florida Sandhill Cranes With Their Parents, Stephen A. Nesbitt, Paul S. Kubilis, Stephen T. Schwikert

Proceedings of the North American Crane Workshop

We studied the interactions of 46 Florida sandhill crane (Grus canadensis pratensis) chicks and their parents from hatching until the chicks left the family group. Our goal was to see if young remained closer to one parent than the other and if the distance between a chick and its parents increased as the young approached the age of independence. Using a population of individually marked adult pairs, we ranked the distance to and gender of the nearest parent during 233 30-minute observation periods. Between hatching and 180 days of age, chicks showed a greater tendency to be nearer …

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Infectious Bursal Disease In Wild Populations Of Turkeys And Sandhill Cranes: Preliminary Findings, Kristen L. Candelora, Marilyn G. Spalding, Stephen A. Nesbitt, Holly S. Sellers, Jeremy Olson, Larry Perrin, Jeannette Parker Jan 2008

Infectious Bursal Disease In Wild Populations Of Turkeys And Sandhill Cranes: Preliminary Findings, Kristen L. Candelora, Marilyn G. Spalding, Stephen A. Nesbitt, Holly S. Sellers, Jeremy Olson, Larry Perrin, Jeannette Parker

Proceedings of the North American Crane Workshop

Captive-reared whooping cranes (Grus americana) released into Florida for the resident reintroduction project experienced unusually high mortality and morbidity during the 1997-1998 and 2001-2002 release seasons (Spalding et al. 2008). Infectious bursal disease virus (IBDV) serotype 2 is currently under investigation as the factor that precipitated the mortality events. A small percentage of whooping cranes have been exposed to IBDV in the captive setting. However, many more are being exposed postrelease, and prevalence of exposure seems to increase with age or length of time the birds are in the wild in Florida (Spalding et al. 2008). The goals …

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Reduction Of Crop Depredations By Cranes At Daursky State Biosphere Reserve, Siberia, Oleg A. Goroshko, John E. Cornely, Stephen H. Bouffard Jan 2008

Reduction Of Crop Depredations By Cranes At Daursky State Biosphere Reserve, Siberia, Oleg A. Goroshko, John E. Cornely, Stephen H. Bouffard

Proceedings of the North American Crane Workshop

The Daursky State Biosphere Reserve (SBR) in southern Siberia includes the Torey Lakes, the largest lakes in the Trans-Baikal region. The Torey Lakes support tens of thousands of breeding waterbirds and about a million waterbirds during migration. Peak numbers of birds staging during fall coincide with grain harvest. Crop fields around the Torey Lakes attract 50,000 to 70,000 waterbirds, primarily cranes with lesser numbers of waterfowl, causing significant crop damage in fields near Daursky SBR. Investigations of the problem have been ongoing since 1992. Field consultation by Cornely and Bouffard in 2001 resulted in recommendations to reduce depredations. The consultation …

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Reproductive Health Of The Florida Flock Of Introduced Whooping Cranes, Marilyn G. Spalding, Martin J. Folk, Stephen A. Nesbitt Jan 2008

Reproductive Health Of The Florida Flock Of Introduced Whooping Cranes, Marilyn G. Spalding, Martin J. Folk, Stephen A. Nesbitt

Proceedings of the North American Crane Workshop

We examined the reproductive parameters of the introduced non-migratory flock of whooping cranes in Florida. Of 289 cranes introduced, 67 males and 65 females survived at least 3 years. The first behavioral pairs appeared in 1995, and eggs were first laid in 1999. In total, eggs were laid in 47 nests, 17 chicks hatched, and 4 young fledged by 2005. Severe drought conditions through 2001 were thought to be the reason for low reproductive nest success. In 2003 nesting conditions improved and 71% of nests with eggs, hatched chicks. During the next 2 years, with continued wet conditions, the proportion …

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Distribution And Dispersion Patterns Of Sandhill Crane Flocks In The Platte River Valley, Brian Lorenz, Felipe Chavez-Ramirez Jan 2008

Distribution And Dispersion Patterns Of Sandhill Crane Flocks In The Platte River Valley, Brian Lorenz, Felipe Chavez-Ramirez

Proceedings of the North American Crane Workshop

We evaluated sandhill crane (Grus canadensis) flock distribution and dispersion patterns along the Platte River Valley, Nebraska, in 2002-2003. The objectives were to: (a) determine the overall distribution and relationship between roosting and foraging flock numbers by bridge segments, (b) evaluate flocking characteristics in relation to abundance of cranes in different bridge segments and total abundance, and (c) correlate dispersion patterns and habitat use to period of migration, roost locations, and habitat types. Preliminary predictions included: foraging flock dispersions would be correlated with roost locations; greater numbers and larger flock sizes will be present in bridge segments with …

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Responses Of Nesting Sandhill Cranes To Research Activities And Effects On Nest Survival, Jane E. Austin, Deborah A. Buhl Jan 2008

Responses Of Nesting Sandhill Cranes To Research Activities And Effects On Nest Survival, Jane E. Austin, Deborah A. Buhl

Proceedings of the North American Crane Workshop

We examined the response of nesting greater sandhill cranes (Grus canadensis tabida) to research-related activities at Grays Lake, Idaho, during 1997–2000. Data were collected on >500 crane nests from 53 fields that were exposed to variable levels of research activity, from fields subjected to only periodic searches for and monitoring of crane nests (crane-only fields) to fields subjected to periodic searches for and monitoring of all waterbird nests as well as breeding bird surveys, nocturnal amphibian surveys, and other research-related activities (multi-use fields). For each nest, we calculated the visit rate to the field during the period the …

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Whooping Cranes And Human Disturbance: An Historical Perspective And Literature Review, Thomas E. Lewis, R. Douglas Slack Jan 2008

Whooping Cranes And Human Disturbance: An Historical Perspective And Literature Review, Thomas E. Lewis, R. Douglas Slack

Proceedings of the North American Crane Workshop

Whooping cranes (Grus americana) generally are not tolerant of human disturbance. Much anecdotal evidence in the literature and recent studies has shown that human disturbances cause aversive behavior in whooping cranes. Herein, we review and summarize the long history of acceptance by researchers and managers that human disturbance impacts whooping cranes and support actions to minimize human disturbance to this critically endangered species.

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Spring Migratory Habits And Breeding Distribution Of Lesser Sandhill Cranes That Winter In West-Central New Mexico And Arizona, Gary L. Krapu, David A. Brandt Jan 2008

Spring Migratory Habits And Breeding Distribution Of Lesser Sandhill Cranes That Winter In West-Central New Mexico And Arizona, Gary L. Krapu, David A. Brandt

Proceedings of the North American Crane Workshop

Little information exists on the spring migratory habits and breeding distribution of lesser sandhill cranes (Grus canadensis canadensis) that winter in west-central New Mexico and southeastern Arizona. To address this question, we captured and attached a total of 6 Platform Transmitting Terminals (PTT) to adult lesser sandhill cranes at 2 sites each in west-central New Mexico and southeastern Arizona during December 2001 and monitored the birds’ movements to arrival on their arctic breeding grounds. After departing from their wintering grounds, 2 of the cranes stopped at Monte Vista NWR in south-central Colorado where they stayed for 17 and …

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Egg Breakage By Captive Cranes At The International Crane Foundation, Stacy Puchta, Michael S. Putnam, Kelly Maguire Jan 2008

Egg Breakage By Captive Cranes At The International Crane Foundation, Stacy Puchta, Michael S. Putnam, Kelly Maguire

Proceedings of the North American Crane Workshop

Captive cranes can break eggs through deliberate destruction, clumsy parental behavior, or accidentally because of thin shells. We report on the frequency of egg breakage by pairs of captive cranes at the International Crane Foundation (ICF). Among the 15 species of cranes and 1 hybrid female, all except a grey-crowned crane (Balearica regulorum) have broken eggs at ICF. Some pairs broke 1/3 or more of their eggs despite efforts by aviculturists to retrieve them before breakage. We compared the proportion of broken eggs among 7 species where we have data from >5 individual females and more than 150 eggs …

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West Nile Encephalitis In A Captive Florida Sandhill Crane, Cristina M. Hansen, Barry K. Hartup, Olga D. Gonzalez, Douglas E. Lyman, Howard Steinberg Jan 2008

West Nile Encephalitis In A Captive Florida Sandhill Crane, Cristina M. Hansen, Barry K. Hartup, Olga D. Gonzalez, Douglas E. Lyman, Howard Steinberg

Proceedings of the North American Crane Workshop

A 37 year old captive male Florida sandhill crane (Grus canadensis pratensis) housed at the International Crane Foundation exhibited abnormal neurologic signs in the fall of 2006. Despite therapy and supportive care, the neurologic signs worsened and the crane was euthanized after 6 days. Antemortem and postmortem serum was positive for flavivirus antibody, and a cloacal swab was positive for West Nile virus (WNV) by reverse transcriptase polymerase chain reaction (RT-PCR). Pectoral muscle atrophy and multifocal myocardial necrosis were observed at necropsy. Histopathologic findings included inflammatory and necrotic lesions in sections of brain, spinal cord, eye, heart, blood …

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Survival, Movements, Social Structure, And Reproductive Behavior During Development Of A Population Of Reintroduced, Migratory Whooping Cranes, Richard P. Urbanek, Lara E. A. Fondow Jan 2008

Survival, Movements, Social Structure, And Reproductive Behavior During Development Of A Population Of Reintroduced, Migratory Whooping Cranes, Richard P. Urbanek, Lara E. A. Fondow

Proceedings of the North American Crane Workshop

An effort to reintroduce a migratory population of whooping cranes (Grus americana) into eastern North America began in 2001. During 2001-2004, 53 juveniles were released. All chicks were hatched at Patuxent Wildlife Research Center, Maryland, and transferred to Necedah National Wildlife Refuge (NWR), Wisconsin. Chicks were costume/isolation-reared and, with few exceptions, trained to follow ultralight aircraft, which led them to Chassahowitzka NWR, Central Gulf Coast of Florida. All individuals successfully returned to Central Wisconsin during their first spring migration except for the following: 5 individuals that were unable to navigate around Lake Michigan after taking an easterly migration …

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Common Crane Management In Germany: Monitoring, Protection, And Scientific Work, Hartwig Prange Jan 2008

Common Crane Management In Germany: Monitoring, Protection, And Scientific Work, Hartwig Prange

Proceedings of the North American Crane Workshop

About 200,000 common cranes (Grus grus) from northern, middle, and northeastern parts of Europe are migrating on the West-European route. In the northeast part of Germany 160,000 cranes stop over simultaneously during migration. This number has increased since the early 1980´s by 3-fold. About 60 sites with from 200 to 50,000 cranes are systematically observed from August to December by local expert groups. The overnight roosts are in ponds, swamps, and lakes, actively flooded meadows, and brown coal mines as well as in shallow backwaters of the Baltic Sea. They have been used year after year. More than …

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A Landscape Perspective Of Whooping Crane Migration Through Nebraska: Conservation And Management Implications, Felipe Chavez-Ramirez, Chris Helzer, Paul Tebbel Jan 2008

A Landscape Perspective Of Whooping Crane Migration Through Nebraska: Conservation And Management Implications, Felipe Chavez-Ramirez, Chris Helzer, Paul Tebbel

Proceedings of the North American Crane Workshop

Past and current discussions of conservation of whooping crane (Grus americana) stopover habitat in Nebraska have long been focused on the Platte River. We evaluated the distribution of whooping crane stopover sites in Nebraska in a broader context to (a) determine the distribution of whooping crane stopover sites on the Platte River relative to other landscapes and (b) use whooping migratory behavior data to systematically define and explain patterns of stopover clusters. The distribution of stopover clusters suggests rainwater basin wetlands and the Platte River may be used interchangeably by migrating whooping cranes. The Rainwater Basin and Platte River appear …

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Mississippi Sandhill Crane Conservation Update, 2003–2005, Scott G. Hereford, Tracy E. Grazia Jan 2008

Mississippi Sandhill Crane Conservation Update, 2003–2005, Scott G. Hereford, Tracy E. Grazia

Proceedings of the North American Crane Workshop

The Mississippi sandhill crane (Grus canadensis pulla) is an endangered non-migratory subspecies found on and near the Mississippi Sandhill Crane National Wildlife Refuge in southeastern Mississippi. From 2003 to 2005, conservation efforts for the recovery of this population included management activities such as protection and law enforcement, restocking, predator management, farming, prescribed burning, mechanical vegetation removal, hydrological restoration, pest plant management, and education. To maintain open savanna, 1842 hectares were burned annually, with 38% during the growing season. To restore open savanna, 506 hectares of woody vegetation were removed using mechanical methods. To bolster the population, we released 17-25 captive-reared …

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Characterization Of Changes In Hyaluronan Following Epidermal Barrier Injury In An Organotypic Model, Gati Ajani Jan 2008

Characterization Of Changes In Hyaluronan Following Epidermal Barrier Injury In An Organotypic Model, Gati Ajani

ETD Archive

The stratum corneum, the outermost layer of the epidermis of skin, provides a functional permeability barrier that is essential for our survival and must be rapidly repaired after injury. Of interest to us, a ubiquitous matrix molecule called hyaluronan (HA) has come to the forefront in wound healing research because it is induced after epidermal injury and may be crucial for barrier repair. This thesis examines the role of HA during recovery from the most fundamental form of skin injury, i.e. selective damage to the stratum corneum. The overall question is whether this form of stratum corneum injury can lead …

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Policy Administration And Political Rights;The Experiences Of High-Level Women In The Kuwaiti Government, Hani A. Alsarraf Jan 2008

Policy Administration And Political Rights;The Experiences Of High-Level Women In The Kuwaiti Government, Hani A. Alsarraf

ETD Archive

Women in Kuwait were traditionally excluded from the formulation of public policy because they lacked political rights. In mid 2005, women received the right to vote and to run for office. There is little known today about the influence of these political rights on women who work with the implementation of public policies in the higher administrative levels of government. Little is known specifically about the influence of the franchise on promotion of women to high administrative posts. The purpose of this study is to lay a foundation for research on the factors that encourage women's access to high positions …

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Mass Spectrometric Analysis Of Environmental Contaminants, Protein Structure And Expression, Ian E. Atkinson Jan 2008

Mass Spectrometric Analysis Of Environmental Contaminants, Protein Structure And Expression, Ian E. Atkinson

ETD Archive

There are a wide array of sciences at our disposal to further our understanding of the roles of toxins in the environment and their effects on living organisms. Of these disciplines, the field of mass spectrometry offers a powerful analytical means to identify compounds in varying and complex sample media. The presence of altered expressions of biomolecules upon exposure to toxins, the effects that these toxins may have on biomolecule structure and the identity of toxins in the sample all can be determined by mass spectrometry. In this study mass spectrometric analysis has been applied to environmental toxicological problems. First, …

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A Retrospective Study Between The Relationships Of Gender, Age Of Onset, And Frequency Of Problematic Behaviors In Early Onset Bipolar Disorder, Miriam Mimi Becker Jan 2008

A Retrospective Study Between The Relationships Of Gender, Age Of Onset, And Frequency Of Problematic Behaviors In Early Onset Bipolar Disorder, Miriam Mimi Becker

ETD Archive

This retrospective study examined adult individuals between 18-40 years of age who self-reported or were formally diagnosed with a bipolar disorder during their adolescent years. This study examined the relationship between gender, age-of-onset of bipolar disorder, and problematic behaviors in the early-onset bipolar disordered population. The relationship between satisfaction with treatment and the perception of quality of treatment received during adolescence were also examined. T-tests and another statistical test were conducted with the two independent variables and the dependent variables comprising the frequency of problematic behaviors. Significance was found between the younger the age-of-onset of bipolar disorder and high-risk behaviors, …

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The Impact Of Data Imputation Methodologies On Knowledge Discovery, Marvin Lane Brown Jan 2008

The Impact Of Data Imputation Methodologies On Knowledge Discovery, Marvin Lane Brown

ETD Archive

The purpose of this research is to investigate the impact of Data Imputation Methodologies that are employed when a specific Data Mining algorithm is utilized within a KDD (Knowledge Discovery in Databases) process. This study will employ certain Knowledge Discovery processes that are widely accepted in both the academic and commercial worlds. Several Knowledge Discovery models will be developed utilizing secondary data containing known correct values. Tests will be conducted on the secondary data both before and after storing data instances with known results and then identifying imprecise data values. One of the integral stages in the accomplishment of successful …

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Factor Va Directs Catalysis By Factor Xa During Prothrombin Activation, Michael Anthony Bukys Jan 2008

Factor Va Directs Catalysis By Factor Xa During Prothrombin Activation, Michael Anthony Bukys

ETD Archive

Hemostasis occurs through the controlled activation and inactivation of clotting factors resulting in the arrest of bleeding without blockage to the vasculature, while thrombosis is the undesired formation of vascular blood clots, which adversely affects millions of people annually. Clotting factors circulate in blood as inactive zymogens, which are proteolytically activated in response to vascular injury, assembled into enzymatic complexes and in turn activate additional coagulation factors culminating in the production of thrombin from the enzymatic complex prothrombinase. The prothrombinase complex is composed of the activated enzymatic component factor Xa (fXa) complexed to the activated cofactor portion factor Va (fVa) …

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Novel Antifreeze Protein Constructs For Improved Activity, Ozge Can Jan 2008

Novel Antifreeze Protein Constructs For Improved Activity, Ozge Can

ETD Archive

Many organisms are exposed to subzero temperatures in nature and can survive these temperatures by the effect of antifreeze proteins (AFPs), which inhibit ice crystal growth and change the morphology of ice crystals. Although the effects of these proteins, such as recrystallization inhibition, ice growth inhibition, and crystal habit changes, are known, a conclusive description of the protein-ice crystal interaction including interaction energy, surface coverage, and lifetime of adsorbate has been elusive. In this study, different antifreeze protein constructs are designed and expressed such that they can be conjugated to polymers to increase the thermal hysteresis activity especially at low …

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A Case In Kinase 2 Inhibitor Is A Potent Anti-Cancer Drug Candidate, Alieta Ciocea Jan 2008

A Case In Kinase 2 Inhibitor Is A Potent Anti-Cancer Drug Candidate, Alieta Ciocea

ETD Archive

Cancer is so widespread and lethal that it can be considered the biggest health problem of our century. Cancer drug development is a real challenge. Efforts outlined in this work were directed towards showing solid evidence that casein kinase 2 inhibitors can be used as a starting point for the development of potential cancer therapy. We first studied the effect of a specific CK2 inhibitor, DMAT, in a malignant megakaryoblastic leukemia cell line (MEG-01). Treated cells grew at a significantly lower rate than non-treated cells. Apoptosis was induced by DMAT in MEG-01 cells, dose and time dependent. When stimulated with …

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